Нейрокс Таблетки, 50 шт, 125 мг, в пленочной оболочке

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На поперечном разрезе ядро\nбелого или белого с желтоватым оттенком цвета."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"антиоксидантное\nсредство."}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакодинамика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Этилметилгидроксипиридина\nсукцинат является ингибитором свободнорадикальных процессов, мембранопротектором,            обладающим антигипоксическим,\nстресс-протекторным, ноотропным, противосудорожным и анксиолитическим\nдействием. Этилметилгидроксипиридина сукцинат повышает резистентность организма\nк воздействию различных повреждающих факторов (шок, гипоксия и ишемия,\nнарушения мозгового кровообращения, интоксикация алкоголем и антипсихотическими\nсредствами (нейролептиками)."}},{"type":"paragraph","data":{"text":"Механизм\nдействия этилметилгидроксипиридина сукцината обусловлен его антиоксидантным,\nантигипоксантным и мембранопротекторным действием. Он ингибирует перекисное\nокисление липидов, повышает активность супероксиддисмутазы, повышает соотношение липид-белок,\nуменьшает вязкость мембраны, увеличивает ее текучесть.\nЭтилметилгидроксипнридина сукцинат модулирует активность мембраносвязанных\nферментов (кальций независимой фосфодиэстеразы, аденилатциклазы, ацетилхолинового),\nрецепторных комплсксов (бензодиазепинового, гамма-аминомасляной кислоты,\nацетилхолинового), что усиливает их способность связывания с лигандами,\nспособствует сохранению структурно-функциональной организации биомембран,\nтранспорта нейромедиаторов и улучшению синаптической передачи. Этилметилгидроксипиридина\nсукцинат повышает содержание в головном мозге дофамина. Вызывает усиление компенсаторной\nактивации аэробного гликолиза и снижение степени угнетения окислительных\nпроцессов в цикле Кребса в условиях гипоксии с увеличением содержания аденозинтрифосфата\nи креатинфосфата, активацию энергосинтезирующих функций митохондрий,\nстабилизацию клеточных мембран. "}},{"type":"paragraph","data":{"text":"Улучшает\nметаболизм и кровоснабжение головного мозга, улучшает микроциркуляцию и реологические свойства крови, уменьшает\nагрегацию тромбоцитов. Стабилизирует мембранные структуры крови (эритроцитов\nи тромбоцитов) при гемолизе. Обладает гиполипидемическим действием, уменьшает\nсодержание общего холестерина и липопротеидов низкой плотности."}},{"type":"paragraph","data":{"text":"Антистрессорное\nдействие проявляется в нормализации постстрессового поведения, соматовегетативных нарушений, восстановлении\nциклов сон-бодрствование, нарушенных процессов обучения и памяти, снижении\nдистрофических и морфологических изменений в различных структурах головного\nмозга."}},{"type":"paragraph","data":{"text":"Этилметилгидроксипиридина\nсукцинат обладает выраженным антитоксическим действием при абстинентном\nсиндроме. Устраняет неврологические и нейротоксические проявления острой\nалкогольной интоксикации, восстанавливает нарушения поведения, вегетативные\nфункции, а также способен снимать когнитивные нарушения, вызванные длительным\nприемом этанола и его отменой. Под влиянием этилмстилгидроксипиридина сукцината\nусиливается действие транквилизирующих, нейролептических, антидепрессивных,\nснотворных и противосудорожных средств, что позволяет снизить их дозы и\nуменьшить побочные эффекты. Этилметилгидроксипиридина сукцинат улучшает\nфункциональное состояние ишемизированного миокарда. В условиях коронарной\nнедостаточности увеличивает коллатеральное кровоснабжение ишемизированного\nмиокарда, способствует сохранению целостности кардимиоцитов и поддержанию их\nфункциональной активности. Эффективно восстанавливает сократимость миокарда при\nобратимой сердечной дисфункции."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Быстро\nвсасывается при приеме внутрь, максимальная концентрация при дозах 400-500 мг\nсоставляет 3,5-4,0 мкг/мл. быстро распределяется в органах и тканях, среднее\nвремя удержания препарата в организме при приеме внутрь 4.9-5.2 ч.\nметаболизируется в печени путем глюкуронконъюгирования. Идентифицировано 5\nметаболитов: 3-оксипиридина фосфат — образуется в печени и при участии щелочной\nфосфатазы распадается па фосфорную кислоту и з-оксипиридип; 2-й метаболит — фармакологически\nактивный, образуется в 60льших количествах и обнаруживается в моче на 1-2 сут\nпосле введения; 3-й — выводится в больших количествах с мочой; 4-й и 5-й — глюкуронконъюгаты.\nТ\u003csub\u003e1/2\u003c/sub\u003e при приеме внутрь — 2,0-2,6 ч. быстро выводится с мочой в\nосновном в виде метаболитов и в незначительном количестве — в неизмененном виде.\nНаиболее интенсивно выводится в течение\nпервых 4 ч после приема препарата. Показатели выведения с мочой\nнеизмененного препарата и метаболитов имеют индивидуальную вариабельность."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"·     последствия\nострых нарушений мозгового кровообращения, в том числе после транзиторных\nишемических атак, в фазе субкомпенсации в качестве профилактических\nкурсов;"}},{"type":"paragraph","data":{"text":"·     легкая\nчерепно-мозговая травма, послсдствия чсрепно-мозговых травм;"}},{"type":"paragraph","data":{"text":"·     энцефалопатии различного\nгенеза (дисциркуляторные, дисметаболичсские, посттравматические, смешанные);"}},{"type":"paragraph","data":{"text":"·     синдром\nвегетативной дистонии,"}},{"type":"paragraph","data":{"text":"·     легкие\nкогнитивные расстройства атеросклеротического генеза; "}},{"type":"paragraph","data":{"text":"·     тревожные\nрасстройства при невротических и неврозоподобных состояниях;"}},{"type":"paragraph","data":{"text":"·     ишемическая\nболезнь сердца в составе комплексной терапии; "}},{"type":"paragraph","data":{"text":"·     купирование\nабстипентнoго синдрома при\nалкоголизме с преобладанием неврозоподобных и вегетативно-сосудистых расстрoйств,\nпостабстинентные расстройства; "}},{"type":"paragraph","data":{"text":"·     состояния после\nострой интоксикации антипсихотическими средствами; "}},{"type":"paragraph","data":{"text":"·     астенические\nсостояния, а также для профилактики развития соматических заболеваний под воздействием\nэкстремальных факторов и нагрузок;"}},{"type":"paragraph","data":{"text":"·     воздействие\nэкстремальных (стрессорных) факторов."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Острая печеночная\nи/или почечная недостаточность, повышенная индивидуальная чувствительность к\nпрепарату. В связи с недостаточной изученностью действия препарата — детский возраст, беременность, грудное вскармливание. Непереносимость\nлактозы, дефицит лактазы и синдром глюкозо-галактозной мальабсорбции."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Препарат противопоказан при беременности\nи в период грудного вскармливания в связи с недостаточными данными по\nэффективности и безопасности препарата в данные периоды."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, по 125-250 мг З раза в сутки."}},{"type":"paragraph","data":{"text":"Начальная доза 125-250 мг (l-2 таблетки) 1-2\nраза в сутки с постепенным повышением до получения терапевтического эффекта;\nмаксимальная суточная доза — 800 мг,"}},{"type":"paragraph","data":{"text":"Длительность лечения — 2-6 нед; для\nкупирования алкогольной абстиненции — 5-7 дней. "}},{"type":"paragraph","data":{"text":"Лечение\nпрекращают постепенно, уменьшая дозу в течение 2-3 дней."}},{"type":"paragraph","data":{"text":"Продолжительность\nкурса терапии у пациентов с ишемической болезнью сердца не менее 1,5-2 месяцев,\nПовторные курсы (по рекомендации врача), желательно проводить в весенне-осенние\nпериоды."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Возможно появление\nиндивидуальных побочных реакций: диспептического или диспепсического характера,\nаллергических реакций."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При\nпередозировке возможно развитие сонливости."}},{"type":"paragraph","data":{"text":"В связи с низкой\nтоксичностью передозировка маловероятна. Лечение, как правило, не требуется —\nсимптомы исчезают самостоятельно в течение суток. При выраженных проявлениях\nпроводится поддерживающее и симптоматическое лечение."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Нейрокс\nсочетается со всеми препаратами, используемыми для лечения соматических\nзаболеваний. Усиливает действие бензодиазепиновых препаратов, антидепрессантов,\nанксиолитикoв,\nпротивосудорожных средств и противопаркинсонических средств. Уменьшает\nтоксические эффекты этилового спирта."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В\nпериод лечения необходимо соблюдать осторожность при вождении транспорта и\nзанятии другими потенциально опасными видами деятельности, требующими\nповышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки,\nпокрытые пленочной оболочкой, 125 мг"}},{"type":"paragraph","data":{"text":"По 10 таблеток в\nконтурной ячейковой упаковке из пленки ПВХ/ПЭ/ПВДХ белой и фольги алюминиевой\nпечатной лакированной."}},{"type":"paragraph","data":{"text":"1, 3 или 5\nконтурных ячейковых упаковок вместе с инструкцией по применению в пачке из\nкартона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от\nсвета месте при температуре не выше 25 \u003csup\u003eо \u003c/sup\u003eс. "}},{"type":"paragraph","data":{"text":"Хранить в недоступном\nдля детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не применять\nпо истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по\nрецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО «Рафарма», Россия"}},{"type":"paragraph","data":{"text":"Липецкая обл., Тербунский\nрайон, поселение Тербунский с/с, с. Тербуны, ул. Дорожная, д. 6А"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО «ФармФирма «Сотекс»"}},{"type":"paragraph","data":{"text":"141345, Россия,\nМосковская область, Сергиево-Посадский муниципальный район, сельское поселение Березняковское,\nпос. Беликово, д. 11"}},{"type":"paragraph","data":{"text":"Т./ф.:\n+7(495) 956-29-30"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаЭтилметилгидроксипиридина сукцинат является ингибитором свободнорадикальных процессов, мембранопротектором, обладающим антигипоксическим, стресс-протекторным, ноотропным, противосудорожным и анксиолитическим действием. Этилметилгидроксипиридина сукцинат повышает резистентность организма к воздействию различных повреждающих факторов (шок, гипоксия и ишемия, нарушения мозгового кровообращения, интоксикация алкоголем и антипсихотическими средствами (нейролептиками). Механизм действия этилметилгидроксипиридина сукцината обусловлен его антиоксидантным, антигипоксантным и мембранопротекторным действием. Он ингибирует перекисное окисление липидов, повышает активность супероксиддисмутазы, повышает соотношение липид-белок, уменьшает вязкость мембраны, увеличивает ее текучесть. Этилметилгидроксипнридина сукцинат модулирует активность мембраносвязанных ферментов (кальций независимой фосфодиэстеразы, аденилатциклазы, ацетилхолинового), рецепторных комплсксов (бензодиазепинового, гамма-аминомасляной кислоты, ацетилхолинового), что усиливает их способность связывания с лигандами, способствует сохранению структурно-функциональной организации биомембран, транспорта нейромедиаторов и улучшению синаптической передачи. Этилметилгидроксипиридина сукцинат повышает содержание в головном мозге дофамина. Вызывает усиление компенсаторной активации аэробного гликолиза и снижение степени угнетения окислительных процессов в цикле Кребса в условиях гипоксии с увеличением содержания аденозинтрифосфата и креатинфосфата, активацию энергосинтезирующих функций митохондрий, стабилизацию клеточных мембран. Улучшает метаболизм и кровоснабжение головного мозга, улучшает микроциркуляцию и реологические свойства крови, уменьшает агрегацию тромбоцитов. Стабилизирует мембранные структуры крови (эритроцитов и тромбоцитов) при гемолизе. Обладает гиполипидемическим действием, уменьшает содержание общего холестерина и липопротеидов низкой плотности. Антистрессорное действие проявляется в нормализации постстрессового поведения, соматовегетативных нарушений, восстановлении циклов сон-бодрствование, нарушенных процессов обучения и памяти, снижении дистрофических и морфологических изменений в различных структурах головного мозга. Этилметилгидроксипиридина сукцинат обладает выраженным антитоксическим действием при абстинентном синдроме. Устраняет неврологические и нейротоксические проявления острой алкогольной интоксикации, восстанавливает нарушения поведения, вегетативные функции, а также способен снимать когнитивные нарушения, вызванные длительным приемом этанола и его отменой. Под влиянием этилмстилгидроксипиридина сукцината усиливается действие транквилизирующих, нейролептических, антидепрессивных, снотворных и противосудорожных средств, что позволяет снизить их дозы и уменьшить побочные эффекты. Этилметилгидроксипиридина сукцинат улучшает функциональное состояние ишемизированного миокарда. В условиях коронарной недостаточности увеличивает коллатеральное кровоснабжение ишемизированного миокарда, способствует сохранению целостности кардимиоцитов и поддержанию их функциональной активности. Эффективно восстанавливает сократимость миокарда при обратимой сердечной дисфункции.ФармакокинетикаБыстро всасывается при приеме внутрь, максимальная концентрация при дозах 400-500 мг составляет 3,5-4,0 мкг/мл. быстро распределяется в органах и тканях, среднее время удержания препарата в организме при приеме внутрь 4.9-5.2 ч. метаболизируется в печени путем глюкуронконъюгирования. Идентифицировано 5 метаболитов: 3-оксипиридина фосфат — образуется в печени и при участии щелочной фосфатазы распадается па фосфорную кислоту и з-оксипиридип; 2-й метаболит — фармакологически активный, образуется в 60льших количествах и обнаруживается в моче на 1-2 сут после введения; 3-й — выводится в больших количествах с мочой; 4-й и 5-й — глюкуронконъюгаты. Т1/2при приеме внутрь — 2,0-2,6 ч. быстро выводится с мочой в основном в виде метаболитов и в незначительном количестве — в неизмененном виде. Наиболее интенсивно выводится в течение первых 4 ч после приема препарата. 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