Анальгин Раствор, 10 шт, 2 мл, 25 %, для внутривенного введения

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Внутривенное введение должно осуществляться медленно (скорость введения не более 1 мл (500 мг метамизола натрия в минуту)) в положении лежа, при контроле за артериальным давлением, пульсом и частотой дыхания."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Со стороны мочевыделительной системы: нарушение функции почек, олигурия, анурия, протеинурия, очень редко развитие острого интерстициального нефрита, окрашивание мочи в красный цвет (за счет выделения метаболита – рубазоновой кислоты). Аллергические реакции: крапивница, в том числе на конъюктиве и слизистых оболочках носоглотки, отек Квинке; в редких случаях – злокачественная экссудативная эритема (синдром Стивенса-Джонсона), анафилактический шок, токсический эпидермальный некролиз (синдром Лайелла), бронхоспастический синдром (не только при склонности к бронхоспазму). Со стороны органов кроветворения: лейкопения, редко агранулоцитоз и тромбоцитопения иммунного генеза. Прочие: возможно снижение артериального давления, нарушение сердечного ритма. Местные реакции: при в/м введении возможны инфильтраты в месте введения."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В случае передозировки необходимо проконсультироваться с врачом. Возможно появление следующих симптомов: тошнота, рвота, боли в желудке, олигурия, гипотермия, снижение артериального давления, тахикардия, одышка, шум в ушах, сонливость, бред, нарушения сознания, острый агранулоцитоз, геморрагический синдром, острая почечная и/или печеночная недостаточность, судороги, паралич дыхательной мускулатуры. Лечение: симптоматическое. Специфического антидота для метамизола натрия не существует. В условиях лечебного учреждения – проведение форсированного диуреза, гемодиализа, при развитии судорожного синдрома – внутривенное введение диазепама и быстродействующих барбитуратов."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"С циклоспорином"}},{"type":"paragraph","data":{"text":"Метамизол натрия может снижать концентрацию циклоспорина в сыворотке крови, поэтому при их совместном применении следует контролировать концентрацию циклоспорина."}},{"type":"paragraph","data":{"text":"С другими ненаркотическими анальгезирующими средствами"}},{"type":"paragraph","data":{"text":"Одновременное применение метамизола натрия с другими ненаркотическими анальгезирующими средствами может привести к взаимному усилению токсических эффектов."}},{"type":"paragraph","data":{"text":"С трициклическими антидепрессантами, пероральными контрацептивами, аллопуринолом"}},{"type":"paragraph","data":{"text":"Трициклические антидепрессанты, пероральные контрацептивы, аллопуринол нарушают метаболизм метамизола натрия в печени и повышают его токсичность."}},{"type":"paragraph","data":{"text":"С барбитуратами, фенилбутазоном и другими индукторами микросомальных ферментов печени"}},{"type":"paragraph","data":{"text":"Барбитураты, фенилбутазон и другие индукторы микросомальных ферментов печени ослабляют действие метамизола натрия."}},{"type":"paragraph","data":{"text":"С седативными средствами и транквилизаторами"}},{"type":"paragraph","data":{"text":"Седативные средства и транквилизаторы усиливают обезболивающее действие метамизола натрия. Одновременное применение с хлорпромазином или другими производными фенотиазина может привести к развитию выраженной гипотермии."}},{"type":"paragraph","data":{"text":"С лекарственными средствами, имеющими высокую связь с белками плазмы (пероральные гипогликемические средства, непрямые антикоагулянты, глюкокортикостероиды и индометацин)"}},{"type":"paragraph","data":{"text":"крови пероральные гипогликемические препарата, непрямые антикоагулянты, глюкокортикостероиды и индометацин, увеличивает их активность."}},{"type":"paragraph","data":{"text":"С миелотоксичными лекарственными средствами"}},{"type":"paragraph","data":{"text":"Миелотоксичные лекарственные средства усиливают проявление гематотоксичности метамизола натрия."}},{"type":"paragraph","data":{"text":"С метотрексатом"}},{"type":"paragraph","data":{"text":"Добавление метамизола натрия к лечению метотрексатом может усиливать гематотоксическое действие метотрексата, особенно у пациентов пожилого возраста. Поэтому данной комбинации следует избегать."}},{"type":"paragraph","data":{"text":"С тиамазолом и сарколизином"}},{"type":"paragraph","data":{"text":"Тиамазол и сарколизин повышают риск развития лейкопении."}},{"type":"paragraph","data":{"text":"С кодеином, блокаторами Н2-гистаминовых рецепторов и пропранололом"}},{"type":"paragraph","data":{"text":"Кодеин, блокаторы Н2-гистаминовых рецепторов и пропранолол усиливают эффекты метамизола натрия."}},{"type":"paragraph","data":{"text":"С рентгеноконтрастными веществами, коллоидными кровезаменителями и пенициллином"}},{"type":"paragraph","data":{"text":"Рентгеноконтрастные вещества, коллоидные кровезаменители и пенициллин не должны применяться во время лечения метамизолом натрия (повышенный риск развития анафилактических/анафилактоидных реакций)."}},{"type":"paragraph","data":{"text":"С ацетилсалициловой кислотой"}},{"type":"paragraph","data":{"text":"При совместном применении с ацетилсалициловой кислотой метамизол натрия может уменьшать влияние ацетилсалициловой кислоты на агрегацию тромбоцитов. Поэтому данную комбинацию следует применять с осторожностью при лечении пациентов, принимающих низкие дозы ацетилсалициловой кислоты для кардиопротекции (профилактики тромбообразования)."}},{"type":"paragraph","data":{"text":"С бупропионом"}},{"type":"paragraph","data":{"text":"Метамизол натрия может снижать концентрацию бупропиона в крови, что следует принимать во внимание при одновременном применении метамизола натрия и бупропиона."}},{"type":"paragraph","data":{"text":"Из-за высокой вероятности фармацевтической несовместимости метамизол натрия нельзя смешивать с другими лекарственными средствами в одном шприце."}},{"type":"paragraph","data":{"text":"С вальпроевой кислотой"}},{"type":"paragraph","data":{"text":"Предполагается, что метамизол натрия в дозе 4 г/сутки оказывает соответствующее влияние на уровень вальпроата (снижает содержание) и связанный с ним клинический исход. Это может быть связано с возможной индукцией CYPB6 и усилением метаболизма вальпроата. В случае лечение вальпроатом в сочетании с метамизолом натриярекомендуется тщательный мониторинг уровня вальпроата в плазме крови."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"У больных, страдающих бронхиальной астмой и поллинозами возможно развитие реакций повышенной чувствительности. При длительном применении (более 7 суток) необходимо контролировать картину периферической крови. На фоне приема метамизола натрия возможно развитие агранулоцитоза, в связи с чем при выявлении немотивированного подъема температуры, озноба, болей в горле, затрудненного глотания, стоматита, эрозивно-язвенных поражений ротовой полости, вагинита или проктита, необходима немедленная отмена препарата. Не применять для снятия острых болей в животе (до выяснения причин). Для снижения риска развития нежелательных явлений со стороны желудочно-кишечного тракта следует использовать минимально эффективную дозу минимально возможным коротким курсом. При лечении больных, получающих цитостатические средства, прием метамизола натрия должен проводится только под наблюдением врача. При в/м введении необходимо использовать длинную иглу. Беременность и кормление грудью: в течение первых и последних трех месяцев беременности принимать Анальгин нельзя. С четвертого по шестой месяцы беременности прием Анальгина должен осуществляться по строгим медицинским показаниям. После приема Анальгина кормление грудью должно быть прекращено на 48 часов."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Учитывая побочное действие лекарственного препарата, в период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При комнатной температуре."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":" Дальхимфарм ОАО (Россия)."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Метамизол натрия является производным пиразолона. 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