Урсолив Капсулы, 10 шт, 250 мг

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Проникает через плацентарный барьер. При систематическом приеме в дозах 13-15 мг/кг/сут УДХК становится основной желчной кислотой в сыворотке и составляет от 30 до 50% от общего содержания желчных кислот в крови. Терапевтический эффект препарата зависит от концентрации УДХК в желчи."}},{"type":"paragraph","data":{"text":"Метаболизируется в печени с превращением в тауриновый и глициновый конъюгаты которые секретируются в желчь. Около 50-70% принятой внутрь дозы препарата выводится с желчью. Выведение с мочой не превышает 1%. Незначительное количество невсосавшейся после перорального приема УДХК поступает в толстую кишку где подвергается расщеплению бактериями (7-дегидроксилирование); образующаяся литохолевая кислота частично всасывается из толстой кишки сульфатируется в печени и быстро выводится в виде сульфолитохолилглицинового или сульфолитохолилтауринового конъюгата."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Первичный билиарный цирроз при от­сутствии признаков декомпенсации (симптоматическая терапия);"}},{"type":"paragraph","data":{"text":"- Растворение мелких и средних холе­стериновых камней при функциони­рующем желчном пузыре;"}},{"type":"paragraph","data":{"text":"- Билиарный рефлюкс-гастрит;"}},{"type":"paragraph","data":{"text":"- Хронические гепатиты различного генеза;"}},{"type":"paragraph","data":{"text":"- Первичный склерозирующий холангит;"}},{"type":"paragraph","data":{"text":"- Кистозный фиброз (муковисцидоз);"}},{"type":"paragraph","data":{"text":"- Неалкогольный стеатогепатит;"}},{"type":"paragraph","data":{"text":"- Алкогольная болезнь печени;"}},{"type":"paragraph","data":{"text":"- Дискинезия желчевыводящих путей."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Размер холестериновых камней в желчном пузыре более 20 мм."}},{"type":"paragraph","data":{"text":"Наличие рентгеноконтрастных (с высоким содержанием кальция) камней желчного пузыря и общего желчного протока."}},{"type":"paragraph","data":{"text":"Атрофия желчного пузыря при желчнокаменной болезни нефункционирующий желчный пузырь. Обструкция желчевыводящих путей."}},{"type":"paragraph","data":{"text":"Острые воспалительные заболевания желчного пузыря желчных протоков и кишечника."}},{"type":"paragraph","data":{"text":"Цирроз печени в стадии декомпенсации."}},{"type":"paragraph","data":{"text":"Выраженная печеночная и почечная недостаточность."}},{"type":"paragraph","data":{"text":"Панкреатит (активная фаза)."}},{"type":"paragraph","data":{"text":"Гиперчувствительность к препарату."}},{"type":"paragraph","data":{"text":"Беременность период лактации."}},{"type":"paragraph","data":{"text":"Взрослые и дети с массой тела до 34 кг (для данной лекарственной формы)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано применение при беременности и в период грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат назначают внутрь. "}},{"type":"paragraph","data":{"text":"При растворении холестериновых желчных камней капсулы принимают вечером, перед сном, не разжевывая и запивая небольшим количеством жидкости."}},{"type":"paragraph","data":{"text":"Доза 10 мг/кг массы тела ежедневно, что соответствует: 2 капсулам препарата Урсолив у больных с массой тела до 60 кг; 3 капсулам - у больных с массой тела до 80 кг; 4 капсулам - у больных с массой тела до 100 кг; 5 капсулам - у больных с массой тела свыше 100 кг. "}},{"type":"paragraph","data":{"text":"Длительность лечения - 6-12 месяцев."}},{"type":"paragraph","data":{"text":"Для профилактики повторного образования камней рекомендуется прием препарата в течение еще нескольких месяцев после растворения камней."}},{"type":"paragraph","data":{"text":"При симптоматическом лечении первичного билиарного цирроза суточная доза зависит от массы тела и составляет от 2 до 6 капсул (от 10 до 15 мг/кг массы тела)."}},{"type":"paragraph","data":{"text":"Препарат принимают с пищей, запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"Для лечения билиарного рефлюкс-гастрита назначают по 1 капсуле 1 раз/сут перед сном. Курс лечения - от 10-14 дней до 6 месяцев, при необходимости - до 2 лет."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота рвота боль в эпигастральной области и правом подреберье запор транзиторное повышение активности \"печеночных\" трансаминаз; редко - диарея (может быть дозозависимой) кальцинирование желчных камней."}},{"type":"paragraph","data":{"text":"При лечении первичного билиарного цирроза может наблюдаться преходящая декомпенсация цирроза печени которая исчезает после отмены препарата."}},{"type":"paragraph","data":{"text":"Прочие: головная боль недомогание миалгии головокружение аллергические реакции (кожный зуд крапивница ангионевротический отек) обострение ранее имевшегося псориаза алопеция."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаи передозировки УДХК до настоящего времени не описаны."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При совместном применении антациды содержащие алюминий и ионообменные смолы (колестирамин) снижают абсорбцию УДХК."}},{"type":"paragraph","data":{"text":"При одновременном применении гиполипидемические лекарственные средства (особенно клофибрат) эстрогены неомицин или прогестогены (пероральные контрацептивы) увеличивают насыщение желчи холестерином и могут снижать способность урсодезоксихолевой кислоты растворять холестериновые желчные камни."}},{"type":"paragraph","data":{"text":"При одновременном применении УДХК может увеличить абсорбцию циклоспорина."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Для растворения желчных камней УДХК конкременты должны быть холестериновыми (не рентгеноконтрастными) размером не более 15-20 мм. При этом желчный пузырь должен оставаться функциональным а проходимость пузырного и общего желчного протоков должна быть сохранена."}},{"type":"paragraph","data":{"text":"При назначении с целью растворения желчных камней необходимо ежемесячно а затем - каждые 3 мес. проводить биохимический анализ крови для определения активности \"печеночных\" трансаминаз щелочной фосфатазы гамма-глутамилтранспептидазы а также концентрации билирубина. При сохранении повышенных показателей препарат следует отменить."}},{"type":"paragraph","data":{"text":"Для контроля эффективности лечения рекомендуется каждые 6 мес. проводить рентгенологическое и ультразвуковое исследование желчевыводящих путей."}},{"type":"paragraph","data":{"text":"При обызвествлении желчных камней нарушении сократительной способности желчного пузыря или частых приступах желчной колики лечение следует прекратить. Если в течение 6-12 мес после начала терапии частичного растворения конкрементов не произошло маловероятно что лечение будет эффективным. Обнаружение во время лечения невизуализируемого желчного пузыря является свидетельством того что полного растворения конкрементов не произошло и лечение следует прекратить."}},{"type":"paragraph","data":{"text":"После полного растворения камней для исключения рецидивов рекомендуется продолжать применение урсодезоксихолевой кислоты в течение 3 месяцев."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не оказывает негативного влияния на способность управлять транспортными средствами и/или другими механизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 250 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в сухом защищенном от света месте при температуре не выше 25°С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года"}},{"type":"paragraph","data":{"text":"Не использовать после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное общество \"АВВА РУС\" (АО \"АВВА РУС\"), 610044, Кировская обл., г. Киров, ул. Луганская, д. 53а, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"АВВА РУС\""}}]}],"source":null},"description_toggle":false,"short_description":"Оказывает гепатопротекторное желчегонное холелитолитическое гиполипидемическое гипохолестеринемическое и некоторое иммуномодулирующее действие. В исследованиях in vitro показано что урсодезоксихолевая кислота (УДХК) оказывает прямое протекторное действие на клетки печени и уменьшает гепатотоксичность гидрофобных солей желчных кислот. Основные эффекты УДХК на обмен холестерина включают: снижение секреции холестерина уменьшение его кишечной абсорбции и стимуляцию выхода холестерина из холестериновых камней в желчь. УДХК тормозя ГМК-КоА-редуктазу оказывает также умеренный подавляющий эффект на синтез холестерина в печени Повышает растворимость холестерина в желчевыводящей системе. Вызывает частичное или полное растворение холестериновых желчных камней при энтеральном применении уменьшает насыщенность желчи холестерином Стимулирует образование и выделение желчи ускоряет выведение токсичных желчных кислот через кишечник. При пероральном приеме доля УДХК в общем пуле желчных кислот значительно возрастает; УДХК конкурирует с другими желчными кислотами в процессе абсорбции в тонкой кишке а также при проникновении через мембрану гепатоцита что приводит к уменьшению всасывания токсичных желчных кислот в кишечнике и поступления их в печень предотвращая их цитопатогенное действие. Уменьшает литогенность желчи увеличивает в ней концентрацию желчных кислот вызывает усиление желудочной и панкреатической секреции усиливает активность липазы оказывает гипогликемическое действие. Оказывает влияние на иммунологические реакции уменьшая патологическую экспрессию антигенов главного комплекса гистосовместимости HLAI на гепатоцитах и HLA II на холангиоцитах подавляет продукцию интерлейкина 2 уменьшает количество эозинофилов. УДХК абсорбируется в тонкой кишке (около 90%) при этом максимальная концентрация (Сmах) в плазме крови при приеме препарата внутрь в дозе 250 мг составляет около 33 мкг/мл время достижения максимальной концентрации - около 2 часов. Связывание с белками плазмы неконъюгированной УДХК у здоровых людей составляет не менее 70%. Проникает через плацентарный барьер. При систематическом приеме в дозах 13-15 мг/кг/сут УДХК становится основной желчной кислотой в сыворотке и составляет от 30 до 50% от общего содержания желчных кислот в крови. Терапевтический эффект препарата зависит от концентрации УДХК в желчи. Метаболизируется в печени с превращением в тауриновый и глициновый конъюгаты которые секретируются в желчь. Около 50-70% принятой внутрь дозы препарата выводится с желчью. Выведение с мочой не превышает 1%. Незначительное количество невсосавшейся после перорального приема УДХК поступает в толстую кишку где подвергается расщеплению бактериями (7-дегидроксилирование); образующаяся литохолевая кислота частично всасывается из толстой кишки сульфатируется в печени и быстро выводится в виде сульфолитохолилглицинового или сульфолитохолилтауринового конъюгата.","substance":[{"id":179,"title":"Урсодезоксихолевая кислота","title_latin":"Acidum ursodeoxycholicum","slug":"ursodezoksiholevaya_kislota_179"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":{"count":5,"url":"/review/24275-ursoliv/"},"image_alt":"Урсолив - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/125271/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/125271/share_default/"}},"diseases":[],"other_packages":[{"id":97073,"title":"Урсолив","subtitle":{"full":"Капсулы, 50 шт, 250 мг","short":"Капсулы, 50 шт, 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