Комплексная
терапия острых кишечных инфекций ротавирусной этиологии у детей старше
12 лет.
Противопоказания
Повышенная
чувствительность к умифеновиру или любому компоненту препарата; детский возраст
до 12 лет. Первый триместр беременности. Период грудного вскармливания.
Инструкция
Регистрационный номер
ЛП-002690
Торговое название препарата
Арбидол Максимум
Лекарственная форма
Капсулы
Состав
Действующее вещество: умифеновира
гидрохлорида моногидрат (в пересчете на умифеновира гидрохлорид) – 207 мг (в
пересчете на умифеновира гидрохлорид) – 200 мг.
Состав оболочки капсулы (корпус и крышечка): титана
диоксид (Е 171) – 1,92 мг, желатин – 94,08 мг. Общая масса капсулы – 376 мг.
Описание
Капсулы твердые желатиновые № 0 белого цвета.
Содержимое капсулы – смесь, содержащая гранулы и порошок от белого или белого с
зеленовато-желтым или кремовым оттенком цвета до светло-желтого или
светло-желтого с зеленоватым оттенком цвета.
Фармакотерапевтическая группа
противовирусное средство.
Код АТХ: J05AX13
Фармакологические свойства
Фармакодинамика
Противовирусное
средство. Специфически подавляет in vitro вирусы гриппа А и В (Influenza virus A, B), включая высокопатогенные подтипы
A(H1N1)pdm09 и A(H5N1), а также другие вирусы - возбудители острых респираторных
вирусных инфекций (ОРВИ) (коронавирус (Сoronavirus), ассоциированный с тяжелым острым респираторным
синдромом (ТОРС), риновирус (Rhinovirus), аденовирус (Adenovirus), респираторно-синцитиальный вирус (Pneumovirus) и вирус парагриппа (Paramyxovirus)).
В исследованиях in vitro специфически подавляет вирус SARS-CoV-2, вызывающий
новую коронавирусную инфекцию (COVID-19). EC50 (полумаксимальная эффективная
концентрация) в клетках Vero E6 составляет 4,11 мкмоль, что соответствует 2,11
мкг/мл. Клиническая значимость этого требует дополнительного изучения.
По
механизму противовирусного действия относится к ингибиторам слияния (фузии),
взаимодействует с гемагглютинином вируса и препятствует слиянию липидной
оболочки вируса и клеточных мембран. Оказывает умеренное иммуномодулирующее действие,
повышает устойчивость организма к вирусным инфекциям. Обладает
интерферон-индуцирующей активностью – в исследовании на мышах индукция
интерферонов отмечалась уже через 16 часов, а высокие титры интерферонов
сохранялись в крови до 48 часов после введения. Стимулирует клеточные и
гуморальные реакции иммунитета: повышает число лимфоцитов в крови, в
особенности Т-клеток (СD3), повышает число Т-хелперов (CD4), не влияя на уровень Т‑супрессоров
(CD8), нормализует
иммунорегуляторный индекс, стимулирует фагоцитарную функцию макрофагов и
повышает число естественных киллеров (NK-клеток).
Терапевтическая
эффективность при вирусных инфекциях проявляется в уменьшении продолжительности
и тяжести течения болезни и ее основных симптомов, а также в снижении частоты
развития осложнений, связанных с вирусной инфекцией, и обострений хронических
бактериальных заболеваний.
При лечении гриппа или ОРВИ у взрослых пациентов в
клиническом исследовании показано, что
эффект препарата у взрослых пациентов наиболее выражен в остром периоде
заболевания и проявляется сокращением сроков разрешения симптомов болезни,
снижением тяжести проявлений заболевания и сокращением сроков элиминации
вируса.
Терапия препаратом приводит к более высокой частоте
купирования симптомов заболевания на третьи сутки терапии по сравнению с
плацебо - через 60 ч после начала терапии разрешение всех симптомов лабораторно
подтвержденного гриппа более чем в 5 раз превышает аналогичный показатель в
группе плацебо.
Установлено значимое влияние препарата на скорость
элиминации вируса гриппа, что, в частности, проявлялось уменьшением частоты
выявления РНК вируса на 4-е сутки.
Относится
к малотоксичным препаратам (LD50 > 4 г/кг).
Не оказывает какого-либо отрицательного воздействия на организм человека при
пероральном применении в рекомендуемых дозах.
Фармакокинетика
Быстро абсорбируется и распределяется по органам и тканям.
Максимальная концентрация в плазме крови при приеме в дозе 50 мг достигается
через 1,2 ч, в дозе 100 мг – через 1,5 ч. Метаболизируется в печени. Период
полувыведения в среднем равен 17-21 ч. Около 40 % выводится в неизмененном виде, в основном с желчью (38,9 %) и в незначительном количестве
почками (0,12 %). В течение
первых суток выводится 90 % от
введенной дозы.
Показания к применению
Профилактика
и лечение у взрослых и детей с 12 лет: грипп А и В, другие ОРВИ.
Комплексная
терапия острых кишечных инфекций ротавирусной этиологии у детей старше
12 лет.
Противопоказания
Повышенная
чувствительность к умифеновиру или любому компоненту препарата; детский возраст
до 12 лет. Первый триместр беременности. Период грудного вскармливания.
С осторожностью
Второй и третий триместры беременности.
Применение при беременности и в период грудного вскармливания
В исследованиях на животных не было
выявлено вредных воздействий на течение беременности, развитие эмбриона и
плода, родовую деятельность и постнатальное развитие.
Применение препарата Арбидол Максимум в первом триместре беременности противопоказано.
Во втором и третьем триместре
беременности Арбидол Максимум может применяться только для лечения и
профилактики гриппа и в том случае, если предполагаемая польза для матери
превышает потенциальный риск для плода. Соотношение польза/риск определяется
лечащим врачом.
Неизвестно, проникает ли Арбидол Максимум в грудное
молоко у женщин в период лактации. При необходимости применения Арбидол Максимум следует прекратить грудное вскармливание.
Способ применения и дозы
Внутрь, до приема пищи.
Разовая доза взрослым и детям старше 12 лет – 200 мг (1 капсула).
У взрослых и детей старше 12 лет:
Неспецифическая профилактика в период эпидемии гриппа и других ОРВИ - в разовой дозе 2 раза в неделю в течение 3 недель.
Неспецифическая профилактика при непосредственном контакте с больными гриппом и другими ОРВИ - в разовой дозе 1 раз в день в течение 10-14 дней.
Лечение гриппа и других ОРВИ - в разовой дозе 4 раза в сутки (каждые 6 часов) в течение 5 суток.
Комплексная терапия рецидивирующей герпетической инфекции - в разовой дозе 4 раза в сутки (каждые 6 часов) в течение 5-7 суток, затем в разовой дозе 2 раза в неделю в течение 4 недель.
Профилактика послеоперационных инфекционных осложнений - в разовой дозе за 2 суток до опе-рации, затем на 2 и 5 сутки после операции.
У детей с 12 лет:
Комплексная терапия острых кишечных инфекций ротавирусной этиологии - в разовой дозе 4 раза в сутки (каждые 6 часов) в течение 5 суток.
Прием препарата начинают с момента появления первых
симптомов заболевания гриппом и другими ОРВИ, желательно не позднее 3 суток от
начала болезни.
Если после применения препарата Арбидол Максимум в течение трех суток при лечении гриппа и других ОРВИ сохраняется
выраженность симптомов заболевания, в том числе высокая температура (38 °С и
более), то необходимо обратиться к врачу для оценки обоснованности приема
препарата.
Применяйте препарат только согласно тем показаниям, тому
способу применения и в тех дозах, которые указаны в инструкции.
При лечении гриппа и
ОРВИ возможна сопутствующая симптоматическая терапия, включая прием
жаропонижающих препаратов, муколитических и местных сосудосуживающих средств.
Побочное действие
Препарат Арбидол Максимум относится к малотоксичным препаратам и обычно хорошо переносится.
Побочные эффекты возникают редко, обычно слабо или умеренно
выражены и носят преходящий характер.
Частота возникновения нежелательных лекарственных реакций
определена в соответствии с классификацией ВОЗ: очень часто (с частотой более 1/10), часто (с частотой не
менее 1/100, но менее 1/10), нечасто (с частотой не менее 1/1000, но менее
1/100), редко (с частотой не менее 1/10000, но менее 1/1000), очень редко (с
частотой менее 1/10000), частота неизвестна
(не может быть установлена по имеющимся данным).
Нарушения со стороны иммунной системы: редко – аллергические реакции.
Если любые из указанных в инструкции побочных эффектов
усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в
инструкции, сообщите об этом врачу.
Передозировка
Не отмечена.
Взаимодействие с другими лекарственными средствами
При назначении с другими лекарственными средствами
отрицательных эффектов отмечено не было.
Специальные клинические исследования, посвященные изучению
взаимодействий препарата Арбидол Максимум с другими лекарственными
средствами, не проводились.
Сведения о наличии нежелательного взаимодействия с жаропонижающими,
муколитическими и местными сосудосуживающими лекарственными средствами в
условиях клинического исследования не были выявлены.
Особые указания
Необходимо соблюдать рекомендованную в инструкции схему и
длительность приема препарата. В случае пропуска приема одной дозы препарата,
пропущенную дозу следует принять как можно раньше и продолжить курс приема
препарата по начатой схеме.
Если
после применения препарата Арбидол Максимум в течение трех суток
при лечении гриппа и других ОРВИ сохраняется выраженность симптомов
заболевания, в том числе высокая температура (38 °С и более), то необходимо обратиться к врачу для оценки
обоснованности приема препарата.
Влияние на способность управлять автомобилем и движущимися механизмами
Не проявляет центральной
нейротропной активности и может применяться в медицинской практике у лиц
различных профессий, в т.ч. требующих повышенного внимания и координации
движений (водители транспорта, операторы и т.д.).
Форма выпуска
Капсулы 200 мг.
По 10 капсул в контурную ячейковую упаковку из
пленки поливинилхлоридной и фольги алюминиевой печатной лакированной.
1 или 2 контурные упаковки с инструкцией по применению
помещают в пачку из картона.
Условия хранения
Хранить при температуре не выше 25 оС. Хранить в
недоступном для детей месте.
Срок годности
2 года. Не использовать по истечении срока годности, указанного на упаковке.
Для описания товара использована информация от партнера 36.6
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"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества: \u003c/i\u003eкрахмал картофельный – 45,67 мг, целлюлоза микрокристаллическая – 11,20 мг, кремния диоксид коллоидный (аэросил) – 2,80 мг, повидон (коллидон 25) – 7,73 мг, кальция стеарат – 2,80 мг, натрия кроскармеллоза – 2,80\nмг, масса содержимого капсулы – 280 мг."}},{"type":"paragraph","data":{"text":"Капсулы твердые желатиновые №0: "}},{"type":"paragraph","data":{"text":"Состав оболочки капсулы (корпус и крышечка): титана\nдиоксид (Е 171) – 1,92 мг, желатин – 94,08 мг. Общая масса капсулы – 376 мг."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Капсулы твердые желатиновые № 0 белого цвета.\nСодержимое капсулы – смесь, содержащая гранулы и порошок от белого или белого с\nзеленовато-желтым или кремовым оттенком цвета до светло-желтого или\nсветло-желтого с зеленоватым оттенком цвета. "}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"противовирусное средство."}},{"type":"paragraph","data":{"text":"\u003cb\u003eКод АТХ:\u003c/b\u003e J05AX13"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eФармакодинамика\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Противовирусное\nсредство. Специфически подавляет \u003ci\u003ein \u003c/i\u003e\u003ci\u003evitro\u003c/i\u003e вирусы гриппа А и В (\u003ci\u003eInfluenza \u003c/i\u003e\u003ci\u003evirus \u003c/i\u003e\u003ci\u003eA, \u003c/i\u003e\u003ci\u003eB\u003c/i\u003e), включая высокопатогенные подтипы\n\u003ci\u003eA(\u003c/i\u003e\u003ci\u003eH1\u003c/i\u003e\u003ci\u003eN1)\u003c/i\u003e\u003ci\u003epdm09\u003c/i\u003e и \u003ci\u003eA(\u003c/i\u003e\u003ci\u003eH5\u003c/i\u003e\u003ci\u003eN1)\u003c/i\u003e, а также другие вирусы - возбудители острых респираторных\nвирусных инфекций (ОРВИ) (коронавирус (\u003ci\u003eС\u003c/i\u003e\u003ci\u003eoronavirus\u003c/i\u003e), ассоциированный с тяжелым острым респираторным\nсиндромом (ТОРС), риновирус (\u003ci\u003eRhinovirus\u003c/i\u003e), аденовирус (\u003ci\u003eAdenovirus\u003c/i\u003e), респираторно-синцитиальный вирус (\u003ci\u003ePneumovirus\u003c/i\u003e) и вирус парагриппа (\u003ci\u003eParamyxovirus\u003c/i\u003e)).\nВ исследованиях \u003ci\u003ein \u003c/i\u003e\u003ci\u003evitro\u003c/i\u003e специфически подавляет вирус SARS-CoV-2, вызывающий\nновую коронавирусную инфекцию (COVID-19). EC\u003csub\u003e50 \u003c/sub\u003e(полумаксимальная эффективная\nконцентрация) в клетках Vero E6 составляет 4,11 мкмоль, что соответствует 2,11\nмкг/мл. Клиническая значимость этого требует дополнительного изучения. "}},{"type":"paragraph","data":{"text":"По\nмеханизму противовирусного действия относится к ингибиторам слияния (фузии),\nвзаимодействует с гемагглютинином вируса и препятствует слиянию липидной\nоболочки вируса и клеточных мембран. Оказывает умеренное иммуномодулирующее действие,\nповышает устойчивость организма к вирусным инфекциям. Обладает\nинтерферон-индуцирующей активностью – в исследовании на мышах индукция\nинтерферонов отмечалась уже через 16 часов, а высокие титры интерферонов\nсохранялись в крови до 48 часов после введения. Стимулирует клеточные и\nгуморальные реакции иммунитета: повышает число лимфоцитов в крови, в\nособенности Т-клеток (СD3), повышает число Т-хелперов (CD4), не влияя на уровень Т‑супрессоров\n(CD8), нормализует\nиммунорегуляторный индекс, стимулирует фагоцитарную функцию макрофагов и\nповышает число естественных киллеров (NK-клеток)."}},{"type":"paragraph","data":{"text":"Терапевтическая\nэффективность при вирусных инфекциях проявляется в уменьшении продолжительности\nи тяжести течения болезни и ее основных симптомов, а также в снижении частоты\nразвития осложнений, связанных с вирусной инфекцией, и обострений хронических\nбактериальных заболеваний."}},{"type":"paragraph","data":{"text":"При лечении гриппа или ОРВИ у взрослых пациентов в\nклиническом исследовании показано, что\nэффект препарата у взрослых пациентов наиболее выражен в остром периоде\nзаболевания и проявляется сокращением сроков разрешения симптомов болезни,\nснижением тяжести проявлений заболевания и сокращением сроков элиминации\nвируса."}},{"type":"paragraph","data":{"text":"Терапия препаратом приводит к более высокой частоте\nкупирования симптомов заболевания на третьи сутки терапии по сравнению с\nплацебо - через 60 ч после начала терапии разрешение всех симптомов лабораторно\nподтвержденного гриппа более чем в 5 раз превышает аналогичный показатель в\nгруппе плацебо."}},{"type":"paragraph","data":{"text":"Установлено значимое влияние препарата на скорость\nэлиминации вируса гриппа, что, в частности, проявлялось уменьшением частоты\nвыявления РНК вируса на 4-е сутки."}},{"type":"paragraph","data":{"text":"Относится\nк малотоксичным препаратам (LD\u003csub\u003e50\u003c/sub\u003e > 4 г/кг).\nНе оказывает какого-либо отрицательного воздействия на организм человека при\nпероральном применении в рекомендуемых дозах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФармакокинетика\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Быстро абсорбируется и распределяется по органам и тканям.\nМаксимальная концентрация в плазме крови при приеме в дозе 50 мг достигается\nчерез 1,2 ч, в дозе 100 мг – через 1,5 ч. Метаболизируется в печени. Период\nполувыведения в среднем равен 17-21 ч. Около 40 % выводится в неизмененном виде, в основном с желчью (38,9 %) и в незначительном количестве\nпочками (0,12 %). В течение\nпервых суток выводится 90 % от\nвведенной дозы."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Профилактика\nи лечение у взрослых и детей с 12 лет: грипп А и В, другие ОРВИ."}},{"type":"paragraph","data":{"text":"Комплексная\nтерапия рецидивирующей герпетической инфекции."}},{"type":"paragraph","data":{"text":"Профилактика\nпослеоперационных инфекционных осложнений. "}},{"type":"paragraph","data":{"text":"Комплексная\nтерапия острых кишечных инфекций ротавирусной этиологии у детей старше\n12 лет."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная\nчувствительность к умифеновиру или любому компоненту препарата; детский возраст\nдо 12 лет. Первый триместр беременности. Период грудного вскармливания."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Второй и третий триместры беременности."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"В исследованиях на животных не было\nвыявлено вредных воздействий на течение беременности, развитие эмбриона и\nплода, родовую деятельность и постнатальное развитие."}},{"type":"paragraph","data":{"text":"Применение препарата Арбидол Максимум в первом триместре беременности противопоказано."}},{"type":"paragraph","data":{"text":"Во втором и третьем триместре\nбеременности Арбидол Максимум может применяться только для лечения и\nпрофилактики гриппа и в том случае, если предполагаемая польза для матери\nпревышает потенциальный риск для плода. Соотношение польза/риск определяется\nлечащим врачом."}},{"type":"paragraph","data":{"text":"Неизвестно, проникает ли Арбидол Максимум в грудное\nмолоко у женщин в период лактации. При необходимости применения Арбидол Максимум следует прекратить грудное вскармливание."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nВнутрь, до приема пищи."}},{"type":"paragraph","data":{"text":"Разовая доза взрослым и детям старше 12 лет – 200 мг (1 капсула)."}},{"type":"paragraph","data":{"text":"У взрослых и детей старше 12 лет:"}},{"type":"paragraph","data":{"text":"Неспецифическая профилактика в период эпидемии гриппа и других ОРВИ - в разовой дозе 2 раза в неделю в течение 3 недель."}},{"type":"paragraph","data":{"text":"Неспецифическая профилактика при непосредственном контакте с больными гриппом и другими ОРВИ - в разовой дозе 1 раз в день в течение 10-14 дней."}},{"type":"paragraph","data":{"text":"Лечение гриппа и других ОРВИ - в разовой дозе 4 раза в сутки (каждые 6 часов) в течение 5 суток."}},{"type":"paragraph","data":{"text":"Комплексная терапия рецидивирующей герпетической инфекции - в разовой дозе 4 раза в сутки (каждые 6 часов) в течение 5-7 суток, затем в разовой дозе 2 раза в неделю в течение 4 недель."}},{"type":"paragraph","data":{"text":"Профилактика послеоперационных инфекционных осложнений - в разовой дозе за 2 суток до опе-рации, затем на 2 и 5 сутки после операции."}},{"type":"paragraph","data":{"text":"У детей с 12 лет:"}},{"type":"paragraph","data":{"text":"Комплексная терапия острых кишечных инфекций ротавирусной этиологии - в разовой дозе 4 раза в сутки (каждые 6 часов) в течение 5 суток."}},{"type":"paragraph","data":{"text":"Прием препарата начинают с момента появления первых\nсимптомов заболевания гриппом и другими ОРВИ, желательно не позднее 3 суток от\nначала болезни."}},{"type":"paragraph","data":{"text":"Если после применения препарата Арбидол Максимум в течение трех суток при лечении гриппа и других ОРВИ сохраняется\nвыраженность симптомов заболевания, в том числе высокая температура (38 °С и\nболее), то необходимо обратиться к врачу для оценки обоснованности приема\nпрепарата."}},{"type":"paragraph","data":{"text":"Применяйте препарат только согласно тем показаниям, тому\nспособу применения и в тех дозах, которые указаны в инструкции."}},{"type":"paragraph","data":{"text":"При лечении гриппа и\nОРВИ возможна сопутствующая симптоматическая терапия, включая прием\nжаропонижающих препаратов, муколитических и местных сосудосуживающих средств."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Препарат Арбидол Максимум относится к малотоксичным препаратам и обычно хорошо переносится."}},{"type":"paragraph","data":{"text":"Побочные эффекты возникают редко, обычно слабо или умеренно\nвыражены и носят преходящий характер."}},{"type":"paragraph","data":{"text":"Частота возникновения нежелательных лекарственных реакций\nопределена в соответствии с классификацией ВОЗ: очень часто (с частотой более 1/10), часто (с частотой не\nменее 1/100, но менее 1/10), нечасто (с частотой не менее 1/1000, но менее\n1/100), редко (с частотой не менее 1/10000, но менее 1/1000), очень редко (с\nчастотой менее 1/10000), частота неизвестна\n(не может быть установлена по имеющимся данным).\u003cb\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eНарушения со стороны иммунной системы\u003c/i\u003e\u003c/b\u003e: редко – аллергические реакции."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов\nусугубляются, или Вы заметили любые другие побочные эффекты, не указанные в\nинструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Не отмечена."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При назначении с другими лекарственными средствами\nотрицательных эффектов отмечено не было."}},{"type":"paragraph","data":{"text":"Специальные клинические исследования, посвященные изучению\nвзаимодействий препарата Арбидол Максимум с другими лекарственными\nсредствами, не проводились."}},{"type":"paragraph","data":{"text":"Сведения о наличии нежелательного взаимодействия с жаропонижающими,\nмуколитическими и местными сосудосуживающими лекарственными средствами в\nусловиях клинического исследования не были выявлены."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо соблюдать рекомендованную в инструкции схему и\nдлительность приема препарата. В случае пропуска приема одной дозы препарата,\nпропущенную дозу следует принять как можно раньше и продолжить курс приема\nпрепарата по начатой схеме."}},{"type":"paragraph","data":{"text":"Если\nпосле применения препарата Арбидол Максимум в течение трех суток\nпри лечении гриппа и других ОРВИ сохраняется выраженность симптомов\nзаболевания, в том числе высокая температура (38 °С и более), то необходимо обратиться к врачу для оценки\nобоснованности приема препарата."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не проявляет центральной\nнейротропной активности и может применяться в медицинской практике у лиц\nразличных профессий, в т.ч. требующих повышенного внимания и координации\nдвижений (водители транспорта, операторы и т.д.)."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 200 мг."}},{"type":"paragraph","data":{"text":"По 10 капсул в контурную ячейковую упаковку из\nпленки поливинилхлоридной и фольги алюминиевой печатной лакированной.\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"1 или 2 контурные упаковки с инструкцией по применению\nпомещают в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 \u003csup\u003eо\u003c/sup\u003eС. Хранить в\nнедоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не использовать по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"Фармстандарт-Лексредства\" "}}]},{"id":0,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"Отисифарм\", Россия"}},{"type":"paragraph","data":{"text":"123112, г. Москва, ул. Тестовская, д. 10"}},{"type":"paragraph","data":{"text":"эт. 12, пом. II, ком. 29"}},{"type":"paragraph","data":{"text":"Тел.: +7 (800) 775-98-19"}},{"type":"paragraph","data":{"text":"Факс: +7 (495) 221-18-02"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.otcpharm.ru\"\u003ewww.otcpharm.ru\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.arbidol.ru\"\u003ewww.arbidol.ru\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаПротивовирусное средство. Специфически подавляетinvitroвирусы гриппа А и В (InfluenzavirusA,B), включая высокопатогенные подтипыA(H1N1)pdm09иA(H5N1), а также другие вирусы - возбудители острых респираторных вирусных инфекций (ОРВИ) (коронавирус (Сoronavirus), ассоциированный с тяжелым острым респираторным синдромом (ТОРС), риновирус (Rhinovirus), аденовирус (Adenovirus), респираторно-синцитиальный вирус (Pneumovirus) и вирус парагриппа (Paramyxovirus)). В исследованияхinvitroспецифически подавляет вирус SARS-CoV-2, вызывающий новую коронавирусную инфекцию (COVID-19). EC50(полумаксимальная эффективная концентрация) в клетках Vero E6 составляет 4,11 мкмоль, что соответствует 2,11 мкг/мл. Клиническая значимость этого требует дополнительного изучения. По механизму противовирусного действия относится к ингибиторам слияния (фузии), взаимодействует с гемагглютинином вируса и препятствует слиянию липидной оболочки вируса и клеточных мембран. Оказывает умеренное иммуномодулирующее действие, повышает устойчивость организма к вирусным инфекциям. Обладает интерферон-индуцирующей активностью – в исследовании на мышах индукция интерферонов отмечалась уже через 16 часов, а высокие титры интерферонов сохранялись в крови до 48 часов после введения. Стимулирует клеточные и гуморальные реакции иммунитета: повышает число лимфоцитов в крови, в особенности Т-клеток (СD3), повышает число Т-хелперов (CD4), не влияя на уровень Т‑супрессоров (CD8), нормализует иммунорегуляторный индекс, стимулирует фагоцитарную функцию макрофагов и повышает число естественных киллеров (NK-клеток). Терапевтическая эффективность при вирусных инфекциях проявляется в уменьшении продолжительности и тяжести течения болезни и ее основных симптомов, а также в снижении частоты развития осложнений, связанных с вирусной инфекцией, и обострений хронических бактериальных заболеваний. При лечении гриппа или ОРВИ у взрослых пациентов в клиническом исследовании показано, что эффект препарата у взрослых пациентов наиболее выражен в остром периоде заболевания и проявляется сокращением сроков разрешения симптомов болезни, снижением тяжести проявлений заболевания и сокращением сроков элиминации вируса. Терапия препаратом приводит к более высокой частоте купирования симптомов заболевания на третьи сутки терапии по сравнению с плацебо - через 60 ч после начала терапии разрешение всех симптомов лабораторно подтвержденного гриппа более чем в 5 раз превышает аналогичный показатель в группе плацебо. Установлено значимое влияние препарата на скорость элиминации вируса гриппа, что, в частности, проявлялось уменьшением частоты выявления РНК вируса на 4-е сутки. Относится к малотоксичным препаратам (LD50\u003e 4 г/кг). Не оказывает какого-либо отрицательного воздействия на организм человека при пероральном применении в рекомендуемых дозах.ФармакокинетикаБыстро абсорбируется и распределяется по органам и тканям. Максимальная концентрация в плазме крови при приеме в дозе 50 мг достигается через 1,2 ч, в дозе 100 мг – через 1,5 ч. Метаболизируется в печени. Период полувыведения в среднем равен 17-21 ч. Около 40 % выводится в неизмененном виде, в основном с желчью (38,9 %) и в незначительном количестве почками (0,12 %). В течение первых суток выводится 90 % от введенной дозы.","substance":[{"id":657,"title":"Умифеновир","title_latin":"Umifenovirum","slug":"umifenovir_657"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Арбидол Максимум - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/222382/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/222382/share_default/"}},"diseases":[],"other_packages":[{"id":103706,"title":"Арбидол Максимум","subtitle":{"full":"Капсулы, 10 шт, 200 мг","short":"Капсулы, 10 шт, 200 мг","package":"10 шт, 200 мг"},"prescription":false,"catalog_section_id":100314,"manufacturer":{"id":58,"title":"Фармстандарт","slug":"farmstandart_58","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Капсулы","slug":"103706-arbidol_maksimum","attributes":{"count":"10 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