симптоматическое лечение боли, спазмов, дисфункции и дискомфорта в области кишечника, связанных с синдромом раздраженного кишечника. Симптомы могут включать: боль в области живота, спазмы, ощущение вздутия и метеоризм, изменение частоты стула (диарея, запор или чередование диареи и запоров), изменение консистенции стула.
Противопоказания
гиперчувствительность к любому компоненту препарата. Возраст до 18 лет. Врожденная непереносимость галактозы (лактозы) или фруктозы, недостаточность лактазы, дефицит сахаразы/изомальтазы, синдром глюкозо-галактозной мальабсорбции. Беременность и период грудного вскармливания.
Инструкция
Регистрационный номер
ЛП-001454
Торговое название препарата
Дюспаталин
Лекарственная форма
таблетки покрытые оболочкой
Состав
1 таблетка, покрытая оболочкой, содержит:
Активное вещество: мебеверина гидрохлорид - 135,0 мг.
Круглые таблетки, покрытые оболочкой, белого цвета.
Фармакотерапевтическая группа
Спазмолитическое средство
Фармакологические свойства
Фармакодинамика:
Спазмолитик миотропного действия оказывает прямое действие на гладкую мускулатуру желудочно-кишечного тракта без влияния на нормальную перистальтику кишечника.
Точный механизм действия неизвестен но множественные механизмы такие как снижение проницаемости ионных каналов блокада обратного захвата норадреналина местное анестезирующее действие а также изменение абсорбции воды могут вызвать местное действие мебеверина на желудочно-кишечный тракт.
Посредством этих механизмов мебеверин обладает спазмолитическим действием нормализуя перистальтику кишечника и не вызывая постоянной релаксации гладкомышечных клеток желудочно-кишечного тракта ("гипотонию").
Системные побочные эффекты в том числе антихолинергические отсутствуют.
Фармакокинетика:
Всасывание
Мебеверин быстро и полностью всасывается после приема внутрь.
Распределение
При приеме повторных доз препарата значительной аккумуляции не происходит.
Метаболизм
Мебеверина гидрохлорид в основном метаболизируется эстеразами которые на первом этапе расщепляют эфир на вератровую кислоту и спирт мебеверина. Основным метаболитом циркулирующим в плазме является деметилированная карбоновая кислота.
Период полувыведения в равновесном состоянии деметилированной карбоновой кислоты составляет приблизительно 245 ч.
При приеме повторных доз максимальная концентрация деметилированной карбоновой кислоты в крови (Сmax) составляет 1670 нг/мл время достижения максимальной концентрации деметилированной карбоновой кислоты в крови (Tmax) - 1 час.
Выведение
Мебеверин как таковой не выводится из организма но полностью метаболизируется; его метаболиты практически полностью выводятся из организма. Вератровая кислота выводится почками. Спирт мебеверина также выводится почками частично в виде карбоновой кислоты и частично в виде деметилированной карбоновой кислоты.
Показания к применению
симптоматическое лечение боли, спазмов, дисфункции и дискомфорта в области кишечника, связанных с синдромом раздраженного кишечника. Симптомы могут включать: боль в области живота, спазмы, ощущение вздутия и метеоризм, изменение частоты стула (диарея, запор или чередование диареи и запоров), изменение консистенции стула.
Противопоказания
гиперчувствительность к любому компоненту препарата. Возраст до 18 лет. Врожденная непереносимость галактозы (лактозы) или фруктозы, недостаточность лактазы, дефицит сахаразы/изомальтазы, синдром глюкозо-галактозной мальабсорбции. Беременность и период грудного вскармливания.
Применение при беременности и в период грудного вскармливания
Не рекомендуется применять Дюспаталин во время беременности. Не следует принимать
Дюспаталин во время кормления грудью.
Способ применения и дозы
для приема внутрь. По одной таблетке 3 раза в день, приблизительно за 20 минут до еды.
Побочное действие
со стороны кожных покровов: крапивница (аллергическая сыпь), ангионевротический отек (серьезная
аллергическая реакция, которая может включать: затруднение дыхания, отечность
лица, шеи, губ, языка, горла), отек лица, экзантема (кожная сыпь). Со
стороны иммунной системы: реакции
гиперчувствительности (анафилактические реакции − серьезные аллергические
реакции, которые могут включать: затруднение дыхания, учащенный пульс, резкое
снижение артериального давления (слабость и головокружение), потоотделение).
Перечень всех побочных эффектов
представлен в инструкции по медицинскому применению.
Передозировка
В случае передозировки препаратом Дюспаталин необходимо незамедлительно обратиться к врачу. Рекомендуется
симптоматическое лечение.
Взаимодействие с другими лекарственными средствами
исследования на животных продемонстрировали
отсутствие какого-либо взаимодействия между препаратом Дюспаталин и
этиловым спиртом.
Особые указания
перед приемом препарата
Дюспаталиннеобходимо проконсультироваться с врачом, в случае:
если симптомы заболевания возникли впервые; непреднамеренной и необъяснимой
потери веса; анемии; ректального кровотечения или примеси крови в стуле;
лихорадки; если у кого-то в вашей семье был диагностирован рак толстой кишки,
целиакия или воспалительные заболевания кишечника; возраста старше 50 лет и
если симптомы заболевания возникли впервые; недавнего применения антибиотиков.
Обратитесь к врачу, если на фоне приема препарата состояние ухудшилось или не
наступило улучшение симптомов после 2 недель применения.
Влияние на способность управлять автомобилем и движущимися механизмами
фармакологические свойства препарата, а также опыт его применения не свидетельствуют о каком-либо неблагоприятном влиянии мебеверина на способность к управлению автомобилем и другими механизмами.
Форма выпуска
Таблетки покрытые оболочкой 135 мг.
Условия хранения
Хранить при температуре не выше 30 °С.
Хранить в недоступном для детей месте.
Срок годности
5 лет.
Не применять по истечении срока годности указанного на упаковке.
Условия отпуска
без рецепта
Производитель
Майлан Лэбораториз САС, Route de Belleville, Lieu-dit Maillard, 01400 Chatillon-sur-Chalaronne, France, Франция
Организация, принимающая претензии потребителей
Эбботт Хелскеа Продактс Б.В.
Для описания товара использована информация от партнера 36.6
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"фармакологические свойства препарата, а также опыт его применения не свидетельствуют о каком-либо неблагоприятном влиянии мебеверина на способность к управлению автомобилем и другими механизмами. 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