Анальгезирующее средство (анальгезирующее ненаркотическое средство спазмолитическое средство барбитурат).
Фармакологические свойства
Фармакологические свойства
Комбинированный препарат. Сочетание компонентов препарата приводит к взаимному усилению их фармакологического действия. Метамизол натрия – производное пиразолона, оказывает анальгезирующее и жаропонижающее действие. Бендазол (дибазол) - вазодилатирующее средство; обладает сосудорасширяющим действием, стимулирует функцию спинного мозга.
Оказывает непосредственное спазмолитическое действие на гладкие мышцы кровеносных сосудов и внутренних органов. Облегчает синаптическую передачу в спинном мозге. Папаверина гидрохлорид – спазмолитическое средство, оказывает гипотензивное действие, снижает тонус и расслабляет гладкие мышцы внутренних органов и сосудов. Фенобарбитал, в малых дозах оказывает седативный эффект и усиливает действие других компонентов.
Показания к применению
Болевой синдром (слабо или умеренно выраженный) при спазмах гладкой мускулатуры внутренних органов:
дети младше 8 лет, беременность, период лактации, тахиаритмии, тяжелая стенокардия, коллапс, декомпенсированная хроническая сердечная недостаточность;
закрытоугольная глаукома;
гиперплазия предстательной железы;
кишечная непроходимость, мегаколон.
Применение при беременности и в период грудного вскармливания
Препарат противопоказан при беременности и в период грудного вскармливания.
Беременность
Данные о применении комбинированного препарата Андипал во время беременности ограничены. Метамизол натрия входящий в состав препарата проникает через плаценту. По результатам доклинических исследований тератогенное действие метамизола натрия не обнаружено. Несмотря на то что метамизол натрия слабо ингибирует синтез простагландинов нельзя исключить преждевременное (внутриутробное) закрытие артериального протока а также перинатальные осложнения обусловленные нарушением агрегации тромбоцитов у матери или новорожденного.
Грудное вскармливание
Метаболиты метамизола натрия проникают в грудное молоко поэтому при применении препарата Андипал а также в течение 48 часов после приема последней дозы необходимо отказаться от грудного вскармливания.
Способ применения и дозы
Внутрь, взрослым и детям старше 8 лет по 1 таблетке 2-3 раза в сутки. Длительность применения без консультации врача не должна превышать 7 дней.
Побочное действие
Аллергические реакции.
Со стороны центральной нервной системы: сонливость, снижение скорости психомоторных реакций.
Со стороны желудочно-кишечного тракта: тошнота, запор.
Со стороны сердечной-сосудистой системы: артериальная гипотензия.
При длительном применении: лейкопения, агранулоцитоз, нарушение функции печени и почек.
Передозировка
Андипал
Симптомы передозировки: передозировка препарата обусловлена свойствами входящих в него компонентов. При передозировке возникает выраженная сонливость головокружение коллаптоидное состояние.
Лечение: оказание первой помощи - промывание желудка прием активированного угля. Симптоматическая терапия направленная на поддержание жизненно важных функций. Лечение интоксикации как и профилактика серьезных осложнений требуют интенсивного медицинского наблюдения и лечения.
Метамизол натрия
Симптомы передозировки: острая передозировка проявляется тошнотой рвотой болью в животе нарушением функции почек/острой почечной недостаточностью (например как проявление интерстициального нефрита) и редко симптомами со стороны ЦНС (комой судорогами) и снижением артериального давления приводящим к тахикардии и шоку. При высокой передозировке экскреция рубазоновой кислоты может окрасить мочу в красный цвет.
Лечение: специфический антидот не известен. При недавней передозировке в целях ограничения поступления препарата в организм проводят первичную детоксикацию (например промывание желудка) или сорбционную терапию (например активированный уголь). Основной метаболит (4N-метиламиноантипирин) удаляется при гемодиализе гемофильтрации гемоперфузии и плазмафильтрации. Лечение передозировки равно как и профилактика серьезных осложнений может потребовать общего и специального интенсивного медицинского наблюдения и лечения.
Фенобарбитал
Симптомы передозировки: нистагм атаксия головная боль заторможенность смазанная речь выраженная слабость снижение или утрата рефлексов возбуждение повышение или понижение температуры тела угнетение дыхания одышка снижение артериального давления сужение зрачков (сменяющееся паралитическим расширением) олигурия тахи- или брадикардия цианоз спутанность сознания прекращение электрической активности мозга отек легких кома позже - пневмония аритмии сердечная недостаточность; при приеме 2-10 г - летальный исход; при хронической токсичности - раздражительность ослабление способности к критической оценке нарушения сна спутанность сознания.
Лечение: специфического антидота нет. Промывание желудка прием активированного угля проведение дезинтоксикационной терапии симптоматическое лечение поддержание жизненно важных функций организма.
Бендазол
Симптомы передозировки: сведения о случаях передозировки отсутствуют. Наиболее вероятным нежелательным явлением может быть выраженное снижение артериального давления.
Лечение: при выраженном снижении артериального давления придать пациенту положение "лежа" с приподнятыми нижними конечностями проводить симптоматическую терапию.
Папаверина гидрохлорид
Симптомы передозировки: диплопия (двоение в глазах) слабость снижение артериального давления.
Взаимодействие с другими лекарственными средствами
Комбинация с нитратами (нитроглицерин, нитросорбид, сустак и др.), блокаторами кальциевых каналов (нифедипин, коринфар и др.), бета-адреноблокаторами (анаприлин, метопролол, талинолол и др.), ганглиоблокаторами (пентамин и др.), диуретиками (фуросемид, гипотиазид и др.), миотропными спазмолитиками (дипиридамол, эуфиллин и др.) усиливает гипотензивное действие указанных препаратов.
Одновременное применение с другими ненаркотическими анальгетиками может привести к взаимному усилению токсических эффектов. Совместное применение с адсорбентами, вяжущими и обволакивающими средствами снижает всасывание препарата в желудочно-кишечном тракте.
Особые указания
При длительном (более 7 дней) применении необходим контроль картины периферической крови и функционального состояния печени.
При отсутствии эффекта в течение 3-х дней следует прекратить прием препарата и обратиться к врачу.
Во время лечения следует отказаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Детям и подросткам до 18 лет препарат следует применять только по назначению врача.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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вещество: \u003ca href=\"https://www.eapteka.ru/goods/active_ingredient/bendazol_metamizol_natriya_papaverin_fenobarbital/\"\u003eБендазол, Метамизол натрия, Папаверин, Фенобарбитал\u003c/a\u003e. "}},{"type":"paragraph","data":{"text":"\n\nАктивные вещества: метамизол натрия (анальгин) – 250 мг, фенобарбитал – 20 мг, бендазол (дибазол) – 20 мг, папаверина гидрохлорид – 20 мг."}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: крахмал картофельный – 46 мг, тальк – 7 мг, кислота стеариновая – 3 мг, кальция стеарат – 4 мг.\n\n"}}]},{"id":7,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Анальгезирующее средство (анальгезирующее ненаркотическое средство спазмолитическое средство барбитурат)."}}]},{"id":8,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\n\nФармакологические свойства"}},{"type":"paragraph","data":{"text":"Комбинированный препарат. Сочетание компонентов препарата приводит к взаимному усилению их фармакологического действия. Метамизол натрия – производное пиразолона, оказывает анальгезирующее и жаропонижающее действие. Бендазол (дибазол) - вазодилатирующее средство; обладает сосудорасширяющим действием, стимулирует функцию спинного мозга."}},{"type":"paragraph","data":{"text":"Оказывает непосредственное спазмолитическое действие на гладкие мышцы кровеносных сосудов и внутренних органов. Облегчает синаптическую передачу в спинном мозге. Папаверина гидрохлорид – спазмолитическое средство, оказывает гипотензивное действие, снижает тонус и расслабляет гладкие мышцы внутренних органов и сосудов. Фенобарбитал, в малых дозах оказывает седативный эффект и усиливает действие других компонентов."}}]},{"id":9,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nБолевой синдром (слабо или умеренно выраженный) при спазмах гладкой мускулатуры внутренних органов: "}},{"type":"list","data":{"style":"ordered","items":["почечная колика, желчная колика, кишечная колика;","дискинезия желчевыводящих путей, постхолецистэктомический синдром;","спазм мочеточников и мочевого пузыря;","альгодисменорея."]}},{"type":"paragraph","data":{"text":"Спазм сосудов головного мозга, мигрень."}},{"type":"paragraph","data":{"text":"В качестве вспомогательного лекарственного средства: болевой синдром после хирургического вмешательства и диагностических процедур.\n\n"}}]},{"id":10,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["Гиперчувствительность (в т.ч. к производным пиразолона);","угнетение костномозгового кроветворения;","выраженная печеночная и/или почечная недостаточность;","дефицит глюкозо-6-фосфатдегидрогеназы;","дети младше 8 лет, беременность, период лактации, тахиаритмии, тяжелая стенокардия, коллапс, декомпенсированная хроническая сердечная недостаточность;","закрытоугольная глаукома;","гиперплазия предстательной железы;","кишечная непроходимость, мегаколон."]}}]},{"id":12,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Препарат противопоказан при беременности и в период грудного вскармливания."}},{"type":"paragraph","data":{"text":"Беременность"}},{"type":"paragraph","data":{"text":"Данные о применении комбинированного препарата Андипал во время беременности ограничены. Метамизол натрия входящий в состав препарата проникает через плаценту. По результатам доклинических исследований тератогенное действие метамизола натрия не обнаружено. Несмотря на то что метамизол натрия слабо ингибирует синтез простагландинов нельзя исключить преждевременное (внутриутробное) закрытие артериального протока а также перинатальные осложнения обусловленные нарушением агрегации тромбоцитов у матери или новорожденного."}},{"type":"paragraph","data":{"text":"Грудное вскармливание"}},{"type":"paragraph","data":{"text":"Метаболиты метамизола натрия проникают в грудное молоко поэтому при применении препарата Андипал а также в течение 48 часов после приема последней дозы необходимо отказаться от грудного вскармливания."}}]},{"id":13,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, взрослым и детям старше 8 лет по 1 таблетке 2-3 раза в сутки. Длительность применения без консультации врача не должна превышать 7 дней."}}]},{"id":14,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nАллергические реакции."}},{"type":"paragraph","data":{"text":"Со стороны центральной нервной системы: сонливость, снижение скорости психомоторных реакций."}},{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта: тошнота, запор."}},{"type":"paragraph","data":{"text":"Со стороны сердечной-сосудистой системы: артериальная гипотензия."}},{"type":"paragraph","data":{"text":"При длительном применении: лейкопения, агранулоцитоз, нарушение функции печени и почек.\n\n"}}]},{"id":15,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Андипал"}},{"type":"paragraph","data":{"text":"Симптомы передозировки: передозировка препарата обусловлена свойствами входящих в него компонентов. При передозировке возникает выраженная сонливость головокружение коллаптоидное состояние."}},{"type":"paragraph","data":{"text":"Лечение: оказание первой помощи - промывание желудка прием активированного угля. Симптоматическая терапия направленная на поддержание жизненно важных функций. Лечение интоксикации как и профилактика серьезных осложнений требуют интенсивного медицинского наблюдения и лечения."}},{"type":"paragraph","data":{"text":"Метамизол натрия"}},{"type":"paragraph","data":{"text":"Симптомы передозировки: острая передозировка проявляется тошнотой рвотой болью в животе нарушением функции почек/острой почечной недостаточностью (например как проявление интерстициального нефрита) и редко симптомами со стороны ЦНС (комой судорогами) и снижением артериального давления приводящим к тахикардии и шоку. При высокой передозировке экскреция рубазоновой кислоты может окрасить мочу в красный цвет."}},{"type":"paragraph","data":{"text":"Лечение: специфический антидот не известен. При недавней передозировке в целях ограничения поступления препарата в организм проводят первичную детоксикацию (например промывание желудка) или сорбционную терапию (например активированный уголь). Основной метаболит (4N-метиламиноантипирин) удаляется при гемодиализе гемофильтрации гемоперфузии и плазмафильтрации. Лечение передозировки равно как и профилактика серьезных осложнений может потребовать общего и специального интенсивного медицинского наблюдения и лечения."}},{"type":"paragraph","data":{"text":"Фенобарбитал"}},{"type":"paragraph","data":{"text":"Симптомы передозировки: нистагм атаксия головная боль заторможенность смазанная речь выраженная слабость снижение или утрата рефлексов возбуждение повышение или понижение температуры тела угнетение дыхания одышка снижение артериального давления сужение зрачков (сменяющееся паралитическим расширением) олигурия тахи- или брадикардия цианоз спутанность сознания прекращение электрической активности мозга отек легких кома позже - пневмония аритмии сердечная недостаточность; при приеме 2-10 г - летальный исход; при хронической токсичности - раздражительность ослабление способности к критической оценке нарушения сна спутанность сознания."}},{"type":"paragraph","data":{"text":"Лечение: специфического антидота нет. Промывание желудка прием активированного угля проведение дезинтоксикационной терапии симптоматическое лечение поддержание жизненно важных функций организма."}},{"type":"paragraph","data":{"text":"Бендазол"}},{"type":"paragraph","data":{"text":"Симптомы передозировки: сведения о случаях передозировки отсутствуют. Наиболее вероятным нежелательным явлением может быть выраженное снижение артериального давления."}},{"type":"paragraph","data":{"text":"Лечение: при выраженном снижении артериального давления придать пациенту положение \"лежа\" с приподнятыми нижними конечностями проводить симптоматическую терапию."}},{"type":"paragraph","data":{"text":"Папаверина гидрохлорид"}},{"type":"paragraph","data":{"text":"Симптомы передозировки: диплопия (двоение в глазах) слабость снижение артериального давления."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое (поддержание артериального давления)."}}]},{"id":16,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nКомбинация с нитратами (нитроглицерин, нитросорбид, сустак и др.), блокаторами кальциевых каналов (нифедипин, коринфар и др.), бета-адреноблокаторами (анаприлин, метопролол, талинолол и др.), ганглиоблокаторами (пентамин и др.), диуретиками (фуросемид, гипотиазид и др.), миотропными спазмолитиками (дипиридамол, эуфиллин и др.) усиливает гипотензивное действие указанных препаратов."}},{"type":"paragraph","data":{"text":"Одновременное применение с другими ненаркотическими анальгетиками может привести к взаимному усилению токсических эффектов. Совместное применение с адсорбентами, вяжущими и обволакивающими средствами снижает всасывание препарата в желудочно-кишечном тракте.\n\n"}}]},{"id":17,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nПри длительном (более 7 дней) применении необходим контроль картины периферической крови и функционального состояния печени."}},{"type":"paragraph","data":{"text":"При отсутствии эффекта в течение 3-х дней следует прекратить прием препарата и обратиться к врачу."}},{"type":"paragraph","data":{"text":"Во время лечения следует отказаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}},{"type":"paragraph","data":{"text":"Детям и подросткам до 18 лет препарат следует применять только по назначению врача.\n\n"}}]},{"id":19,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Т\u003ca href=\"https://www.eapteka.ru/goods/drugs/pain/analgesics/?drug_form=tabletki\"\u003eаблетки\u003c/a\u003e."}}]},{"id":20,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света и недоступном для детей месте."}}]},{"id":21,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n2 года 6 месяцев."}},{"type":"paragraph","data":{"text":"Препарат нельзя использовать после истечения срока годности.\n\n"}}]},{"id":22,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":23,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/firm/851\"\u003eОБНОВЛЕНИЕ, ПФК АО\u003c/a\u003e (Россия). "}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Фармакологические свойства Комбинированный препарат. Сочетание компонентов препарата приводит к взаимному усилению их фармакологического действия. Метамизол натрия – производное пиразолона, оказывает анальгезирующее и жаропонижающее действие. Бендазол (дибазол) - вазодилатирующее средство; обладает сосудорасширяющим действием, стимулирует функцию спинного мозга. Оказывает непосредственное спазмолитическое действие на гладкие мышцы кровеносных сосудов и внутренних органов. Облегчает синаптическую передачу в спинном мозге. Папаверина гидрохлорид – спазмолитическое средство, оказывает гипотензивное действие, снижает тонус и расслабляет гладкие мышцы внутренних органов и сосудов. 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