ГКС для интраназального применения. Беклометазон в форме дип... Инструкция
Показания к применению
Сезонный и круглогодичный аллергический ринит; вазомоторный ринит.
Противопоказания
Геморрагический диатез; частые носовые кровотечения; туберкулез органов дыхания; грибковые инфекции; вирусные инфекции; детский возраст до 6 лет; I триместр беременности; повышенная чувствительность к беклометазону и вспомогательным веществам применяемого препарата.
Инструкция
Фармакологические свойства
ГКС для интраназального применения.
Беклометазон в форме дипропионата является пролекарством и обладает слабой тропностью к глюкокортикоидным рецепторам. Под действием эстераз превращается в активный метаболит – беклометазона-17-монопропионат, который оказывает выраженный местный противовоспалительный эффект за счет снижения образования субстанции хемотаксиса (влияние на аллергические реакции замедленного типа). Подавляя продукцию метаболитов арахидоновой кислоты и снижая выделение из тучных клеток медиаторов воспаления, тормозит развитие аллергической реакции немедленного типа.
Предупреждает краевое скопление нейтрофилов, уменьшает воспалительную экссудацию и продукцию лимфокинов, тормозит миграцию макрофагов, снижает интенсивность процессов инфильтрации и грануляции, образование субстанции хемотаксиса. Уменьшает отек слизистой оболочки носа, продукцию слизи. Улучшает мукоцилиарный транспорт.
Не обладает минералокортикоидной активностью, практически не оказывает резорбтивного действия.
Показания к применению
Сезонный и круглогодичный аллергический ринит; вазомоторный ринит.
Противопоказания
Геморрагический диатез; частые носовые кровотечения; туберкулез органов дыхания; грибковые инфекции; вирусные инфекции; детский возраст до 6 лет; I триместр беременности; повышенная чувствительность к беклометазону и вспомогательным веществам применяемого препарата.
С осторожностью
Амебиаз; глаукома; тяжелая печеночная недостаточность; гипотиреоз; недавно перенесенный инфаркт миокарда; изъязвления носовой перегородки; после недавно перенесенных хирургических вмешательств в полости носа или травмах носа; во II и III триместрах беременности; период лактации (грудного вскармливания).
Применение при беременности и в период грудного вскармливания
Противопоказан в I триместре беременности.
Интраназальное применение беклометазона во II и III триместрах беременности допускается только в том случае, если ожидаемая польза для матери превышает возможный риск для плода.
В период грудного вскармливания беклометазон интраназально следует применять с осторожностью.
Способ применения и дозы
Взрослые и дети старше 12 лет: по 50-100 мкг (1-2 дозы) в каждый носовой ход 2 раза/сут; суточная доза составляет 200-400 мкг. Максимальная суточная доза - 400 мкг. Суточную дозу можно разделить на 2-4 приема.
Дети в возрасте от 6 до 12 лет: начальная доза - по 50 мкг (1 доза) в каждый носовой ход 2 раза/сут, при необходимости - 100 мкг (2 дозы) в каждый носовой ход 2 раза/сут. Максимальная суточная доза - 400 мкг. Суточную дозу можно разделить на 2-4 приема.
При достижении терапевтического эффекта препарат отменяют, постепенно снижая дозу.
Пациентам пожилого возраста коррекция дозы не требуется.
Побочное действие
Аллергические реакции: редко - кожная сыпь, крапивница, ангионевротический отек.
Со стороны нервной системы: редко - нарушение обонятельных и вкусовых ощущений, сонливость, головная боль, головокружение.
Со стороны органа зрения: неизвестно - повышение внутриглазного давления, в т.ч. глаукома, катаракта (при длительном применении), гиперемия конъюнктивы, снижение зрения.
Со стороны дыхательной системы: редко - сухость и раздражение носоглотки, чиханье, жжение, заложенность носа, кровотечение из носа, атрофия слизистой оболочки носа, кашель, ринорея; очень редко - изъязвление слизистой оболочки носа, перфорация носовой перегородки (обычно у пациентов, которые ранее перенесли хирургическое вмешательство в полости носа).
Прочие: редко - миалгия, кандидоз полости рта и верхних дыхательных путей (при длительном применении и/или в высоких дозах (более 400 мкг/сут)); неизвестно - при длительном применении возможно развитие надпочечниковой недостаточности, снижение темпа роста у детей, снижение минеральной плотности костей.
Взаимодействие с другими лекарственными средствами
Метандростенолон, эстрогены, бета2-адреномиметики, теофиллин, ГКС для приема внутрь - усиление действия беклометазона.
Бета-адреномиметики - при совместном применении беклометазон усиливает эффект бета-адреномиметиков.
Особые указания
Не допускать попадания препарата в глаза.
Облегчение симптомов ринита обычно проявляется в течение нескольких дней от начала лечения.
Пациентов, у которых на фоне терапии ГКС возможно снижение иммунитета, следует предупредить об опасности контакта с больными определенными инфекциями (например, ветряной оспой, корью) и необходимости обращения к врачу в случае такого контакта. Это имеет особое значение для детей.
Поскольку беклометазон замедляет заживление ран, пациенты, недавно перенесшие травму или операцию носа, не должны применять препарат до полного заживления ран.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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Суточную дозу можно разделить на 2-4 приема."}},{"type":"paragraph","data":{"text":"При достижении терапевтического эффекта препарат отменяют, постепенно снижая дозу."}},{"type":"paragraph","data":{"text":"Пациентам пожилого возраста коррекция дозы не требуется."}}]},{"id":14,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции: \u003c/i\u003eредко - кожная сыпь, крапивница, ангионевротический отек."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы: \u003c/i\u003eредко - нарушение обонятельных и вкусовых ощущений, сонливость, головная боль, головокружение."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органа зрения: \u003c/i\u003eнеизвестно - повышение внутриглазного давления, в т.ч. глаукома, катаракта (при длительном применении), гиперемия конъюнктивы, снижение зрения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы: \u003c/i\u003eредко - сухость и раздражение носоглотки, чиханье, жжение, заложенность носа, кровотечение из носа, атрофия слизистой оболочки носа, кашель, ринорея; очень редко - изъязвление слизистой оболочки носа, перфорация носовой перегородки (обычно у пациентов, которые ранее перенесли хирургическое вмешательство в полости носа)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие: \u003c/i\u003eредко - миалгия, кандидоз полости рта и верхних дыхательных путей (при длительном применении и/или в высоких дозах (более 400 мкг/сут)); неизвестно - при длительном применении возможно развитие надпочечниковой недостаточности, снижение темпа роста у детей, снижение минеральной плотности костей."}}]},{"id":16,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eФенобарбитал, фенитоин, рифампицин \u003c/i\u003e- снижение эффективноста беклометазона (индукция ферментов микросомального окисления)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетандростенолон, эстрогены, бета\u003csub\u003e2\u003c/sub\u003e-адреномиметики, теофиллин, ГКС для приема внутрь\u003c/i\u003e - усиление действия беклометазона."}},{"type":"paragraph","data":{"text":"\u003ci\u003eБета-адреномиметики\u003c/i\u003e - при совместном применении беклометазон усиливает эффект бета-адреномиметиков."}}]},{"id":17,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не допускать попадания препарата в глаза."}},{"type":"paragraph","data":{"text":"Облегчение симптомов ринита обычно проявляется в течение нескольких дней от начала лечения."}},{"type":"paragraph","data":{"text":"Пациентов, у которых на фоне терапии ГКС возможно снижение иммунитета, следует предупредить об опасности контакта с больными определенными инфекциями (например, ветряной оспой, корью) и необходимости обращения к врачу в случае такого контакта. 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