Омепразол Капсулы, 30 шт, 20 мг, для взрослых

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У пожилых пациентов выведение уменьшается биодоступность возрастает."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Язвенная болезнь желудка и 12-перстной кишки (в том числе профилактика рецидивов);"}},{"type":"paragraph","data":{"text":"- рефлюкс-эзофагит;"}},{"type":"paragraph","data":{"text":"- гиперсекреторные состояния (синдром Золлингера-Эллисона стрессовые язвы желудочно-кишечного тракта полиэндокринный аденоматоз системный мастоцитоз);"}},{"type":"paragraph","data":{"text":"- профилактика аспирации кислого содержимого желудка в дыхательные пути во время общей анестезии (синдром Мендельсона);"}},{"type":"paragraph","data":{"text":"- язвы и эрозии желудка и 12-перстной кишки вызванные приемом нестероидных противовоспалительных препаратов;"}},{"type":"paragraph","data":{"text":"- эрадикация Helicobacter pylori у инфицированных больных с язвенной болезнью желудка и 12-перстной кишки (в составе комбинированной терапии)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к компонентам входящим в состав препарата;"}},{"type":"paragraph","data":{"text":"- дефицит сахаразы/изомальтазы непереносимость фруктозы непереносимость лактозы дефицит лактазы глюкозо-галактозная мальабсорбция (из-за наличия сахарозы и лактозы);"}},{"type":"paragraph","data":{"text":"- детский возраст до 18 лет;"}},{"type":"paragraph","data":{"text":"- период лактации."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Почечная и/или печеночная недостаточность сахарный диабет (в связи с наличием сахара в составе препарата)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение омепразола при беременности возможно только в том случае если предполагаемая польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"Омепразол проникает в грудное молоко. При необходимости применения препарата в период лактации следует прекратить грудное вскармливание."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь запивая небольшим количеством воды (непосредственно перед едой или во время приема пищи). Капсулы обычно принимают утром. Капсулы нельзя разжевывать."}},{"type":"paragraph","data":{"text":"При обострении язвенной болезни рефлюкс-эзофагите язвах и эрозиях желудка и 12-перстной кишки вызванных приемом нестероидных противовоспалительных препаратов - по 20 мг 1 раз в сутки. Пациентам с тяжелым течением рефлюкс-эзофагита дозу увеличивают до 40 мг 1 раз в сутки. Курс лечения при язвенной болезни 12-перстной кишки - 2-3 недели при необходимости - 4-5 недель; при язвенной болезни желудка и эзофагите - 4-8 недель. Больным резистентным к лечению другими противоязвенными лекарственными средствами назначают по 40 мг 1 раз в сутки. Курс лечения при язвенной болезни 12-перстной кишки - 4 недели при язвенной болезни желудка и рефлюкс- эзофагите - 8 недель. Для профилактики рецидивов язвенной болезни - по 10 мг 1 раз в сутки."}},{"type":"paragraph","data":{"text":"При синдроме Золлингера-Эллисона - по 60 мг 1 раз в сутки; при необходимости дозу увеличивают до 80-120 мг в сутки (в этом случае ее назначают в 2-3 приема). Профилактика синдрома Мендельсона - по 40 мг за 1 час до операции (в случае проведения операции дольше 2 часов необходимую дозу препарата следует ввести повторно)."}},{"type":"paragraph","data":{"text":"Для эрадикации Helicobacter pyloriиспользуют трехкомпонентную схему лечения (в течение 1 недели: омепразол 20 мг амоксициллин 1 г кларитромицин 500 мг - по 2 раза в сутки; либо омепразол 20 мг кларитромицин 250 мг метронидазол 400 мг - по 2 раза в сутки; либо омепразол 40 мг 1 раз в сутки амоксициллин 500 мг и метронидазол 400 мг - по 3 раза в сутки) или двухкомпонентную схему лечения (в течение 2 недель: омепразол 20-40 мг и амоксициллин 750 мг - по 2 раза в сутки; либо омепразол 40 мг - 1 раз в сутки и кларитромицин 500 мг - 3 раза в сутки или амоксициллин 075-15 г - 2 раза в сутки)."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: диарея или запор боль в животе тошнота рвота метеоризм повышение активности \"печеночных\" ферментов нарушения вкуса сухость слизистой оболочки полости рта стоматит у больных с предшествующим тяжелым заболеванием печени - гепатит (в том числе с желтухой) нарушение функции печени."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: лейкопения тромбоцитопения агранулоцитоз панцитопения."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: у больных с тяжелыми сопутствующими соматическими заболеваниями - головокружение головная боль возбуждение депрессия у больных с предшествующим тяжелым заболеванием печени - энцефалопатия."}},{"type":"paragraph","data":{"text":"Со стороны опорно-двигательного аппарата: артралгия миастения миалгия."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов: кожная сыпь и/или зуд фотосенсибилизация мультиформная экссудативная эритема алопеция."}},{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница ангионевротический отек лихорадка бронхоспазм интерстициальный нефрит и анафилактический шок."}},{"type":"paragraph","data":{"text":"Прочие: гинекомастия недомогание нарушение зрения периферические отеки усиление потоотделения образование желудочных гландулярных кист во время длительного лечения (следствие ингибирования секреции соляной кислоты; носит доброкачественный обратимый характер)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: спутанность сознания нечеткость зрения сонливость сухость во рту головная боль тошнота тахикардия аритмия."}},{"type":"paragraph","data":{"text":"Лечение: проведение симптоматической терапии. Специфического антидота нет."}},{"type":"paragraph","data":{"text":"Гемодиализ недостаточно эффективен для удаления омепразола из организма в связи с высокой степенью его связывания с белками плазмы."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Может снижать абсорбцию эфиров ампициллина солей железа итраконазола и кетоконазола и других лекарственных средств (ЛC) всасывание которых зависит от значения pH."}},{"type":"paragraph","data":{"text":"Являясь ингибитором цитохрома Р450 омепразол может повышать концентрацию и снижать выведение диазепама антикоагулянтов непрямого действия фенитоина (ЛC которые метаболизируются в печени посредством изофермента CYP2C19) что в некоторых случаях может потребовать снижения доз этих ЛC. В то же время длительное применение омепразола в дозе 20 мг 1 раз в сутки в комбинации с кофеином теофиллином пироксикамом диклофенаком напроксеном метопрололом пропранололом этанолом циклоспорином лидокаином хинидином и эстрадиолом не приводит к изменению их концентрации в плазме."}},{"type":"paragraph","data":{"text":"Не отмечено клинически значимого взаимодействия омепразола с одновременно принимаемыми антацидными препаратами."}},{"type":"paragraph","data":{"text":"Усиливает ингибирующее действие на систему кроветворения других ЛC."}},{"type":"paragraph","data":{"text":"Не отмечено взаимодействия омепразола с одновременно принимаемыми антацидами. Концентрации омепразола и кларитромицина в плазме возрастают при совместном применении этих препаратов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Перед началом терапии необходимо исключить наличие злокачественного процесса (особенно при язве желудка) так как лечение маскируя симптоматику может отсрочить постановку правильного диагноза."}},{"type":"paragraph","data":{"text":"Прием одновременно с пищей не влияет на эффективность препарата."}},{"type":"paragraph","data":{"text":"Больным сахарным диабетом следует обратить внимание на содержание сахара в составе препарата. В одной капсуле Омепразола содержится 637 мг сахарозы (соответствует 0005 хлебным единицам (ХЕ))."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Учитывая возможные побочные действия препарата следует соблюдать осторожность при управлении автотранспортом или другими потенциально опасными механизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы кишечнорастворимые 20 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при темпе­ратуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не использовать после истечения срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное общество \"Валента Фармацевтика\" (АО \"Валента Фарм\"), 141101, Московская обл., г. Щелково, ул. Фабричная, д. 2, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"Валента Фарм\""}}]}],"source":null},"description_toggle":false,"short_description":"Ингибитор протонного насоса снижает кислотопродукцию - ингибирует Н+/К+-АТФ-азу париетальных клеток желудка и блокирует тем самым заключительную стадию секреции со­ляной кислоты. Препарат является пролекарст­вом и активируется в кислой среде секретор­ных канальцев париетальных клеток слизистой оболочки желудка.Снижает базальную и стимулированную сек­рецию независимо от природы раздражителя. Антисекреторный эффект после приема 20 мг наступает в течение первого часа максимум - через 2 часа Ингибирование 50 % максимальной секреции продолжается 24 часа. Однократный прием в сутки обеспечивает бы­строе и эффективное угнетение дневной и ноч­ной желудочной секреции достигающее сво­его максимума через 4 дня лечения и исче­зающее к исходу 3-4 дня после окончания приема. У больных с язвенной болезнью 12-перстной кишки прием 20 мг омепразола поддерживает внутрижелудочный pH на уров­не 3 в течение 17 часов. Омепразол быстро абсорбируется из желудочно-кишечного тракта максимальная концентрация в плазме крови достигается через 05-1 час. Биодоступность составляет 30-40 % (при печеночной недостаточности возрастает практически до 100 %) обладая высокой липофильностью легко проникает в париетальные клетки желудка. При повторном приеме биодоступность достигает 60-70 % и зависит от принятой дозы. Связь с белками плазмы - 90 %. Омепразол практически полностью метаболизируется в печени с участием ферментной системы CYP2C19 с образованием 6 метаболитов (гидроксиомепразол сульфидные и сульфоновые производные и другие) фармакологически неактивных. Является ингибитором изофермента CYP2C19. Период полувыведения - 05-1 час (при печеночной недостаточности - 3 часа) клиренс - 500-600 мл/мин. Выводится в основном почками (70-80 %) в виде метаболитов и с желчью (20-30 %). При хронической почечной недостаточности выведение снижается пропорционально снижению клиренса креатинина. У пожилых пациентов выведение уменьшается биодоступность возрастает.","substance":[{"id":137,"title":"Омепразол","title_latin":"Omeprazolum","slug":"omeprazol_137"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Омепразол - фото упаковки","image_share":{"isTouch":{"default":null},"isFromTablet":{"default":null}},"diseases":[],"other_packages":[{"id":183097,"title":"Омепразол","subtitle":{"full":"Капсулы, 30 шт, 20 мг","short":"Капсулы, 30 шт, 20 мг","package":"30 шт, 20 мг"},"prescription":true,"catalog_section_id":146,"manufacturer":{"id":186,"title":"Канонфарма Продакшн","slug":"kanonfarma_prodakshn_186","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Капсулы","slug":"183097-omeprazol","attributes":{"count":"30 шт","dose":"20 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