Эссенциальные фосфолипиды Капсулы, 30 шт, 300 мг

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Большая часть их расщепляется фосфолипазой А до 1-ацил-лизофосфатидилхолина 50% которого немедленно подвергается обратному ацетилированию в полиненасыщенный фосфатидилхолин ещё в ходе процесса всасывания в слизистой оболочке кишечника. Этот полиненасыщенный фосфатидилхолин с током лимфы попадает в кровь и оттуда главным образом в связанном с липопротеинами высокой плотности виде поступает в печень."}},{"type":"paragraph","data":{"text":"Исследования фармакокинетики у людей проводились с помощью дилинолеил фосфатидилхолина с радиоактивной меткой (\u003csup\u003e3\u003c/sup\u003eН и \u003csup\u003e14\u003c/sup\u003eС). Холиновая часть была мечена \u003csup\u003e3\u003c/sup\u003eН а остаток линолевой кислоты имел в качестве метки \u003csup\u003e14\u003c/sup\u003eС."}},{"type":"paragraph","data":{"text":"Максимальная концентрация \u003csup\u003e3\u003c/sup\u003eН достигается через 6-24 часа после введения и составляет 199% от назначенной дозы. Период полувыведения холинового компонента составляет 66 часов."}},{"type":"paragraph","data":{"text":"Максимальная концентрация \u003csup\u003e14\u003c/sup\u003eС достигается через 4-12 часов после введения и составляет до 279% от назначенной дозы. Период полувыведения этого компонента составляет 32 часа. В кале обнаруживается 2% от введенной дозы \u003csup\u003e3\u003c/sup\u003eН и 45% от введенной дозы \u003csup\u003e14\u003c/sup\u003eС в моче - 6% от \u003csup\u003e3\u003c/sup\u003eН и лишь минимальное количество \u003csup\u003e14\u003c/sup\u003eС."}},{"type":"paragraph","data":{"text":"Оба изотопа более чем на 90% всасываются в кишечнике."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Гепатит (острый и хронический);"}},{"type":"paragraph","data":{"text":"- жировая дистрофия печени различного генеза (сахарный диабет хронические инфекции);"}},{"type":"paragraph","data":{"text":"- токсический гепатит;"}},{"type":"paragraph","data":{"text":"- алкогольный гепатит;"}},{"type":"paragraph","data":{"text":"- цирроз печени;"}},{"type":"paragraph","data":{"text":"- гестоз;"}},{"type":"paragraph","data":{"text":"- лучевая болезнь;"}},{"type":"paragraph","data":{"text":"- псориаз (в качестве средства вспомогательной терапии);"}},{"type":"paragraph","data":{"text":"- нарушение функции печени при других соматических заболеваниях;"}},{"type":"paragraph","data":{"text":"- профилактика рецидивов образования желчных камней;"}},{"type":"paragraph","data":{"text":"- токсикоз беременности."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Известная повышенная чувствительность к фосфатидилхолину или другим вспомогательным ингредиентам препарата."}},{"type":"paragraph","data":{"text":"Детский возраст до 12 лет (отсутствие достаточной доказательной базы)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Возможно применение препарата при беременности только в случаях когда ожидаемая польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"Не рекомендуется применять в период грудного вскармливания в связи с отсутствием данных о безопасности применения препарата."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"Капсулы следует проглатывать целиком запивая достаточным количеством воды (примерно 1 стакан)."}},{"type":"paragraph","data":{"text":"Для подростков старше 12 лет и с массой тела более 43 кг а также для взрослых препарат рекомендуется принимать по 2 капсулы 3 раза в день во время еды."}},{"type":"paragraph","data":{"text":"Как правило продолжительность применения не ограничена."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Препарат обычно хорошо переносится пациентами."}},{"type":"paragraph","data":{"text":"В целях оценки частоты побочных эффектов используются следующие определения: очень часто (≥ 1/10) часто (≥ 1/100 - < 1/10) нечасто (≥ 1/1000 - < 1/100) редко (≥ 1/10000 - < 1/1000) очень редко (< 1/10000) неизвестная частота (по имеющимся данным не возможно установить частоту возникновения)."}},{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта: в некоторых случаях прием препарата может вызвать желудочный дискомфорт мягкий стул или диарею."}},{"type":"paragraph","data":{"text":"Аллергические реакции: в очень редких случаях возможны кожные аллергические реакции (сыпь экзантема крапивница зуд)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Сообщений о передозировке не было."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"До настоящего времени неизвестны."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"По мере улучшения состояния пациента парентеральное введение заменяют пероральным приемом препарата, содержащего фосфолипиды, в соответствующей лекарственной форме."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не выявлена."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 300 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Озон\" (ООО \"Озон\"), 445351, Самарская обл., г. Жигулёвск, ул. Гидростроителей, д. 6, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Озон\""}}]}],"source":null},"description_toggle":false,"short_description":"Эссенциальные фосфолипиды являются основными структуры оболочки клеток и клеточных органелл. При болезнях печени всегда имеется повреждение оболочек печеночных клеток и их органелл которое приводит к нарушениям активности связанных с ними ферментов и систем рецепторов ухудшению функциональной активности печеночных клеток и снижению способности к регенерации. Фосфолипиды входящие в состав препарата соответствуют по своей химической структуре эндогенным фосфолипидам но превосходят эндогенные фосфолипиды по активности за счет более высокого содержания в них полиненасыщенных (эссенциальных) жирных кислот. Встраивание этих высокоэнергетических молекул в поврежденные участки клеточных мембран гепатоцитов восстанавливает целостность печеночных клеток способствует их регенерации. Цис-двойные связи их полиненасыщенных жирных кислот предотвращают параллельное расположение углеводородных цепей в фосфолипидах клеточных оболочек фосфолипидная структура клеточных оболочек гепатоцитов \"разрыхляется\" что обусловливает повышение их текучести и эластичности улучшает обмен веществ. Образующиеся функциональные блоки повышают активность фиксированных на мембранах ферментов и способствуют нормальному физиологическому пути протекания важнейших метаболических процессов. Фосфолипиды входящие в состав препарата регулируют метаболизм липопротеинов перенося нейтральные жиры и холестерин к местам окисления главным образом это происходит за счет повышения способности липопротеинов высокой плотности связываться с холестерином. Таким образом оказывается нормализующее действие на метаболизм липидов и белков; на дезинтоксикационную функцию печени; на восстановление и сохранение клеточной структуры печени и фосфолипидозависимых ферментных систем; что в конечном итоге препятствует формированию соединительной ткани в печени и способствует естественному восстановлению клеток печени. При экскреции фосфолипидов в желчь происходит снижение литогенного индекса и стабилизация желчи. Более 90% принятых внутрь фосфолипидов всасывается в тонком кишечнике. Большая часть их расщепляется фосфолипазой А до 1-ацил-лизофосфатидилхолина 50% которого немедленно подвергается обратному ацетилированию в полиненасыщенный фосфатидилхолин ещё в ходе процесса всасывания в слизистой оболочке кишечника. Этот полиненасыщенный фосфатидилхолин с током лимфы попадает в кровь и оттуда главным образом в связанном с липопротеинами высокой плотности виде поступает в печень. Исследования фармакокинетики у людей проводились с помощью дилинолеил фосфатидилхолина с радиоактивной меткой (3Н и14С). Холиновая часть была мечена3Н а остаток линолевой кислоты имел в качестве метки14С. Максимальная концентрация3Н достигается через 6-24 часа после введения и составляет 199% от назначенной дозы. Период полувыведения холинового компонента составляет 66 часов. Максимальная концентрация14С достигается через 4-12 часов после введения и составляет до 279% от назначенной дозы. Период полувыведения этого компонента составляет 32 часа. В кале обнаруживается 2% от введенной дозы3Н и 45% от введенной дозы14С в моче - 6% от3Н и лишь минимальное количество14С. 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