Локоид липокрем - синтетический негалогенизированный глюкокортикоидный препарат для наружного применения. Этерификация молекулы гидрокортизона остатком масляной кислоты (бутиратом) позволила радикально повысить активность препарата по сравнению с нативным гидрокортизоном. Оказывает быстро наступающее противовоспалительное, противоотечное, противозудное действие.
Применение препарата Локоид Липокрем® в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-надпочечниковой системы. Хотя применение препарата в высоких дозах в течение длительного времени, особенно при использовании окклюзионных повязок, может привести к увеличению содержания кортизола в плазме крови, это обычно не сопровождается снижением реактивности гипофизарно-надпочечниковой системы, а отмена препарата приводит к быстрой нормализации продукции кортизола.
Фармакокинетика: Всасывание
После аппликации происходит накопление активного вещества в эпидермисе, в основном в зернистом слое. Системная абсорбция незначительна. Небольшое количество гидрокортизона 17-бутирата всасывается в системный кровоток в неизмененном виде.
Метаболизм
Большая часть гидрокортизона 17-бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и, в последующем, в печени.
Выведение
Метаболиты и незначительная часть неизмененного гидрокортизона 17-бутирата выводятся с почками и через кишечник.
Показания к применению
Поверхностные, неинфицированные, чувствительные к местным ГКС заболевания кожи:
— экзема;
— дерматиты (в т.ч. атопический, контактный, себорейный);
— псориаз.
Противопоказания
— бактериальные инфекции кожи (стрепто- и стафилодермии, грамотрицательный фолликулит);
— неопластические изменения кожи (доброкачественные и злокачественные опухоли);
— акне, розацеа, периоральный дерматит;
— поствакцинальный период;
— нарушение целостности кожных покровов (раны, язвы);
— повышенная чувствительность к препарату Локоид Липокрем.
С осторожностью следует назначать препарат при беременности и в период лактации.
Способ применения и дозы
Режим дозирования инъекций индивидуальный. Применяют внутривенно струйно и капельно, редко - внутримышечно. Начальная доза составляет 100 мг (вводится за 30 сек) - 500 мг (вводится за 10 мин), затем повторно через каждые 2-6 ч, в зависимости от клинической ситуации. Высокие дозы препарата Локоид Липокрем следует назначать только до стабилизации состояния больного, но обычно не более 48-72 ч. Детям назначают в дозе не менее 25 мг/кг массы тела в сут. Глазная мазь Локоид Липокрем: вводят непосредственно из тюбика в конъюнктивальный мешок 1-3 раза в день в зависимости от характера заболевания. Наружно препарат Локоид Липокрем в виде крема, мази или лосьона назначают 1-3 раза в сут.
Особые указания
Следует избегать попадания мази в глаза. Детям до 12 лет препарат назначают только под строгим врачебным контролем. Если после 7 дней применения не наступает улучшения или наблюдается ухудшение состояния, а также в случае возобновления симптомов через несколько дней после отмены, применение препарата следует прекратить и проконсультироваться с врачом. Не следует применять препарат без консультации с врачом в случаях, когда зуд в области гениталий у женщин сопровождается выделениями из влагалища. При длительном лечении и/или нанесении на большие поверхности рекомендуется назначить диету с ограничением Na+ и повышенным содержанием K+; вводить в организм достаточное количество белка. Необходимо контролировать АД, концентрацию глюкозы и кортизола в крови, свертываемость крови, диурез, массу тела больного.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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глюкокортикостероид для местного применения."}}]},{"id":8,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Локоид липокрем - синтетический негалогенизированный глюкокортикоидный препарат для наружного применения. Этерификация молекулы гидрокортизона остатком масляной кислоты (бутиратом) позволила радикально повысить активность препарата по сравнению с нативным гидрокортизоном. Оказывает быстро наступающее противовоспалительное, противоотечное, противозудное действие."}},{"type":"paragraph","data":{"text":"Применение препарата Локоид Липокрем® в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-надпочечниковой системы. Хотя применение препарата в высоких дозах в течение длительного времени, особенно при использовании окклюзионных повязок, может привести к увеличению содержания кортизола в плазме крови, это обычно не сопровождается снижением реактивности гипофизарно-надпочечниковой системы, а отмена препарата приводит к быстрой нормализации продукции кортизола."}},{"type":"paragraph","data":{"text":"Фармакокинетика: Всасывание"}},{"type":"paragraph","data":{"text":"После аппликации происходит накопление активного вещества в эпидермисе, в основном в зернистом слое. Системная абсорбция незначительна. Небольшое количество гидрокортизона 17-бутирата всасывается в системный кровоток в неизмененном виде."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Большая часть гидрокортизона 17-бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и, в последующем, в печени."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"Метаболиты и незначительная часть неизмененного гидрокортизона 17-бутирата выводятся с почками и через кишечник.\n\n"}}]},{"id":9,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nПоверхностные, неинфицированные, чувствительные к местным ГКС заболевания кожи:"}},{"type":"paragraph","data":{"text":"— экзема;"}},{"type":"paragraph","data":{"text":"— дерматиты (в т.ч. атопический, контактный, себорейный);"}},{"type":"paragraph","data":{"text":"— псориаз.\n\n"}}]},{"id":10,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\n— бактериальные инфекции кожи (стрепто- и стафилодермии, грамотрицательный фолликулит);"}},{"type":"paragraph","data":{"text":"— вирусные инфекции кожи (простой герпес, ветряная оспа, опоясывающий лишай);"}},{"type":"paragraph","data":{"text":"— грибковые инфекции кожи;"}},{"type":"paragraph","data":{"text":"— туберкулезные и сифилитические поражения кожи;"}},{"type":"paragraph","data":{"text":"— паразитарные инфекции кожи;"}},{"type":"paragraph","data":{"text":"— неопластические изменения кожи (доброкачественные и злокачественные опухоли);"}},{"type":"paragraph","data":{"text":"— акне, розацеа, периоральный дерматит;"}},{"type":"paragraph","data":{"text":"— поствакцинальный период;"}},{"type":"paragraph","data":{"text":"— нарушение целостности кожных покровов (раны, язвы);"}},{"type":"paragraph","data":{"text":"— повышенная чувствительность к препарату Локоид Липокрем."}},{"type":"paragraph","data":{"text":"С осторожностью следует назначать препарат при беременности и в период лактации.\n\n"}}]},{"id":13,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Режим дозирования инъекций индивидуальный. Применяют внутривенно струйно и капельно, редко - внутримышечно. Начальная доза составляет 100 мг (вводится за 30 сек) - 500 мг (вводится за 10 мин), затем повторно через каждые 2-6 ч, в зависимости от клинической ситуации. Высокие дозы препарата Локоид Липокрем следует назначать только до стабилизации состояния больного, но обычно не более 48-72 ч. Детям назначают в дозе не менее 25 мг/кг массы тела в сут. Глазная мазь Локоид Липокрем: вводят непосредственно из тюбика в конъюнктивальный мешок 1-3 раза в день в зависимости от характера заболевания. Наружно препарат Локоид Липокрем в виде крема, мази или лосьона назначают 1-3 раза в сут."}}]},{"id":17,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Следует избегать попадания мази в глаза. Детям до 12 лет препарат назначают только под строгим врачебным контролем. Если после 7 дней применения не наступает улучшения или наблюдается ухудшение состояния, а также в случае возобновления симптомов через несколько дней после отмены, применение препарата следует прекратить и проконсультироваться с врачом. Не следует применять препарат без консультации с врачом в случаях, когда зуд в области гениталий у женщин сопровождается выделениями из влагалища. При длительном лечении и/или нанесении на большие поверхности рекомендуется назначить диету с ограничением Na+ и повышенным содержанием K+; вводить в организм достаточное количество белка. Необходимо контролировать АД, концентрацию глюкозы и кортизола в крови, свертываемость крови, диурез, массу тела больного."}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Локоид липокрем - синтетический негалогенизированный глюкокортикоидный препарат для наружного применения. 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Небольшое количество гидрокортизона 17-бутирата всасывается в системный кровоток в неизмененном виде. Метаболизм Большая часть гидрокортизона 17-бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и, в последующем, в печени. 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