Таблетки
плоскоцилиндрической формы, с риской и фаской, от белого
до почти белого цвета. На плоской стороне с риской нанесена надпись MATERIA
MEDICA, на другой плоской стороне нанесена надпись RAPHAMIN.
Фармакологические свойства
Экспериментально
доказано, что комплексный препарат Рафамин® эффективен при инфекциях
вирусной и бактериальной этиологии вследствие активации гуморального и клеточного
звеньев иммунной системы.
Установлено,
что технологическая обработка антительных субстанций путем повторяющегося
разбавления в сочетании с внешним воздействием приводит к появлению у компонентов
препарата способности непосредственного воздействия на молекулы-мишени: гамма интерферон
(ИФНγ), CD4 рецептор, а также молекулы главного комплекса гистосовместимости: β1-домена
МНС класса II и β2-микроглобулина МНС класса I.
Технологически обработанные аффинно очищенные антитела
к ИФНγ – один из ключевых факторов противовирусного иммунного ответа, вызывают
конформационные перестройки в молекуле ИФНγ, затрагивающие область
взаимодействия ИФНγ со своим рецептором (CD119), что приводит к увеличению
количества ИФНγ, связывающегося с CD119, активации ИФНγ зависимых генов, в том
числе противовирусных белков, которые останавливают размножение вирусов и
защищают здоровые клетки от инфицирования.
Технологически обработанные аффинно очищенные антитела
к
Технологически обработанные аффинно очищенные антитела
к β1-домену МНС класса II, регулирующему восприимчивость к внеклеточным
патогенам, обусловливают антибактериальную активность препарата Рафамин®.
Установлено стимулирующее действие на созревание дендритных клеток, отвечающих
за презентацию антигенов инфекционных агентов клеткам иммунной системы.
Препарат увеличивает экспрессию маркера созревания дендритных клеток (CD83), а
также продукцию противовоспалительных
(ИЛ-10) и провоспалительных (ИЛ-6, ИЛ-12, ИЛ-23) цитокинов.
Технологически обработанные аффинно очищенные антитела
к CD4 увеличивают эффективность Т-клеточного иммунного ответа, заключающуюся в
активации распознавания иммунной системой инфекционных агентов за счет влияния
на ассоциированную с CD4 лимфоцитспецифическую киназу – молекулу,
обеспечивающую передачу сигнала от рецептора.
Экспериментально выявлено, что препарат Рафамин®,
а также его отдельные компоненты, эффективны при вирусных инфекциях, вызываемых
как РНК- (грипп А/H1N1, A/H3N2 и A/H3N8, риновирус, респираторно-синцитиальный вирус), так и ДНК-содержащими
вирусами (вирус герпеса человека 2 типа). Также установлена способность
препарата оказывать антибактериальное действие при инфекциях, вызываемых Escherichia coli, Klebsiella pneumoniae и Salmonella
enteritidis.
На модели пневмонии, вызванной вирусом гриппа А/H1N1 и
Staphylococcus aureus,
продемонстрирована эффективность препарата в отношении смешанной вирусно-бактериальной
инфекции.
При совместном применении с антибактериальными
препаратами показана возможность усиления эффекта антибиотика в случае исходной
резистентности бактерий к антибиотику.
В доклинических и клинических исследованиях установлено,
что Рафамин® и его компоненты снижают инфекционную нагрузку на
организм, уменьшают выраженность симптомов инфекционного заболевания и сокращают
его продолжительность, снижают риск развития осложнений (в том числе требующих
назначения антибиотиков), увеличивают сопротивляемость организма инфекциям
дыхательной системы, что можетспособствовать
уменьшению риска развития острых инфекций дыхательных
путей.
Фармакокинетика
Чувствительность современных физико-химических методов
анализа (газожидкостная хроматография, высокоэффективная жидкостная
хроматография, хромато-масс-спектрометрия) не позволяет оценивать содержание действующих
веществ препарата Рафамин® в биологических жидкостях, органах и
тканях, что делает технически невозможным изучение фармакокинетики.
Показания к применению
Лечение острых респираторных вирусных инфекций у взрослых пациентов.
Противопоказания
Повышенная
индивидуальная чувствительность к компонентам препарата.
Применение при беременности и в период грудного вскармливания
Применение
препарата во время беременности и в период грудного вскармливания
противопоказано (в связи с отсутствием клинических данных по эффективности и
безопасности).
Способ применения и дозы
Риска
не предназначена для деления таблетки на части.
Принимать
внутрь – не во время приема пищи. Таблетку держать во рту до полного
растворения.
В
1-й день лечения принимают 8 таблеток по следующей схеме: по 1 таблетке каждые
30 минут в первые 2 часа (всего 5 таблеток за 2 часа), затем в течение этого же
дня принимают еще по 1 таблетке 3 раза через равные промежутки времени. На 2-ой
день и далее принимают по 1 таблетке 3 раза в день. Длительность лечения составляет
5 дней.
При отсутствии положительного эффекта от проводимой в
течение 5 дней терапии препаратом или ухудшении состояния следует обратиться к
врачу.
Побочное действие
Возможны
реакции повышенной индивидуальной чувствительности к компонентам препарата. Если
у Вас отмечаются нежелательные реакции, указанные в инструкции, или они
усугубляются, или Вы заметили любые другие нежелательные реакции, не указанные
в инструкции, сообщите об этом врачу.
Передозировка
При
передозировке возможны диспепсические явления, обусловленные входящими в состав
препарата вспомогательными веществами.
Лечение:
симптоматическое.
Взаимодействие с другими лекарственными средствами
Случаев несовместимости с другими лекарственными
средствами не выявлено.
При необходимости препарат можно сочетать с другими
противовирусными, симптоматическими и антибактериальными средствами.
Особые указания
В состав препарата входит лактозы моногидрат, в
связи с чем его не рекомендуется назначать пациентам с редкой врожденной
непереносимостью галактозы, дефицитом лактазы или глюкозо-галактозной
мальабсорбцией.
Условия хранения
При
температуре не выше 25 °С.
Хранить
в недоступном для детей месте.
В
течение периода применения препарата хранить контурную ячейковую упаковку в
картонной пачке, предусмотренной производителем.
Срок годности
3 года.
Не
применять по истечении срока годности.
Условия отпуска
Отпускают без рецепта.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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гамма интерферону человека аффинно очищенные – 10000 ЕМД*,"}},{"type":"paragraph","data":{"text":"антитела\nк CD4 аффинно очищенные ‒ 10000 ЕМД*,"}},{"type":"paragraph","data":{"text":"антитела\nк β2-микроглобулину МНС класса I аффинно "}},{"type":"paragraph","data":{"text":"\nочищенные ‒ 10000 ЕМД*,"}},{"type":"paragraph","data":{"text":"антитела\nк β1-домену МНС класса II аффинно очищенные ‒ 10000 ЕМД*."}},{"type":"paragraph","data":{"text":"\u003ci\u003e* ЕМД – Единицы Модифицирующего Действия.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: лактозы моногидрат,\nцеллюлоза микрокристаллическая, магния стеарат."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Таблетки\nплоскоцилиндрической формы, с риской и фаской, о\u003ca\u003e\u003c/a\u003eт белого\nдо почти белого цвета. На плоской стороне с риской нанесена надпись MATERIA\nMEDICA, на другой плоской стороне нанесена надпись RAPHAMIN."}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Экспериментально\nдоказано, что комплексный препарат Рафамин\u003csup\u003e®\u003c/sup\u003e эффективен при инфекциях\nвирусной и бактериальной этиологии вследствие активации гуморального и клеточного\nзвеньев иммунной системы."}},{"type":"paragraph","data":{"text":"Установлено,\nчто технологическая обработка антительных субстанций путем повторяющегося\nразбавления в сочетании с внешним воздействием приводит к появлению у компонентов\nпрепарата способности непосредственного воздействия на молекулы-мишени: гамма интерферон\n(ИФНγ), CD4 рецептор, а также молекулы главного комплекса гистосовместимости: β1-домена\nМНС класса II и β2-микроглобулина МНС класса I."}},{"type":"paragraph","data":{"text":"Технологически обработанные аффинно очищенные антитела\nк ИФНγ – один из ключевых факторов противовирусного иммунного ответа, вызывают\nконформационные перестройки в молекуле ИФНγ, затрагивающие область\nвзаимодействия ИФНγ со своим рецептором (CD119), что приводит к увеличению\nколичества ИФНγ, связывающегося с CD119, активации ИФНγ зависимых генов, в том\nчисле противовирусных белков, которые останавливают размножение вирусов и\nзащищают здоровые клетки от инфицирования."}},{"type":"paragraph","data":{"text":"Технологически обработанные аффинно очищенные антитела\nк "}},{"type":"paragraph","data":{"text":"Технологически обработанные аффинно очищенные антитела\nк β1-домену МНС класса II, регулирующему восприимчивость к внеклеточным\nпатогенам, обусловливают антибактериальную активность препарата Рафамин\u003csup\u003e®\u003c/sup\u003e.\nУстановлено стимулирующее действие на созревание дендритных клеток, отвечающих\nза презентацию антигенов инфекционных агентов клеткам иммунной системы.\nПрепарат увеличивает экспрессию маркера созревания дендритных клеток (CD83), а\nтакже продукцию противовоспалительных "}},{"type":"paragraph","data":{"text":"\n(ИЛ-10) и провоспалительных (ИЛ-6, ИЛ-12, ИЛ-23) цитокинов."}},{"type":"paragraph","data":{"text":"Технологически обработанные аффинно очищенные антитела\nк CD4 увеличивают эффективность Т-клеточного иммунного ответа, заключающуюся в\nактивации распознавания иммунной системой инфекционных агентов за счет влияния\nна ассоциированную с CD4 лимфоцитспецифическую киназу – молекулу,\nобеспечивающую передачу сигнала от рецептора."}},{"type":"paragraph","data":{"text":"Экспериментально выявлено, что препарат Рафамин\u003csup\u003e®\u003c/sup\u003e,\nа также его отдельные компоненты, эффективны при вирусных инфекциях, вызываемых\nкак РНК- (грипп А/H1N1, A/H3N2 и A/H3N8, риновирус, респираторно-синцитиальный вирус), так и ДНК-содержащими\nвирусами (вирус герпеса человека 2 типа). Также установлена способность\nпрепарата оказывать антибактериальное действие при инфекциях, вызываемых \u003ci\u003eEscherichia coli\u003c/i\u003e, \u003ci\u003eKlebsiella pneumoniae\u003c/i\u003e и \u003ci\u003eSalmonella\nenteritidis\u003c/i\u003e."}},{"type":"paragraph","data":{"text":"На модели пневмонии, вызванной вирусом гриппа А/H1N1 и\n\u003ci\u003eStaphylococcus aureus\u003c/i\u003e,\nпродемонстрирована эффективность препарата в отношении смешанной вирусно-бактериальной\nинфекции."}},{"type":"paragraph","data":{"text":"При совместном применении с антибактериальными\nпрепаратами показана возможность усиления эффекта антибиотика в случае исходной\nрезистентности бактерий к антибиотику."}},{"type":"paragraph","data":{"text":"В доклинических и клинических исследованиях установлено,\nчто Рафамин\u003csup\u003e®\u003c/sup\u003e и его компоненты снижают инфекционную нагрузку на\nорганизм, уменьшают выраженность симптомов инфекционного заболевания и сокращают\nего продолжительность, снижают риск развития осложнений (в том числе требующих\nназначения антибиотиков), увеличивают сопротивляемость организма инфекциям\nдыхательной системы, что может\u003ci\u003e \u003c/i\u003eспособствовать\nуменьшению риска развития острых инфекций дыхательных\nпутей."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Чувствительность современных физико-химических методов\nанализа (газожидкостная хроматография, высокоэффективная жидкостная\nхроматография, хромато-масс-спектрометрия) не позволяет оценивать содержание действующих\nвеществ препарата Рафамин\u003csup\u003e®\u003c/sup\u003e в биологических жидкостях, органах и\nтканях, что делает технически невозможным изучение фармакокинетики."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Лечение острых респираторных вирусных инфекций у взрослых пациентов."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная\nиндивидуальная чувствительность к компонентам препарата."}},{"type":"paragraph","data":{"text":"Возраст\nдо 18 лет."}},{"type":"paragraph","data":{"text":"Непереносимость\nлактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция."}},{"type":"paragraph","data":{"text":"Беременность\nи период грудного вскармливания."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение\nпрепарата во время беременности и в период грудного вскармливания\nпротивопоказано (в связи с отсутствием клинических данных по эффективности и\nбезопасности)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Риска\nне предназначена для деления таблетки на части."}},{"type":"paragraph","data":{"text":"Принимать\nвнутрь – не во время приема пищи. Таблетку держать во рту до полного\nрастворения."}},{"type":"paragraph","data":{"text":"В\n1-й день лечения принимают 8 таблеток по следующей схеме: по 1 таблетке каждые\n30 минут в первые 2 часа (всего 5 таблеток за 2 часа), затем в течение этого же\nдня принимают еще по 1 таблетке 3 раза через равные промежутки времени. На 2-ой\nдень и далее принимают по 1 таблетке 3 раза в день. Длительность лечения составляет\n5 дней."}},{"type":"paragraph","data":{"text":"При отсутствии положительного эффекта от проводимой в\nтечение 5 дней терапии препаратом или ухудшении состояния следует обратиться к\nврачу."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Возможны\nреакции повышенной индивидуальной чувствительности к компонентам препарата. Если\nу Вас отмечаются нежелательные реакции, указанные в инструкции, или они\nусугубляются, или Вы заметили любые другие нежелательные реакции, не указанные\nв инструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При\nпередозировке возможны диспепсические явления, обусловленные входящими в состав\nпрепарата вспомогательными веществами."}},{"type":"paragraph","data":{"text":"Лечение:\nсимптоматическое."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Случаев несовместимости с другими лекарственными\nсредствами не выявлено."}},{"type":"paragraph","data":{"text":"При необходимости препарат можно сочетать с другими\nпротивовирусными, симптоматическими и антибактериальными средствами."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В состав препарата входит лактозы моногидрат, в\nсвязи с чем его не рекомендуется назначать пациентам с редкой врожденной\nнепереносимостью галактозы, дефицитом лактазы или глюкозо-галактозной\nмальабсорбцией."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При\nтемпературе не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить\nв недоступном для детей месте."}},{"type":"paragraph","data":{"text":"В\nтечение периода применения препарата хранить контурную ячейковую упаковку в\nкартонной пачке, предусмотренной производителем."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не\nприменять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]}],"source":null},"description_toggle":false,"short_description":"Экспериментально доказано, что комплексный препарат Рафамин®эффективен при инфекциях вирусной и бактериальной этиологии вследствие активации гуморального и клеточного звеньев иммунной системы. Установлено, что технологическая обработка антительных субстанций путем повторяющегося разбавления в сочетании с внешним воздействием приводит к появлению у компонентов препарата способности непосредственного воздействия на молекулы-мишени: гамма интерферон (ИФНγ), CD4 рецептор, а также молекулы главного комплекса гистосовместимости: β1-домена МНС класса II и β2-микроглобулина МНС класса I. Технологически обработанные аффинно очищенные антитела к ИФНγ – один из ключевых факторов противовирусного иммунного ответа, вызывают конформационные перестройки в молекуле ИФНγ, затрагивающие область взаимодействия ИФНγ со своим рецептором (CD119), что приводит к увеличению количества ИФНγ, связывающегося с CD119, активации ИФНγ зависимых генов, в том числе противовирусных белков, которые останавливают размножение вирусов и защищают здоровые клетки от инфицирования. Технологически обработанные аффинно очищенные антитела к Технологически обработанные аффинно очищенные антитела к β1-домену МНС класса II, регулирующему восприимчивость к внеклеточным патогенам, обусловливают антибактериальную активность препарата Рафамин®. Установлено стимулирующее действие на созревание дендритных клеток, отвечающих за презентацию антигенов инфекционных агентов клеткам иммунной системы. Препарат увеличивает экспрессию маркера созревания дендритных клеток (CD83), а также продукцию противовоспалительных (ИЛ-10) и провоспалительных (ИЛ-6, ИЛ-12, ИЛ-23) цитокинов. Технологически обработанные аффинно очищенные антитела к CD4 увеличивают эффективность Т-клеточного иммунного ответа, заключающуюся в активации распознавания иммунной системой инфекционных агентов за счет влияния на ассоциированную с CD4 лимфоцитспецифическую киназу – молекулу, обеспечивающую передачу сигнала от рецептора. Экспериментально выявлено, что препарат Рафамин®, а также его отдельные компоненты, эффективны при вирусных инфекциях, вызываемых как РНК- (грипп А/H1N1, A/H3N2 и A/H3N8, риновирус, респираторно-синцитиальный вирус), так и ДНК-содержащими вирусами (вирус герпеса человека 2 типа). Также установлена способность препарата оказывать антибактериальное действие при инфекциях, вызываемыхEscherichia coli,Klebsiella pneumoniaeиSalmonella enteritidis. На модели пневмонии, вызванной вирусом гриппа А/H1N1 иStaphylococcus aureus, продемонстрирована эффективность препарата в отношении смешанной вирусно-бактериальной инфекции. При совместном применении с антибактериальными препаратами показана возможность усиления эффекта антибиотика в случае исходной резистентности бактерий к антибиотику. 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