болезнь Паркинсона (мышечная ригидность, тремор, гипо- или акинезия);
экстрапирамидные расстройства, вызванные приемом нейролептиков или другими препаратами;
невралгия при опоясывающем герпесе.
Для в/в введения
болезнь Паркинсона, синдром паркинсонизма (акинетический криз, острая декомпенсация);
нарушение вигильности (инициативности) в посткоматозном периоде;
невралгия при опоясывающем герпесе.
Фармакологическое действие
Блокатор глутаматных N-метил-D-аспартат-рецепторов (NMDA-рецепторов). Противопаркинсонический препарат. Амантадин оказывает непрямое агонистическое действие на стриарные допаминовые рецепторы. Повышает внеклеточную концентрацию допамина, посредством как интенсификации его выработки, так и блокады обратного захвата допамина пресинаптическими нейронами. В терапевтических концентрациях амантадин замедляет выработку ацетилхолина и, тем самым, оказывает антихолинергическое действие.
Лекарственное взаимодействие
Противопоказан одновременный прием амантадина и препаратов, вызывающих увеличение интервала QT, в частности:
антиаритмические препараты класса I А (например, хинидин, дизопирамид, прокаинамид) и класса III (например, амиодарон и соталол);
антипсихотические препараты (например, тиоридазин, хлорпромазин, пимозид);
трициклические и тетрациклические антидепрессанты (например, амитриптилин);
антигистаминные препараты (например, астемизол, терфенадин);
макролидные антибиотики (например, эритромицин, кларитромицин);
ингибиторы гиразы (например, спарфлоксацин);
противогрибковые препараты группы азолов;
другие препараты (бидупин, галофантрин, ко-тримоксазол, пентамидин, цизаприд и бепридил).
Одновременный прием мочегонных средств, представляющих собой комбинацию триамтерена/гидрохлоротиазида может привести к повышению концентрации амантадина в плазме крови.
При одновременном приеме с другими противопаркинсоническими препаратами (леводопа, бромокриптин, мемантин, тригексифенидил) может оказаться необходимым понизить дозу одновременно принимаемого препарата, либо обоих препаратов во избежание нежелательных последствий, в частности, психотических реакций.
Антихолинергические средства, симпатомиметики и мемантин усиливают побочные эффекты амантадина.
Средства, стимулирующие ЦНС (в т.ч. психостимуляторы), этанол увеличивают риск развития побочных эффектов амантадина.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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