Гастростат Таблетки, коробка, 30 шт, 100 мг, для приема внутрь, покрытые оболочкой

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Оказывает цитопротекторное действие в отношении слизистой желудка при повреждающем воздействии этанола, кислот и щелочей, ацетилсалициловой кислоты. "}},{"type":"paragraph","data":{"text":"Способствует активации энзимов, ускоряющих биосинтез высокомолекулярных гликопротеинов, и повышает содержание слизи на поверхности стенки желудка. "}},{"type":"paragraph","data":{"text":"Способствует улучшению кровоснабжения слизистой желудка, активизирует ее барьерную функцию, активизирует щелочную секрецию желудка, усиливает пролиферацию и обмен эпителиальных клеток желудка, очищает слизистую от гидроксильных радикалов и подавляет супероксиды, продуцируемые полиморфноядерными лейкоцитами и нейтрофилами в присутствии Helicobacter pylori, защищает слизистую желудка от поражения бактериями, оказывает гастропротекторное действие при воздействии  на слизистую нестероидными противовоспалительными препаратами (НПВП)."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"Абсорбция при приеме внутрь – высокая. После приема в дозе 100 мг пик концентрации в плазме крови (С\u003csub\u003emax\u003c/sub\u003e) достигается приблизительно через 2 ч и составляет 340 нг/мл. Период полувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) равен приблизительно 1,0 ч. Повторные приемы препарата не приводят к его кумуляции в организме. "}},{"type":"paragraph","data":{"text":"Приблизительно 10 % препарата выводится почками, преимущественно в неизмененном виде. При приеме в дозе 600 мг удается выделить следы гидроксилированного метаболита."}},{"type":"paragraph","data":{"text":"В опытах in vitro показано, что от 98,4 % до 98,6 % препарата связывается белками плазмы."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Язвенная болезнь желудка. Хронический гастрит с повышенной кислотообразующей функцией желудка в стадии обострения, эрозивный гастрит. Предотвращение возникновения повреждений слизистой оболочки на фоне приема нестероидных противовоспалительных средств. Может использоваться в составе комбинированной терапии."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Безопасность применения ребамипида в период беременности не доказана. Не применять во время беременности. Поскольку ребамипид проникает в грудное молоко, следует прекратить вскармливание или решить вопрос об искусственном вскармливании ребенка в случае необходимости назначения матери ребамипида в период кормления грудью."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nВнутрь, по 1 таблетке 3 раза в сутки, запивая небольшим количеством жидкости. Курс лечения составляет 2-4 недели, в случае необходимости может быть продлен до 8 недель. 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Реакции взаимодействия с другими лекарственными средствами не изучены."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Действие препарата на скорость психомоторных реакций и/или способность управлять транспортными средствами или механизмами не изучено. В случае приема препарата следует с осторожностью относиться к вождению автомобиля и другим видам деятельности, требующим, повышенной концентрации внимания."}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика Ребамипид повышает содержание простагландина Е2 (РGE2) в слизистой желудка и повышает содержание РGE2 и GI2 в содержимом желудочного сока. Оказывает цитопротекторное действие в отношении слизистой желудка при повреждающем воздействии этанола, кислот и щелочей, ацетилсалициловой кислоты. Способствует активации энзимов, ускоряющих биосинтез высокомолекулярных гликопротеинов, и повышает содержание слизи на поверхности стенки желудка. 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