Таблетки плоскоцилиндрической формы,
с риской и фаской от белого до почти белого цвета.
На плоской стороне с риской нанесена
надпись MATERIA MEDICA.
Фармакологические свойства
Препарат модифицирует функциональную
активность мозгоспецифического белка S-100, а также улучшает интегративную
деятельность головного мозга на всех уровнях организации нейронных систем
(клеточном, межклеточном, структурном и системном).
Белок S-100 широко представлен в ЦНС
и принадлежит к семейству Са2+-связывающих белков. Белок регулирует
следующие фундаментальные процессы в мозге: генерация и проведение нервного
импульса, синаптическая передача сигнала; стимуляция дифференцировки и
пролиферации нейронов; на системном уровне белок S-100 модифицирует соотношение
процессов активации и торможения, позитивно влияя на интегративную деятельность
мозга. Благодаря этому S-100 обладает ноотропным, нейропротекторным и
нейротрофическим эффектами.
Экспериментально показано, что
препарат:
– проявляет ноотропную активность
путём улучшения формирования памятного следа на модели амнезии условного
рефлекса; компенсации возрастного ослабления механизмов кратковременной памяти;
усиления долговременной синаптической пластичности (основы клеточных механизмов
памяти и обучения);
– нормализует эмоциональное
состояние и поведение у животных (уменьшает соматовегетативные проявления
стресса, восстанавливает локомоторно-исследовательскую активность).
Также показано, что препарат обладает
нейропротективным и нейрорепаративным действием: повышает устойчивость тканей
мозга к гипоксии и токсическим воздействиям, обладает мембраностабилизирующим,
антиоксидантным действием. В постинсультный или посттравматический период
мобилизует внутриклеточные функционально сопряженные с белком S-100 компенсаторные
резервы поврежденных и здоровых нейронов, а также находящихся в поврежденной
области глиальных клеток. Обладает умеренно выраженным анксиолитическим
эффектом (устраняет чувство тревоги).
За счет изменения биоэлектрической
активности мозга может влиять на структуру сна.
Механизм действия
В исследованиях на мембранах клеток,
экспрессирующих человеческие рецепторы ГАМК, серотонина и дофамина (ГАМКB1А/B2,
5-HT2В, 5-HT2C, 5-HT3 и D3,
соответственно), показано, что препарат увеличивает количество комплексов
«лиганд-рецептор», то есть способен влиять как на тормозящие, так и на
активирующие нейромедиаторные системы. Нормализуя баланс уровней основных
нейромедиаторов, препарат поддерживает интегративную деятельность мозга.
Экспериментально продемонстрировано
изменение спектральной мощности биоэлектрической активности коры больших
полушарий, гиппокампа и гипоталамуса под действием Проспекты.
Ноотропное действие препарата было
доказано в клиническом исследовании по лечению пациентов в раннем
восстановительном периоде ишемического инсульта. Показано улучшение когнитивных
функций пациентов по Монреальской шкале когнитивной оценки (MoCA), которая
оценивает различные когнитивные сферы (внимание и концентрацию, исполнительные
функции, память, язык, зрительно-конструктивные навыки, абстрактное мышление,
счет и ориентацию). Наблюдалось восстановление активности в повседневной
жизнедеятельности по шкале Бартел, которая оценивает такие сферы деятельности
как способность принимать пищу, самостоятельно ухаживать за собой, в том числе
принимать душ и одеваться, физиологические отправления (стул, мочеиспускание),
возможность перемещаться (с постели в кресло и назад), подвижность на ровной
поверхности и подъем по лестнице. Согласно тестированию по шкале оценки
качества жизни при инсульте (SS-QOL), у пациентов наблюдалось улучшение
большинства показателей (речь, зрение, мышление, настроение, мобильность и
др.). Нормализация поведения и настроения пациентов проявлялась в виде
уменьшения раздражительности, повышения уровня самообслуживания, уменьшения
трудностей с выполнением повседневной работы по дому, повышения социальной роли
в семье.
Фармакокинетика
Чувствительность современных
физико-химических методов анализа (газожидкостная хроматография,
высокоэффективная жидкостная хроматография, хромато-масс-спектрометрия) не
позволяет оценивать содержание действующего вещества препарата Проспекта в
биологических жидкостях, органах и тканях ввиду специфического состава
препарата (см. раздел «Состав»), что делает технически невозможным изучение
фармакокинетики.
Показания к применению
Препарат Проспекта показан к
применению у взрослых.
Когнитивные нарушения различного
происхождения, в том числе после перенесенных острых нарушений мозгового
кровообращения.
Противопоказания
Повышенная индивидуальная чувствительность
к компонентам препарата. Детский возраст до 18 лет.
Применение при беременности и в период грудного вскармливания
Безопасность применения Проспекты у
беременных и в период грудного вскармливания не изучалась. При необходимости приема
препарата следует учитывать соотношение риск/польза.
Способ применения и дозы
Риска не предназначена для деления таблетки
на части.
Внутрь. На один прием – 2 таблетки
(держать во рту до полного растворения – не во время приема пищи). Принимать 2
раза в день. Курс лечения – 6 месяцев; при необходимости курс лечения можно повторить
через 1-2 месяца.
При отсутствии улучшения состояния в
течение 4 недель после начала лечения необходимо обратиться к врачу.
Побочное действие
Возможны реакции повышенной индивидуальной
чувствительности к компонентам препарата.
В редких случаях препарат может
вызывать сонливость.
Передозировка
При передозировке возможны
диспепсические явления, обусловленные входящими в состав препарата
вспомогательными веществами.
Взаимодействие с другими лекарственными средствами
Случаев несовместимости с другими лекарственными средствами до настоящего
времени не зарегистрировано.
Особые указания
В состав препарата входит лактоза, в
связи с чем его не рекомендуется назначать пациентам с врожденной
галактоземией, синдромом мальабсорбции глюкозы или галактозы, либо при
врожденной лактазной недостаточности.
Влияние на способность управлять автомобилем и движущимися механизмами
Возможно в редких случаях появление
сонливости, поэтому следует соблюдать осторожность при управлении транспортными
средствами.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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вещество:"}},{"type":"paragraph","data":{"text":"Антитела к мозгоспецифическому белку S-100 аффинно очищенные, модифицированные\n– 10 000 ЕМД*."}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: лактозы\nмоногидрат (лактоза), целлюлоза микрокристаллическая, магния стеарат."}},{"type":"paragraph","data":{"text":"* ЕМД – единицы модифицирующего действия."}}]},{"id":4,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Таблетки плоскоцилиндрической формы,\nс риской и фаской от белого до почти белого цвета."}},{"type":"paragraph","data":{"text":"На плоской стороне с риской нанесена\nнадпись MATERIA MEDICA."}}]},{"id":6,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Препарат модифицирует функциональную\nактивность мозгоспецифического белка S-100, а также улучшает интегративную\nдеятельность головного мозга на всех уровнях организации нейронных систем\n(клеточном, межклеточном, структурном и системном)."}},{"type":"paragraph","data":{"text":"Белок S-100 широко представлен в ЦНС\nи принадлежит к семейству Са\u003csup\u003e2+\u003c/sup\u003e-связывающих белков. Белок регулирует\nследующие фундаментальные процессы в мозге: генерация и проведение нервного\nимпульса, синаптическая передача сигнала; стимуляция дифференцировки и\nпролиферации нейронов; на системном уровне белок S-100 модифицирует соотношение\nпроцессов активации и торможения, позитивно влияя на интегративную деятельность\nмозга. Благодаря этому S-100 обладает ноотропным, нейропротекторным и\nнейротрофическим эффектами."}},{"type":"paragraph","data":{"text":"Экспериментально показано, что\nпрепарат:"}},{"type":"paragraph","data":{"text":"– проявляет ноотропную активность\nпутём улучшения формирования памятного следа на модели амнезии условного\nрефлекса; компенсации возрастного ослабления механизмов кратковременной памяти;\nусиления долговременной синаптической пластичности (основы клеточных механизмов\nпамяти и обучения);"}},{"type":"paragraph","data":{"text":"– нормализует эмоциональное\nсостояние и поведение у животных (уменьшает соматовегетативные проявления\nстресса, восстанавливает локомоторно-исследовательскую активность)."}},{"type":"paragraph","data":{"text":"Также показано, что препарат обладает\nнейропротективным и нейрорепаративным действием: повышает устойчивость тканей\nмозга к гипоксии и токсическим воздействиям, обладает мембраностабилизирующим,\nантиоксидантным действием. В постинсультный или посттравматический период\nмобилизует внутриклеточные функционально сопряженные с белком S-100 компенсаторные\nрезервы поврежденных и здоровых нейронов, а также находящихся в поврежденной\nобласти глиальных клеток. Обладает умеренно выраженным анксиолитическим\nэффектом (устраняет чувство тревоги)."}},{"type":"paragraph","data":{"text":"За счет изменения биоэлектрической\nактивности мозга может влиять на структуру сна."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМеханизм действия\u003c/i\u003e\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В исследованиях на мембранах клеток,\nэкспрессирующих человеческие рецепторы ГАМК, серотонина и дофамина (ГАМК\u003csub\u003eB1А/B2\u003c/sub\u003e,\n5-HT\u003csub\u003e2В\u003c/sub\u003e, 5-HT\u003csub\u003e2C\u003c/sub\u003e, 5-HT\u003csub\u003e3\u003c/sub\u003e и D\u003csub\u003e3\u003c/sub\u003e,\nсоответственно), показано, что препарат увеличивает количество комплексов\n«лиганд-рецептор», то есть способен влиять как на тормозящие, так и на\nактивирующие нейромедиаторные системы. Нормализуя баланс уровней основных\nнейромедиаторов, препарат поддерживает интегративную деятельность мозга."}},{"type":"paragraph","data":{"text":"Экспериментально продемонстрировано\nизменение спектральной мощности биоэлектрической активности коры больших\nполушарий, гиппокампа и гипоталамуса под действием Проспекты."}},{"type":"paragraph","data":{"text":"Ноотропное действие препарата было\nдоказано в клиническом исследовании по лечению пациентов в раннем\nвосстановительном периоде ишемического инсульта. Показано улучшение когнитивных\nфункций пациентов по Монреальской шкале когнитивной оценки (MoCA), которая\nоценивает различные когнитивные сферы (внимание и концентрацию, исполнительные\nфункции, память, язык, зрительно-конструктивные навыки, абстрактное мышление,\nсчет и ориентацию). Наблюдалось восстановление активности в повседневной\nжизнедеятельности по шкале Бартел, которая оценивает такие сферы деятельности\nкак способность принимать пищу, самостоятельно ухаживать за собой, в том числе\nпринимать душ и одеваться, физиологические отправления (стул, мочеиспускание),\nвозможность перемещаться (с постели в кресло и назад), подвижность на ровной\nповерхности и подъем по лестнице. Согласно тестированию по шкале оценки\nкачества жизни при инсульте (SS-QOL), у пациентов наблюдалось улучшение\nбольшинства показателей (речь, зрение, мышление, настроение, мобильность и\nдр.). Нормализация поведения и настроения пациентов проявлялась в виде\nуменьшения раздражительности, повышения уровня самообслуживания, уменьшения\nтрудностей с выполнением повседневной работы по дому, повышения социальной роли\nв семье."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Чувствительность современных\nфизико-химических методов анализа (газожидкостная хроматография,\nвысокоэффективная жидкостная хроматография, хромато-масс-спектрометрия) не\nпозволяет оценивать содержание действующего вещества препарата Проспекта в\nбиологических жидкостях, органах и тканях ввиду специфического состава\nпрепарата (см. раздел «Состав»), что делает технически невозможным изучение\nфармакокинетики."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Препарат Проспекта показан к\nприменению у взрослых."}},{"type":"paragraph","data":{"text":"Когнитивные нарушения различного\nпроисхождения, в том числе после перенесенных острых нарушений мозгового\nкровообращения.\u003ca\u003e\u003c/a\u003e"}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная индивидуальная чувствительность\nк компонентам препарата. Детский возраст до 18 лет."}},{"type":"paragraph","data":{"text":"Дефицит лактазы, непереносимость лактозы, глюкозо-галактозная\nмальабсорбция"}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Безопасность применения Проспекты у\nбеременных и в период грудного вскармливания не изучалась. При необходимости приема\nпрепарата следует учитывать соотношение риск/польза."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Риска не предназначена для деления таблетки\nна части."}},{"type":"paragraph","data":{"text":"Внутрь. На один прием – 2 таблетки\n(держать во рту до полного растворения – не во время приема пищи). Принимать 2\nраза в день. Курс лечения – 6 месяцев; при необходимости курс лечения можно повторить\nчерез 1-2 месяца."}},{"type":"paragraph","data":{"text":"При отсутствии улучшения состояния в\nтечение 4 недель после начала лечения необходимо обратиться к врачу."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Возможны реакции повышенной индивидуальной\nчувствительности к компонентам препарата."}},{"type":"paragraph","data":{"text":"В редких случаях препарат может\nвызывать сонливость."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При передозировке возможны\nдиспепсические явления, обусловленные входящими в состав препарата\nвспомогательными веществами."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Случаев несовместимости с другими лекарственными средствами до настоящего\nвремени не зарегистрировано."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В состав препарата входит лактоза, в\nсвязи с чем его не рекомендуется назначать пациентам с врожденной\nгалактоземией, синдромом мальабсорбции глюкозы или галактозы, либо при\nврожденной лактазной недостаточности."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Возможно в редких случаях появление\nсонливости, поэтому следует соблюдать осторожность при управлении транспортными\nсредствами."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей\nместе."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Препарат модифицирует функциональную активность мозгоспецифического белка S-100, а также улучшает интегративную деятельность головного мозга на всех уровнях организации нейронных систем (клеточном, межклеточном, структурном и системном). Белок S-100 широко представлен в ЦНС и принадлежит к семейству Са2+-связывающих белков. Белок регулирует следующие фундаментальные процессы в мозге: генерация и проведение нервного импульса, синаптическая передача сигнала; стимуляция дифференцировки и пролиферации нейронов; на системном уровне белок S-100 модифицирует соотношение процессов активации и торможения, позитивно влияя на интегративную деятельность мозга. Благодаря этому S-100 обладает ноотропным, нейропротекторным и нейротрофическим эффектами. Экспериментально показано, что препарат: – проявляет ноотропную активность путём улучшения формирования памятного следа на модели амнезии условного рефлекса; компенсации возрастного ослабления механизмов кратковременной памяти; усиления долговременной синаптической пластичности (основы клеточных механизмов памяти и обучения); – нормализует эмоциональное состояние и поведение у животных (уменьшает соматовегетативные проявления стресса, восстанавливает локомоторно-исследовательскую активность). Также показано, что препарат обладает нейропротективным и нейрорепаративным действием: повышает устойчивость тканей мозга к гипоксии и токсическим воздействиям, обладает мембраностабилизирующим, антиоксидантным действием. В постинсультный или посттравматический период мобилизует внутриклеточные функционально сопряженные с белком S-100 компенсаторные резервы поврежденных и здоровых нейронов, а также находящихся в поврежденной области глиальных клеток. Обладает умеренно выраженным анксиолитическим эффектом (устраняет чувство тревоги). За счет изменения биоэлектрической активности мозга может влиять на структуру сна.Механизм действияВ исследованиях на мембранах клеток, экспрессирующих человеческие рецепторы ГАМК, серотонина и дофамина (ГАМКB1А/B2, 5-HT2В, 5-HT2C, 5-HT3и D3, соответственно), показано, что препарат увеличивает количество комплексов «лиганд-рецептор», то есть способен влиять как на тормозящие, так и на активирующие нейромедиаторные системы. Нормализуя баланс уровней основных нейромедиаторов, препарат поддерживает интегративную деятельность мозга. Экспериментально продемонстрировано изменение спектральной мощности биоэлектрической активности коры больших полушарий, гиппокампа и гипоталамуса под действием Проспекты. Ноотропное действие препарата было доказано в клиническом исследовании по лечению пациентов в раннем восстановительном периоде ишемического инсульта. 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