Клотримазол Крем, 20 г, 1 %

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Крем следует наносить на пораженные участки кожи 2-3 раза в день."}},{"type":"paragraph","data":{"text":"Для профилактики рецидивов лечение следует продолжать, по крайней мере, в течение двух недель после исчезновения всех симптомов инфекции."}},{"type":"paragraph","data":{"text":"Крем следует наносить на чистые сухие участки пораженной кожи (вымытой мылом с нейтральным pH), на стопы крем следует наносить между пальцами."}},{"type":"paragraph","data":{"text":"Продолжительность лечения зависит от тяжести заболевания, его локализации, эффективности лечения."}},{"type":"paragraph","data":{"text":"Продолжительность лечения:"}},{"type":"list","data":{"style":"ordered","items":["дерматомикозы – в течение 3-4 недель;","эритразма – 2-4 недели;","разноцветный лишай – 1-3 недели;","кандидозный вульвит и баланит – 1-2 недели."]}},{"type":"paragraph","data":{"text":"Продолжительность лечения может меняться в соответствии с индивидуальными особенностями, но не рекомендуется продолжительность лечения менее 3 недель. Для профилактики рецидивов инфекции следует продолжать применение препарата в течение 1-2 недель после исчезновения всех симптомов заболевания. Если после 7 дней лечения не наступает улучшение симптоматики, необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Особые группы пациентов"}},{"type":"paragraph","data":{"text":"Отсутствуют данные по коррекции дозы для детей, пациентов пожилого возраста, пациентов с нарушением функции почек и печени."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Частота встречаемости определяется следующим образом: очень часто (≥1/10), часто (≥1/100 и <1/10), нечасто (≥1/1 000 и <1/100), редко (≥1/10 000 и <1/1000), очень редко (<1/10000, включая отдельные случаи), неизвестно (частота не может быть оценена по имеющимся на настоящий момент данным)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной системы"}},{"type":"paragraph","data":{"text":"Неизвестно: аллергическая реакция (проявляющаяся крапивницей, обмороком, артериальной гипотензией, одышкой)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей"}},{"type":"paragraph","data":{"text":"Неизвестно: сыпь, зуд, волдыри, шелушение, боль или дискомфорт, отек, жжение, раздражение, эритема, покалывание."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы"}},{"type":"paragraph","data":{"text":"При случайном приеме препарата внутрь возможно проявление следующих симптомов: головокружение, тошнота, рвота."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"При случайном приеме крема внутрь следует проводить симптоматическое лечение."}},{"type":"paragraph","data":{"text":"При наружном применении препарата передозировка маловероятна."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не изучалось."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо избегать попадания крема на слизистую оболочку глаз. Не глотать."}},{"type":"paragraph","data":{"text":"Все инфицированные области следует лечить одновременно."}},{"type":"paragraph","data":{"text":"В состав препарата Клотримазол входит цетостеариловый спирт, который может вызывать местные кожные реакции (например, контактный дерматит)."}},{"type":"paragraph","data":{"text":"При появлении симптомов повышенной чувствительности или раздражения лечение прекращают."}},{"type":"paragraph","data":{"text":"Данные лабораторных исследований свидетельствуют о том, что использование контрацептивов, содержащих латекс, может вызывать их повреждение при совместном применении c клотримазолом. Следовательно, эффективность таких контрацептивов может снижаться. Пациентам следует рекомендовать применение альтернативных методов контрацепции в течение, по крайней мере, пяти дней после применения клотримазола."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Нет данных об отрицательном влиянии препарата на способность к выполнению потенциально опасных видов деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций (управление автотранспортом, работа с движущимися механизмами)."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Крем для наружного применения, 1 %."}},{"type":"paragraph","data":{"text":"По 20 г в алюминиевой тубе, покрытой изнутри лаком, запаянной мембраной, укупоренной завинчивающимся полиэтиленовым или полипропиленовым колпачком. По 1 тубе вместе с инструкцией по применению в пачку картонную с контролем первого вскрытия."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25°С."}},{"type":"paragraph","data":{"text":"Не замораживать."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять после истечения срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\n«ГлаксоСмитКляйн Фармасьютикалз С.А.» / GlaxoSmithKline Pharmaceuticals S.A."}},{"type":"paragraph","data":{"text":"г. Познань, 60-322, ул. Грюнвальдска, 189, Польша / ul. Grunwaldzka, 189, 60-322, Poznan, Poland\n\n"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"\n\nАО «ГлаксоСмитКляйн Трейдинг», Россия"}},{"type":"paragraph","data":{"text":"125167, г. Москва, Ленинградский проспект, д. 37А, корпус 4, этаж 3, помещение XV, комната 1\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика Механизм действия Клотримазол является противогрибковым средством широкого спектра действия для наружного применения. Противогрибковый эффект клотримазола (производное имидазола) связан с нарушением синтеза эргостерина, входящего в состав клеточной мембраны грибов, что изменяет проницаемость мембраны и вызывает последующий лизис клетки. В низких концентрациях действует фунгистатически, в высоких – фунгицидно, причем не только на пролиферирующие клетки. В фунгицидных концентрациях взаимодействует с митохондриальными и пероксидазными ферментами, в результате чего происходит увеличение концентрации перекиси водорода до токсического уровня, что также способствует разрушению грибковых клеток. Эффективен в отношении дерматофитов (Epidermophyton, Microsporum, Trichophyton), дрожжеподобных (в основном Candida albicans), плесневых грибов и простейших, а также возбудителя разноцветного лишая Pityriasis versicolor (Malazessia furfur) и возбудителя эритразмы. Оказывает антимикробное действие в отношении грамположительных микроорганизмов и анаэробов. Клотримазол не оказывает влияние на лактобацилы. Фармакокинетика Клотримазол плохо всасывается через кожу и практически не оказывает системного действия. 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