Аспаркам-L Раствор, 10 шт, 10 мл, 45.2 / 40 мг/мл, для внутривенного введения

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Доза препарата определяется индивидуально в зависимости от показаний к применению."}},{"type":"paragraph","data":{"text":"Внутривенно капельно вводят со скоростью 25 капель в 1 минуту 1-2 раза в день по 10 - 20 мл (1-2 ампулы по 10 мл или 2-4 ампулы по 5 мл), разведенные в 100-200 мл изотонического раствора натрия хлорида или 5% раствора глюкозы."}},{"type":"paragraph","data":{"text":"При струйном введении содержимое 1 ампулы по 10 мл или 2 ампул по 5 мл разводят в 20 мл стерильной воды для инъекций или 5% раствора глюкозы и вводят медленно (не более 5 мл в минуту) в вену."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"list","data":{"style":"ordered","items":["Возможны тошнота, головокружение,","покраснение лица,","жажда,","понижение артериального давления, гипорефлексия.","гиперкалиемия (тошнота, рвота, диарея, парестезия) и гипермагниемия (гиперемия кожи лица, жажда, брадикардия, снижение артериального давления, мышечная слабость, усталость, парез, кома, арефлексия, угнетение дыхания, судороги);","при парентеральном введении - атриовентрикулярная блокада, парадоксальная реакция (увеличение числа экстрасистол), флебит.","при быстром внутривенном введении могут появиться все симптомы гиперкалиемии и гипермагниемии."]}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: гиперкалиемия и гипермагниемия."}},{"type":"paragraph","data":{"text":"Лечение: в/в кальция хлорид; при необходимости - гемодиализ и перитонеальный диализ."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Калийсберегающие диуретики (триамтерен, спиронолактон), бета-адреноблокаторы, циклоспорин, гепарин, ингибиторы ангиотензинпревращающего фермента, нестероидные противовоспалительные препараты - риск развития гиперкалиемии вплоть до развития аритмии и асистолии."}},{"type":"paragraph","data":{"text":"Устраняет гипокалиемию, вызванную глюкокортикостероидами."}},{"type":"paragraph","data":{"text":"Снижает нежелательные эффекты сердечных гликозидов."}},{"type":"paragraph","data":{"text":"За счет содержания ионов магния снижает эффект неомицина, полимиксина В, тетрациклина и стрептомицина."}},{"type":"paragraph","data":{"text":"Анестетики усиливают угнетающее действие магния на центральную нервную систему."}},{"type":"paragraph","data":{"text":"Может усиливать нервно-мышечную блокаду, вызванную деполяризующими миорелаксантами (атракурия безилатом, декаметония бромидом, суксаметония (хлоридом, бромидом, йодидом))."}},{"type":"paragraph","data":{"text":"Кальцитриол повышает концентрацию магния в плазме крови, препараты кальция - снижают эффект магния."}},{"type":"paragraph","data":{"text":"Раствор фармацевтически совместим с растворами сердечных гликозидов (улучшает их переносимость)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Исследований по оценке влияния препарата на способность управлять транспортными средствами и занятия другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций, не проводилось."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного введения."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте, при температуре 0–25 °C."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Биосинтез."}}]}],"source":null},"description_toggle":false,"short_description":"Механизм действия препарата Аспаркам связан с эффективным участием L-аспарагината в транспорте ионов магния и калия во внутриклеточное пространство.Магний активирует натрий-калий-ATФазу, удаляя из клетки ионы натрия и возвращая ионы калия; снижает концентрацию натрия и препятствует обмену его на кальций в гладких мышцах сосудов, понижая их резистентность. Калий стимулирует синтез АТФ, гликогена, белков, ацетилхолина и др. Оба иона поддерживают поляризацию клеточных мембран. Препарат регулирует проведение импульсов по нервным волокнам, синаптическую передачу, мышечное сокращение, работу сердечной мышцы. 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