Лечение инфекционно-воспалительных заболеваний, вызванных чувствительными к препарату микроорганизмами:
Инфекции верхних отделов дыхательных путей и ЛОР-органов (в т.ч. острый и хронический синусит, острый и хронический средний отит, заглоточный абсцесс, тонзиллит, фарингит)
Инфекции нижних отделов дыхательных путей (в т.ч. острый бронхит с бактериальной суперинфекцией, хронический бронхит, пневмония)
Амоксициллин (в форме натриевой соли) 1000 мг клавулановая кислота (в форме калиевой соли) 200 мг
Фармакологические свойства
Антибиотик широкого спектра действия . содержит полусинтетический пенициллин амоксициллин и ингибитор β .-лактамаз клавулановую кислоту. Клавулановая кислота образует стойкий инактивированный комплекс с β .-лактамазами и обеспечивает устойчивость амоксициллина к их воздействию. Клавулановая кислота, подобная по структуре бета-лактамным антибиотикам, обладает слабой собственной антибактериальной активностью. Таким образом, Амоксиклав . действует бактерицидно на широкий спектр грамположительных и грамотрицательных бактерий (в т.ч. на штаммы, которые приобрели устойчивость к бета-лактамным антибиотикам вследствие продукции β .-лактамаз). Амоксиклав . активен в отношении аэробных грамположительных бактерий: Streptococcus spp. (в т.ч. Streptococcus pneumoniae, Streptococcus viridans, Streptococcus pyogenes, Streptococcus bovis), Enterococcus spp., Staphylococcus aureus (кроме метициллин-резистентных штаммов), Staphylococcus epidermidis (кроме метициллин-резистентных штаммов), Staphylococcus saprophyticus, Listeria spp. . аэробных грамотрицательных бактерий: Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae, Helicobacter pylori, Klebsiella spp., Moraxella catarrhalis, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Proteus spp., Providencia spp., Salmonella spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica, Eikenella corrodens . анаэробных грамположительных бактерий: Peptococcus spp., Actinomyces israelii, Prevotella spp., Clostridium spp., Peptostreptococcus spp., Fusobacterium spp. . анаэробных грамотрицательных бактерий: Bacteroides spp.
Показания к применению
Лечение инфекционно-воспалительных заболеваний, вызванных чувствительными к препарату микроорганизмами:
Инфекции верхних отделов дыхательных путей и ЛОР-органов (в т.ч. острый и хронический синусит, острый и хронический средний отит, заглоточный абсцесс, тонзиллит, фарингит)
Инфекции нижних отделов дыхательных путей (в т.ч. острый бронхит с бактериальной суперинфекцией, хронический бронхит, пневмония)
Инфекции мочевыводящих путей
Гинекологические инфекции
Инфекции кожи и мягких тканей, включая укусы человека и животных
Инфекции костей и суставов
Инфекции брюшной полости, в т.ч. желчных путей (холецистит, холангит)
Одонтогенные инфекции
Инфекции, передаваемые половым путем (гонорея, шанкроид)
Профилактика инфекций после хирургических вмешательств
Применение при беременности и в период грудного вскармливания
Назначение препарата при беременности возможно только при наличии четких показаний. Амоксициллин и клавулановая кислота в небольших количествах выделяются с грудным молоком.
Побочное действие
Со стороны пищеварительной системы: потеря аппетита, тошнота, рвота, диарея . редко - нарушения функции печени, повышение активности АЛТ и АСТ . в единичных случаях - холестатическая желтуха, гепатит, псевдомембранозный колит. Аллергические реакции: зуд, крапивница, эритематозные высыпания . редко - многоформная экссудативная эритема, ангионевротический отек, анафилактический шок . в единичных случаях - эксфолиативный дерматит, синдром Стивенса-Джонсона. Прочие: обратимое увеличение протромбинового времени (при совместном применении с антикоагулянтами) . редко - кандидоз и другие виды суперинфекции.
Особые указания
Со стороны пищеварительной системы: потеря аппетита, тошнота, рвота, диарея . редко - нарушения функции печени, повышение активности АЛТ и АСТ . в единичных случаях - холестатическая желтуха, гепатит, псевдомембранозный колит. Аллергические реакции: зуд, крапивница, эритематозные высыпания . редко - многоформная экссудативная эритема, ангионевротический отек, анафилактический шок . в единичных случаях - эксфолиативный дерматит, синдром Стивенса-Джонсона. Прочие: обратимое увеличение протромбинового времени (при совместном применении с антикоагулянтами) . редко - кандидоз и другие виды суперинфекции.
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