Ингавирин Сироп, 1 шт, 90 мл, 6 мг / мл, для приема внутрь, для детей

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свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакодинамика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Противовирусный препарат."}},{"type":"paragraph","data":{"text":"В доклинических и клинических исследованиях показана эффективность\nпрепарата Ингавирин в отношении вирусов гриппа типа A (A(H1N1), в\nт.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В,\nаденовируса, вируса парагриппа, респираторно-синцитиального вируса; в\nдоклинических исследованиях: коронавируса, метапневмовируса, энтеровирусов, в\nтом числе вируса Коксаки и риновируса."}},{"type":"paragraph","data":{"text":"Ингавирин снижает вирусную нагрузку, ускоряет элиминацию\nвирусов, сокращает продолжительность болезни, снижает риск развития осложнений.\nМеханизм действия реализуется на уровне инфицированных клеток за счет активации\nфакторов врожденного иммунитета, подавляемых вирусными белками. В\nэкспериментальных исследованиях, в частности, показано, что препарат Ингавирин повышает экспрессию рецептора интерферона первого типа IFNAR на поверхности\nэпителиальных и иммунокомпетентных клеток. Увеличение плотности интерфероновых\nрецепторов приводит к повышению чувствительности клеток к сигналам эндогенного\nинтерферона. Процесс сопровождается активацией (фосфорилированием)\nбелка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза\nпротивовирусных генов. Показано, что в условиях инфекции препарат активирует\nсинтез антивирусного эффекторного белка МхА (ранний фактор противовирусного\nответа, ингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов\nразличных вирусов) и фосфорилированной формы PKR, подавляющей трансляцию вирусных\nбелков, таким образом замедляя и останавливая процесс вирусной репродукции. "}},{"type":"paragraph","data":{"text":"\nДействие препарата Ингавирин заключается в значительном уменьшении\nпризнаков цитопатического и цитодеструктивного действия вируса, снижении\nколичества инфицированных клеток, ограничении патологического процесса,\nнормализации состава и структуры клеток и морфологической картины тканей в зоне\nинфекционного процесса, как на ранних, так и на поздних его стадиях. Противовоспалительное\nдействие обусловлено подавлением продукции ключевых провоспалительных цитокинов\n(фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением активности миелопероксидазы."}},{"type":"paragraph","data":{"text":"В экспериментальных исследованиях показано, что совместное использование\nпрепарата Ингавирин с антибиотиками повышает эффективность терапии\nна модели бактериального сепсиса, в том числе вызванного\nпенициллин-резистентными штаммами стафилококка."}},{"type":"paragraph","data":{"text":"Проведенные экспериментальные токсикологические исследования свидетельствуют\nо низком уровне токсичности и высоком профиле безопасности препарата."}},{"type":"paragraph","data":{"text":"По параметрам острой токсичности препарат Ингавирин относится к\n4 классу токсичности ‒ «Малотоксичные вещества» (при определении LD\u003csub\u003e50\u003c/sub\u003e в экспериментах по острой токсичности летальные дозы\nпрепарата определить не удалось)."}},{"type":"paragraph","data":{"text":"Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и\nканцерогенными свойствами, не оказывает местнораздражающего действия. Препарат\nИнгавирин не влияет на репродуктивную функцию, не оказывает\nэмбриотоксического и тератогенного действия."}},{"type":"paragraph","data":{"text":"Отсутствует влияние препарата Ингавирин на систему\nкроветворения при приеме соответствующей возрасту дозы рекомендованными схемой\nи курсом."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Всасывание и распределение"}},{"type":"paragraph","data":{"text":"В эксперименте с использованием радиоактивной метки установлено: действующее\nвещество быстро поступает в кровь из желудочно-кишечного тракта, распределяясь\nпо внутренним органам. В исследовании у здоровых добровольцев при однократном\nприеме препарата в дозе    90 мг максимальная\nконцентрация (C\u003csub\u003emax\u003c/sub\u003e) составила 441,45 ± 252,99 нг/мл; время ее\nдостижения (T\u003csub\u003emax\u003c/sub\u003e) – 1,30 ± 0,41 часа."}},{"type":"paragraph","data":{"text":"В доклинических исследованиях было установлено, что при курсовом приеме\nпрепарата один раз в сутки происходит его накопление во внутренних органах и\nтканях. При этом качественные характеристики фармакокинетических кривых после\nкаждого введения препарата тождественны: быстрое повышение концентрации\nпрепарата после каждого введения через 0,5-1 час после приема и затем медленное снижение к 24 часам. Величины AUC (площадь под фармакокинетической кривой «концентрация‒время»)\nпочек, печени и легких незначительно превышают AUC крови. Величины AUC для\nселезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Препарат не метаболизируется в организме и выводится в неизмененном виде."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"В исследовании у здоровых добровольцев при однократном приеме препарата в\nдозе 90 мг период полувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) составил 1,82 ± 0,23 часа. В\nдоклинических исследованиях было установлено, что основной процесс выведения\nпроисходит в течение 24 часов. За этот период выводится 80 % принятой дозы:\n34,8 % выводится во временном интервале от 0 до 5 часов и 45,2 % во временном\nинтервале от 5 до 24 часов. Из них 77 % выводится через кишечник и     23 % ‒ через почки."}}]},{"id":30,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Лечение и профилактика гриппа А и В и других острых респираторных вирусных\nинфекций (аденовирусная инфекция, парагрипп, респираторно-синцитиальная\nинфекция, риновирусная инфекция) у взрослых и детей от 3 лет."}}]},{"id":31,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к действующему веществу или любому другому\nкомпоненту препарата."}},{"type":"paragraph","data":{"text":"Дефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная\nмальаб-сорбция."}},{"type":"paragraph","data":{"text":"Беременность."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания."}},{"type":"paragraph","data":{"text":"Детский возраст до 3 лет."}}]},{"id":33,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата во время беременности не изучалось."}},{"type":"paragraph","data":{"text":"Применение препарата во время лактации не изучалось, поэтому при\nнеобходимости применения препарата в период грудного вскармливания следует\nпрекратить грудное вскармливание."}}]},{"id":34,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь. Независимо от приема пищи."}},{"type":"paragraph","data":{"text":"Плотно вставьте\nмерный шприц в горлышко флакона. Переверните флакон вверх дном и плавно\nпотяните поршень вниз, набирая сироп до нужной отметки. После употребления\nпромойте шприц в теплой воде и высушите его."}},{"type":"paragraph","data":{"text":"Для лечения и профилактики гриппа и острых респираторных вирусных инфекций\nвзрослым назначают по 90 мг (15 мл) 1 раз в день, детям от 7 лет ‒ по 60 мг (10\nмл) 1 раз в день, детям от 3 до 6 лет ‒ по 30 мг (5 мл) 1 раз в день."}},{"type":"paragraph","data":{"text":"Длительность лечения гриппа и острых респираторных вирусных инфекций у\nвзрослых и детей от 7 лет ‒ 5\u003cb\u003e-\u003c/b\u003e7 дней (в зависимости от тяжести\nсостояния). Длительность лечения гриппа и острых респираторных вирусных\nинфекций у детей от 3 до 6 лет ‒ 5 дней. "}},{"type":"paragraph","data":{"text":"Прием препарата начинают с момента появления первых симптомов заболевания,\nжелательно не позднее 2 суток от начала болезни."}},{"type":"paragraph","data":{"text":"Взрослым и детям при выраженных симптомах, а также при наличии сопутствующих\nзаболеваний (болезни дыхательной и сердечно-сосудистой систем, сахарный диабет,\nожирение), следует принимать двойную дозу препарата в первые 3 дня заболевания,\nдалее продолжить приём в обычной дозировке в течение 2-4 дней."}},{"type":"paragraph","data":{"text":"Для профилактики гриппа и острых респираторных вирусных инфекций после\nконтакта с больными лицами взрослым и детям от 7 лет препарат назначают в\nтечение 7 дней, детям от 3 до   6 лет ‒ в\nтечение 5 дней."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли через 5 дней лечения улучшения не наступает или симптомы усугубляются,\nили появляются новые симптомы, необходимо проконсультироваться с врачом.\nПрименяйте препарат только согласно тем показаниям, тому способу применения и в\nтех дозах, которые указаны в инструкции.\u003c/i\u003e"}}]},{"id":35,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции (редко)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли любые из указанных в инструкции побочных эффектов усугубляются или Вы\nзаметили любые другие побочные эффекты, не указанные в инструкции, сообщите об\nэтом врачу.\u003c/i\u003e"}}]},{"id":36,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"О случаях передозировки препарата Ингавирин до настоящего\nвремени не сообщалось."}}]},{"id":37,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Лекарственное взаимодействие препарата Ингавирин не описано."}}]},{"id":38,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не рекомендуется одновременный прием других противовирусных препаратов без\nпредварительной консультации врача."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСохраняйте инструкцию. Она может\nпонадобиться вновь. Если у Вас возникли вопросы, обратитесь к врачу.\u003c/i\u003e"}}]},{"id":39,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не изучалось, однако, учитывая механизм действия и профиль побочных\nреакций, можно предположить, что препарат не оказывает влияния на способность\nуправлять транспортными средствами, механизмами."}}]},{"id":40,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Сироп 30 мг/5 мл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФасовка и упаковка на \u003c/i\u003e\u003ci\u003eABC\u003c/i\u003e\u003ci\u003e Фармацойтичи С.п.А., Италия: \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По 50 мл или по 90 мл\nво флаконы коричневого цвета из полиэтилентерефталата, снабженные\nкольцом-адаптером, укупоренные крышками винтовыми из полипропилена с контролем\nпервого вскрытия и защитой от вскрытия детьми."}},{"type":"paragraph","data":{"text":"Один флакон вместе с\nмерным шприцем и инструкцией по применению помещают в пачку из картона."}},{"type":"paragraph","data":{"text":"\u003ci\u003eУпаковка на АО «Валента Фарм», Россия: \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Один флакон вместе с\nмерным шприцем и инструкцией по применению помещают в пачку из картона."}}]},{"id":41,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В оригинальной упаковке при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"После вскрытия флакона хранить не более 7 дней."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":42,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года"}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":43,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":44,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО «Валента Фарм»"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаПротивовирусный препарат. В доклинических и клинических исследованиях показана эффективность препарата Ингавирин в отношении вирусов гриппа типа A (A(H1N1), в т.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В, аденовируса, вируса парагриппа, респираторно-синцитиального вируса; в доклинических исследованиях: коронавируса, метапневмовируса, энтеровирусов, в том числе вируса Коксаки и риновируса. Ингавирин снижает вирусную нагрузку, ускоряет элиминацию вирусов, сокращает продолжительность болезни, снижает риск развития осложнений. Механизм действия реализуется на уровне инфицированных клеток за счет активации факторов врожденного иммунитета, подавляемых вирусными белками. В экспериментальных исследованиях, в частности, показано, что препарат Ингавирин повышает экспрессию рецептора интерферона первого типа IFNAR на поверхности эпителиальных и иммунокомпетентных клеток. Увеличение плотности интерфероновых рецепторов приводит к повышению чувствительности клеток к сигналам эндогенного интерферона. Процесс сопровождается активацией (фосфорилированием) белка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза противовирусных генов. Показано, что в условиях инфекции препарат активирует синтез антивирусного эффекторного белка МхА (ранний фактор противовирусного ответа, ингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов различных вирусов) и фосфорилированной формы PKR, подавляющей трансляцию вирусных белков, таким образом замедляя и останавливая процесс вирусной репродукции. Действие препарата Ингавирин заключается в значительном уменьшении признаков цитопатического и цитодеструктивного действия вируса, снижении количества инфицированных клеток, ограничении патологического процесса, нормализации состава и структуры клеток и морфологической картины тканей в зоне инфекционного процесса, как на ранних, так и на поздних его стадиях. Противовоспалительное действие обусловлено подавлением продукции ключевых провоспалительных цитокинов (фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением активности миелопероксидазы. В экспериментальных исследованиях показано, что совместное использование препарата Ингавирин с антибиотиками повышает эффективность терапии на модели бактериального сепсиса, в том числе вызванного пенициллин-резистентными штаммами стафилококка. Проведенные экспериментальные токсикологические исследования свидетельствуют о низком уровне токсичности и высоком профиле безопасности препарата. По параметрам острой токсичности препарат Ингавирин относится к 4 классу токсичности ‒ «Малотоксичные вещества» (при определении LD50в экспериментах по острой токсичности летальные дозы препарата определить не удалось). Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и канцерогенными свойствами, не оказывает местнораздражающего действия. Препарат Ингавирин не влияет на репродуктивную функцию, не оказывает эмбриотоксического и тератогенного действия. Отсутствует влияние препарата Ингавирин на систему кроветворения при приеме соответствующей возрасту дозы рекомендованными схемой и курсом.ФармакокинетикаВсасывание и распределение В эксперименте с использованием радиоактивной метки установлено: действующее вещество быстро поступает в кровь из желудочно-кишечного тракта, распределяясь по внутренним органам. В исследовании у здоровых добровольцев при однократном приеме препарата в дозе 90 мг максимальная концентрация (Cmax) составила 441,45 ± 252,99 нг/мл; время ее достижения (Tmax) – 1,30 ± 0,41 часа. В доклинических исследованиях было установлено, что при курсовом приеме препарата один раз в сутки происходит его накопление во внутренних органах и тканях. При этом качественные характеристики фармакокинетических кривых после каждого введения препарата тождественны: быстрое повышение концентрации препарата после каждого введения через 0,5-1 час после приема и затем медленное снижение к 24 часам. Величины AUC (площадь под фармакокинетической кривой «концентрация‒время») почек, печени и легких незначительно превышают AUC крови. Величины AUC для селезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови. Метаболизм Препарат не метаболизируется в организме и выводится в неизмененном виде. Выведение В исследовании у здоровых добровольцев при однократном приеме препарата в дозе 90 мг период полувыведения (Т1/2) составил 1,82 ± 0,23 часа. В доклинических исследованиях было установлено, что основной процесс выведения происходит в течение 24 часов. За этот период выводится 80 % принятой дозы: 34,8 % выводится во временном интервале от 0 до 5 часов и 45,2 % во временном интервале от 5 до 24 часов. 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