Фармакологическое действие — противовирусное, иммуностимулир... Инструкция
Показания к применению
иммунодефицитные состояния, вызванные вирусными инфекциями у пациентов с нормальной и ослабленной иммунной системой, в т.ч. заболевания, вызванные вирусом Herpes simplex (тип I и тип II, генитальный герпес и герпес прочей локализации);подострый склерозирующий панэнцефалит.
Противопоказания
повышенная чувствительность к инозину пранобексу и другим компонентам препарата;подагра;мочекаменная болезнь;хроническая почечная недостаточность;аритмии;беременность;период кормления грудью;детский возраст до 3 лет (масса тела до 15–20 кг).С осторожностью: при одновременном назначении с ингибиторами ксантиноксидазы, диуретиками, зидовудином; при острой ...
Таблетки: белые или почти белые продолговатые, двояковыпуклые, с риской на одной стороне.
Фармакологические свойства
Фармакологическое действие — противовирусное, иммуностимулирующее.
Показания к применению
иммунодефицитные состояния, вызванные вирусными инфекциями у пациентов с нормальной и ослабленной иммунной системой, в т.ч. заболевания, вызванные вирусом Herpes simplex (тип I и тип II, генитальный герпес и герпес прочей локализации);подострый склерозирующий панэнцефалит.
Противопоказания
повышенная чувствительность к инозину пранобексу и другим компонентам препарата;подагра;мочекаменная болезнь;хроническая почечная недостаточность;аритмии;беременность;период кормления грудью;детский возраст до 3 лет (масса тела до 15–20 кг).С осторожностью: при одновременном назначении с ингибиторами ксантиноксидазы, диуретиками, зидовудином; при острой печеночной недостаточности.
Применение при беременности и в период грудного вскармливания
Противопоказан беременным и женщинам, кормящим грудью, т.к. безопасность препарата не исследовалась.
Способ применения и дозы
Внутрь, после еды, запивая небольшим количеством воды, через равные промежутки времени (8 или 6 ч) 3–4 раза в сутки. Взрослые: от 6 до 8 табл. в сутки, в 3–4 приема.Дети от 3 до 12 лет: 50мг/кг/сут, в 3–4 приема.Взрослые и дети при тяжелых инфекционных заболеваниях: дозу можно увеличить до 100мг/кг/сут, в 4–6 приемов. Максимальная суточная доза у взрослых составляет 3–4 г в сутки, у детей— 50 мг/кг/сут.При острых заболеваниях: лечение обычно продолжается от 5 до 14 дней. После исчезновения симптомов лечение следует продолжить в течение 1–2 дней или более, в зависимости от показаний.При хронических рецидивирующих заболеваниях: лечение у взрослых и детей проводится курсами продолжительностью 5–10 дней с интервалами 8 дней. Длительность поддерживающего лечения может составлять до 30 дней, при этом доза может быть снижена до 500–1000 мг/сут.Лечение инфекций, вызванных вирусом герпеса, у взрослых и детей: следует провести несколько курсов продолжительностью 5–10 дней до исчезновения симптомов. Для сокращения количества рецидивов рекомендуется проводить поддерживающее лечение по 1 табл. 2 раза в день в течение 30 дней.Особые группы пациентовПожилые. Необходимости в коррекции дозы нет, препарат применяется так же, как у пациентов среднего возраста. У пожилых пациентов чаще происходит повышение концентрации мочевой кислоты в сыворотке крови и в моче, чем у пациентов среднего возраста.Дети. Применяется у детей старше 3 лет.Почечная и печеночная недостаточность. На фоне лечения препаратом Гроприносин® следует каждые 2 нед проводить контроль содержания мочевой кислоты в сыворотке крови и моче. Контроль активности печеночных ферментов рекомендуется проводить каждые 4 нед при длительных курсах лечения препаратом.
Побочное действие
Побочные действия определяются следующим образом: часто— >1/100 и <1/10; и нечасто— >1/1000 и <1/100.Со стороны нервной системы: часто— головная боль, головокружение, утомляемость, плохое самочувствие; нечасто— нервозность, сонливость, бессонница.Со стороны ЖКТ: часто— снижение аппетита, тошнота, рвота, боль в эпигастрии; нечасто— диарея, запор. Со стороны гепатобилиарной системы: часто— повышение активности печеночных ферментов, ЩФ.Со стороны кожи и подкожно-жировой клетчатки: часто— зуд, сыпь.Со стороны почек и мочевыводящих путей: нечасто— полиурия.Аллергические реакции: нечасто— пятнисто-папулезная сыпь, крапивница, ангионевротический отек.Общие расстройства: часто— боль в суставах, обострение подагры.Лабораторные и инструментальные данные: часто— повышение концентрации азота мочевины крови.
Передозировка
Лечение: промывание желудка и симптоматическая терапия.
Взаимодействие с другими лекарственными средствами
Иммунодепрессанты ослабляют иммуностимулирующий эффект препарата Гроприносин®.Гроприносин® следует применять с осторожностью пациентам, принимающим одновременно ингибиторы ксантиноксидазы (аллопуринол) или петлевые диуретики (фуросемид, торасемид, этакриновая кислота), т.к. это может приводить к повышению концентрации мочевой кислоты в сыворотке крови.Совместное применение препарата Гроприносин® с зидовудином приводит к увеличению концентрации зидовудина в плазме крови и удлиняет его T1/2. Таким образом, при совместном применении препарата Гроприносин® с зидовудином может потребоваться коррекция дозы зидовудина.
Условия хранения
При температуре не выше 25°C. Хранить в недоступном для детей месте.
Срок годности
3 года. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России
Условия отпуска
По рецепту.
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