Комбинированный препарат, действие которого определяется компонентами, входящими в его состав. Парацетамол оказывает анальгезирующее и жаропонижающее действие. Механизм действия связан со способностью ингибировать синтез простагландинов и с влиянием на центр терморегуляции в гипоталамусе. Кофеин уменьшает сонливость и чувство усталости, повышает умственную и физическую работоспособность, увеличивает ЧСС, повышает АД при гипотонии. Кодеин оказывает центральное противокашлевое действие за счет подавления возбудимости кашлевого центра, а также анальгезирующее действие, обусловленное возбуждением опиатных рецепторов. Пропифеназон оказывает анальгезирующее действие.
Лекарственное взаимодействие
Не рекомендуется одновременное применение Каффетина с барбитуратами, противоэпилептическими средствами, зидовудином, рифампицином и этанолом, т.к. возрастает риск гепатотоксического действия. Парацетамол, входящий в состав Каффетина, увеличивает период выведения хлорамфеникола в 5 раз. При повторном приеме парацетамол может усилить действие антикоагулянтов - производных дикумарина. Метоклопрамид ускоряет всасывание парацетамола. Кофеин, входящий в состав Каффетина, ускоряет всасывание эрготамина. Кодеин, входящий в состав Каффетина, усиливает действие снотворных, анальгетиков и седативных средств.
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