Усиливает моторику желудочно-кишечного тракта (ЖКТ) за счет... Инструкция
Показания к применению
Применяют для лечения желудочно-кишечных симптомов связанных с нарушением моторики желудка или его замедленным опорожнением таких как вздутие живота быстрое насыщение чувство переполнения в желудке после приема пищи боль или дискомфорт в эпигастральной области снижение аппетита изжога тошнота и рвота; функциональная (неязвенная) диспепсия или хронический ...
Усиливает моторику желудочно-кишечного тракта (ЖКТ) за счет антагонизма D2-дофаминовых рецепторов и ингибирования ацетилхолинэстеразы. Активирует высвобождение ацетилхолина и подавляет его разрушение.
Обладает противорвотным эффектом за счет взаимодействия с D2-рецепторами расположенными в триггерной зоне. Вызывает дозозависимое подавление рвоты вызванной апоморфином.
Активирует пропульсивную моторику желудка за счет антагонизма D2-рецепторами и дозозависимого ингибирования активности ацетилхолинэстеразы.
Действие препарата у пациентов с функциональной диспепсией приводит к снижению выраженности симптомов (общая оценка пациентом постпрандиальная тяжесть в животе раннее насыщение).
Применение итоприда пациентами с диабетическим гастропарезом способствовало ускорению эвакуации из желудка жидкой и твердой пищи.
У пациентов с гастроэзофагеальной рефлюксной болезнью (ГЭРБ) итоприд уменьшает количество преходящих расслаблений нижнего пищеводного сфинктера и уменьшает продолжительность времени с высокой кислотностью в пищеводе (pH < 4).
Оказывает специфическое действие на гладкую мускулатуру ЖКТ ускоряет транзит по желудку и улучшает его опорожнение. Не влияет на сывороточные концентрации гастрина.
Фармакокинетика:
Всасывание
Быстро и практически полностью всасывается в ЖКТ. Относительная биодоступность его составляет 60% что связано с метаболизмом при первом прохождении через печень.
Максимальная концентрация в плазме (Сmах) 028 мкг/мл после приема 50 мг препарата достигается через 05-075 ч
При повторном приеме препарата внутрь в дозе 50-200 мг три раза в сутки в течение 7 дней фармакокинетика имеет линейный характер кумуляция минимальна.
Распределение
Связывается с белками плазмы на 96% в основном с альбумином. Связывание с альфа1-кислым гликопротеином составляет менее 15%.
Активно распределяется в тканях (объем распределения 61 л/кг) и обнаруживается в высоких концентрациях в почках тонком кишечнике печени надпочечниках и желудке. В терапевтических дозах незначительно проникает в головной и спинной мозг в грудное молоко.
Метаболизм
Метаболизируется в печени. Идентифицированы 3 метаболита один из которых проявляет незначительную активность которая не имеет фармакологического значения (примерно 2-3% от таковой итоприда). Первичным метаболитом у человека является N-оксид который образуется в результате окисления четвертичной амино-N-диметильной группы.
Метаболизируется под действием флавин-зависимой монооксигеназы (FMО3). Количество и эффективность изоферментов человека может отличаться в зависимости от генетического полиморфизма который в редких случаях приводит к развитию аутосомно-рецессивного состояния известного под названием триметиламинурии (синдром рыбного запаха).
У пациентов с триметиламинурией период полуэлиминации препарата увеличивается.
Препарат не оказывает ингибирующего или индуцирующего действия на CYP2C19 и CYP2E1. Применение итоприда не влияет на активность уридиндифосфатглюкуронизилтрансферазы.
Выведение
Итоприд и его метаболиты выводятся почками. Почечная экскреция итоприда и его N-оксида после однократного приема препарата внутрь в терапевтических дозах у здоровых людей составляла 37 и 754% соответственно.
Период полувыведения препарата (Т1/2) составляет 6 ч.
Показания к применению
Применяют для лечения желудочно-кишечных симптомов связанных с нарушением моторики желудка или его замедленным опорожнением таких как вздутие живота быстрое насыщение чувство переполнения в желудке после приема пищи боль или дискомфорт в эпигастральной области снижение аппетита изжога тошнота и рвота; функциональная (неязвенная) диспепсия или хронический гастрит.
Противопоказания
- Повышенная чувствительность к итоприду или любому вспомогательному компоненту препарата;
- пациенты с желудочно-кишечным кровотечением механической обструкцией или перфорацией;
С осторожностью назначают пациентам для которых развитие холинергических побочных реакций (связанных с усилением действия ацетилхолина во время терапии препаратом) может усугубить течение основного заболевания; пациентам с нарушением функции печени и почек; пациентам пожилого возраста.
Применение при беременности и в период грудного вскармливания
Беременность
Нет достаточных данных применения итоприда гидрохлорида беременными. Применение во время беременности возможно только в случае когда отсутствует альтернативная терапия а потенциальная польза для матери превышает потенциальный риск для плода.
Период грудного вскармливания
Существует потенциальный риск развития побочных реакций у грудного ребенка также имеются данные о выделении итоприда с молоком у крыс. При необходимости приема в период лактации грудное вскармливание необходимо прекратить
Способ применения и дозы
Обычно взрослым назначают внутрь по 1 таблетке препарата Ретч 50 мг 3 раза в сутки до еды.
Рекомендуемая суточная доза составляет 3 таблетки (150 мг).
Указанная доза может быть снижена с учетом возраста и симптомов больного.
Если препарат не был принят вовремя то в дальнейшем его следует принимать через равные промежутки времени. Не рекомендуется принимать в двойной дозе для компенсации пропущенной.
В клинических исследованиях продолжительность лечения итопридом составляла до 8 недель.
Побочное действие
Классификация частоты побочных реакций Всемирной организации здравоохранения (ВОЗ) по частоте развития: очень часто (≥ 1/10) часто (≥ 1/100 и < 1/10) нечасто (≥ 1/1 000 и < 1/100) редко (≥ 1/10 000 и < 1/1 000) очень редко (</10 000 включая отдельные случаи).
Нарушения со стороны крови и лимфатической системы: нечасто - лейкопения частота неизвестна - тромбоцитопения.
Нарушения со стороны иммунной системы: редко - гиперемия кожи кожный зуд сыпь частота неизвестна - анафилактоидные реакции.
Нарушения со стороны эндокринной системы: нечасто - гиперпролактинемия частота неизвестна - гинекомастия.
Нарушения со стороны нервной системы: нечасто - головокружение головная боль нарушение сна раздражительность частота неизвестна - тремор.
Нарушения со стороны желудочно-кишечного тракта: нечасто - диарея запор боль в животе повышенное слюноотделение частота неизвестна - тошнота желтуха.
Нарушения со стороны скелетно-мышечной и соединительной ткани: нечасто - боль в груди или в области спины.
Влияние на результаты лабораторных и инструментальных исследований: нечасто - повышение уровня креатинина и мочевинного азота в крови (BUN) частота неизвестна - повышение активности аспартатаминотрансферазы (ACT) аланинаминотрансферазы (АЛТ) гаммаглютамилтранспептидазы щелочной фосфатазы и уровня билирубина.
Прочие: нечасто - утомляемость.
Передозировка
Случаи передозировки у человека не описаны.
При передозировке показаны промывание желудка и симптоматическая терапия.
Взаимодействие с другими лекарственными средствами
Не обнаружено взаимодействия при одновременном приеме итоприда с варфарином диазепамом диклофенаком тиклопидином нифедипином и никардипином.
Метаболическое взаимодействие на уровне изоферментов системы CYP450 не предполагается поскольку метаболизм итоприда происходит главным образом посредством флавин-монооксигеназы.
Итоприда усиливает моторику желудка что может повлиять на абсорбцию препаратов при совместном применении внутрь. Особую осторожность следует соблюдать при приеме препаратов с узким терапевтическим индексом препаратов с пролонгированным высвобождением активного вещества или препаратов с кишечнорастворимой оболочкой.
Противоязвенные препараты такие как циметидин ранитидин тепренон и цетраксат не влияют на прокинетическую эффективность итоприда.
Холинергическое действие итоприда может возрасти при одновременном применении М-холиномиметиков а также ингибиторов холинэстеразы.
Особые указания
Итоприд усиливает действие ацетилхолина и может вызвать холинэргические побочные реакции.
Пациенты с нарушением функции печени или почек должны находиться под тщательным контролем врача в случае необходимости дозу препарата снижают или прекращают терапию препаратом.
При проявлении симптомов галактореи и гинекомастии лечение необходимо прервать или полностью прекратить
Влияние на способность управлять автомобилем и движущимися механизмами
Исследований относительно влияния итоприда на способность к управлению автомобилем и механизмами не проводилось.
Однако в период лечения препаратом следует соблюдать осторожность при выполнении потенциально опасных видов деятельности требующих повышенной концентрации внимания и быстроты психомоторных реакций (управления транспортными средствами работа с движущимися механизмами работа диспетчера и оператора) так как применение препарат может вызвать головокружение.
Форма выпуска
Таблетки 50 мг.
Условия хранения
Хранить при температуре не выше 25 °С в оригинальной упаковке.
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Активирует высвобождение ацетилхолина и подавляет его разрушение."}},{"type":"paragraph","data":{"text":"Обладает противорвотным эффектом за счет взаимодействия с D\u003csub\u003e2\u003c/sub\u003e-рецепторами расположенными в триггерной зоне. Вызывает дозозависимое подавление рвоты вызванной апоморфином."}},{"type":"paragraph","data":{"text":"Активирует пропульсивную моторику желудка за счет антагонизма D\u003csub\u003e2\u003c/sub\u003e-рецепторами и дозозависимого ингибирования активности ацетилхолинэстеразы."}},{"type":"paragraph","data":{"text":"Действие препарата у пациентов с функциональной диспепсией приводит к снижению выраженности симптомов (общая оценка пациентом постпрандиальная тяжесть в животе раннее насыщение)."}},{"type":"paragraph","data":{"text":"Применение итоприда пациентами с диабетическим гастропарезом способствовало ускорению эвакуации из желудка жидкой и твердой пищи."}},{"type":"paragraph","data":{"text":"У пациентов с гастроэзофагеальной рефлюксной болезнью (ГЭРБ) итоприд уменьшает количество преходящих расслаблений нижнего пищеводного сфинктера и уменьшает продолжительность времени с высокой кислотностью в пищеводе (pH < 4)."}},{"type":"paragraph","data":{"text":"Оказывает специфическое действие на гладкую мускулатуру ЖКТ ускоряет транзит по желудку и улучшает его опорожнение. Не влияет на сывороточные концентрации гастрина."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Всасывание"}},{"type":"paragraph","data":{"text":"Быстро и практически полностью всасывается в ЖКТ. Относительная биодоступность его составляет 60% что связано с метаболизмом при первом прохождении через печень."}},{"type":"paragraph","data":{"text":"Максимальная концентрация в плазме (С\u003csub\u003emах\u003c/sub\u003e) 028 мкг/мл после приема 50 мг препарата достигается через 05-075 ч"}},{"type":"paragraph","data":{"text":"При повторном приеме препарата внутрь в дозе 50-200 мг три раза в сутки в течение 7 дней фармакокинетика имеет линейный характер кумуляция минимальна."}},{"type":"paragraph","data":{"text":"Распределение"}},{"type":"paragraph","data":{"text":"Связывается с белками плазмы на 96% в основном с альбумином. Связывание с альфа\u003csub\u003e1\u003c/sub\u003e-кислым гликопротеином составляет менее 15%."}},{"type":"paragraph","data":{"text":"Активно распределяется в тканях (объем распределения 61 л/кг) и обнаруживается в высоких концентрациях в почках тонком кишечнике печени надпочечниках и желудке. В терапевтических дозах незначительно проникает в головной и спинной мозг в грудное молоко."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Метаболизируется в печени. Идентифицированы 3 метаболита один из которых проявляет незначительную активность которая не имеет фармакологического значения (примерно 2-3% от таковой итоприда). Первичным метаболитом у человека является N-оксид который образуется в результате окисления четвертичной амино-N-диметильной группы."}},{"type":"paragraph","data":{"text":"Метаболизируется под действием флавин-зависимой монооксигеназы (FMО3). Количество и эффективность изоферментов человека может отличаться в зависимости от генетического полиморфизма который в редких случаях приводит к развитию аутосомно-рецессивного состояния известного под названием триметиламинурии (синдром рыбного запаха)."}},{"type":"paragraph","data":{"text":"У пациентов с триметиламинурией период полуэлиминации препарата увеличивается."}},{"type":"paragraph","data":{"text":"Препарат не оказывает ингибирующего или индуцирующего действия на CYP2C19 и CYP2E1. Применение итоприда не влияет на активность уридиндифосфатглюкуронизилтрансферазы."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"Итоприд и его метаболиты выводятся почками. Почечная экскреция итоприда и его N-оксида после однократного приема препарата внутрь в терапевтических дозах у здоровых людей составляла 37 и 754% соответственно."}},{"type":"paragraph","data":{"text":"Период полувыведения препарата (Т\u003csub\u003e1/2\u003c/sub\u003e) составляет 6 ч."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Применяют для лечения желудочно-кишечных симптомов связанных с нарушением моторики желудка или его замедленным опорожнением таких как вздутие живота быстрое насыщение чувство переполнения в желудке после приема пищи боль или дискомфорт в эпигастральной области снижение аппетита изжога тошнота и рвота; функциональная (неязвенная) диспепсия или хронический гастрит."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к итоприду или любому вспомогательному компоненту препарата;"}},{"type":"paragraph","data":{"text":"- пациенты с желудочно-кишечным кровотечением механической обструкцией или перфорацией;"}},{"type":"paragraph","data":{"text":"- детский возраст (до 16 лет);"}},{"type":"paragraph","data":{"text":"- беременность и период лактации;"}},{"type":"paragraph","data":{"text":"- дефицит лактазы непереносимость лактозы глюкозо-галактозная мальабсорбция."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью назначают пациентам для которых развитие холинергических побочных реакций (связанных с усилением действия ацетилхолина во время терапии препаратом) может усугубить течение основного заболевания; пациентам с нарушением функции печени и почек; пациентам пожилого возраста."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Беременность"}},{"type":"paragraph","data":{"text":"Нет достаточных данных применения итоприда гидрохлорида беременными. Применение во время беременности возможно только в случае когда отсутствует альтернативная терапия а потенциальная польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания"}},{"type":"paragraph","data":{"text":"Существует потенциальный риск развития побочных реакций у грудного ребенка также имеются данные о выделении итоприда с молоком у крыс. При необходимости приема в период лактации грудное вскармливание необходимо прекратить"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Обычно взрослым назначают внутрь по 1 таблетке препарата Ретч 50 мг 3 раза в сутки до еды."}},{"type":"paragraph","data":{"text":"Рекомендуемая суточная доза составляет 3 таблетки (150 мг)."}},{"type":"paragraph","data":{"text":"Указанная доза может быть снижена с учетом возраста и симптомов больного."}},{"type":"paragraph","data":{"text":"Если препарат не был принят вовремя то в дальнейшем его следует принимать через равные промежутки времени. Не рекомендуется принимать в двойной дозе для компенсации пропущенной."}},{"type":"paragraph","data":{"text":"В клинических исследованиях продолжительность лечения итопридом составляла до 8 недель."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты побочных реакций Всемирной организации здравоохранения (ВОЗ) по частоте развития: очень часто (≥ 1/10) часто (≥ 1/100 и < 1/10) нечасто (≥ 1/1 000 и < 1/100) редко (≥ 1/10 000 и < 1/1 000) очень редко (</10 000 включая отдельные случаи)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны крови и лимфатической системы: нечасто - лейкопения частота неизвестна - тромбоцитопения."}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной системы: редко - гиперемия кожи кожный зуд сыпь частота неизвестна - анафилактоидные реакции."}},{"type":"paragraph","data":{"text":"Нарушения со стороны эндокринной системы: нечасто - гиперпролактинемия частота неизвестна - гинекомастия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы: нечасто - головокружение головная боль нарушение сна раздражительность частота неизвестна - тремор."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта: нечасто - диарея запор боль в животе повышенное слюноотделение частота неизвестна - тошнота желтуха."}},{"type":"paragraph","data":{"text":"Нарушения со стороны скелетно-мышечной и соединительной ткани: нечасто - боль в груди или в области спины."}},{"type":"paragraph","data":{"text":"Влияние на результаты лабораторных и инструментальных исследований: нечасто - повышение уровня креатинина и мочевинного азота в крови (BUN) частота неизвестна - повышение активности аспартатаминотрансферазы (ACT) аланинаминотрансферазы (АЛТ) гаммаглютамилтранспептидазы щелочной фосфатазы и уровня билирубина."}},{"type":"paragraph","data":{"text":"Прочие: нечасто - утомляемость."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаи передозировки у человека не описаны."}},{"type":"paragraph","data":{"text":"При передозировке показаны промывание желудка и симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не обнаружено взаимодействия при одновременном приеме итоприда с варфарином диазепамом диклофенаком тиклопидином нифедипином и никардипином."}},{"type":"paragraph","data":{"text":"Метаболическое взаимодействие на уровне изоферментов системы CYP450 не предполагается поскольку метаболизм итоприда происходит главным образом посредством флавин-монооксигеназы."}},{"type":"paragraph","data":{"text":"Итоприда усиливает моторику желудка что может повлиять на абсорбцию препаратов при совместном применении внутрь. Особую осторожность следует соблюдать при приеме препаратов с узким терапевтическим индексом препаратов с пролонгированным высвобождением активного вещества или препаратов с кишечнорастворимой оболочкой."}},{"type":"paragraph","data":{"text":"Противоязвенные препараты такие как циметидин ранитидин тепренон и цетраксат не влияют на прокинетическую эффективность итоприда."}},{"type":"paragraph","data":{"text":"М-холиноблокаторы понижают эффективность итоприда."}},{"type":"paragraph","data":{"text":"Холинергическое действие итоприда может возрасти при одновременном применении М-холиномиметиков а также ингибиторов холинэстеразы."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Итоприд усиливает действие ацетилхолина и может вызвать холинэргические побочные реакции."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции печени или почек должны находиться под тщательным контролем врача в случае необходимости дозу препарата снижают или прекращают терапию препаратом."}},{"type":"paragraph","data":{"text":"При проявлении симптомов галактореи и гинекомастии лечение необходимо прервать или полностью прекратить"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Исследований относительно влияния итоприда на способность к управлению автомобилем и механизмами не проводилось."}},{"type":"paragraph","data":{"text":"Однако в период лечения препаратом следует соблюдать осторожность при выполнении потенциально опасных видов деятельности требующих повышенной концентрации внимания и быстроты психомоторных реакций (управления транспортными средствами работа с движущимися механизмами работа диспетчера и оператора) так как применение препарат может вызвать головокружение."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 50 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С в оригинальной упаковке."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не применять после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Санека Фармасьютикалс а.с., Nitrianska 100, 920 27 Hlohovec, Slovak Republic, Словацкая республика"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Ксантис Фарма Лимитед"}}]}],"source":null},"description_toggle":false,"short_description":"Усиливает моторику желудочно-кишечного тракта (ЖКТ) за счет антагонизма D2-дофаминовых рецепторов и ингибирования ацетилхолинэстеразы. Активирует высвобождение ацетилхолина и подавляет его разрушение. Обладает противорвотным эффектом за счет взаимодействия с D2-рецепторами расположенными в триггерной зоне. Вызывает дозозависимое подавление рвоты вызванной апоморфином. Активирует пропульсивную моторику желудка за счет антагонизма D2-рецепторами и дозозависимого ингибирования активности ацетилхолинэстеразы. Действие препарата у пациентов с функциональной диспепсией приводит к снижению выраженности симптомов (общая оценка пациентом постпрандиальная тяжесть в животе раннее насыщение). Применение итоприда пациентами с диабетическим гастропарезом способствовало ускорению эвакуации из желудка жидкой и твердой пищи. У пациентов с гастроэзофагеальной рефлюксной болезнью (ГЭРБ) итоприд уменьшает количество преходящих расслаблений нижнего пищеводного сфинктера и уменьшает продолжительность времени с высокой кислотностью в пищеводе (pH\u003c4). Оказывает специфическое действие на гладкую мускулатуру ЖКТ ускоряет транзит по желудку и улучшает его опорожнение. Не влияет на сывороточные концентрации гастрина. Всасывание Быстро и практически полностью всасывается в ЖКТ. Относительная биодоступность его составляет 60% что связано с метаболизмом при первом прохождении через печень. Максимальная концентрация в плазме (Сmах) 028 мкг/мл после приема 50 мг препарата достигается через 05-075 ч При повторном приеме препарата внутрь в дозе 50-200 мг три раза в сутки в течение 7 дней фармакокинетика имеет линейный характер кумуляция минимальна. Распределение Связывается с белками плазмы на 96% в основном с альбумином. Связывание с альфа1-кислым гликопротеином составляет менее 15%. Активно распределяется в тканях (объем распределения 61 л/кг) и обнаруживается в высоких концентрациях в почках тонком кишечнике печени надпочечниках и желудке. В терапевтических дозах незначительно проникает в головной и спинной мозг в грудное молоко. Метаболизм Метаболизируется в печени. Идентифицированы 3 метаболита один из которых проявляет незначительную активность которая не имеет фармакологического значения (примерно 2-3% от таковой итоприда). Первичным метаболитом у человека является N-оксид который образуется в результате окисления четвертичной амино-N-диметильной группы. Метаболизируется под действием флавин-зависимой монооксигеназы (FMО3). Количество и эффективность изоферментов человека может отличаться в зависимости от генетического полиморфизма который в редких случаях приводит к развитию аутосомно-рецессивного состояния известного под названием триметиламинурии (синдром рыбного запаха). У пациентов с триметиламинурией период полуэлиминации препарата увеличивается. Препарат не оказывает ингибирующего или индуцирующего действия на CYP2C19 и CYP2E1. Применение итоприда не влияет на активность уридиндифосфатглюкуронизилтрансферазы. Выведение Итоприд и его метаболиты выводятся почками. 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