Колхицин Лирка Таблетки, 30 шт, 1 мг

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Оказывает положительное влияние на кожу\n(смягчение, уменьшение сухости) при системной склеродермии."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Колхицин быстро и интенсивно всасывается из\nжелудочно-кишечного тракта. Средняя максимальная концентрация в плазме крови\nсоставляет 4,2 нг/мл и достигается примерно через 70 минут после приёма в дозе\n1 мг. Период полувыведения составляет 9,3 часа. Колхицин быстро проникает в\nткани, имеет высокий объём распределения 473 л. Высокие концентрации колхицина\nобнаруживаются в печени, почках, селезёнке, лейкоцитах и ЖКТ. Колхицин\nметаболизируется в печени и выводится главным образом с желчью."}},{"type":"paragraph","data":{"text":"Энтерогепатическая циркуляция обнаруживается через 4-6 часов\nпосле введения внутрь. 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"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- повышенная чувствительность к действующему веществу\nили любому из вспомогательных веществ; непереносимость лактозы, фруктозы,\nдефицит лактазы, сахаразы/изомальтазы, глюкозо-галактозная мальабсорбция (в\nсостав входят лактоза, сахароза);"}},{"type":"paragraph","data":{"text":"- острая сердечная недостаточность, печеночная и/или\nпочечная недостаточность, тяжелые нарушения функции желудочно-кишечного тракта,\nвыраженное угнетение костномозгового кроветворения;"}},{"type":"paragraph","data":{"text":"- колхицин\nпротивопоказан пациентам с поражениями почек или печени, которые принимают\nингибиторы Р-гликопротеина или энзим CYP3A4; "}},{"type":"paragraph","data":{"text":"- беременность\nи период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"- детский\nвозраст до 18 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Колхицин следует назначать с особой осторожностью\nпожилым и ослабленным пациентам, в особенности, страдающим заболеваниями почек,\nжелудочно-кишечного тракта и сердца, пациентам с кахексией. При назначении\nпациентам с сахарным диабетом необходимо учитывать, что в составе препарата\nсодержится сахароза и лактоза."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Прием лекарственного препарата при беременности и в\nпериод кормления грудью противопоказан. "}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Для\nприема внутрь. Таблетку можно проглатывать целиком или разделить пополам по\nнанесенной риске для получения одноразовой дозы 0,5 мг."}},{"type":"paragraph","data":{"text":"При остром приступе подагры принимают по 1 мг\nколхицина (1 таблетка), затем по 0,5 -1,5 мг через каждые 1-2 часа до\nослабления боли. Суммарная доза препарата, принятая за день, не должна\nпревышать 8 мг. Повторное назначение по схеме лечения острого приступа подагры\nможет быть проведено не ранее, чем через 3 дня."}},{"type":"paragraph","data":{"text":"Для профилактики острых приступов подагры в первые\nнесколько месяцев лечения урикозурическими средствами принимают по 0,5 – 1,5 мг\nежедневно или через день в течение (как правило) 3 месяцев."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Частота нежелательных явлений классифицируется\nследующим образом: очень часто (> 1/10), часто (> 1/100 до < 1/10),\nнечасто (> 1/1000 до < 1/100), редко (> 1/10000 до < 1/1000), очень\nредко (< 1/10000), неизвестна (не может быть установлена по имеющимся\nданным)."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны системы кроветворения и\nлимфатической системы:\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: лейкопения."}},{"type":"paragraph","data":{"text":"Редко: тромбоцитоз, носовые кровотечения,\nзаболевания костного мозга (апластическая или гемолитическая анемия,\nпанцитопения, нейтропения, тромбоцитопения, агранулоцитоз)."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны нервной системы:\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: периферическая моторная нейропатия."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны желудочно-кишечного\nтракта:\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Часто: тошнота, рвота, диарея, боли в области\nживота."}},{"type":"paragraph","data":{"text":"Неизвестно: профузная диарея,\nжелудочно-кишечные кровотечения."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны печени и желчевыводящих\nпутей:\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Неизвестно: гипертрансаминаземия, повреждения\nпечени."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны почек и мочевыводящих\nпутей:\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Неизвестно: повреждение почек."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны кожи и подкожной\nклетчатки: \u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: алопеция."}},{"type":"paragraph","data":{"text":"Редко: аллергическая сыпь,\nвезикулезно-буллезная сыпь, геморрагическая сыпь, покраснение кожи, отеки."}},{"type":"paragraph","data":{"text":"Неизвестно: аллергическая сыпь."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны скелетной мускулатуры и\nсоединительной ткани:\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: миотония, мышечная слабость, миопатия,\nболь в мышцах, острый некроз скелетных мышц.\u003cb\u003e\u003ci\u003e\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны половых органов и\nмолочной железы:\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Редко: азооспермия, олигоспермия."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Острая интоксикация наблюдалась у взрослых после\nприема дозы около 20 мг и у детей – после приема дозы 5 мг. Хроническая\nинтоксикация может наблюдаться у больных, страдающих подагрой, после приема\nсуммарной дозы 10 мг или выше в течение нескольких дней."}},{"type":"paragraph","data":{"text":"Поскольку колхицин обладает антимитотической\nактивностью, поражению подвергаются чаще органы, для которых характерна высокая\nскорость пролиферации."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eСимптоматика интоксикации колхицином\u003c/i\u003e\u003c/b\u003e\u003ci\u003e.\u003c/i\u003e Примерно через 2 – 6 часов после\nприема внутрь токсической дозы отмечаются жжение и першение в горле и во рту,\nпозывы к рвоте и затрудненное глотание, тошнота, жажда и рвота, а после этого –\nпозывы к мочеиспусканию и дефекации, тенезмы и колики (как правило, у\nистощенных больных). Слизисто-водянистая и/или геморрагическая диарея может\nповлечь за собой потерю жидкости и электролитов, вследствие чего возможно\nразвитие гипокалиемии, гипонатриемии и метаболического ацидоза. Часто больные\nжалуются одновременно на стеснение и боль в области сердца. В дальнейшем\nнаблюдаются бледность, снижение температуры тела, цианоз и диспноэ. Возможно\nразвитие тахикардии и артериальной гипотензии (вплоть до коллапса)."}},{"type":"paragraph","data":{"text":"Неврологические расстройства проявляются в форме снижения\nчувствительности, судорог и симптомов паралича. Возможен смертельный исход в\nпервые три дня вследствие сердечно-сосудистой недостаточности и паралича\nдыхания. "}},{"type":"paragraph","data":{"text":"Через 1 - 2 недели после излечения интоксикации может\nнаблюдаться полная, иногда долговременная алопеция. В некоторых случаях\nотмечались нарушения функции почек, легких и печени. Имеются сообщения о редких\nслучаях слепоты. \u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЛечение интоксикации.\u003c/i\u003e\u003c/b\u003e Лечение проводится\nв условиях токсикологического центра. Специфического антидота нет. Гемодиализ\nнеэффективен. Необходимы промывание желудка, контроль за проходимостью\nдыхательных путей, вспомогательная вентиляция, мониторинг и поддержание\nжизненно важных функций, нормализация газового состава крови, электролитного\nбаланса, проведение противошоковых мероприятий. Лечение симптоматическое,\nнаправлено на стабилизацию и поддержание сердечно-сосудистой системы и основных\nжизненных функций: инфузионная терапия, сердечные гликозиды для поддержания\nсократимости миокарда при необходимости. При спазмах в животе назначают\nатропин, папаверин или танналбин. Не следует применять опиаты."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"В сочетании с циклоспорином, особенно у\nпациентов с нарушением функции почек, повышается вероятность развития миопатии."}},{"type":"paragraph","data":{"text":"Усиливает эффект депримирующих и\nсимпатомиметических средств."}},{"type":"paragraph","data":{"text":"Нарушает всасывание цианкобаламина."}},{"type":"paragraph","data":{"text":"Нестероидные противовоспалительные\nпрепараты и другие препараты, вызывающие миелодепрессию, повышают риск развития\nлейкопении и тромбоцитопении."}},{"type":"paragraph","data":{"text":"Противоподагрическую активность снижают\nцитостатики (увеличивают концентрацию мочевой кислоты) и закисляющие мочу\nпрепараты, ощелачивающие усиливают эффект."}},{"type":"paragraph","data":{"text":"Колхицин можно применять в комбинации с аллопуринолом\nи препаратами урикозурического действия."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При применении Колхицина очень важно\nсоблюдать рекомендуемую дозировку. Лечение необходимо проводить под тщательным\nгематологическим и клиническим контролем. При появлении выраженных побочных эффектов\nсо стороны ЖКТ следует уменьшить дозу или отменить препарат. При снижении\nколичества лейкоцитов ниже 3000/мкл и тромбоцитов ниже 100000/мкл прием\nпрекращают до нормализации картины крови."}},{"type":"paragraph","data":{"text":"Колхицин необходимо назначать с особой\nосторожностью для приема пожилыми и ослабленными пациентами, в особенности\nстрадающими заболеваниями почек, желудочно-кишечного тракта и сердца. При\nпоявлении слабости, анорексии, тошноты, рвоты или диареи дозировку необходимо\nснизить или отменить, так как это может быть первыми признаками интоксикации."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eКларитромицин:\u003c/i\u003e\u003c/b\u003e\u003ci\u003e \u003c/i\u003eсообщалось о пострегистрационных случаях токсичности колхицина при\nсочетанном применении колхицина и кларитромицина, особенно у пожилых пациентов;\nнекоторые из этих случаев отмечались у пациентов с почечной недостаточностью.\nБыли зарегистрированы случаи смерти некоторых из этих пациентов. При\nнеобходимости приема колхицина одновременно с кларитромицином пациент должен\nнаходиться под тщательным наблюдением во избежание появления клинических\nсимптомов токсичности, вызванных приемом колхицина."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eКолхицин содержит лактозу и сахарозу:\u003c/i\u003e\u003c/b\u003e\nпациенты, страдающие от редких генетических заболеваний, включающих\nнепереносимость галактозы, фруктозы, лактозную или сахаразо-изомальтазную недостаточность,\nглюкозо-галактозную мальабсорбцию, не должны принимать данный лекарственный\nпрепарат. "}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не влияет на способность управлять\nтранспортными средствами и занятия другими потенциально опасными видами деятельности,\nтребующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки,\n1 мг."}},{"type":"paragraph","data":{"text":"По\n30 таблеток в блистер из пленки поливинилхлоридной непрозрачной и фольги\nалюминиевой. "}},{"type":"paragraph","data":{"text":"Один,\nдва или три блистера вместе с инструкцией по применению помещают в пачку\nкартонную."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет."}},{"type":"paragraph","data":{"text":"Не применять препарат по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Производство\nпрепарата осуществляется на основании договора о лицензировании между \u003cb\u003e«АКАРПИА Фармасьютичи С.р.л.»\u003c/b\u003e, \u003cb\u003eВиа Виваио, 17 20122, Милан, Италия\u003c/b\u003e и "}},{"type":"paragraph","data":{"text":"\u003cb\u003eЗАО «Московская фармацевтическая\nфабрика»\u003c/b\u003e, \u003cb\u003eРоссийская Федерация\u003c/b\u003e."}},{"type":"paragraph","data":{"text":"\u003cb\u003eПроизводитель/фасовщик (первичная\nупаковка)\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Хаупт\nФарма Амарег ГмбХ"}},{"type":"paragraph","data":{"text":"Донаустауфер\nШтр. 378, 93055 Регенсбург, Германия."}},{"type":"paragraph","data":{"text":"\u003cb\u003eПроизводитель/упаковщик (вторичная\n(потребительская) упаковка)\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"ЗАО\n«Московская фармацевтическая фабрика»"}},{"type":"paragraph","data":{"text":"Россия,\n125329, г. Москва, Фармацевтический проезд, д. 1"}},{"type":"paragraph","data":{"text":"тел.\n(495) 956-05-11, факс (495) 459-41-12"}},{"type":"paragraph","data":{"text":"www.mosfarma.ru"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО «Московская фармацевтическая фабрика»"}},{"type":"paragraph","data":{"text":"Россия, 125329, г. Москва,\nФармацевтический проезд, д. 1"}},{"type":"paragraph","data":{"text":"тел. (495) 956-05-11, факс (495) 459-41-12"}},{"type":"paragraph","data":{"text":"www.mosfarma.ru"}}]}],"source":null},"description_toggle":false,"short_description":"Противоподагрическое действие колхицина связано со снижением миграции лейкоцитов в очаг воспаления и угнетением фагоцитоза микрокристаллов солей мочевой кислоты. Обладает также антимитотическим действием, подавляет (полностью или частично) клеточное деление в стадии анафазы и метафазы, предотвращает дегрануляцию нейтрофилов. Снижая образование амилоидных фибрилл, препятствует развитию амилоидоза. Высоко эффективен для купирования острой подагры. В первые 12 ч терапии состояние существенно улучшается более чем у 75 % больных. У 80 % может вызывать побочные реакции со стороны желудочно-кишечного тракта (ЖКТ) ранее клинического улучшения или одновременно с ним. В суточной дозе 1-2 мг при ежедневном приеме у 3/4 больных с подагрой уменьшает вероятность развития повторных острых приступов. Предупреждает острые атаки у больных семейной средиземноморской лихорадкой (понижает активность дофамин-бета-гидроксилазы). Увеличивает продолжительность жизни больных с первичным АГ-амилоидозом. Оказывает положительное влияние на кожу (смягчение, уменьшение сухости) при системной склеродермии.ФармакокинетикаКолхицин быстро и интенсивно всасывается из желудочно-кишечного тракта. Средняя максимальная концентрация в плазме крови составляет 4,2 нг/мл и достигается примерно через 70 минут после приёма в дозе 1 мг. Период полувыведения составляет 9,3 часа. Колхицин быстро проникает в ткани, имеет высокий объём распределения 473 л. Высокие концентрации колхицина обнаруживаются в печени, почках, селезёнке, лейкоцитах и ЖКТ. Колхицин метаболизируется в печени и выводится главным образом с желчью. Энтерогепатическая циркуляция обнаруживается через 4-6 часов после введения внутрь. 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