Основным действующим компонентом препарата является сумма фл... Инструкция
Показания к применению
Принимают при токсических повреждениях печени, хроническом гепатите, циррозе печени (в составе комплексной терапии), после перенесенного гепатита
Профилактически применяют при хронических интоксикациях (в том числе профессиональных), длительном приеме лекарственных препаратов и алкоголя
Противопоказания
Индивидуальная непереносимость, повышенная чувствительность к компонентам препарата, беременность, период грудного вскармливания, детский возраст до 12 лет, непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция
Инструкция
Состав
Таблетки - 1 таб.:Активный компонент: Расторопши пятнистой плодов экстракт сухой (Силимарин экстракт сухой) (с содержанием суммы флаволигнанов в пересчете на силибин не менее 65%) - 100,0 мг;
Таблетки круглой, двояковыпуклой формы, от светло-коричневого до коричневого цвета, с вкраплениями
Фармакологические свойства
Основным действующим компонентом препарата является сумма флаволигнанов (силимарин), получаемых из плодов расторопши пятнистой Silybum marianum (L.) Gaerth сем. астровые - Asteraceae (в том числе силибинин, изосилибинин, силидианин, силикристин)
Фармакодинамика Препарат обладает гепатопротективным и антитоксическим действием
Лечебный эффект обусловлен воздействием на метаболизм гепатоцитов. Активизирует синтез белков и ферментов в гепатоцитах, оказывает стабилизирующее воздействие на мембрану гепатоцитов, тормозит проникновение токсинов в клетки печени, ингибирует дистрофические и потенцирует регенеративные процессы печени
Адсорбция силибинина довольно низкая и только 2-3% выделяются с желчью в течение первых 24 часов. В результате расщепления кишечной микрофлорой до 40% выделившегося с желчью силибинина вновь реабсорбируется, в результате чего имеет место энтеро-печеночная циркуляция. Пик силибинина в плазме после перорального приема достигается через 3-4 часа. Силимарин выводится из организма преимущественно с желчью и, в меньшей степени, почками. Время полувыведения - от 6 до 8 часов. Не кумулирует в организме
Показания к применению
Принимают при токсических повреждениях печени, хроническом гепатите, циррозе печени (в составе комплексной терапии), после перенесенного гепатита
Профилактически применяют при хронических интоксикациях (в том числе профессиональных), длительном приеме лекарственных препаратов и алкоголя
Противопоказания
Индивидуальная непереносимость, повышенная чувствительность к компонентам препарата, беременность, период грудного вскармливания, детский возраст до 12 лет, непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция
С осторожностью
Пациенты с сахарным диабетом, детский возраст с 12
Побочное действие
Возможны аллергические реакции, в отдельных случаях послабляющее действие
При появлении побочных эффектов, не описанных в данной инструкции, следует прекратить прием препарата и сообщить об этом лечащему врачу
Взаимодействие с другими лекарственными средствами
При совместном применении препарата с пероральными контрацептивами и препаратами, которые используются при гормональной заместительной терапии, возможно уменьшение эффектов последнихПрепарат может усилить эффекты таких лекарственных средств, как диазепам, алпрозолам, кетоконазол, ловастатин, винбластин из-за его подавляющего действия на систему изоферментов цитохрома Р450
Для описания товара использована информация от партнера 36.6
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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