ПирогеналЛатинское названиеАТХ:Фармакологическая группа Нозологическая классификация (МКБ-10)Описание лекарственной формыХарактеристикаФармакологическое действиеФармакодинамикаФармакокинетикаПоказания препарата ПирогеналПротивопоказанияПрименение при беременности и кормлении грудьюПобочные действияВзаимодействиеОсобые указанияУсловия хранения препарата ПирогеналСрок годности препарата Пирогенал Евросервис фирма ЗАО (Россия) раствор для внутримышечного введения 25 мкг/мл; ампула 1 мл с ножом ампульным, коробка (коробочка) 10; код EAN: 4602379000023; № Р N003478/01, 2009-06-30 от Медгамал (филиал ГУ НИИЭМ им. Н.Ф. Гамалеи РАМН) (Россия) Pyrogenalum L03AX Иммуностимуляторы другие Другие иммуномодуляторы A16 Туберкулез органов дыхания, не подтвержденный бактериологически или гистологическиA64 Болезни, передающиеся половым путем, неуточненныеB00.5 Герпетическая болезнь глазG98 Другие нарушения нервной системы, не классифицированные в других рубриках (остаточные явления черепно-мозговых травм)H17 Рубцы и помутнение роговицыH19.1 Кератит, обусловленный вирусом простого герпеса, и кератоконъюнктивит (B00.5+)H20 ИридоциклитK66.0 Брюшинные спайкиK76.9 Болезнь печени неуточненнаяL40 ПсориазL98.9 Поражение кожи и подкожной клетчатки неуточненноеN13.5 Перегиб и стриктура мочеточника без гидронефрозаN34.1 Неспецифический уретритN35.9 Стриктура уретры неуточненнаяN41.1 Хронический простатитN46 Мужское бесплодиеN70 Сальпингит и оофоритN97 Женское бесплодиеS06 Внутричерепная травмаT14 Травма неуточненной локализацииT30 Термические и химические ожоги неуточненной локализации Суппозитории желтовато-белого цвета, однородной консистенции, цилиндрической формы с заостренным концом, диаметром не более 10 мм.
Фармакологическое действие
Иммуномодулятор широкого спектра действия. Главным механизмом иммуномодулирующего действия является активация системы гипоталамус-гипофиз-кора надпочечников, а также ретикулоэндотелиальной и фибринолитической систем. Оказывая влияние на функцию коры надпочечников, повышает концентрацию кортикостероидов в крови. Пирогенал обладает адъювантным, десенсибилизирующим и противовоспалительным эффектами, повышает общую и специфическую резистентность организма, влияет на терморегулирующие центры гипоталамуса, создает регулируемый пирогенный эффект. Действуя на клетки фагоцитарной системы, активирует фагоцитоз, секрецию кислородных радикалов, синтез ИЛ-1, ИЛ-2, фактора некроза опухоли (ФНОα), интерферона (ИФНα), стимулирует кининовую систему. Препятствует синтезу коллагена фибробластами, ускоряет процесс созревания фиброцитов. Стимуляция активности гиалуронидазы и подавление образования коллагеновых волокон в фибробластах обеспечивает увеличение проницаемости тканей, улучшение фибринолитических свойств крови и ускорение проникновения лекарственных веществ в очаг поражения. Способствует рассасыванию очагов воспаления, восстановлению кровообращения, тормозит формирование новых и сглаживает ранее образовавшиеся плотные рубцы в местах повреждения. Препятствует формированию и ускоряет рассасывание образовавшихся спаек. Обладает регенерирующим действием, способствует восстановлению утраченных функций органов. При введении пирогенала в организм до 85–90% фиксируется на поверхности циркулирующих лейкоцитов крови, около 10% остается в циркулирующей плазме и около 5% адсорбируется на мембранах эритроцитов. Выводится из организма с мочой.
Общие для обеих лекарственных форм
Неспецифическая терапия таких заболеваний, как: хронические заболевания печени; стриктуры уретры и мочеточников; хронические простатиты и уретриты; воспалительные процессы придатков матки; вторичное бесплодие; спаечная болезнь брюшной полости; ожоговая болезнь; венерические заболевания.
Суппозитории
Неспецифическая терапия таких заболеваний и состояний, как: папилломавирусная инфекция; иммунопрофилактика и иммунореабилитация при неполном выздоровлении после перенесенного острого бактериального и вирусного заболевания. Повышение температуры до 37–37,6 °C, в редких случаях — гриппоподобный синдром (лихорадка, головная боль, повышенная утомляемость, миалгия, озноб, артралгия, анорексия, тошнота).
Раствор для инъекций
Неспецифическая терапия таких заболеваний и состояний, как: травматические повреждения центральной и периферической нервной системы; вялотекущая форма туберкулеза в фазе рассасывания; увеиты; иридоциклиты; герпесвирусная инфекция глаз; помутнение роговицы; хронические заболевания кожи, в т.ч. псориаз; необходимость проведения пиротерапии (в качестве пирогенного препарата). гиперчувствительность; сердечная недостаточность; печеночная и/или почечная недостаточность; аутоиммунные заболевания (в анамнезе); беременность; лактация. Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание. Гипертермия до 37,5 °C, сопровождающаяся слабым ознобом и легким недомоганием. Такое состояние может длиться от 3 до 8 ч. В этом случае доза, вызвавшая подобную реакцию, в последующие дни повторяется до прекращения реакции на ее введение (обычно — 1–3 инъекции), после чего дозу последовательно повышают. В редких случаях у отдельных лиц может наблюдаться сильный озноб, повышение температуры до 39,5 °C, головная боль, боль в пояснице. Эти реакции продолжаются обычно от 6 до 8 ч, после чего температура снижается, и побочные явления исчезают. В этих случаях рекомендуется снизить дозу препарата. При использовании препарата для пиротерапии вышеописанные реакции допустимы. Препарат совместим и хорошо сочетается со всеми ЛС, применяемыми при лечении указанных в показаниях заболеваний и состояний. Усиливает эффективность химиотерапевтических препаратов в составе комплексной терапии.
Раствор для инъекций.
В сухом, защищенном от света месте, при температуре 2–10 °C.
Хранить в недоступном для детей месте.
2 года. Не применять по истечении срока годности, указанного на упаковке. 2000-2015. Регистр лекарственных средств РоссииБаза данных предназначена для специалистов сферы здравоохранения.Не разрешается коммерческое использование материалов.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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Гамалеи РАМН) (Россия)\u003cbr /\u003ePyrogenalum\u003cbr /\u003eL03AX Иммуностимуляторы другие\u003cbr /\u003eДругие иммуномодуляторы\u003cbr /\u003eA16 Туберкулез органов дыхания, не подтвержденный бактериологически или гистологическиA64 Болезни, передающиеся половым путем, неуточненныеB00.5 Герпетическая болезнь глазG98 Другие нарушения нервной системы, не классифицированные в других рубриках (остаточные явления черепно-мозговых травм)H17 Рубцы и помутнение роговицыH19.1 Кератит, обусловленный вирусом простого герпеса, и кератоконъюнктивит (B00.5+)H20 ИридоциклитK66.0 Брюшинные спайкиK76.9 Болезнь печени неуточненнаяL40 ПсориазL98.9 Поражение кожи и подкожной клетчатки неуточненноеN13.5 Перегиб и стриктура мочеточника без гидронефрозаN34.1 Неспецифический уретритN35.9 Стриктура уретры неуточненнаяN41.1 Хронический простатитN46 Мужское бесплодиеN70 Сальпингит и оофоритN97 Женское бесплодиеS06 Внутричерепная травмаT14 Травма неуточненной локализацииT30 Термические и химические ожоги неуточненной локализации\u003cbr /\u003eСуппозитории желтовато-белого цвета, однородной консистенции, цилиндрической формы с заостренным концом, диаметром не более 10 мм."}}]},{"id":1,"name":"Фармакологическое действие","slug":"farmakologicheskoe_deystvie","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Иммуномодулятор широкого спектра действия. Главным механизмом иммуномодулирующего действия является активация системы гипоталамус-гипофиз-кора надпочечников, а также ретикулоэндотелиальной и фибринолитической систем. Оказывая влияние на функцию коры надпочечников, повышает концентрацию кортикостероидов в крови.\u003cbr /\u003eПирогенал обладает адъювантным, десенсибилизирующим и противовоспалительным эффектами, повышает общую и специфическую резистентность организма, влияет на терморегулирующие центры гипоталамуса, создает регулируемый пирогенный эффект.\u003cbr /\u003eДействуя на клетки фагоцитарной системы, активирует фагоцитоз, секрецию кислородных радикалов, синтез ИЛ-1, ИЛ-2, фактора некроза опухоли (ФНОα), интерферона (ИФНα), стимулирует кининовую систему.\u003cbr /\u003eПрепятствует синтезу коллагена фибробластами, ускоряет процесс созревания фиброцитов. Стимуляция активности гиалуронидазы и подавление образования коллагеновых волокон в фибробластах обеспечивает увеличение проницаемости тканей, улучшение фибринолитических свойств крови и ускорение проникновения лекарственных веществ в очаг поражения. Способствует рассасыванию очагов воспаления, восстановлению кровообращения, тормозит формирование новых и сглаживает ранее образовавшиеся плотные рубцы в местах повреждения. Препятствует формированию и ускоряет рассасывание образовавшихся спаек. Обладает регенерирующим действием, способствует восстановлению утраченных функций органов.\u003cbr /\u003eПри введении пирогенала в организм до 85–90% фиксируется на поверхности циркулирующих лейкоцитов крови, около 10% остается в циркулирующей плазме и около 5% адсорбируется на мембранах эритроцитов.\u003cbr /\u003eВыводится из организма с мочой."}}]},{"id":2,"name":"Общие для обеих лекарственных форм","slug":"obschie_dlya_obeih_lekarstvennyh_form","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Неспецифическая терапия таких заболеваний, как:\u003cbr /\u003eхронические заболевания печени;\u003cbr /\u003eстриктуры уретры и мочеточников;\u003cbr /\u003eхронические простатиты и уретриты;\u003cbr /\u003eвоспалительные процессы придатков матки;\u003cbr /\u003eвторичное бесплодие;\u003cbr /\u003eспаечная болезнь брюшной полости;\u003cbr /\u003eожоговая болезнь;\u003cbr /\u003eвенерические заболевания."}}]},{"id":3,"name":"Суппозитории","slug":"suppozitorii","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Неспецифическая терапия таких заболеваний и состояний, как:\u003cbr /\u003eпапилломавирусная инфекция;\u003cbr /\u003eиммунопрофилактика и иммунореабилитация при неполном выздоровлении после перенесенного острого бактериального и вирусного заболевания.\u003cbr /\u003eПовышение температуры до 37–37,6 °C, в редких случаях — гриппоподобный синдром (лихорадка, головная боль, повышенная утомляемость, миалгия, озноб, артралгия, анорексия, тошнота)."}}]},{"id":4,"name":"Раствор для инъекций","slug":"rastvor_dlya_inektsiy","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Неспецифическая терапия таких заболеваний и состояний, как:\u003cbr /\u003eтравматические повреждения центральной и периферической нервной системы;\u003cbr /\u003eвялотекущая форма туберкулеза в фазе рассасывания;\u003cbr /\u003eувеиты;\u003cbr /\u003eиридоциклиты;\u003cbr /\u003eгерпесвирусная инфекция глаз;\u003cbr /\u003eпомутнение роговицы;\u003cbr /\u003eхронические заболевания кожи, в т.ч. псориаз;\u003cbr /\u003eнеобходимость проведения пиротерапии (в качестве пирогенного препарата).\u003cbr /\u003eгиперчувствительность;\u003cbr /\u003eсердечная недостаточность;\u003cbr /\u003eпеченочная и/или почечная недостаточность;\u003cbr /\u003eаутоиммунные заболевания (в анамнезе);\u003cbr /\u003eбеременность;\u003cbr /\u003eлактация.\u003cbr /\u003eПротивопоказано при беременности. На время лечения следует прекратить грудное вскармливание.\u003cbr /\u003eГипертермия до 37,5 °C, сопровождающаяся слабым ознобом и легким недомоганием. Такое состояние может длиться от 3 до 8 ч. В этом случае доза, вызвавшая подобную реакцию, в последующие дни повторяется до прекращения реакции на ее введение (обычно — 1–3 инъекции), после чего дозу последовательно повышают.\u003cbr /\u003eВ редких случаях у отдельных лиц может наблюдаться сильный озноб, повышение температуры до 39,5 °C, головная боль, боль в пояснице. Эти реакции продолжаются обычно от 6 до 8 ч, после чего температура снижается, и побочные явления исчезают. В этих случаях рекомендуется снизить дозу препарата.\u003cbr /\u003eПри использовании препарата для пиротерапии вышеописанные реакции допустимы.\u003cbr /\u003eПрепарат совместим и хорошо сочетается со всеми ЛС, применяемыми при лечении указанных в показаниях заболеваний и состояний. 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