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Механизм действия связан с ингибированием сквален-2,3-эпоксидазы, что приводит к снижению образования эргостерола, входящего в состав клеточной стенки гриба. Активен в отношении дерматофитов, таких как трихофитон, эпидермофитон и микроспорум, плесеней (Aspergillus spp.), дрожжевых грибов (Candida spp., Pityrosporum) и других грибов (например, Sporothrix schenckii). В отношении дерматофитов и аспергилл нафтифин действует фунгицидно. В отношении дрожжевых грибов препарат проявляет фунгицидную или фунгистатическую активность в зависимости от штамма микроорганизма. Обладает антибактериальной активностью в отношении грамположительных и грамотрицательных микроорганизмов, которые могут вызвать вторичные бактериальные инфекции. Обладает противовоспалительным действием, которое способствует быстрому исчезновению симптомов воспаления, особенно зуда."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"При наружном применении нафтифин быстро проникает в кожу, создавая устойчивые противогрибковые концентрации в различных ее слоях, что делает возможным его применение один раз в день."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"грибковые инфекции кожи и кожных складок (tinea corporis, tinea inguinalis);"}},{"type":"paragraph","data":{"text":"межпальцевые микозы (tinea manum, tinea pedum);"}},{"type":"paragraph","data":{"text":"грибковые инфекции ногтей (онихомикозы);"}},{"type":"paragraph","data":{"text":"кандидозы кожи;"}},{"type":"paragraph","data":{"text":"разноцветный (отрубевидный) лишай;"}},{"type":"paragraph","data":{"text":"дерматомикозы (с сопутствующим зудом или без него)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к нафтифину или пропиленгликолю."}},{"type":"paragraph","data":{"text":"Беременность и период грудного вскармливания (безопасность и эффективность применения не установлены)."}},{"type":"paragraph","data":{"text":"Противопоказано нанесение препарата на раневую поверхность."}},{"type":"paragraph","data":{"text":"С осторожностью"}},{"type":"paragraph","data":{"text":"Детский возраст (опыт клинического применения ограничен)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата Мизол Эвалар во время беременности и в период грудного вскармливания противопоказано (безопасность и эффективность нафтифина у данной категории пациентов не изучена)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Наружно."}},{"type":"paragraph","data":{"text":"Мизол\u003csup\u003e®\u003c/sup\u003e Эвалар наносят 1 раз в день на пораженную поверхность кожи и соседние с ней участки (приблизительно 1 см здорового участка кожи по краям зоны поражения) после их тщательной очистки и высушивания. Длительность терапии при дерматомикозах – 2-4 недели (при необходимости – до 8 недель), при кандидозах – 4 недели."}},{"type":"paragraph","data":{"text":"При поражении ногтей Мизол\u003csup\u003e® \u003c/sup\u003eЭвалар наносят 2 раза в день на пораженный ноготь. Перед первым применением препарата максимально удаляют пораженную часть ногтя ножницами или пилкой для ногтей. Длительность терапии при онихомикозах – до 6 месяцев."}},{"type":"paragraph","data":{"text":"Для предотвращения рецидива лечение следует продолжить в течение минимум 2 недель после исчезновения клинических симптомов."}},{"type":"paragraph","data":{"text":"Если после лечения улучшения не наступает или появляются новые симптомы, необходимо проконсультироваться с врачом. Применяйте препарат только согласно тому способу применения и в тех дозах, которые указаны в инструкции. В случае необходимости, пожалуйста, проконсультируйтесь с врачом перед применением лекарственного препарата."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"В отдельных случаях могут наблюдаться местные реакции: сухость кожи, гиперемия кожи и жжение. Побочные эффекты носят обратимый характер и не требуют отмены лечения."}},{"type":"paragraph","data":{"text":"Если у Вас отмечаются побочные эффекты, указанные в инструкции или они усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При применении препарата в соответствии с инструкцией по применению передозировка маловероятна. При случайном приеме внутрь показано промывание желудка, симптоматическая терапия."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nПрепарат Мизол Эвалар не предназначен для применения в офтальмологии. 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