Ингибитор АПФ, уменьшает образование ангиотензина II из анги... Инструкция
Показания к применению
Артериальная гипертензия, Хроническая сердечная недостаточность, Раннее лечение острого инфаркта миокарда в составе комбинированной терапии, Диабетическая нефропатия.
Противопоказания
Повышенная чувствительность к лизиноприлу или другим ингибиторам АПФ, Ангионевротический отек в анамнезе, в т. ч. на фоне применения ингибиторов АПФ, Наследственный отек Квинке или идиопатический ангионевротический отек, Дефицит лактазы, непереносимость лактозы, синдром глюкозо-галактозной мальабсорбции.
Лизиноприл предназначен для мягкого понижения кровяного давления. Препарат оказывает оказывает гипотензивное, вазодилатирующее, кардиопротективное, натрийуретическое действие.
Фармакологические свойства
Ингибитор АПФ, уменьшает образование ангиотензина II из ангиотензина I. Снижение содержания ангиотензина II ведет к прямому уменьшению выделения альдостерона. Уменьшает деградацию брадикинина и увеличивает синтез простагландинов. Снижает общее периферическое сосудистое сопротивление, артериальное давление (АД), преднагрузку, давление в легочных капиллярах, вызывает увеличение минутного объема крови и повышение толерантности миокарда к нагрузкам у больных с хронической сердечной недостаточностью. Расширяет артерии в большей степени, чем вены. При длительном применении уменьшается гипертрофия миокарда и стенок артерий резистивного типа. Улучшает кровоснабжение ишемизированного миокарда. Начало действия - через 1ч. Максимальный эффект определяется через 6-7ч и сохраняется в течение 24ч. При артериальной гипертензии эффект отмечается в первые дни после начала лечения, стабильное действие развивается через 1-2 мес.
Показания к применению
Артериальная гипертензия, Хроническая сердечная недостаточность, Раннее лечение острого инфаркта миокарда в составе комбинированной терапии, Диабетическая нефропатия.
Противопоказания
Повышенная чувствительность к лизиноприлу или другим ингибиторам АПФ, Ангионевротический отек в анамнезе, в т. ч. на фоне применения ингибиторов АПФ, Наследственный отек Квинке или идиопатический ангионевротический отек, Дефицит лактазы, непереносимость лактозы, синдром глюкозо-галактозной мальабсорбции.
Применение при беременности и в период грудного вскармливания
Противопоказано
Способ применения и дозы
Внутрь, 1 раз в сутки утром, независимо от приема пищи, предпочтительно в одно и то же время. При артериальной гипертензии больным, не получающим другие гипотензивные средства, назначают по 5 мг 1 раз в сутки. При отсутствии эффекта дозу повышают каждые 2-3 дня на 5 мг до средней терапевтической дозы 20-40 мг/сут (увеличение дозы свыше 40 мг/сутки обычно не ведет к дальнейшему снижению АД). Обычная суточная поддерживающая доза — 20 мг. Максимальная суточная доза — 40 мг. Полный эффект развивается обычно через 2-4 недели от начала лечения, что следует учесть при увеличении дозы. При недостаточном клиническом эффекте возможно комбинирование препарата с другими гипотензивными средствами.
Побочное действие
Выраженное снижение АД, ортостатическая гипотензия, парестезии, лабильность настроения, растерянность, сонливость, судорожные подергивания мышц конечностей и губ.
Передозировка
Симптомы (возникают при приеме однократной дозы 50 мг): выраженное снижение АД, сухость слизистой оболочки полости рта, сонливость, задержка мочеиспускания, запор, беспокойство, повышенная раздражительность. Лечение: специфический антидот отсутствует. Симптоматическая терапия. Промывание желудка, применение энтеросорбентов и слабительных средств. Показано внутривенное введение 0,9 % раствора натрия хлорида. В случае устойчивой к лечению брадикардии, необходимо применение искусственного водителя ритма. Необходим контроль АД, показателей водно-электролитного баланса. Гемодиализ эффективен.
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