Экзифин Гель, туба, 15 г, 1 %, для наружного применения

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В небольших концентрациях тербинафин оказывает \u003ci\u003eфунгицидное действие в отношении\u003c/i\u003e дерматофитов (Trychophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton violaceum, Trichophyton tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых (например, Scopulariopsis brevicaulis) и определенных диморфных грибов (Pityrosporum orbiculare). Активность в отношении дрожжевых грибов, в основном Сandida albicans, в зависимости от их вида, может быть фунгицидной или фунгистатической."}},{"type":"paragraph","data":{"text":"Тербинафин специфическим образом изменяет ранний этап биосинтеза стеролов, происходящего в грибах. Это ведет к дефициту эргостерола и к внутриклеточному накоплению сквалена, что вызывает гибель клетки гриба. Действие тербинафина осуществляется путем ингибирования фермента скваленэпоксидазы, расположенного на клеточной мембране гриба."}},{"type":"paragraph","data":{"text":"Тербинафин не оказывает влияния на изоферменты системы цитохрома Р450 у человека и, соответственно, на метаболизм гормонов или других лекарственных препаратов."}},{"type":"header","data":{"text":"Фармакокинетика","level":4}},{"type":"paragraph","data":{"text":"При наружном применении всасывание - менее 5%. Оказывает незначительное системное действие."}}]},{"id":9,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Профилактика и лечение грибковых инфекций кожи, вызванных чувствительными возбудителями, в т.ч микозов стоп (\"грибок\" стопы), паховой эпидермофитии (tinea cruris), грибковых поражений гладкой кожи тела (tinea cruris), грибковые поражения гладкой кожи тела (tinea corporus), вызванных такими дерматофитами, как Trichophyton (в т.ч. 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