СУЛЬФАСАЛАЗИН Таблетки, 30 шт, 500 мг, в пленочной оболочке

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Кишечником выводится 5% сульфапиридина и 67% 5-АСК почками - 75-91% всосавшегося сульфасалазина (в течение 3 дней)."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Язвенный колит (лечение обострений и поддерживающая терапия в фазе ремисии);"}},{"type":"paragraph","data":{"text":"- болезнь Крона (легкие и среднетяжелые формы в фазе обострения);"}},{"type":"paragraph","data":{"text":"- ревматоидный артрит; ювенильный ревматоидный артрит при неэффективности нестероидных противовоспалительных препаратов (НПВП)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к сульфасалазину или другим компонентам препарата а так же сульфонамидам или салицилатам;"}},{"type":"paragraph","data":{"text":"- порфирия;"}},{"type":"paragraph","data":{"text":"- гранулоцитопения;"}},{"type":"paragraph","data":{"text":"- апластическая анемия;"}},{"type":"paragraph","data":{"text":"- врожденный дефицит глюкозо-6-фосфатдегидрогеназы (риск развития желтухи);"}},{"type":"paragraph","data":{"text":"- печеночная и/или почечная недостаточность;"}},{"type":"paragraph","data":{"text":"- дети младше 10 лет и/или массой тела 35 кг и менее с хроническими воспалительными заболеваниями кишки (для данной лекарственной формы и дозировки);"}},{"type":"paragraph","data":{"text":"- обструкция кишечника или мочевыводящих путей;"}},{"type":"paragraph","data":{"text":"- дети младше 6 лет с ювенильным ревматоидным aртритом (эффективность и безопасность не установлены);"}},{"type":"paragraph","data":{"text":"- период грудного вскармливания."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Бронхиальная астма атопический дерматит аллергические реакции в анамнезе (возможны перекрестные аллергические реакции к фуросемиду тиазидным диуретикам производным сульфонилмочевины ингибиторам карбоангидразы) системные формы ювенильного ревматоидного артрита (риск развития сывороточной болезни); беременность."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Во время беременности назначение препарата возможно только по строгим показаниям и в минимально эффективной дозе. Если позволяет течение заболевания то в последнем триместре беременности прием препарата следует прекратить (сульфасалазин вытесняет билирубин из связи с белками плазмы тем самым увеличивая риск развития ядерной желтухи и гипербилирубинемии новорожденных - токсическое поражение нервных центров головного мозга). У новорожденных с дефицитом глюкозо-6-фосфатдегидрогеназы возможно развитие гемолитической анемии."}},{"type":"paragraph","data":{"text":"Сульфасалазин в норме секретируется в материнское молоко в очень небольшом количестве; у недоношенных новорожденных и у детей группы повышенного риска увеличивается риск развития ядерной желтухи. Концентрация же сульфапиридина в материнском молоке составляет 40% концентраций в плазме матери. При необходимости применения сульфасалазина в период лактации грудное вскармливание следует прекратить."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь после приема пищи."}},{"type":"paragraph","data":{"text":"Язвенный колит болезнь Крона"}},{"type":"paragraph","data":{"text":"Взрослым и детям старше 16 лет: в 1-й день - по 500 мг 4 раза в сутки; во 2-й - по 1 г 4 раза в сутки; в 3-й и последующие дни - по 15-2 г 4 раза в сутки."}},{"type":"paragraph","data":{"text":"После стихания острых клинических симптомов язвенного колита взрослым и подросткам и/или массой тела более 65 кг назначают поддерживающую дозу - по 500 мг 3-4 раза в сутки в течение нескольких месяцев."}},{"type":"paragraph","data":{"text":"Детям с 10 до 16 лет и/или массой тела от 35 до 50 кг - по 500 мг 4 раза в сутки."}},{"type":"paragraph","data":{"text":"Поддерживающая терапия для детей и подростков до 16 лет и/или массой тела менее 65 кг не рекомендуется."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза для взрослых - 8 г для детей до 16 лет - 2 г."}},{"type":"paragraph","data":{"text":"Ревматоидный артрит и ювенильный ревматоидный артрит"}},{"type":"paragraph","data":{"text":"Взрослым и детям старше 16 лет: в течение первой недели - по 500 мг 1 раз в сутки в течение второй - по 500 мг 2 раза в сутки третьей и далее - по 500 мг 3 раза в сутки."}},{"type":"paragraph","data":{"text":"Терапевтическая доза может составлять от 15 до 3 г/сут. Клинический эффект проявляется после 6-10 нед терапии. Курс лечения - 6 мес и более."}},{"type":"paragraph","data":{"text":"Дети от 6 до 8 лет и/или массой тела 20-29 кг: 1 табл. 2 раза в сутки;"}},{"type":"paragraph","data":{"text":"Дети от 8 до 12 лет и/или массой тела 30-39 кг: 1 табл. 2-3 раза в сутки;"}},{"type":"paragraph","data":{"text":"Дети от 12 до 16 лет и/или массой тела 40-50 кг: 1 табл. 3 раза в сутки или 2 табл. 2 раза в сутки;"}},{"type":"paragraph","data":{"text":"Дети старше 16 лет и/или массой тела более 50 кг: 2 табл. 2 раза в сутки."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза для детей составляет 2 г или 40-50 мг/кг массы тела."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Побочные эффекты связаны со степенью плазменной концентрации сульфапиридина особенно у людей с медленным ацетилированием. Чаще побочные эффекты наблюдаются у пациентов с ревматоидным артритом."}},{"type":"paragraph","data":{"text":"Со стороны центральной и периферической нервной системы: головная боль периферическая нейропатия головокружение нарушение сна галлюцинации атаксия судороги депрессия асептический менингит."}},{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта: тошнота рвота диарея снижение аппетита панкреатит стоматит боль в животе лекарственный гепатит."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: макроцитоз лейкопения нейтропения мегалобластная анемия гемолитическая анемия гемолитическая анемия вследствие ферментных нарушений - при нестабильных молекулах гемоглобина (тельца Гейнца-Эрлиха) метгемоглобинемия агранулоцитоз тромбоцитопения апластическая анемия гипопротромбинемия."}},{"type":"paragraph","data":{"text":"Со стороны мочеполовой системы: протеинурия гематурия кристаллурия нефротический синдром преходящие олигоспермия и мужское бесплодие."}},{"type":"paragraph","data":{"text":"Со стороны дыхательной системы: одышка кашель интерстициальный пневмонит фиброзирующий альвеолит инфильтраты в легочной ткани."}},{"type":"paragraph","data":{"text":"Со стороны органов чувств: шум в ушах."}},{"type":"paragraph","data":{"text":"Лабораторные данные: гипербилирубинемия повышение активности щелочной фосфатазы \"печеночных\" трансаминаз."}},{"type":"paragraph","data":{"text":"Аллергические реакции: генерализованная кожная сыпь крапивница эритема кожный зуд эксфолиативный дерматит фотосенсибилизация злокачественная экссудативная эритема (синдром Стивенса-Джонсона) токсический эпидермальный некролиз (синдром Лайелла) лихорадка лимфаденопатия сывороточная болезнь периорбитальная отечность эозинофилия узелковый периартериит анафилактический шок."}},{"type":"paragraph","data":{"text":"Прочие: гипертермия паротит возможно окрашивание мочи кожи или мягких контактных линз в желто-оранжевый цвет."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: тошнота рвота боль в животе головокружение. При применении очень высоких доз могут иметь место: анурия кристаллурия гематурия симптомы токсического поражения центральной нервной системы (судороги)."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое. Необходимо: спровоцировать рвоту промыть желудок кишечник; провести защелачивание мочи форсированный диурез. При анурии и/или почечной недостаточности следует ограничить потребление жидкости и электролитов."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Сульфасалазин уменьшает всасывание фолиевой кислоты и дигоксина."}},{"type":"paragraph","data":{"text":"Усиливает действие антикоагулянтов противоэпилептических и пероральных гипогликемических средств а также побочные эффекты цитостатиков иммунодепрессантов гепато- и нефротоксичных средств."}},{"type":"paragraph","data":{"text":"Лекарственные средства угнетающие костномозговое кроветворение увеличивают риск миелосупрессии."}},{"type":"paragraph","data":{"text":"Антибактериальные средства в связи с угнетающим действием на кишечную флору уменьшают эффективность сульфасалазина при язвенном колите."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения рекомендованы: периодический контроль активности \"печеночных\" ферментов в плазме крови общего анализа крови (в начале терапии: 1-2 раза в месяц затем каждые 3-6 месяцев лечения) и анализа мочи (при почечной недостаточности) употребление повышенного количества жидкости."}},{"type":"paragraph","data":{"text":"Сульфасалазин рекомендовано с осторожностью назначать пациентам с системными формами ювенильного ревматоидного артрита т.к. существует риск развития нежелательных эффектов в т.ч. сывороточной болезни (лихорадка тошнота рвота головная боль кожная сыпь нарушение функции печени)."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо соблюдать осторожность при управлении автотранспортом и работе со сложными техническими устройствами в связи с возможностью возникновения головокружения."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки покрытые пленочной оболочкой 500 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Озон\" (ООО \"Озон\"), 445351, Самарская обл., г. Жигулёвск, ул. Гидростроителей, д. 6, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Атолл\""}}]}],"source":null},"description_toggle":false,"short_description":"Сульфасалазин избирательно накапливается в соединительной ткани кишечника с высвобождением 5-аминосалициловой кислоты (5-АСК) обладающей противовоспалительной активностью и сульфапиридина обладающего противомикробной бактериостатической активностью. Около 30% сульфасалазина в таблетках покрытых пленочной оболочкой абсорбируются из тонкой кишки остальные 70% подвергаются расщеплению микрофлора кишечника с образованием сульпиридина 60-80% и 25% - 5-АСК. Существуют большие индивидуальные различия в максимальных сывороточных концентрациях (Сmах) сульфасалазина и его метаболитов; у \"медленных ацетиляторов\" они выше что увеличивает риск развития нежелательных эффектов. Сульфасалазин достигает максимальной концентрации через 3-12 часов после приема таблеток покрытых пленочной оболочкой. Связь с белками плазмы сульфасалазина - 99% сульфапиридина -50% 5-АСК - 43%. Сульфапиридин подвергается метаболизму в печени путем гидроксилирования с образованием неактивных метаболитов 5-АСК - путем ацетилирования. Период полувыведения (Т1/2) сульфасалазина - 5-10 ч сульфапиридина - 6-14 ч 5-АСК - 06-14 ч. Кишечником выводится 5% сульфапиридина и 67% 5-АСК почками - 75-91% всосавшегося сульфасалазина (в течение 3 дней).","substance":[{"id":985,"title":"Сульфасалазин","title_latin":"Sulfasalazinum","slug":"sulfasalazin_985"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"СУЛЬФАСАЛАЗИН - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/122791/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/122791/share_default/"}},"diseases":[],"other_packages":[{"id":117644,"title":"Сульфасалазин","subtitle":{"full":"Таблетки, пачка, 50 шт, 500 мг, для приема внутрь, в пленочной оболочке","short":"Таблетки, 50 шт, 500 мг","package":"50 шт, 500 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