Болевой синдром (головная, зубная, менструальная, посттравматическая и послеоперационная боль), лихорадка различного происхождения (при острых респираторных вирусных инфекциях, других инфекционно-воспалительных заболеваниях). Воспалительные заболевания опорно-двигательного аппарата - артриты, остеоартриты, тендовагиниты, бурситы, миозиты.
Противопоказания
Эрозивно-язвенные поражения ЖКТ (в фазе обострения). Желудочно-кишечное кровотечение. «Аспириновая астма». Печёночная недостаточность. Почечная недостаточность (при клиренсе креатинина <30 мл/мин). Гиперчувствительность к нимесулиду и другим НПВП. Беременность (III триместр). Кормление грудью. Детский возраст (до 12 лет).
Инструкция
Регистрационный номер
П N014987/01
Торговое название препарата
Апонил
Лекарственная форма
таблетки
Состав
Каждая таблетка содержит 100 мг нимесулида и вспомогательные вещества (лактозы моногидрат, целлюлоза микрокристаллическая, натрия докузат, крахмал, натрия гликолят, гидроксипропилцеллюлоза, гидрогенизированное растительное масло, магния стеарат).
Описание
Белые с желтоватым оттенком, круглые, плоские таблетки с риской с одной стороны
НПВП. Селективный ингибитор циклооксигеназы-2 (ЦОГ-2). Препарат оказывает противовоспалительное, анальгезирующее и жаропонижающее действие, механизм которого обусловлен селективным ингибированием ЦОГ-2, что приводит к снижению синтеза простагландинов в очаге воспаления, а также в гипоталамусе. Влияние на синтез простагландинов в слизистой оболочке желудка и почках значительно менее выражено, что обуславливает хорошую переносимость нимесулида. Препарат также угнетает перекисное окисление липидов и образование свободных кислородных радикалов, снижает образование фактора активации тромбоцитов, фактора некроза опухоли альфа, высвобождение гистамина, протеиназ и некоторых других медиаторов воспаления.
Показания к применению
Болевой синдром (головная, зубная, менструальная, посттравматическая и послеоперационная боль), лихорадка различного происхождения (при острых респираторных вирусных инфекциях, других инфекционно-воспалительных заболеваниях). Воспалительные заболевания опорно-двигательного аппарата - артриты, остеоартриты, тендовагиниты, бурситы, миозиты.
Противопоказания
Эрозивно-язвенные поражения ЖКТ (в фазе обострения). Желудочно-кишечное кровотечение. «Аспириновая астма». Печёночная недостаточность. Почечная недостаточность (при клиренсе креатинина <30 мл/мин). Гиперчувствительность к нимесулиду и другим НПВП. Беременность (III триместр). Кормление грудью. Детский возраст (до 12 лет).
С осторожностью
С осторожностью применять при артериальной гипертензии сердечной недостаточности, сахарном диабете 2 типа.
Применение при беременности и в период грудного вскармливания
Хотя эмбриотоксическое и тератогенное действие нимесулида не описано, при беременности препарат может быть назначен только в том случае, когда предполагаемая польза для матери превышает возможный риск для плода. В период лактации назначать нимесулид не рекомендуется.
Способ применения и дозы
Разовая доза для взрослых составляет 50-200 мг (в среднем 100 мг, максимальная доза - 400 мг в сутки), для детей - 1,5 мг/кг (не более 100 мг, максимальная доза - 5 мг/кг в сутки). Принимается внутрь 2 раза в день после еды, запивается водой.
Побочное действие
Со стороны пищеварительной системы: повышение активности «печеночных» трансаминаз, боли в эпигастральной области, изъязвление слизистой оболочки ЖКТ, диарея, изжога, тошнота, рвота (редко).
Со стороны центральной нервной системы: головная боль, головокружение, сонливость.
Со стороны мочевыделителъной системы (редко): гематурия, олигурия, задержка жидкости, отёки.
Со стороны системы крови: тромбоцитопения, лейкопения, анемия, агранулоцитоз, удлинение времени кровотечения.
Аллергические реакции: кожная сыпь, крапивница, анафилактический шок.
Передозировка
Передозировка препарата не описана. Возможно появление тошноты и рвоты. Для лечения рекомендуется промывание желудка, назначение адсорбентов, инфузионной терапии, осмотических диуретиков и симптоматических средств.
Взаимодействие с другими лекарственными средствами
Нимесулид вытесняется из связи с белками ацетилсалициловой кислотой, которая повышает концентрацию свободного нимесулида в плазме крови в 2-3 раза. Конкуренция за связь с белками возможна также при сочетании нимесулида с пероральными гипогликемизирующими средствами (толбутамидом), другими сульфаниламидами, гидантоином, препаратами наперстянки (дигоксином), циклоспорином, метотрексатом. При одновременном применении непрямых антикоагулянтов возможно усиление их действия. При сочетании с солями лития нимесулид повышает их концентрацию в плазме крови.
Особые указания
Нимесулид должен применяться с осторожностью и в уменьшенных дозах при хронической почечной недостаточности и других заболеваниях почек, при сниженной функции печени, язвенной болезни желудка или двенадцатиперстной кишки в анамнезе, системной красной волчанке, хронической сердечной недостаточности, применении диуретиков, антикоагулянтов, а также у больных пожилого возраста. При назначении нимесулида у больных с непереносимостью других НПВП возможна аллергия.
Форма выпуска
Таблетки по 100 мг.
По 10 таблеток в блистер из пленки поливинилхлоридной и алюминиевой фольги. По 1, 2, 10 блистеров вместе с инструкцией по применению в пачку картонную.
Условия хранения
В сухом, защищенном от света месте при температуре до 25°С. Беречь от детей. Не использовать по истечению срока годности.
Срок годности
3 года.
Условия отпуска
По рецепту
Производитель
«Медокеми Лтд»
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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