Окофенак Капли, флакон, 1 шт, 5 мл, 0.09 %, глазные

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Концентрация полумаксимального\nингибирования (IC50) для бромфенака             \n(1,1 мкмоль) была ниже, чем для индометацина (4,2 мкмоль) и пранопрофена\n(11,9 мкмоль)."}},{"type":"paragraph","data":{"text":"В экспериментальной модели увеита\nу кроликов бромфенак в концентрациях 0,02 %, 0,05 %, 0,1 % и 0,2 % ингибировал\nпрактически все симптомы глазного воспаления."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВсасывание\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Бромфенак эффективно проникает\nчерез роговицу пациентов с катарактой: при однократном введении средняя максимальная\nконцентрация (С\u003csub\u003emax\u003c/sub\u003e) в водянистой\nвлаге составляет 79±68 нг/мл через 150-180 минут после применения. Данная\nконцентрация сохраняется в течение 12 часов в водянистой влаге, с сохранением\nподдающейся измерению концентрации в основных тканях глаза, включая сетчатку,\nдо 24 часов. При применении глазных капель бромфенака два раза в день,\nконцентрации в плазме не поддавались количественному измерению."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Бромфенак активно связывается с\nбелками плазмы. По данным исследования \u003ci\u003ein\nvitro\u003c/i\u003e, связывание с белками в плазме крови человека составило 99,8 %."}},{"type":"paragraph","data":{"text":"Исследования \u003ci\u003ein vitro\u003c/i\u003e не выявили биологически значимого связывания с меланином."}},{"type":"paragraph","data":{"text":"По данным исследования у кроликов\nс использованием радиоактивно-меченного бромфенака С\u003csub\u003emax\u003c/sub\u003e после местного\nприменения наблюдается в роговице, высокая - в конъюнктиве и водянистой влаге\nглаза, низкая - в хрусталике и стекловидном теле."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По результатам исследования \u003ci\u003ein vitro\u003c/i\u003e, основной метаболизм бромфенака\nосуществляется ферментом CYP2C9, который отсутствует в иридоцилиарной зоне,\nсетчатке и сосудистой оболочке. Уровень этого фермента в роговице составляет\nменее 1 % по сравнению с соответствующим печеночным уровнем."}},{"type":"paragraph","data":{"text":"При пероральном приеме у человека\nв плазме в основном обнаруживается неизмененное исходное вещество. Выделено\nнесколько конъюгированных и неконъюгированных метаболитов, основным из которых\nявляется циклический амид, который выводится почками."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При закапывании в глаза период\nполувыведения бромфенака из водянистой влаги глаза составляет около 1,4 ч, что\nсвидетельствует о быстрой элиминации."}},{"type":"paragraph","data":{"text":"После перорального приема \u003csup\u003e14\u003c/sup\u003eС-бромфенака\nздоровыми добровольцами было установлено, что препарат преимущественно\nвыводится почками (около 82 % введенной дозы), в то время как через кишечник\nвыводится около 13 % введенной дозы."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Лечение неинфекционных воспалительных заболеваний\nпереднего отрезка глаза и послеоперационного воспаления."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к действующему\nвеществу и любому из вспомогательных веществ препарата, а также к другим\nнестероидным противовоспалительным препаратам."}},{"type":"paragraph","data":{"text":"Применение препарата\nпротивопоказано у пациентов, у которых приступы бронхиальной астмы, крапивницы\nи симптоматика острого ринита усиливаются при приеме ацетилсалициловой кислоты\nи других НПВП."}},{"type":"paragraph","data":{"text":"Возраст до 18 лет (безопасность и\nэффективность применения препарата у детей не исследовались)."}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eБеременность\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Достаточные данные о применении\nбромфенака у беременных женщин отсутствуют. Исследования на животных\nпродемонстрировали наличие репродуктивной токсичности. Поскольку системное\nвоздействие после лечения препаратом у небеременных женщин является\nнезначительным, риск во время беременности можно считать низким."}},{"type":"paragraph","data":{"text":"Однако из-за известных эффектов\nлекарственных препаратов, ингибирующих биосинтез простагландинов, на\nсердечно-сосудистую систему плода (закрытие протока), применения данного\nпрепарата в третьем триместре беременности следует избегать. В целом,\nприменение данного препарата во время беременности не рекомендуется, за\nисключением случаев, когда польза превышает потенциальный риск."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПериод грудного вскармливания\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Следует соблюдать осторожность\nпри применении у женщин в период грудного вскармливания."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Местно. Инстилляции в\nконъюнктивальный мешок."}},{"type":"paragraph","data":{"text":"Лечение неинфекционных\nвоспалительных заболеваний переднего отрезка глаза: по одной капле два раза в\nдень не более 15 дней. "}},{"type":"paragraph","data":{"text":"Лечение послеоперационного\nвоспаления: по одной капле один раз в день. Лечение начинают за 1 день до\nхирургического вмешательства и продолжают в течение первых 14 дней\nпослеоперационного периода (включая день операции)."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eУказания в случае пропуска одного или нескольких приемов\nлекарственного препарата\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"В случае пропуска приема\nпрепарата следует применить препарат как можно скорее в дозе, предусмотренной\nинструкцией. Если пропуск в применении препарата приближается к 24 ч, препарат\nследует применить в следующее назначенное время, не удваивая дозу для\nкомпенсации пропущенной. "}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eПациенты с почечной и печеночной недостаточностью\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Действие препарата у пациентов с\nпочечной и печеночной недостаточностью не изучено."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЛица пожилого возраста\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Режим приёма препарата у\nпациентов старше 65 лет не отличается от режима приема у более молодых\nпациентов."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Нежелательные реакции на препарат отмечались у 72 из 3843\nпациентов (1,87%), данные о которых были получены в рамках клинических\nисследований или при пострегистрационном применении. Серьезные нежелательные\nреакции включали эрозию роговицы в 16 случаях (0,42%), конъюнктивит (включая\nконъюнктивальную инъекцию и конъюнктивальные фолликулы) в 11 случаях (0,29%),\nблефарит в 9 случаях (0,23%), раздражение в 8 случаях (0,21%), боль в глазу\n[транзиторная] в 8 случаях (0,21%), поверхностный точечный кератит в 6 случаях\n(0,16%), зуд в 6 случаях (0,16%), отслойка эпителия роговицы в 1 случае (0,03%)\nи чувство жжения [веки] в 1 случае (0,03%)."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"На данный момент информация о\nпередозировке при местном применении у человека отсутствует."}},{"type":"paragraph","data":{"text":"По данным зарубежных отчетов, у\nпациентов, которые принимали препарат бромфенака внутрь в общей дозе,\nпревышающей 1500 мг, в течение длительного периода времени более 1 месяца,\nнаблюдались серьезные нарушения функции печени (включая летальные случаи). В\nсвязи с этим, при обнаружении отклонений, которые предположительно связаны с\nранними симптомами печеночной недостаточности, необходимо прекратить лечение\nданным препаратом и принять соответствующие меры."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Исследований взаимодействия с другими лекарственными\nсредствами не проводилось."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат ОКОФЕНАК должен\nприменяться в рамках симптоматического лечения, а не в целях этиотропной\nтерапии."}},{"type":"paragraph","data":{"text":"Данный препарат следует\nиспользовать только в качестве глазных капель."}},{"type":"paragraph","data":{"text":"Препарат следует закапывать с\nосторожностью, убедившись, что кончик флакона не касается поверхности глаза."}},{"type":"paragraph","data":{"text":"Данный препарат содержит натрия\nсульфит, который может вызывать реакции аллергического типа, в том числе\nсимптомы анафилаксии и угрожающие жизни или менее тяжелые астматические эпизоды\nу восприимчивых пациентов."}},{"type":"paragraph","data":{"text":"Все местные НПВП могут замедлить\nили отсрочить заживление подобно местным глюкокортикостероидам. Совместное\nприменение НПВП и местных кортикостероидов может увеличить вероятность\nвозникновения проблем с заживлением."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПерекрестная чувствительность \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Существует вероятность развития\nперекрестной чувствительности к ацетилсалициловой кислоте, производным\nфенилацетиловой кислоты и другим НПВП. Поэтому следует соблюдать осторожность\nпри лечении лиц, у которых ранее наблюдалась чувствительность к данным\nлекарственным препаратам, и следует тщательно оценить потенциальные риски и\nпользу."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОсобые группы пациентов\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У восприимчивых пациентов\nдлительное применение местных НПВП, включая бромфенак, может привести к разрыву\nэпителия, истончению роговицы, эрозии роговицы, изъязвлению роговицы или\nперфорации роговицы Данные события могут угрожать потерей зрения. Пациентам с\nпризнаками разрушения эпителия роговицы следует немедленно прекратить\nприменение местных НПВС и необходимо внимательно следить за здоровьем роговицы.\nСледовательно, у пациентов, подверженных риску, одновременное применение\nофтальмологических кортикостероидов с НПВП может привести к повышенному риску\nнежелательных явлений со стороны роговицы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПострегистрационный опыт применения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Пострегистрационный опыт\nприменения местных НПВП свидетельствует о том, что у пациентов с осложнениями\nпосле офтальмологических хирургических вмешательств, с денервацией роговицы,\nдефектами эпителия роговицы, сахарным диабетом и поверхностными заболеваниями\nглаз, ревматоидным артритом или повторными офтальмологическими хирургическими\nвмешательствами, проведенными в течение короткого периода времени, может\nнаблюдаться повышенный риск нежелательных явлений со стороны роговицы, которые\nмогут стать угрожающими потерей зрения. Местные НПВС у таких пациентов следует\nприменять с осторожностью."}},{"type":"paragraph","data":{"text":"Сообщалось, что\nофтальмологические НПВП могут вызывать повышенную кровоточивость в тканях глаза\n(в том числе гифему) в сочетании с офтальмологическим хирургическим\nвмешательством. Местные НПВП должны применяться с осторожностью у пациентов, в\nанамнезе которых зафиксирована склонность к кровотечению, или если пациенты\nполучают другие лекарственные препараты, которые могут повышать время\nсвертываемости крови."}},{"type":"paragraph","data":{"text":"\u003ci\u003eИнфекции глаз\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Следует тщательно контролировать\nприменение препарата и с осторожностью назначать его пациентам с воспалениями,\nвызванными инфекциями, так как препарат может маскировать симптомы инфекционных\nзаболеваний глаз."}},{"type":"paragraph","data":{"text":"\u003ci\u003eИспользование контактных линз\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В целом, ношение контактных линз\nв период лечения данным препаратом не рекомендуется. В связи с этим, пациентам\nне рекомендуется носить контактные линзы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Поскольку в состав препарата\nвходит бензалкония хлорид, необходимо тщательное наблюдение за пациентами в\nслучае частого или длительного применения препарата. Известно, что бензалкония\nхлорид может обесцвечивать мягкие контактные линзы. Следует избегать контакта с\nмягкими контактными линзами."}},{"type":"paragraph","data":{"text":"Сообщается, что бензалкония\nхлорид может вызывать раздражение глаз, точечную кератопатию и/или токсическую\nязвенную кератопатию."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"После инстилляции может отмечаться преходящее\nзатуманивание зрения. В случае развития затуманивания зрения после инстилляции\nнеобходимо воздержаться от управления транспортными средствами и механизмами до\nвосстановления четкости зрения."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капли глазные, 0,09 %."}},{"type":"paragraph","data":{"text":"По 1,7 мл во флакон-капельницу\nполимерный из полиэтилена высокого давления с крышками навинчиваемыми и\nпробками-капельницами из полиэтилена низкого давления\u003ci\u003e.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По 1,7 мл или по 5 мл во флакон-капельницу с винтовой горловиной,\nизготовленный по технологии «blow-fill-seal»\n«выдувание-наполнение-герметизация» из гранул полиэтилена низкой плотности\nбелого цвета или полиэтилена высокого давления (низкой плотности) и колпачком\nполимерным навинчиваемым из полиэтилена низкого давления."}},{"type":"paragraph","data":{"text":"На флакон-капельницу\nнаклеивают этикетку самоклеящуюся."}},{"type":"paragraph","data":{"text":"По 1 флакону-капельницe с\nинструкцией по применению в пачке из картона."}},{"type":"paragraph","data":{"text":"Допускается упаковка одного флакона-капельницы по 1,7 мл в пакет из\nфольгированной пленки. Один пакет из фольгированной пленки вместе с инструкцией\nпо применению в пачке из картона. "}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В оригинальной упаковке\n(флакон-капельница в пачке или флакон-капельница в пакете из фольгированной\nпленки и в пачке) при температуре не выше 25 ºС. "}},{"type":"paragraph","data":{"text":"Хранить в недоступном для\nдетей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"После вскрытия флакон-капельницы:\nне более 30 суток."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают\nпо рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное\nобщество «Фармстандарт-Уфимский витаминный завод» "}},{"type":"paragraph","data":{"text":"(ОАО\n«Фармстандарт-УфаВИТА»),"}},{"type":"paragraph","data":{"text":"Республика Башкортостан,\nг. Уфа, ул. Худайбердина, д. 28, "}},{"type":"paragraph","data":{"text":"тел./факс: (347)\n272-92-85,"}},{"type":"paragraph","data":{"text":"www.pharmstd.ru"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Акционерное\nобщество «Отисифарм»"}},{"type":"paragraph","data":{"text":"(АО «Отисифарм»), "}},{"type":"paragraph","data":{"text":"123112, г. Москва, ул.\nТестовская, д. 10, эт. 12, пом. II, ком. 29"}},{"type":"paragraph","data":{"text":"Тел.: +7 (800) 775-98-19"}},{"type":"paragraph","data":{"text":"факс: +7 (495) 221-18-02"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.otcpharm.ru\"\u003ewww.otcpharm.ru\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаБромфенак - нестероидный противовоспалительный препарат (НПВП), противовоспалительное действие которого реализуется за счет блокирования синтеза простагландинов при ингибировании циклооксигеназы 1 и 2. В исследованияхin vitroбромфенак ингибировал синтез простагландинов в цилиарном теле кролика. Концентрация полумаксимального ингибирования (IC50) для бромфенака (1,1 мкмоль) была ниже, чем для индометацина (4,2 мкмоль) и пранопрофена (11,9 мкмоль). В экспериментальной модели увеита у кроликов бромфенак в концентрациях 0,02 %, 0,05 %, 0,1 % и 0,2 % ингибировал практически все симптомы глазного воспаления.ФармакокинетикаВсасываниеБромфенак эффективно проникает через роговицу пациентов с катарактой: при однократном введении средняя максимальная концентрация (Сmax) в водянистой влаге составляет 79±68 нг/мл через 150-180 минут после применения. Данная концентрация сохраняется в течение 12 часов в водянистой влаге, с сохранением поддающейся измерению концентрации в основных тканях глаза, включая сетчатку, до 24 часов. При применении глазных капель бромфенака два раза в день, концентрации в плазме не поддавались количественному измерению.РаспределениеБромфенак активно связывается с белками плазмы. По данным исследованияin vitro, связывание с белками в плазме крови человека составило 99,8 %. Исследованияin vitroне выявили биологически значимого связывания с меланином. По данным исследования у кроликов с использованием радиоактивно-меченного бромфенака Сmaxпосле местного применения наблюдается в роговице, высокая - в конъюнктиве и водянистой влаге глаза, низкая - в хрусталике и стекловидном теле.МетаболизмПо результатам исследованияin vitro, основной метаболизм бромфенака осуществляется ферментом CYP2C9, который отсутствует в иридоцилиарной зоне, сетчатке и сосудистой оболочке. Уровень этого фермента в роговице составляет менее 1 % по сравнению с соответствующим печеночным уровнем. При пероральном приеме у человека в плазме в основном обнаруживается неизмененное исходное вещество. Выделено несколько конъюгированных и неконъюгированных метаболитов, основным из которых является циклический амид, который выводится почками.ВыведениеПри закапывании в глаза период полувыведения бромфенака из водянистой влаги глаза составляет около 1,4 ч, что свидетельствует о быстрой элиминации. 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