Юперио Таблетки, 28 шт, 100(51,4+48,6) мг(мг + мг), для приема внутрь, в пленочной оболочке

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Так как в состав препарата Юперио входит АРА II валсартан, его не следует применять одновременно с другим препаратом, в состав которого входит АРА II. Если у пациентов возникают проблемы с переносимостью препарата Юперио (клинически выраженное снижение АД, гиперкалиемия, нарушение функции почек), следует рассмотреть вопрос о временном снижении дозы или коррекции дозы сопутствующих лекарственных препаратов."}}]},{"id":6,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Выявленные нежелательные явления (НЯ) соответствовали фармакологическим характеристикам препарата Юперио и сопутствующим заболеваниям, имеющимся у пациентов. Наиболее часто встречавшимися НЯ были выраженное снижение артериального давления, гиперкалиемия и нарушение функции почек, вызванные коррекцией дозы препарата Юперио или прекращением терапии. Частота НЯ не зависела от пола, возраста или расовой принадлежности пациентов. НЯ перечислены в соответствии с системно-органным классом медицинского словаря для нормативно-правовой деятельности MedDRA. В пределах каждого системно-органного класса НЯ распределены по частоте возникновения в порядке уменьшения их важности. Для оценки частоты использованы следующие критерии: очень часто (?1/10), часто (от ?1/100 до \u003c1/10), нечасто (от ?1/1,000 до \u003c1/100), редко (от ?1/10000 до \u003c1/1000), очень редко (\u003c1/10000), включая отдельные сообщения. Нарушения со стороны обмена веществ и питания: очень часто – гиперкалиемия, часто – гипокалиемия. Нарушения со стороны нервной системы: часто - головокружение, головная боль, нечасто – ортостатическое головокружение. Нарушения со стороны органа слуха и лабиринтные нарушения: часто – вертиго. Нарушения со стороны сосудов: очень часто – выраженное снижение АД, часто – обморок, ортостатическая гипотензия. Нарушения со стороны дыхательной системы, органов грудной клетки и средостения: часто – кашель. Нарушения со стороны желудочно-кишечного тракта: часто – диарея, тошнота. Нарушения со стороны кожи и подкожных тканей: нечасто – ангионевротический отек. Нарушения со стороны почек и мочевыводящих путей: очень часто – нарушение функции почек, часто – почечная недостаточность (в т.ч. острая почечная недостаточность). Общие расстройства и нарушения в месте введения: часто – повышенная утомляемость, астения. Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":7,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказания: повышенная чувствительность к сакубитрилу или к валсартану, а также к другим вспомогательным компонентам препарата. Одновременное применение с ингибиторами ангиотензинпревращающего фермента (АПФ), а также период 36 часов после отмены ингибиторов АПФ. Наличие ангионевротического отека в анамнезе на фоне предшествующей терапии ингибиторами АПФ или АРА II. Одновременное применение с алискиреном у пациентов с сахарным диабетом или у пациентов с умеренным или тяжелым нарушением функции почек (рСКФ \u003c60 мл/мин/1,73 м2 площади поверхности тела). Нарушение функции печени тяжелой степени (класс С по классификации Чайлд Пью), биллиарный цирроз и холестаз. Препарат Юперио не рекомендуется для применения у детей в возрасте до 18 лет в связи с отсутствием данных по эффективности и безопасности. Беременность, планирование беременности и период грудного вскармливания. Одновременное применение с другими препаратами, содержащими АРА II, т.к. в состав препарата входит валсартан."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Таблетки Юперио в пленочной оболочке. Действие препарата Юперио опосредовано новым механизмом, а именно, одновременным подавлением активности неприлизина (нейтральной эндопептидазы (neutral endopeptidase, NEP)) веществом LBQ657 (активным метаболитом сакубитрила) и блокадой рецепторов к ангиотензину II 1-го типа (AT1) валсартаном, являющегося антагонистом рецепторов ангиотензина II (APA II). Взаимодополняющие благоприятные эффекты сакубитрила и валсартана на состояние сердечно-сосудистой системы и почек у пациентов с сердечной недостаточностью обусловлены увеличением количества пептидов, расщепляемых неприлизином (таких как натрийуретические пептиды (НП)), что опосредовано действием LBQ657, при этом одновременно происходит подавление валсартаном негативных эффектов ангиотензина II. НП активируют мембраносвязанные рецепторы, сопряженные с гуанилилциклазой, что приводит к повышению концентрации циклического гуанозинмонофосфата (цГМФ), вызывающего симптомы вазодилатации, увеличение натрийуреза и диуреза, увеличение скорости клубочковой фильтрации и почечного кровотока, подавление высвобождения ренина и альдостерона, снижение симпатической активности, а также антигипертрофическое и антифибротическое действие. Валсартан, избирательно блокируя AT1-рецептор, подавляет негативные эффекты ангиотензина II на сердечно-сосудистую систему и почки, а также блокирует ангиотензин II-зависимое высвобождение альдостерона. Это предотвращает стойкую активацию ренин-ангиотензин-альдостероновой системы (РААС), которая вызывает сужение сосудов, задержку натрия и воды почками, активацию роста и пролиферацию клеток, а также последующую перестройку сердечно-сосудистой системы, усугубляющей нарушения в ее функционировании.","substance":[{"id":429,"title":"Валсартан","title_latin":"Valsartanum","slug":"valsartan_429"},{"id":1732,"title":"Сакубитрил","title_latin":"Sacubitril","slug":"sakubitril_1732"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Юперио - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/191583/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/191583/share_default/"}},"diseases":[],"other_packages":[{"id":166796,"title":"Юперио","subtitle":{"full":"Таблетки, коробка, 56 шт, 50 мг, для приема внутрь, покрытые оболочкой","short":"Таблетки, 56 шт, 50 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