Суматриптан Таблетки, 2 шт, 100 мг, для взрослых, в пленочной оболочке

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Биодоступность - 14% (за счет пресистемного метаболизма и неполного всасывания)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Связь с белками плазмы составляет 14-21%, средний общий объем распределения составляет 170 л."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Метаболизируется путем окисления при участии моноаминоксидазы (преимущественно изофермента А) с образованием метаболитов, основными из которых являются индолуксусный аналог суматриптана, не обладающий фармакологической активностью в отношении 5-HT\u003csub\u003e1\u003c/sub\u003e и 5-НТ\u003csub\u003e2\u003c/sub\u003e-серотониновых рецепторов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Период полувыведения составляет 2 ч. Основной метаболит (индолуксусный аналог суматриптана) выводится почками в виде свободной кислоты и ее глюкуронидного конъюгата. Средний общий плазменный клиренс составляет примерно 1160 мл/мин, средний почечный клиренс - 260 мл/мин, внепочечный клиренс - около 80% от общего клиренса."}},{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eФармакокинетика у пациентов особых групп\u003c/b\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eУ пациентов с почечной недостаточностью \u003c/i\u003eисследования не проводились."}},{"type":"paragraph","data":{"text":"Была проведена оценка влияния\u003ci\u003e умеренного нарушения функции печени\u003c/i\u003e (класс В по шкале Чайлд-Пью) на фармакокинетику суматриптана при подкожном введении. Не было обнаружено значимых различий в фармакокинетике суматриптана при подкожном введении у пациентов с умеренным нарушением функции печени по сравнению со здоровыми пациентами из группы контроля. У пациентов с нарушением функции печени может существенно повыситься биодоступность препарата за счет повышения концентрации суматриптана в плазме в результате снижения пресистемного клиренса."}},{"type":"paragraph","data":{"text":"\u003ci\u003eУ пожилых пациентов \u003c/i\u003eв экспериментальных исследованиях не найдено существенных различий в фармакокинетике суматриптана в сравнении с фармакокинетикой препарата у здоровых добровольцев."}},{"type":"paragraph","data":{"text":"Различий в показателях фармакокинетики суматриптана\u003ci\u003eу мужчин и женщин\u003c/i\u003e не выявлено.\n\n"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Купирование приступов мигрени с аурой или без нее, включая приступы менструально-ассоциированной мигрени."}},{"type":"paragraph","data":{"text":"Назначают только при верифицированном диагнозе мигрень."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Гиперчувствительность к любому из компонентов препарата."}},{"type":"paragraph","data":{"text":"- Гемиплегическая, базилярная или офтальмоплегическая формы мигрени."}},{"type":"paragraph","data":{"text":"- Ишемическая болезнь сердца, в том числе стенокардия (включая стенокардию Принцметала), инфаркт миокарда (в том числе в анамнезе), иостинфарктный кардиосклероз, а также симптомы, позволяющие предположить наличие ишемической болезни сердца."}},{"type":"paragraph","data":{"text":"- Фармакологически неконтролируемая артериальная гипертензия."}},{"type":"paragraph","data":{"text":"- Окклюзионные заболевания периферических сосудов."}},{"type":"paragraph","data":{"text":"- Инсульт или преходящее нарушение мозгового кровообращения (в том числе в анамнезе)."}},{"type":"paragraph","data":{"text":"- Тяжелые нарушения функций печени и/или почек."}},{"type":"paragraph","data":{"text":"- Одновременный прием с эрготамином или его производными (включая метисергид) или другими триптаминами/агонистами 5-НТ\u003csub\u003e1\u003c/sub\u003e-серотониновых рецепторов."}},{"type":"paragraph","data":{"text":"- Применение на фоне приема ингибиторов моноаминоксидазы или ранее чем через 2 недели после отмены этих препаратов."}},{"type":"paragraph","data":{"text":"- Возраст до 18 и старше 65 лет (эффективность и безопасность не установлены)."}},{"type":"paragraph","data":{"text":"- Непереносимость лактозы, синдром мальабсорбции глюкозы/галактозы, врожденная недостаточность лактазы."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Эпилепсия (в том числе любые состояния со снижением порога судорожной готовности). Фармакологически контролируемая артериальная гипертензия."}},{"type":"paragraph","data":{"text":"Заболевания, при которых могут изменяться всасывание, метаболизм или выведение суматриптана (например, нарушение функции почек или печени)."}},{"type":"paragraph","data":{"text":"Гиперчувствительность к сульфаниламидам (введение суматриптана может вызвать аллергические реакции, выраженность которых варьируется от кожных проявлений до анафилаксии). Данные о перекрестной чувствительности ограничены, однако следует соблюдать осторожность при назначении суматриптана таким пациентам."}},{"type":"paragraph","data":{"text":"Беременность и грудное вскармливание."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение суматриптана при беременности возможно только в случае, если предполагаемая польза для матери превышает возможный риск для плода. Данные, полученные при применении суматриптана более чем у 1000 женщин в I триместре беременности, не содержат достаточной информации, чтобы сделать окончательные выводы о риске развития врожденных пороков у плода, опыт применения суматриптана во II и III триместрах беременности также ограничен."}},{"type":"paragraph","data":{"text":"Результаты доклинических исследований у животных не показали прямого тератогенного действия суматриптана на плод или отрицательного влияния на пери- и постнатальное развитие эмбриона или плода у крыс. Однако есть данные о влиянии суматриптана на жизнеспособность эмбриона и плода у кроликов при приеме больших доз суматриптана."}},{"type":"paragraph","data":{"text":"Было показано, что после подкожного введения суматриптан выделяется в грудное молоко. Следует прекратить грудное вскармливание во время применения суматриптана, грудное вскармливание возможно не ранее чем через 24 часа после приема препарата."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат Суматриптан не должен назначаться в качестве профилактики. Нельзя превышать рекомендованную дозу препарата Суматриптан."}},{"type":"paragraph","data":{"text":"Рекомендуется начать прием препарата Суматриптан сразу же, при первых проявлениях приступа мигрени, при этом препарат Суматриптан одинаково эффективен при применении на любой стадии приступа мигрени."}},{"type":"paragraph","data":{"text":"Препарат применяют внутрь, проглатывая таблетку целиком и запивая водой."}},{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eВзрослые\u003c/b\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Рекомендованная доза составляет 50 мг (1 таблетка). Некоторым пациентам может потребоваться доза 100 мг."}},{"type":"paragraph","data":{"text":"Если после приема первой дозы приступ мигрени не купируется, вторую дозу препарата для купирования этого же приступа мигрени назначать не следует. В таких случаях для купирования приступа можно применять парацетамол, ацетилсалициловую кислоту или нестероидные противовоспалительные препараты. Однако препарат Суматриптан можно применять для купирования последующих приступов мигрени."}},{"type":"paragraph","data":{"text":"Если пациент почувствовал улучшение после первой дозы препарата, а затем симптомы возобновились, можно принять вторую дозу при условии, что интервал между дозами составляет не менее 2 часов, и принято не более 300 мг в течение 24-часового периода. Суматриптан можно применять не раньше, чем через 24 ч после приема препаратов, содержащих эрготамин; и наоборот, препараты, содержащие эрготамин, можно применять не раньше, чем через 6 ч после приема суматриптана."}},{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eОсобые группы пациентов\u003c/b\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети и подростки (младше 18 лет)\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Эффективность препарата Суматриптан в данной группе пациентов не была продемонстрирована."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты пожилого возраста (старше 65 лет)\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Опыт применения препарата Суматриптан у пациентов старше 65 лет ограничен. Фармакокинетика у пациентов данной популяции значимо не отличается от таковой у пациентов более молодого возраста, но до тех пор, пока не будут получены дополнительные клинические данные, применение суматриптана у пациентов старше 65 лет не рекомендовано."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Частота побочных эффектов, приведенных ниже, определялась соответственно следующему (классификация Всемирной организации здравоохранения): очень часто (более 10%), часто (более 1% и менее 10%), нечасто (более 0,1% и менее 1%), редко (более 0,01% и менее 0,1%), очень редко (менее 0,01%), включая отдельные сообщения, частота неизвестна (не может быть оценена при помощи доступных данных)."}},{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eДанные клинических исследований\u003c/b\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e часто - головокружение, сонливость, нарушения чувствительности, включая парестезии и снижение чувствительности."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы\u003c/i\u003e: часто - преходящее повышение артериального давления (наблюдается вскоре после приема препарата), \"приливы\"."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы и органов грудной клетки:\u003c/i\u003eчасто - диспноэ."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны желудочно-кишечного тракта: \u003c/i\u003eчасто - тошнота, рвота (причинно-следственная связь возникновения нежелательных реакций с приемом препарата не доказана)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны опорно-двигательного аппарата и соединительной ткани: \u003c/i\u003eчасто - миалгия, чувство тяжести (обычно преходящее, может быть интенсивным и возникать в любой части тела, включая грудную клетку и горло)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие и местные реакции\u003c/i\u003e: часто - болевые ощущения, чувство холода или жара, чувство давления или стягивания (обычно преходящее, могут быть интенсивными и возникать в любой части тела, включая грудную клетку и горло), слабость, утомляемость (обычно слабо или умеренно выраженные, преходящие)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛабораторные показатели: \u003c/i\u003eочень редко - незначительные отклонения показателей печеночных проб."}},{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eДанные пострегистрационных наблюдений\u003c/b\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны иммунной системы: \u003c/i\u003eчастота неизвестна - реакции гиперчувствительности, включая кожные проявления, а также анафилаксию."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы\u003c/i\u003e: частота неизвестна - судорожные припадки (в ряде случаев наблюдавшиеся у пациентов с судорожными приступами в анамнезе или при сопутствующих состояниях, предрасполагающих к возникновению судорог; у части пациентов факторов риска не было выявлено), тремор, дистония, нистагм, скотома."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения психики\u003c/i\u003e: частота неизвестна - тревога."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органа зрения:\u003c/i\u003e частота неизвестна - мелькание, диплопия, снижение остроты зрения, слепота (обычно преходящая). Однако расстройства зрения могут быть обусловлены собственно приступом мигрени."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы\u003c/i\u003e: частота неизвестна - брадикардия, тахикардия, ощущение сердцебиения, аритмии, признаки транзиторной ишемии миокарда на ЭКГ, коронарный вазоспазм, стенокардия, инфаркт миокарда, артериальная гипотензия, синдром Рейно."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны желудочно-кишечного тракта:\u003c/i\u003e частота неизвестна - ишемический колит, диарея."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны опорно-двигательного аппарата и соединительной ткани:\u003c/i\u003e частота неизвестна - ригидность затылочных мышц, артралгия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны кожи и подкожных тканей:\u003c/i\u003e частота неизвестна - гипергидроз."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: Прием суматриптана перорально в дозе 400 мг не вызывал каких-либо нежелательных реакций, помимо перечисленных выше."}},{"type":"paragraph","data":{"text":"Моделирование передозировки на животных приводило к развитию судорог, тремора, паралича, неподвижности, птоза, покраснения конечностей, аномального дыхания, цианоза, атаксии, мидриаза, слюно- и слезотечения, а также к гибели животных."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e: В случае передозировки следует наблюдать за состоянием пациентов не менее 12 ч и при необходимости проводить симптоматическую терапию. Нет данных о влиянии гемодиализа или перитонеального диализа на концентрацию суматриптана в плазме."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении с эрготамином и эрготаминсодержащими лекарственными средствами возможен длительный спазм сосудов."}},{"type":"paragraph","data":{"text":"Имеются ограниченные данные о взаимодействии с препаратами, содержащими эрготамин или другие триптаны/агонисты 5-HT\u003csub\u003e1\u003c/sub\u003e-рецепторов. Теоретически возможно повышение риска коронарного вазоспазма, совместное применение данных препаратов противопоказано. Период времени, который должен пройти между применением суматриптана и препаратов, содержащих эрготамин или другого триптана/агониста 5-HTi- рецепторов, неизвестен. Он будет зависеть, в том числе, от дозы и типа назначаемых препаратов. Действие может носить аддитивный характер. Рекомендуется подождать как минимум 24 часа после применения препаратов, содержащих эрготамин или другой триптан/агонист 5-HT\u003csub\u003e1\u003c/sub\u003e-рецепторов перед применением суматриптана. И наоборот, рекомендуется подождать как минимум 6 часов после применения суматриптана перед применением препаратов, содержащих эрготамин, и как минимум 24 часа до применения другого триптана/5-HT\u003csub\u003e1\u003c/sub\u003e-агониста рецепторов."}},{"type":"paragraph","data":{"text":"Возможно взаимодействие между суматриптаном и ингибиторами моноаминоксидазы (снижение интенсивности метаболизма суматриптана, повышение его концентрации)."}},{"type":"paragraph","data":{"text":"Имеются редкие сообщения о развитии серотонинового синдрома (расстройства психики, развитие слабости, гиперрефлексия, вегетативная лабильность, нарушения координации движений и нервно-мышечные нарушения) в результате одновременного применения селективных ингибиторов обратного захвата серотонина и суматриптана."}},{"type":"paragraph","data":{"text":"Также сообщалось о развитии серотонинового синдрома на фоне одновременного применения триптанов и селективных ингибиторов обратного захвата серотонина и норадреналина. В случае одновременного применения суматриптана с препаратами из группы селективных ингибиторов обратного захвата серотонина и/или селективных ингибиторов обратного захвата серотонина и норадреналина, следует тщательно контролировать состояние пациента."}},{"type":"paragraph","data":{"text":"Не отмечено взаимодействия суматриптана с пропранололом, флунаризином, пизотифеном и этанолом."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат Суматриптан следует назначать только в том случае, если диагноз мигрени не вызывает сомнения."}},{"type":"paragraph","data":{"text":"Препарат Суматриптан противопоказан для применения при гемиплегической, базилярной и офтальмоплегической формах мигрени."}},{"type":"paragraph","data":{"text":"Перед началом лечения препаратом Суматриптан необходимо исключить виды потенциально опасной неврологической патологии (например, инсульт, преходящее нарушение мозгового кровообращения) в случае, когда у пациента присутствуют атипичные симптомы или когда у пациента не диагностировано состояние, требующее применение препарата Суматриптан."}},{"type":"paragraph","data":{"text":"После приема препарата Суматриптан могут возникать преходящие симптомы, включая боль и стеснение в груди, которые могут быть интенсивными и распространяться на область шеи. Если есть основания полагать, что эти симптомы являются проявлением ишемической болезни сердца, необходимо провести соответствующее диагностическое обследование."}},{"type":"paragraph","data":{"text":"Не следует применять препарат Суматриптан у пациентов с факторами риска развития ишемической болезни сердца, в том числе у злостных курильщиков или пользователей никотиновой заместительной терапии, без предварительного обследования сердечнососудистой системы. Особое внимание следует уделять женщинам в постклимактерическом периоде и мужчинам в возрасте старше 40 лет с данными факторами риска. Однако обследование не всегда позволяет выявить заболевание сердца у каждого пациента. В очень редких случаях могут возникнуть серьезные нежелательные реакции со стороны сердечно-сосудистой системы у пациентов, в анамнезе которых не было отмечено сердечно-сосудистой патологии."}},{"type":"paragraph","data":{"text":"Препарат Суматриптан следует применять с осторожностью у пациентов с контролируемой артериальной гипертензией, так как у небольшого количества пациентов наблюдалось транзиторное повышение артериального давления и периферического сосудистого сопротивления."}},{"type":"paragraph","data":{"text":"Имеются редкие сообщения, полученные в результате пострегистрационного наблюдения, о развитии серотонинового синдрома (включая расстройства психики, вегетативную лабильность и нервно-мышечные нарушения) в результате одновременного применения селективных ингибиторов обратного захвата серотонина (СИОЗС) и суматриптана. Также сообщалось о развитии серотонинового синдрома на фоне одновременного применения триптанов с селективными ингибиторами обратного захвата серотонина и норадреналина (СИОЗСН)."}},{"type":"paragraph","data":{"text":"В случае одновременного применения с препаратами из группы СИОЗС и/или СИОЗСН, следует тщательно контролировать состояние пациента."}},{"type":"paragraph","data":{"text":"Одновременное применение любого триптана (5-HT\u003csub\u003e1\u003c/sub\u003e-агониста) с суматриптаном не рекомендуется."}},{"type":"paragraph","data":{"text":"Препарат Суматриптан следует применять с осторожностью у пациентов, у которых могут существенно изменяться всасывание, метаболизм или выведение суматриптана, например, у пациентов с нарушением функции почек или печени (класс А или Б по шкале Чайлд-Пью)."}},{"type":"paragraph","data":{"text":"Препарат Суматриптан необходимо применять с осторожностью у пациентов, имеющих судороги в анамнезе или имеющих другие факторы риска снижения порога судорожной готовности."}},{"type":"paragraph","data":{"text":"Нежелательные реакции могут возникать чаще во время приема триптанов и растительных препаратов, содержащих Зверобой продырявленный (\u003ci\u003eHypericum perforatum\u003c/i\u003e)."}},{"type":"paragraph","data":{"text":"Злоупотребление лекарственными препаратами, предназначенными для купирования острой головной боли, ассоциировано с усилением головных болей у чувствительных пациентов (головная боль, связанная со злоупотреблением лекарственными препаратами). При этом следует рассмотреть возможность отмены препарата."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"У пациентов с мигренью может возникнуть сонливость, связанная как с самим заболеванием, так и с применением препарата Суматриптан. В период лечения необходимо соблюдать осторожность при вождении автотранспорта и при занятиях другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 50 и 100 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С, в оригинальной упаковке."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет."}},{"type":"paragraph","data":{"text":"Не использовать препарат после истечения срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Закрытое акционерное общество \"Березовский фармацевтический завод\" (ЗАО \"БФЗ\"), 623704, Свердловская область, г. Берёзовский, улица Кольцевая, д. 13а, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО \"БФЗ\""}}]}],"source":null},"description_toggle":false,"short_description":"Суматриптан - селективный агонист сосудистых 5-гидрокситриптамин-1-рецепторов (5-HT1D), локализованных преимущественно в кровеносных сосудах головного мозга, и их стимуляция приводит к сужению этих сосудов. Не влияет на другие подтипы 5-НТ- серотониновых рецепторов (5-НТ2-5-НТ7). У животных суматриптан избирательно действует на вазоконстрикцию ветвей сонной артерии, не влияя на кровоток в сосудах головного мозга. Сосудистый бассейн сонной артерии кровоснабжает экстракраниальные и интракраниальные ткани (в том числе менингеальные оболочки), и считается, что расширение этих сосудов и/или отек их стенок является основным механизмом возникновения мигрени у человека. Активирует чувствительность рецепторов тройничного нерва. Терапевтический эффект обычно наступает через 30 минут после приема. Хотя рекомендованная доза при пероральном приеме составляет 50 мг, приступы мигрени различаются по степени тяжести как у одного пациента, так и у разных пациентов. Дозы от 25 мг до 100 мг показали большую эффективность по сравнению с плацебо в клинических исследованиях, но доза 25 мг статистически значительно менее эффективна, чем 50 мг и 100 мг. Суматриптан продемонстрировал эффективность в лечении приступов мигрени, в том числе менструально-ассоциированной мигрени, т.е. мигрени без ауры, которая возникает в промежутке за три дня до начала и до пяти дней после начала менструации. Приступы мигрени не оказывают существенного влияния на фармакокинетику суматриптана, принимаемого внутрь.ВсасываниеПосле приема внутрь быстро всасывается. 70% от максимальной плазменной концентрации достигается через 45 минут. После приема дозы 100 мг среднее значение максимальной концентрации в плазме крови составляет 54 нг/мл. Биодоступность - 14% (за счет пресистемного метаболизма и неполного всасывания).РаспределениеСвязь с белками плазмы составляет 14-21%, средний общий объем распределения составляет 170 л.МетаболизмМетаболизируется путем окисления при участии моноаминоксидазы (преимущественно изофермента А) с образованием метаболитов, основными из которых являются индолуксусный аналог суматриптана, не обладающий фармакологической активностью в отношении 5-HT1и 5-НТ2-серотониновых рецепторов.ВыведениеПериод полувыведения составляет 2 ч. Основной метаболит (индолуксусный аналог суматриптана) выводится почками в виде свободной кислоты и ее глюкуронидного конъюгата. Средний общий плазменный клиренс составляет примерно 1160 мл/мин, средний почечный клиренс - 260 мл/мин, внепочечный клиренс - около 80% от общего клиренса.Фармакокинетика у пациентов особых группУ пациентов с почечной недостаточностьюисследования не проводились. Была проведена оценка влиянияумеренного нарушения функции печени(класс В по шкале Чайлд-Пью) на фармакокинетику суматриптана при подкожном введении. Не было обнаружено значимых различий в фармакокинетике суматриптана при подкожном введении у пациентов с умеренным нарушением функции печени по сравнению со здоровыми пациентами из группы контроля. У пациентов с нарушением функции печени может существенно повыситься биодоступность препарата за счет повышения концентрации суматриптана в плазме в результате снижения пресистемного клиренса.У пожилых пациентовв экспериментальных исследованиях не найдено существенных различий в фармакокинетике суматриптана в сравнении с фармакокинетикой препарата у здоровых добровольцев. 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