Новокаин буфус Раствор, 100 шт, 5 мл, 5 мг / мл

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Для уменьшения всасывания и удлинения действия при местной анестезии, дополнительно вводят 0,1% раствор эпинефрина гидрохлорида - по 1 капле на 2-5-10 мл раствора прокаина."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри паранефральной блокаде (по А.В. Вишневскому)\u003c/i\u003e в околопочечную клетчатку вводят 50-80 мл 5 мг/мл или 100-150 мл раствора 2,5 мг/мл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри вагосимпатической блокаде\u003c/i\u003e вводят 30-100 мл раствора 2,5 мг/мл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДля циркулярной и паравертебральной блокад \u003c/i\u003eвнутрикожно вводят раствор 2,5 мг/мл или 5 мг/мл."}},{"type":"paragraph","data":{"text":"Высшие дозы \u003ci\u003eдля инфильтрационной анестезии для взрослых:\u003c/i\u003e первая разовая доза в начале операции - не более 500 мл раствора 2,5 мг/мл или 150 мл раствора 5 мг/мл."}},{"type":"paragraph","data":{"text":"Максимальная доза для применения у детей до 15 мг/кг."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Головная боль, головокружение, сонливость, слабость, повышение или снижение артериального давления, коллапс, периферическая вазодилатация, брадикардия, аритмия, боль в грудной клетке, тризм, тремор, нарушение зрения и слуха, нистагм, стойкая анестезия, гипотермия, метгемоглобинемия, аллергические реакции (вплоть до анафилактического шока)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e бледность кожных покровов и слизистых оболочек, головокружение, тошнота, рвота, \"холодный\" пот, учащение дыхания, тахикардия, снижение артериального давления вплоть до коллапса, апноэ, метгемоглобинемия. Действие на ЦНС проявляется чувством страха, галлюцинациями, судорогами, двигательным возбуждением."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e поддерживание адекватной легочной вентиляции, дезинтоксикация и симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Усиливает угнетающее действие на центральную нервную систему средств для общей анестезии, снотворных и седативных препаратов, наркотических анальгетиков и транквилизаторов."}},{"type":"paragraph","data":{"text":"Антикоагулянты (ардепарин, далтепарин, данапароид, эноксапарин, гепарин, варфарин) повышают риск развития кровотечений."}},{"type":"paragraph","data":{"text":"При обработке места инъекции местного анестетика дезинфицирующими растворами, содержащими тяжелые металлы, повышается риск развития местной реакции в виде болезненности и отека."}},{"type":"paragraph","data":{"text":"Использование с ингибиторами МАО (фуразолидон, прокарбазин, селегилин) повышает риск развития гипотензии."}},{"type":"paragraph","data":{"text":"Усиливают и удлиняют действие миорелаксантов."}},{"type":"paragraph","data":{"text":"При назначении прокаин а совместно с наркотическими анальгетиками отмечается аддитивный эффект, что используется при проведении спинальной и эпидуральной анестезии, при этом усиливается угнетение дыхания."}},{"type":"paragraph","data":{"text":"Вазоконстрикторы (эпинефрин, метоксамин, фенилэфрин) удлиняют местноанестезирующее действие."}},{"type":"paragraph","data":{"text":"Прокаин снижает антимиастеническое действие лекарственных средств, особенно при использовании его в высоких дозах, что требует дополнительной коррекции лечения миастении."}},{"type":"paragraph","data":{"text":"Ингибиторы холинэстеразы (антимиастенические ЛС, циклофосфамид, демекарин, экотиофат, тиотепа) снижают метаболизм прокаина."}},{"type":"paragraph","data":{"text":"Метаболит прокаина (парааминобензойная кислота) является антагонистом сульфаниламидов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Региональная и местная анестезия должна проводиться опытными специалистами в соответствующем образом оборудованном помещении при доступности готового к немедленному использованию оборудования и препаратов, необходимых для проведения мониторинга сердечной деятельности и реанимационных мероприятий. Персонал, выполняющий анестезию, должен быть квалифицированным и обучен технике выполнения анестезии, должен быть знаком с диагностикой и лечением системных токсических реакций, нежелательных явлений и реакций и других осложнений."}},{"type":"paragraph","data":{"text":"Пациентам требуется контроль за функциями сердечно-сосудистой, дыхательной и центральной нервной систем."}},{"type":"paragraph","data":{"text":"Необходимо отменить ингибиторы МАО за 10 дней до введения местного анестетика."}},{"type":"paragraph","data":{"text":"Перед применением обязательное проведение проб на индивидуальную чувствительность к препарату. Необходимо учитывать, что при проведении местной анестезии при использовании одной и той же общей дозы, токсичность новокаина тем выше, чем более концентрированный раствор используется."}},{"type":"paragraph","data":{"text":"Не всасывается со слизистых оболочек; не обеспечивает поверхностной анестезии при накожном применении."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо воздерживаться от вождения автотранспорта и занятиями потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для инъекций, 5 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25° С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять но истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО \"Производственная фармацевтическая компания Обновление\" (ЗАО \"ПФК Обновление\"), г. Новосибирск, ул. Станционная, д.80, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО \"ПФК Обновление\""}}]}],"source":null},"description_toggle":false,"short_description":"Местноанестезирующее средство с умеренной анестезирующей активностью и большой широтой терапевтического действия. Являясь слабым основанием, блокирует Na+-каналы, препятствует генерации импульсов в окончаниях чувствительных нервов и проведению импульсов по нервным волокнам. Изменяет потенциал действия в мембранах нервных клеток без выраженного влияния на потенциал покоя. Подавляет проведение не только болевых, но и импульсов другой модальности. При всасывании и непосредственном сосудистом введении в ток крови снижает возбудимость периферических холинергических систем, уменьшает образование и высвобождение ацетилхолина из преганглионарных окончаний (обладает некоторым ганглиоблокирующим действием), устраняет спазм гладкой мускулатуры, уменьшает возбудимость миокарда и моторных зон коры головного мозга. При внутривенном введении оказывает анальгезирующее, гипотензивное и антиаритмическое действие (увеличивает эффективный рефрактерный период, снижает возбудимость, автоматизм и проводимость), в больших дозах может нарушать нервно-мышечную проводимость. Устраняет нисходящие тормозные влияния ретикулярной формации ствола мозга. Угнетает полисинаптические рефлексы. В больших дозах может вызывать судороги. Обладает короткой анестезирующей активностью (продолжительность инфильтрационной анестезии составляет 0,5-1 ч). Подвергается полной системной абсорбции. Степень абсорбции зависит от места и пути введения (особенно от васкуляризации и скорости кровотока в области введения) и итоговой дозы (количества и концентрации). Быстро гидролизуется эстеразами плазмы и печени с образованием 2 основных фармакологически активных метаболитов: диэтиламиноэтанола (обладает умеренным сосудорасширяющим действием) и парааминобензойной кислоты (является конкурентным антагонистом сульфаниламидных химиотерапевтических препаратов и может ослабить их противомикробное действие). Период полувыведения - 30-50 секунд, в неонатальном периоде - 54-114 с. 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