инфекции дыхательных путей (бронхит, пневмония);
инфекции ЛОР-органов (синусит, фарингит, средний отит, ларингит);
инфекции кожи и мягких тканей;
инфекции костей и суставов;
инфекционно-воспалительные заболевания брюшной полости (в т.ч. инфекции ЖКТ и желчевыводящих путей);
инфекции почек (пиелонефрит) и мочевыводящих путей (цистит, уретрит);
инфекции органов малого таза (эндометрит, сальпингит, оофорит, цервицит, параметрит, простатит) и половых органов (кольпит, орхит, эпидидимит);
гонорея;
хламидиоз;
септицемия;
менингит;
профилактика инфекций у пациентов с нарушением иммунного статуса (в т.ч. при нейтропении).
Фармакологическое действие
Противомикробный препарат широкого спектра бактерицидного действия из группы фторхинолонов. Действует на фермент ДНК-гиразу, обеспечивающий сверхспирализацию и, таким образом, стабильность ДНК бактерий (дестабилизация цепей ДНК ведет к гибели микроорганизмов).
Активен в отношении
Различной чувствительностью к препарату обладают Enterococcus faecalis, Streptococcus pyogenes, Streptococcus pneumoniae и viridans, Serratia marcescenes, Pseudomonas aeruginosa, Acinetobacter, Mycoplasma hominis и pneumoniae, Mycobacterium tuberculosis, а также Mycobacterium fortuitum, Ureaplasma urealyticum, Clostridium perfringens, Corynebacterium spp., Helicobacter pylori, Listeria monocytogenes, Gardnerella vaginalis.
Лекарственное взаимодействие
При одновременном применении офлоксацин снижает клиренс теофиллина на 25% (при одновременном применении следует снизить дозу теофиллина). При одновременном применении циметидин, фуросемид, метотрексат и препараты, блокирующие канальцевую секрецию, повышают концентрацию офлоксацина в плазме. Офлоксацин увеличивает концентрацию глибенкламида в плазме. При одновременном приеме с непрямыми антикоагулянтами-антагонистами витамина К необходимо осуществлять контроль состояния свертывающей системы крови. При совместном применении с НПВС, производными нитроимидазола и метилксантинов повышается риск развития нейротоксических эффектов. При одновременном назначении с ГКС повышается риск разрыва сухожилий, особенно у пожилых людей. При назначении с препаратами, ощелачивающими мочу (ингибиторы карбоангидразы, цитраты, натрия бикарбонат) увеличивается риск кристаллурии и нефротоксических эффектов.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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