Сульфацил натрия-солофарм Капли, 5 шт, 1 мл, 20 %

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Несовместим с солями серебра."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Пациенты с повышенной чувствительностью к фуросемиду тиазидным диуретикам сульфонилмочевине или ингибиторам карбоангидразы могут иметь повышенную чувствительность к сульфацетамиду."}},{"type":"paragraph","data":{"text":"Возможен чрезмерный рост микроорганизмов нечувствительных к сульфаниламиду а также грибковой флоры."}},{"type":"paragraph","data":{"text":"Снижение антибактериальной активности сульфаниламидов в присутствии высоких концентраций нарааминобензойной кислоты при наличии большого количества гнойного отделяемого."}},{"type":"paragraph","data":{"text":"Необходимо прекратить терапию сульфаниламидами в случае появления симптомов аллергии а также при усилении боли и других признаков инфекционного воспалительного процесса увеличении количества гнойного отделяемого."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В случае развития затуманивания зрения после инсталляции необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций до восстановления четкости зрения."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капли глазные 20 %"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 15 °С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"После вскрытия флакона - 1 месяц. Не применять после окончания срока годности!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Гротекс\" (ООО \"Гротекс\"), 195279, г. Санкт-Петербург, Индустриальный проспект, д. 71, корп. 2, лит. А, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Гротекс\""}}]}],"source":null},"description_toggle":false,"short_description":"Противомикробное бактериостатическое средство сульфаниламид. Механизм действия обусловлен конкурентным антагонизмом с парааминобензойной кислотой угнетением дигидроптероатсинтетазы нарушением синтеза тетрагидрофолиевой кислоты необходимой для синтеза пуринов и пиримидинов.Активен в отношении грамположительных и грамотрицательных кокков Escherichia coli Shigella spp. Vibrio cholerae Clostridium perfringers Bacillus anthracis Corynеbacterium diphtheriae Yersinia pestis Chlamydia spp. Actinomyces israelii Toxoplasma gondii.Возможно развитие резистентности к сульфацетамиду. Проникает в ткани глаза где и оказывает свое специфическое антибактериальное воздействие. Действует преимущественно местно но часть препарата всасывается через воспаленную конъюнктиву и попадает в системный кровоток. Количество препарата попадающее в системный кровоток недостаточно для развития системного терапевтического эффекта но достаточно для сенсибилизации при повторном введении. При местном применении максимальная концентрация (Сmах) сульфаниламидов в роговице (около 3 мг/мл) влаге передней камеры (около 05 мг/мл) и радужке (около 0.1 мг/мл) достигается за первые 30 мин после аппликации. Некоторое количество (менее 05 мг/мл) сохраняется в тканях глазного яблока в течение 3-4 ч. При повреждении эпителия роговицы пенетрация сульфаниламидов усиливается. Сульфацетамид метаболизируется в печени путем N-ацетилирования метаболиты обладают антибактериальной активностью. 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