Омепразол Капсулы, 30 шт, 20 мг

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У больных с язвенной болезнью двенадцатиперстной кишки прием 20 мг омепразола поддерживает внутрижелудочный pH 30 в течение 17 часов. После прекращения приема препарата секреторная активность полностью восстанавливается после 3-5 суток."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Омепразол быстро абсорбируется из ЖКТ пик концентрации в плазме через 05-1 час. Биодоступность составляет 30-40 %. Связывание с белками плазмы - около 90 %. Омепразол практически полностью метаболизируется в печени. Период полувыведения - 05-1 час. Выводится в основном почками в виде метаболитов. При ХПН выведение снижается пропорционально снижению клиренса креатинина. У пожилых пациентов выведение уменьшается биодоступность возрастает. При печеночной недостаточности биодоступность - 100 % период полувыведения - 3 часа."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Язвенная болезнь желудка и двенадцатиперстной кишки;"}},{"type":"paragraph","data":{"text":"- Рефлюкс-эзофагит;"}},{"type":"paragraph","data":{"text":"- Эрозивно-язвенные поражения желудка и двенадцатиперстной кишки связанные с приемом НПВП стрессовые язвы;"}},{"type":"paragraph","data":{"text":"- Эрозивно-язвенные поражения желудка и двенадцатиперстной кишки ассоциированные с Helicobacter pylori (в составе комплексной терапии);"}},{"type":"paragraph","data":{"text":"- Синдром Золлингера - Эллисона."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к препарату детский возраст беременность период лактации."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Почечная и/или печеночная недостаточность."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь запивая небольшим количеством воды (содержимое капсулы нельзя разжевывать)."}},{"type":"paragraph","data":{"text":"Язвенная болезнь двенадцатиперстной кишки в фазе обострения - по 1 капсуле (20 мг) в сутки в течение 2-4 недель (в резистентных случаях до 2 капсулы в сутки)."}},{"type":"paragraph","data":{"text":"Язвенная болезнь желудка в фазе обострения и эрозивно-язвенный эзофагит - по 1-2 капсуле в сутки в течение 4 - 8 недель."}},{"type":"paragraph","data":{"text":"Эрозивно-язвенные поражения ЖКТ вызванные приемом НПВП - по 1 капсуле в сутки в течение 4-8 недель."}},{"type":"paragraph","data":{"text":"Эрадикация Helicobacter pylori - по 1 капсуле 2 раза в сутки в течение 7 дней в сочетании с антибактериальными средствами."}},{"type":"paragraph","data":{"text":"Противорецидивное лечение язвенной болезни желудка и 12-перстной кишки - по 1 капсуле в сутки."}},{"type":"paragraph","data":{"text":"Противорецидивное лечение рефлюкс-эзофагита - 1 капсула в сутки в течение длительного времени (до 6 месяцев)."}},{"type":"paragraph","data":{"text":"Синдром Золингера - Эллисона - доза подбирается индивидуально в зависимости от исходного уровня желудочной секреции обычно начиная с 60 мг в сутки. При необходимости дозу увеличивают до 80 - 120 мг в сутки в этом случае ее делят на два приема."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"В редких случаях могут возникать следующие обычно обратимые побочные явления:"}},{"type":"paragraph","data":{"text":"Со стороны органов пищеварения: диарея или запор тошнота рвота метеоризм боль в животе сухость во рту нарушения вкуса стоматит транзиторное повышение уровня \"печеночных ферментов в плазме; у больных с предшествующим тяжелым заболеванием печени - гепатит (в т.ч. с желтухой) нарушение функции печени."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: головная боль головокружение возбуждение сонливость бессонница парестезии депрессия галлюцинации; у больных с тяжелыми сопутствующими соматическими заболеваниями больных с предшествующим тяжелым заболеванием печени - энцефалопатия."}},{"type":"paragraph","data":{"text":"Со стороны опорно-двигательного аппарата: мышечная слабость миалгия артралгия."}},{"type":"paragraph","data":{"text":"Со стороны системы кроветворения: лейкопения тромбоцитопения в отдельных случаях - агранулоцитоз панцитопения."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов: зуд; редко в отдельных случаях - фотосенсибилизация мультиформная эритема алопеция."}},{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница ангионевротический отек бронхоспазм интерстициальный нефрит и анафилактический шок."}},{"type":"paragraph","data":{"text":"Прочие: нарушения зрения периферические отеки усиление потоотделения лихорадка гинекомастия; редко - образование желудочных грандулярных кист во время длительного лечения (следствие ингибирования секреции соляной.кислоты носит доброкачественный обратимый характер)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомами передозировки являются нарушение зрения сонливость возбуждение спутанность сознания головная боль повышение потоотделения сухость во рту тошнота аритмия."}},{"type":"paragraph","data":{"text":"Специфического антидота не существует. Лечение симптоматическое."}},{"type":"paragraph","data":{"text":"Гемодиализ недостаточно эффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Длительное применение омепразола в дозе 20 мг 1 раз в сутки в комбинации с кофеином теофиллином пироксикамом диклофенаком напроксеном метопрололом пропранололом этанолом циклоспорином лидокаином хинидином и эстрадиолом не приводило к изменению их концентрации в плазме."}},{"type":"paragraph","data":{"text":"Не отмечено взаимодействия с одновременно принимаемыми антацидами."}},{"type":"paragraph","data":{"text":"Изменяет биодоступность любого препарата всасывание которого зависит от значения pH (например солей железа)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Перед началом терапии необходимо исключить наличие злокачественного процесса (особенно при язве желудка) т.к. лечение маскируя симптоматику может отсрочить постановку правильного диагноза."}},{"type":"paragraph","data":{"text":"Прием одновременно с пищей не влияет на его эффективность."}},{"type":"paragraph","data":{"text":"При возникновении трудности с проглатыванием целой капсулы можно проглотить ее содержимое после вскрытия или рассасывание капсулы а также можно смешать содержимое капсулы со слегка подкисленной жидкостью (соком йогуртом) и использовать полученную суспензию в течение 30 мин."}},{"type":"paragraph","data":{"text":"У больных с тяжелой печеночной недостаточностью суточная доза не должна превышать 20 мг."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В связи с тем, что во время терапии могут наблюдаться головокружение, нечеткость зрения и сонливость, пациенты должны соблюдать осторожность при управлении автотранспортом или во время работы с механизмами, требующей повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы по 20 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в сухом защищенном от света месте при температуре не выше 25 °C."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не применять по истечении срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО \"Производство Медикаментов\", 346720, Ростовская обл., Аксайский район, г. Аксай, проспект Ленина, д. 43, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Производство Медикаментов\""}}]}],"source":null},"description_toggle":false,"short_description":"Омепразол ингибирует фермент Н+/К+-АТФ-азу (\"протонный насос\") в париетальных клетках желудка и блокирует тем самым заключительную стадию синтеза соляной кислоты. Это приводит к снижению уровня базальной и стимулированной секреции независимо от природы раздражителя. После однократного приема препарата внутрь действие омепразола наступает в течение первого часа и продолжается в течение 24 часов максимум эффекта достигается через 2 часа. У больных с язвенной болезнью двенадцатиперстной кишки прием 20 мг омепразола поддерживает внутрижелудочный pH 30 в течение 17 часов. После прекращения приема препарата секреторная активность полностью восстанавливается после 3-5 суток. Омепразол быстро абсорбируется из ЖКТ пик концентрации в плазме через 05-1 час. Биодоступность составляет 30-40 %. Связывание с белками плазмы - около 90 %. Омепразол практически полностью метаболизируется в печени. Период полувыведения - 05-1 час. Выводится в основном почками в виде метаболитов. При ХПН выведение снижается пропорционально снижению клиренса креатинина. У пожилых пациентов выведение уменьшается биодоступность возрастает. 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