Травалза Дуо Капли, флакон, 1 шт, 2.5 мл, 5 + 0.04 мг/мл, глазные

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Около 20 %\nтимолола выводится в неизменном виде, остальная часть – в виде метаболитов."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Снижение\nповышенного внутриглазного давления при открытоугольной глаукоме и\nвнутриглазной гипертензии у пациентов, резистентных к монотерапии\nбета-адреноблокаторами или аналогами простагландина."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"-\nГиперчувствительность к действующим веществами или к любому из вспомогательных\nвеществ."}},{"type":"paragraph","data":{"text":"-\nГиперчувствительность к другим бета- адреноблокаторам."}},{"type":"paragraph","data":{"text":"- Реактивное\nзаболевание дыхательных путей, включая бронхиальную астму (в том числе в\nанамнезе), а также тяжелую хроническую обструктивную болезнь легких (ХОБЛ). "}},{"type":"paragraph","data":{"text":"-\nСинусовая брадикардия, синдром слабости синусового узла, включая синоатриальную\nблокаду, атриовентрикулярную блокаду II или III степени без кардиостимулятора. "}},{"type":"paragraph","data":{"text":"-\nДекомпенсированная хроническая сердечная недостаточность."}},{"type":"paragraph","data":{"text":"-\nКардиогенный шок."}},{"type":"paragraph","data":{"text":"- Аллергический\nринит тяжелого течения."}},{"type":"paragraph","data":{"text":"-\nДистрофия роговицы."}},{"type":"paragraph","data":{"text":"-\nБеременность."}},{"type":"paragraph","data":{"text":"-\nПериод грудного вскармливания."}},{"type":"paragraph","data":{"text":"- Детский\nвозраст до 18 лет (безопасность и эффективность не установлены)."}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":" - Неоваскулярная, закрытоугольная,\nузкоугольная глаукома, пигментная и врожденная глаукома, открытоугольная\nглаукома с псевдоафакией, псевдоэксфолиативная глаукома, острые воспалительные\nзаболевания органа зрения, у пациентов с псевдоафакией при разрыве задней\nкапсулы хрусталика или у пациентов с переднекамерной интраокулярной линзой, у\nпациентов с риском развития кистоидного макулярного отека, ирита, увеита;"}},{"type":"paragraph","data":{"text":" - У пациентов с атопией или с тяжелыми\nанафилактическими реакциями на различные аллергены в анамнезе;"}},{"type":"paragraph","data":{"text":" - У пациентов с сахарным диабетом лабильного\nтечения и склонностью к гипогликемии;"}},{"type":"paragraph","data":{"text":" - У пациентов с гипертиреозом, стенокардией\nПринцметала;"}},{"type":"paragraph","data":{"text":" - У пациентов, которым планируется проведение\nхирургических вмешательств. "}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Фертильность"}},{"type":"paragraph","data":{"text":"Сведения\nо влиянии глазных капель Тимолол+Травопрост на фертильность человека\nотсутствуют. Исследования на животных показали отсутствие влияния травопроста\nили тимолола на фертильность в дозах, которые более чем в \u003cb\u003e75 и 21 000 раз соответственно превышали максимальную рекомендованную\nдозу для офтальмологического использования у человека.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eБеременность\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Травопрост\nоказывает негативное фармакологическое действие как на течение беременности,\nтак и на плод или новорожденного."}},{"type":"paragraph","data":{"text":"Данные\nоб использовании препарата или компонентов препарата у беременных женщин\nотсутствуют либо ограничены."}},{"type":"paragraph","data":{"text":"Результаты\nисследований травопроста на животных показали репродуктивную токсичность.\nЭпидемиологические исследования при пероральном использовании бета-блокаторов\nне выявили эффектов, связанных с пороками развития, однако свидетельствуют о\nриске задержки внутриутробного развития."}},{"type":"paragraph","data":{"text":"Кроме\nтого, при использовании системных бета-блокаторов матерью до родов у\nноворожденных отмечали признаки и симптомы блокирования бета-адренорецепторов\n(например, брадикардия, гипотензия, угнетение дыхания и гипогликемия)."}},{"type":"paragraph","data":{"text":"Препарат\nТимолол+Травопрост не рекомендуется применять в период беременности. В случае\nприменения лекарственного препарата до родов следует осуществлять тщательный\nмониторинг состояния новорожденного в первые дни жизни."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПериод грудного вскармливания\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Неизвестно,\nэкскретируется ли травопрост в лекарственной форме капли глазные в грудное\nмолоко у человека. По результатам исследований на животных показано, что\nтравопрост и его метаболиты экскретируются в грудное молоко. Тимолол выделяется\nс грудным молоком, что потенциально может привести к развитию серьезных побочных\nреакций у младенца, находящегося на грудном вскармливании. Однако, при\nприменении тимолола в терапевтических дозах маловероятно, что в грудном молоке\nбудет присутствовать достаточное количество препарата для развития симптомов\nблокады бета-адренорецепторов у ребенка. Применение лекарственного препарата в\nпериод грудного вскармливания не рекомендуется."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Местно."}},{"type":"paragraph","data":{"text":"Препарат\nзакапывают по 1 капле в конъюнктивальный мешок глаза 1 раз в сутки, вечером или\nутром в одно и то же время."}},{"type":"paragraph","data":{"text":"Для\nуменьшения риска развития системных побочных эффектов рекомендуется после\nинстилляции препарата пережимать носослезный канал путем надавливания в области\nего проекции у внутреннего угла глаза."}},{"type":"paragraph","data":{"text":"Если\nдоза препарата была пропущена, то лечение следует продолжить со следующей дозы.\nСуточная доза препарата не должна превышать 1 капли в конъюнктивальный мешок\nглаза 1 раз в сутки."}},{"type":"paragraph","data":{"text":"Препарат\nТимолол+Травопрост может применяться в комбинации с другими местными\nофтальмологическими препаратами для снижения внутриглазного давления. В этом\nслучае интервал между их применением должен составлять не менее 5 минут."}},{"type":"paragraph","data":{"text":"Не\nследует прикасаться кончиком флакона-капельницы к какой-либо поверхности, чтобы\nизбежать загрязнения флакона-капельницы и его содержимого."}},{"type":"paragraph","data":{"text":"Флакон-капельницу\nнеобходимо закрывать после каждого использования."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Общие\nсведения о профиле безопасности препарата"}},{"type":"paragraph","data":{"text":"В\nходе клинических исследований с участием 2170 пациентов, которые получали\nтерапию лекарственным препаратом Тимолол+Травопрост, наиболее частым\nнежелательным явлением была конъюнктивальная инъекция (12,0 %)."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"В\nслучае передозировки препарата при местном офтальмологическом применении не\nожидается токсических явлений со стороны органа зрения."}},{"type":"paragraph","data":{"text":"Рекомендуется\nнемедленное промывание глаз водой."}},{"type":"paragraph","data":{"text":"При\nслучайном приеме внутрь симптомы передозировки в результате системного\nвоздействия бета-адреноблокаторов могут включать брадикардию, гипотензию,\nсердечную недостаточность и бронхоспазм, остановку сердца."}},{"type":"paragraph","data":{"text":"Лечение\nв случае случайного приема препарата внутрь должно включать симптоматическую и\nподдерживающую терапию. Гемодиализ малоэффективен в отношении выведения\nтимолола."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Исследований\nпо взаимодействию с другими препаратами не проводилось."}},{"type":"paragraph","data":{"text":"Во\nвремя комбинированного лечения ингибиторами цитохрома CYP2D6 (например, хинидин, флуоксетин, пароксетин) и\nтимололом отмечали случаи усиления системного эффекта бета-адреноблокаторов\n(например, снижение частоты сердечных сокращений, депрессия)."}},{"type":"paragraph","data":{"text":"При\nиспользовании офтальмологического раствора бета-блокатора одновременно с\nблокаторами кальциевых каналов, бета-адреноблокаторами, противоаритмическими\nсредствами (включая амиодарон), сердечными гликозидами и парасимпатомиметиками\nвозможно развитие аддитивных эффектов, приводящих к гипотензии и (или)\nвыраженной брадикардии."}},{"type":"paragraph","data":{"text":"На\nфоне совместного применения бета-адреноблокаторов и клонидина может развиваться\nрикошетная гипертензия после резкой отмены последнего. Бета-блокаторы могут\nснижать ответ на адреналин, используемый при лечении анафилактических реакций.\nОсобую осторожность следует соблюдать у пациентов с наличием в анамнезе\nуказаний на атопию и анафилаксию (см. раздел «Особые указания»)."}},{"type":"paragraph","data":{"text":"Не\nрекомендуется одновременное использование двух местных бета-адреноблокаторов\nили двух местных аналогов простагландинов!"}},{"type":"paragraph","data":{"text":"Иногда\nсообщалось о развитии мидриаза при одновременном использовании\nофтальмологических бета-блокаторов и адреналина."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие сведения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Как\nи другие офтальмологические препараты для местного применения, травопрост и\nтимолол всасываются в системный кровоток. В связи с наличием в составе\nофтальмологического препарата тимолола, обладающего бета-блокирующим действием,\nвозможно развитие тех же типов нежелательных реакций со стороны\nсердечно-сосудистой системы, легких и других органов, что и при использовании\nсистемных бета-адреноблокаторов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сердца\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У\nпациентов с заболеваниями сердечно-сосудистой системы (например, ишемическая\nболезнь сердца, стенокардия Принцметала, сердечная недостаточность) и\nгипотензией необходимо критично оценивать целесообразность использования\nбета-блокаторов и рассмотреть возможность применения других активных веществ. У\nпациентов с заболеваниями сердечно-сосудистой системы следует оценить наличие\nпризнаков ухудшения течения этих заболеваний и развития нежелательных реакций."}},{"type":"paragraph","data":{"text":"Поскольку\nбета-адреноблокаторы отрицательно влияют на время проведения, их следует с\nосторожностью применять у пациентов с атриовентрикулярной блокадой I степени."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСосудистые нарушения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У\nпациентов с тяжелыми нарушениями или заболеваниями периферического\nкровообращения (т.е. тяжелые формы болезни или синдрома Рейно) лечение следует\nпроводить с осторожностью."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРасстройства дыхания\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Следует\nконтролировать состояние пациента до начала и во время терапии тимололом. После\nиспользования некоторых офтальмологических препаратов из группы бета-блокаторов\nописаны случаи респираторных реакций, включая смерть от бронхоспазма у\nпациентов, страдающих бронхиальной астмой."}},{"type":"paragraph","data":{"text":"У\nпациентов с хронической обструктивной болезнью легких (ХОБЛ) легкой и средней\nстепени тяжести препарат следует применять с осторожностью и только в случае,\nесли предполагаемая польза превышает возможный риск."}},{"type":"paragraph","data":{"text":"\u003ci\u003eГипогликемия/сахарный диабет\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У\nпациентов, склонных к развитию спонтанной гипогликемии, а также у больных с\nлабильным течением сахарного диабета бета-блокаторы следует применять с\nосторожностью, поскольку они могут маскировать признаки и симптомы острой\nгипогликемии."}},{"type":"paragraph","data":{"text":"\u003ci\u003eГипертиреоз\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Бета-блокаторы\nмогут маскировать признаки гипертиреоза."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМышечная слабость\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Сообщалось,\nчто бета-адреноблокаторы могут потенцировать мышечную слабость, что согласуется\nс определенными симптомами миастении (например, диплопия, птоз и\nгенерализованная мышечная слабость)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЗаболевания роговицы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Бета-адреноблокаторы\nдля офтальмологического применения могут вызывать сухость глаз. У пациентов с\nзаболеваниями роговицы препарат следует применять с осторожностью."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОтслойка сосудистой оболочки\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У\nпациентов, применявших препараты, подавляющие выработку водянистой влаги\n(например, тимолола и ацетазоламида), после проведения фистулизирующих операций\nоргана зрения отмечались случаи отслойки сосудистой оболочки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие бета-блокаторы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При\nиспользовании тимолола у пациентов, которые уже применяют системные\nбета-адреноблокаторы, возможно усиление влияния на внутриглазное давление или\nдругих известных эффектов системных бета-блокаторов. Ответ на терапию у таких\nпациентов должен тщательно контролироваться. Использование двух\nбета-адреноблокаторов для местного применения не рекомендуется (см. раздел\n«Взаимодействие с другими лекарственными средствами»)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПопадание на кожу\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Простагландины\nи аналоги простагландинов – биологически активные вещества, которые могут\nвсасываться через кожу. Женщины в период беременности, а также женщины,\nпланирующие беременность, должны применять соответствующие меры\nпредосторожности, чтобы не допустить прямого попадания содержимого флакона на\nкожу. Если существенная часть содержимого флакона все же попадает на кожу (что\nмаловероятно), участок кожи, на который попал препарат, следует немедленно промыть\nводой."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАнафилактические\nреакции\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Применение\nтимолола пациентами с атопией или тяжелыми патологическими реакциями на\nразличные аллергены в анамнезе может спровоцировать более тяжелые реакции в\nответ на введение различных аллергенов. Такие пациенты могут слабо реагировать\nна введение обычных доз эпинефрина для купирования анафилактических реакций."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЭффекты в\nотношении глаз\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Травопрост\nможет постепенно изменять цвет глаз, увеличивая количество меланосом\n(пигментных гранул) в меланоцитах. Перед началом лечения пациентов следует\nпроинформировать о возможности постоянного изменения цвета глаз. Лечение только\nодного глаза может привести к постоянной гетерохромии. Долгосрочное влияние на\nмеланоциты и последствия этого влияния в настоящее время неизвестны."}},{"type":"paragraph","data":{"text":"Изменение\nцвета радужной оболочки происходит медленно и может быть незаметным в течении\nнескольких месяцев или лет."}},{"type":"paragraph","data":{"text":"Изменение\nцвета глаз преимущественно отмечается у пациентов со смешанным цветом радужки\n(сине-коричневый, серо-коричневый, желто-коричневый или зелено-коричневый),\nаналогичный эффект наблюдался у пациентов с карими глазами. В типичных случаях\nкоричневая пигментация вокруг зрачка распространяется концентрически к\nпериферии радужки глаза; в связи с чем вся радужка или ее части приобретают\nболее коричневый цвет. После окончания терапии дальнейшего накопления\nкоричневого пигмента в радужке не отмечалось."}},{"type":"paragraph","data":{"text":"При\nиспользовании травопроста сообщалось о потемнении кожи периорбитальной области\nи (или) век."}},{"type":"paragraph","data":{"text":"Травопрост\nможет постепенно изменять состояние ресниц в пролеченном(ых) глазу(ах); данные\nизменения включают изменение длины, толщины, пигментации и (или) количества\nресниц."}},{"type":"paragraph","data":{"text":"Механизм\nэтих изменений в настоящее время не установлен."}},{"type":"paragraph","data":{"text":"Препарат\nсодержит пропиленгликоль, который может вызывать раздражение кожных покровов!"}},{"type":"paragraph","data":{"text":"Препарат\nсодержит макрогола глицерилгидроксистеарат, который может вызывать реакции со\nстороны кожных покровов."}},{"type":"paragraph","data":{"text":"Во\nвремя лечения аналогами простагландина F2α\nотмечали макулярный отек. Травопрост следует применять с осторожностью у\nпациентов с неоваскулярной, закрытоугольной, узкоугольной глаукомой, пигментной\nи врожденной глаукомой, открытоугольной глаукомой с псевдофакией,\nпсевдоэксфолиативной глаукомой, воспалительными заболеваниями органа зрения,\nафакией, псевдофакией с разрывом задней капсулы хрусталика или переднекамерной\nинтраокулярной линзой, а также пациентов с факторами риска макулярного отека,\nирита, увеита."}},{"type":"paragraph","data":{"text":"При\nиспользовании аналогов простагландина отмечали изменения периорбитальной\nобласти и век. Углубление бороздки век отмечалось только в ходе исследований у\nобезьян, в то время как в ходе клинических исследований у человека не получено\nданных об указанном эффекте, что позволило считать его видоспецифичным."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАнестезия при\nоперативных вмешательствах\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Офтальмологические\nпрепараты из группы бета-блокаторов могут подавлять бета-агонистические\nэффекты, например, адреналина. Следует проинформировать анестезиолога, если\nпациент получал тимолол."}},{"type":"paragraph","data":{"text":"\u003ci\u003eКонтактные линзы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Пациентов\nследует проинструктировать о необходимости извлечь контактные линзы до использования\nпрепарата Тимолол+Травопрост и подождать не менее 15 минут до их повторного\nиспользования."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Временное\nзатуманивание зрения или другие нарушения зрения после применения препарата\nмогут повлиять на возможность водить автомобиль или использовать механизмы.\nЕсли затуманивание зрения возникает после закапывания препарата, то перед\nвождением автотранспорта или управлением механизмами пациент должен дождаться\nвосстановления четкости зрения."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капли глазные, 5 мг/мл+0,04 мг/мл"}},{"type":"paragraph","data":{"text":"По\n2,5 мл во флакон-капельницу с винтовой горловиной полимерный\nи крышкой навинчиваемой из полиэтилена низкого давления или во\nфлакон-капельницу с винтовой горловиной, изготовленный по технологии «blow-fill-seal» «выдувание-наполнение-герметизация» из гранул\nполиэтилена низкой плотности белого цвета или полиэтилена высокого давления\n(низкой плотности) и колпачком полимерным навинчиваемым из полиэтилена низкого\nдавления."}},{"type":"paragraph","data":{"text":"По\n5 мл во флакон-капельницу с винтовой горловиной, изготовленный по технологии «blow-fill-seal» «выдувание-наполнение-герметизация» из гранул\nполиэтилена низкой плотности белого цвета или полиэтилена высокого давления\n(низкой плотности) и колпачком полимерным навинчиваемым из полиэтилена низкого\nдавления."}},{"type":"paragraph","data":{"text":"На\nфлакон-капельницу наклеивают этикетку самоклеящуюся."}},{"type":"paragraph","data":{"text":"По 1\nфлакону-капельнице вместе с инструкцией по применению помещают в пачку из\nкартона."}},{"type":"paragraph","data":{"text":"По 1\nфлакону-капельнице в пакет из фольгированной пленки. Один пакет из\nфольгированной пленки вместе с инструкцией по применению помещают в пачку из\nкартона."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В\nоригинальной упаковке при температуре не выше 25 ºС."}},{"type":"paragraph","data":{"text":"Хранить\nв недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2\nгода. Вскрытый флакон-капельницу использовать в течение 30 суток."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают\nпо рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное\nобщество \"Отисифарм\" (АО \"Отисифарм\"), Россия"}},{"type":"paragraph","data":{"text":"123112,\nг. Москва, ул. Тестовская, д. 10, эт. 12, пом. II, ком. 29,"}},{"type":"paragraph","data":{"text":"тел.:\n+7 (800) 775-98-19"}},{"type":"paragraph","data":{"text":"факс:\n+7 (495) 221-18-02"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.otcpharm.ru\"\u003ewww.otcpharm.ru\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"Открытое\nакционерное общество \"Фармстандарт-Уфимский витаминный завод\" "}},{"type":"paragraph","data":{"text":"\n(ОАО \"Фармстандарт-УфаВИТА\"), Россия,"}},{"type":"paragraph","data":{"text":"Республика\nБашкортостан, г. Уфа, ул. Худайбердина, д. 28, "}},{"type":"paragraph","data":{"text":"тел./факс:\n(347) 272-92-85,"}},{"type":"paragraph","data":{"text":"www.pharmstd.ru"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Акционерное\nобщество \"Отисифарм\" (АО \"Отисифарм\"), Россия"}},{"type":"paragraph","data":{"text":"123112,\nг. Москва, ул. Тестовская, д. 10, эт. 12, пом. II, ком. 29,"}},{"type":"paragraph","data":{"text":"тел.:\n+7 (800) 775-98-19"}},{"type":"paragraph","data":{"text":"факс:\n+7 (495) 221-18-02"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.otcpharm.ru\"\u003ewww.otcpharm.ru\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаПрепарат ТРАВАЛЗА® ДУО содержит два действующих вещества: травопрост и тимолол. Оба компонента снижают внутриглазное давление. Благодаря взаимодополняющим механизмам действия, снижение внутриглазного давления под влиянием комбинации более значительное, чем при действии каждого из этих компонентов в отдельности.ТимололТимолол - неселективный блокатор бета-адренорецепторов без симпатомиметической активности, не оказывает прямого депрессивного влияния на миокард, не обладает мембраностабилизирующей активностью. При местном применении снижает внутриглазное давление за счет уменьшения образования водянистой влаги и небольшого увеличения ее оттока.ТравопростТравопрост - аналог простагландина F2-альфа, является высокоселективным агонистом простагландиновых FP-рецепторов и снижает внутриглазное давление путем увеличения оттока водянистой влаги. Основной механизм действия препарата связан с увеличением увеосклерального оттока. Не оказывает существенного влияния на продукцию водянистой влаги. Внутриглазное давление снижается приблизительно через 2 часа после применения, максимальный эффект достигается через 12 часов. Значительное снижение внутриглазного давления может сохраняться в течение 24 часов после однократного применения препарата.ФармакокинетикаВсасывание и распределениеТравопрост и тимолол абсорбируются через роговицу глаза. В роговице происходит гидролиз травопроста до биологически активной формы – свободной кислоты травопроста. Свободная кислота травопроста быстро выводится из плазмы в течение часа – концентрация в плазме крови снижается ниже порога обнаружения – менее 0,01 нг/мл (может варьироваться от 0,01 до 0,03 нг/мл). Максимальная концентрация (Cmax) тимолола в плазме крови составляет 1,34 нг/мл и сохраняется до порога обнаружения в течение 12 часов, а время достижения максимальной концентрации (Tmax) тимолола достигается в течение 0,69 часа после местного применения. Период полувыведения (Т½) тимолола составляет 4 часа после местного применения Тимолол+Травопрост.Метаболизм и выведениеМетаболизм является основным путем элиминации травопроста и свободной кислоты травопроста. Пути системного метаболизма параллельны путям метаболизма эндогенного простагландина F2α, которые характеризуются восстановлением двойной связи 13-14, окислением 15-гидроксильной группы и β-оксидативным расщеплением звена верхней боковой цепи. Свободная кислота травопроста и ее метаболиты в основном выводятся почками. Менее 2% травопроста обнаруживается в моче в виде свободной кислоты. Тимолол и образующиеся метаболиты выводятся преимущественно почками. Около 20 % тимолола выводится в неизменном виде, остальная часть – в виде метаболитов.","substance":[],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Травалза Дуо - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/88831/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/88831/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"nondrugs","products":[{"id":107152,"title":"Ципромед","subtitle":{"full":"Капли, 5 мл, 0,3 %","short":"Капли, 5 мл, 0,3 %","package":"5 мл, 0,3 %"},"prescription":true,"catalog_section_id":53,"manufacturer":{"id":168,"title":"Сентис 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