болевой синдром различного генеза слабой и средней интенсивности (в т.ч. артралгия, миалгия, радикулит, альгодисменория, невралгия, головная боль, зубная боль);
простудные заболевания и состояния, сопровождающиеся лихорадочным синдромом.
Фармакологическое действие
Комбинированный препарат, оказывает анальгезирующее, жаропонижающее, противомигренозное действие.
Лекарственное взаимодействие
При одновременном применении средств, оказывающих угнетающее влияние на ЦНС (в т.ч. седативных средств и транквилизаторов) вероятно усиление выраженности седативного эффекта и угнетающего действия на дыхательный центр. Усиливает влияние этанола на психомоторную реакцию. Метамизол натрия снижает концентрацию циклоспорина. Метамизол натрия, вытесняя из связи с белком пероральные гипогликемические препараты, непрямые антикоагулянты, ГКС и индометацин, увеличивает их активность. Трициклические антидепрессанты, противозачаточные средства для приема внутрь, аллопуринол нарушают метаболизм метамизола натрия в печени и повышают его токсичность. Одновременное применение препарата Пенталгин®-ICN с другими неопиоидными анальгетиками может привести к усилению токсических эффектов. Барбитураты, фенилбутазон и другие индукторы микросомальных ферментов печени ослабляют действие метамизола натрия.
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