Азитромицин Капсулы, 6 шт, 250 мг

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У пожилых мужчин (65-85 лет) фармакокинетические параметры не меняются у женщин увеличивается максимальная концентрация в плазме крови (на 30-50%) у детей в возрасте 1-5 лет снижаются максимальное содержание в плазме крови период полувыведения."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Инфекционно-воспалительные заболевания вызванные чувствительными к препарату микроорганизмами: инфекции верхних отделов дыхательных путей и ЛОР-органов (фарингит тонзиллит ларингит синусит средний отит); скарлатина; инфекции нижних отделов дыхательных путей (пневмония (в т.ч. вызванная атипичными возбудителями) бронхит); инфекции кожи и мягких тканей (рожа импетиго вторично инфицированные дерматозы); инфекции мочевыводящих путей (гонорейный и негонорейный уретрит цервицит); болезнь Лайма (начальная стадия - erythema migrans) язвенная болезнь желудка и 12-перстной кишки ассоциированная с Helicobacter pylori (в составе комбинированной терапии)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность (в т.ч. к другим макролидам) тяжелая печеночная/почечная недостаточность период лактации дети до 12 лет (с массой тела менее 45 кг)."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Аритмия (возможны желудочковые аритмии и удлинение интервала Q-T) детям с нарушениями функции печени или почек беременность."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Может применяться в тех случаях когда польза от его применения значительно превышает риск существующий всегда при использовании любого препарата в течение беременности. При необходимости назначение препарата в период лактации следует прекратить грудное вскармливание."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь за 1 ч до или через 2 ч после еды 1 раз в сутки."}},{"type":"paragraph","data":{"text":"Взрослым при инфекциях верхних и нижних отделов дыхательных путей - 500 мг/сут за 1 прием в течение 3 дней (курсовая доза - 1500 мг). При инфекциях кожи и мягких тканей - 1000 мг/сут в первый день за 1 прием далее по 500 мг/сут ежедневно с 2 по 5 день (курсовая доза - 3000 мг). При острых инфекциях мочеполовых органов (неосложненный уретрит или цервицит) - однократно 1 г. При болезни Лайма (боррелиоз) для лечения I стадии (erythema migrans) - 1000 мг в первый день и 500 мг ежедневно с 2 по 5 день (курсовая доза - 3 г). При язвенной болезни желудка и 12-перстной кишки ассоциированной с Helicobacter pylori - 1 г/сут в течение 3 дней в составе комбинированной антихеликобактерной терапии."}},{"type":"paragraph","data":{"text":"Детям старше 12 лет (с массой тела более 45 кг) при инфекциях верхних и нижних дыхательных путей кожи и мягких тканей назначают по 500 мг 1 раз в сутки в течение 3 дней."}},{"type":"paragraph","data":{"text":"При лечении erythema migrans у детей (старше 12 лет) препарат назначают 1 раз в сутки в дозе 1000 мг в первый день и по 500 мг со 2 по 5 день."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта: диарея (5%) тошнота (3%) боль в животе (3%); 1% и менее - метеоризм рвота мелена холестатическая желтуха повышение активности \"печеночных\" трансаминаз; у детей - запоры снижение аппетита гастрит; кандидамикоз слизистой оболочки полости рта изменение вкуса (1% и менее)."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: сердцебиение боль в грудной клетке (1% и менее)."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: головокружение головная боль сонливость; у детей - головная боль (при терапии среднего отита) гиперкинезия тревожность невроз нарушения сна (1% и менее)."}},{"type":"paragraph","data":{"text":"Со стороны мочеполовой системы: вагинальный кандидамикоз нефрит (1% и менее). Аллергические реакции: сыпь крапивница зуд кожи ангионевротический отек у детей - конъюнктивит."}},{"type":"paragraph","data":{"text":"Прочие: астения фотосенсибилизация."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: сильная тошнота временная потеря слуха рвота диарея."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Антациды (алюминий- и магнийсодержащие) этанол и пища замедляют и снижают абсорбцию азитромицина."}},{"type":"paragraph","data":{"text":"При совместном назначении варфарина и азитромицина (в обычных дозах) изменения протромбинового времени не выявлено однако учитывая что при взаимодействии макролидов и варфарина возможно усиление антикоагуляционного эффекта пациентам необходим тщательный контроль протромбинового времени."}},{"type":"paragraph","data":{"text":"Повышает концентрацию дигоксина за счет ослабления его инактивации кишечной флорой."}},{"type":"paragraph","data":{"text":"Эрготамин и дигидроэрготамин: усиление токсического действия (вазоспазм дизестезия). Триазолам: снижение клиренса и увеличение фармакологического действия триазолама. Замедляет выведение и повышает концентрацию в плазме и токсичность циклосерина непрямых антикоагулянтов метилпреднизолона фелодипина а также лекарственных средств подвергающихся микросомальному окислению (карбамазепин терфенадин циклоспорин гексобарбитал алкалоиды спорыньи вальпроевая кислота дизопирамид бромокриптин фенитоин пероральные гипогликемические лекарственные средства теофиллин и др. ксантиновые производные) за счет ингибирования микросомального окисления в гепатоцитах азитромицином."}},{"type":"paragraph","data":{"text":"Линкозамиды ослабляют а тетрациклин и хлорамфеникол усиливают эффективность азитромицина."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не принимать с пищей."}},{"type":"paragraph","data":{"text":"В случае пропуска приема дозы пропущенную дозу следует принять как можно раньше а последующие - с интервалом в 24 ч."}},{"type":"paragraph","data":{"text":"Необходимо соблюдать перерыв 2 ч при одновременном применении антацидов."}},{"type":"paragraph","data":{"text":"После отмены лечения реакции гиперчувствительности у некоторых пациентов могут сохраняться что требует специфической терапии под наблюдением врача."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы по 250 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года. Не использовать после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Озон\" (ООО \"Озон\"), 445351, Самарская обл., г. Жигулёвск, ул. Гидростроителей, д. 6, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Озон\""}}]}],"source":null},"description_toggle":false,"short_description":"Антибактериальное средство широкого спектра действия азалид действует бактериостатически. Связываясь с 50S субъединицей рибосом угнетает пептидтранслоказу на стадии трансляции подавляет синтез белка замедляет рост и размножение бактерий в высоких концентрациях оказывает бактерицидный эффект. Действует на вне- и внутриклеточных возбудителей. Активен в отношении грамположительных микроорганизмов: Streptococcus spp. (групп С F и G кроме устойчивых к эритромицину) Streptococcus pneumoniae Streptococcus pyogenes Streptococcus agalactiae Streptococcus viridans Staphylococcus epidermidis Staphylococcus aureus; грамотрицательных бактерий: Haemophilus influenzae Moraxella catarrhalis Bordetella pertussis Bordetella parapertussis Legionella pneumophila Haemophilus ducreyi Helicobacter pylori Campylobacter jejuni Neisseria gonorrhoeae и Gardnerella vaginalis; некоторых анаэробных микроорганизмов: Bacteroides bivius Clostridium perfringens Peptostreptococcus spp; а также внутриклеточных возбудителей: Chlamydia trachomatis Chlamydia pneumoniae Mycoplasma pneumoniae Mycobacterium avium complex Ureaplasma urealyticum Treponema pallidum Borrelia burgdorferi. Неактивен в отношении грамположительных бактерий устойчивых к эритромицину. Абсорбция - высокая кислотоустойчив липофилен. Биодоступность после однократного приема 05 г - 37% (эффект \"первого прохождения\" через печень) максимальная концентрация в плазме крови после перорального приема 05 г - 04 мг/л период достижения максимальной концентрации в плазме крови - 25-29 ч; в тканях и клетках концентрация в 10-50 раз выше чем в сыворотке крови объем распределения - 311 л/кг. Легко проходит гистогематические барьеры. Хорошо проникает в дыхательные пути мочеполовые органы и ткани в предстательную железу в кожу и мягкие ткани; накапливается в среде с низким pH в лизосомах (что особенно важно для эрадикации внутриклеточно расположенных возбудителей). Транспортируется также фагоцитами полиморфно-ядерными лейкоцитами и макрофагами. Проникает через мембраны клеток и создает высокие концентрации в них. Концентрация в очагах инфекции достоверно выше (на 24-34%) чем в здоровых тканях и коррелирует с выраженностью воспалительного отека. Сохраняется в эффективных концентрациях в течение 5-7 дней после приема последней дозы. Связь с белками плазмы - 7-50% (обратно пропорциональна концентрации в крови). В печени деметилируется образующиеся метаболиты не активны. В метаболизме препарата участвуют изоферменты CYP3A4 CYP3A5 CYP3A7 ингибитором которых он является. Плазменный клиренс - 630 мл/мин. Период полувыведения между 8 и 24 ч после приема -14-20 ч период полувыведения в интервале от 24 до 72 ч - 41 ч. 50% выводится с желчью в неизмененном виде 6% - почками. Прием пищи значимо изменяет фармакокинетику (в зависимости от лекарственной формы): капсулы - максимальная концентрация в плазме крови снижается (на 52%). 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