Бетасерк Таблетки, 60 шт, 24 мг, для приема внутрь, для взрослых

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Однако суммарная абсорбция бетагистина одинакова в обоих случаях, что указывает на то, что прием пищи лишь замедляет всасывание бетагистина."}},{"type":"paragraph","data":{"text":"Распределение"}},{"type":"paragraph","data":{"text":"Связывание бетагистина с белками плазмы крови составляет менее 5 %."}},{"type":"paragraph","data":{"text":"Биотрансформация"}},{"type":"paragraph","data":{"text":"После всасывания бетагистин быстро и почти полностью метаболизируется с образованием метаболита 2-пиридилуксусной кислоты (который не обладает фармакологической активностью). Максимальная концентрация 2-пиридилуксусной кислоты в плазме крови (или моче) достигается через час после приема. Период полувыведения приблизительно 3,5 часа."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"2-пиридилуксусная кислота быстро выводится с мочой. При приеме препарата в дозе 8-48 мг около 85 % начальной дозы обнаруживается в моче. Выведение бетагистина почками или через кишечник незначительно."}},{"type":"paragraph","data":{"text":"Линейность"}},{"type":"paragraph","data":{"text":"Скорость выведения остается постоянной при пероральном приеме 8-48 мг препарата, указывая на линейность фармакокинетики бетагистина, и позволяет предположить, что задействованный метаболический путь остается ненасыщенным."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Синдром Меньера, характеризующийся следующими основными симптомами:"}},{"type":"paragraph","data":{"text":"- головокружение (сопровождающееся тошнотой/рвотой)"}},{"type":"paragraph","data":{"text":"- снижение слуха (тугоухость)"}},{"type":"paragraph","data":{"text":"- шум в ушах"}},{"type":"paragraph","data":{"text":"Симптоматическое лечение вестибулярного головокружения (вертиго)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- феохромоцитома;"}},{"type":"paragraph","data":{"text":"- повышенная чувствительность к любому из компонентов препарата."}},{"type":"paragraph","data":{"text":"Бетасерк не рекомендуется для применения у детей в возрасте до 18 лет в связи с недостаточностью данных по эффективности и безопасности."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Пациенты с бронхиальной астмой, язвенной болезнью желудка и/или двенадцатиперстной кишки требуют тщательного наблюдения в период лечения."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Беременность"}},{"type":"paragraph","data":{"text":"\n\nИмеющихся данных о применении бетагистина беременными женщинами недостаточно."}},{"type":"paragraph","data":{"text":"Исследования на животных не выявили прямой или непрямой репродуктивной токсичности. Бетагистин не должен использоваться во время беременности за исключением случаев очевидной необходимости.\n\n"}},{"type":"paragraph","data":{"text":"Грудное вскармливание"}},{"type":"paragraph","data":{"text":"Неизвестно выделяется ли бетагистин с грудным молоком у человека. Бетагистин выделяется с грудным молоком у крыс. Исследования на животных были ограничены применением препарата в очень высоких дозах. Вопрос о назначении лекарственного препарата матери должен приниматься только после сопоставления пользы грудного вскармливания с потенциальным риском для грудного ребенка."}},{"type":"paragraph","data":{"text":"Фертильность"}},{"type":"paragraph","data":{"text":"В исследованиях на животных (крысах) влияния на фертильность не выявлено."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Всегда принимайте Бетасерк точно так, как прописал Ваш лечащий врач. Если у Вас есть какие-либо вопросы, проконсультируйтесь с Вашим лечащим врачом."}},{"type":"paragraph","data":{"text":"Внутрь, во время еды."}},{"type":"paragraph","data":{"text":"Доза препарата для взрослых составляет 48 мг бетагистина в день."}},{"type":"paragraph","data":{"text":"Бетасерк 24 мг следует принимать по 1 таблетке 2 раза в день. Таблетку можно разделить на две равные части"}},{"type":"paragraph","data":{"text":"Дозу следует подбирать индивидуально в зависимости от реакции на лечение. Улучшение иногда наблюдается только через несколько недель лечения. Наилучшие результаты иногда достигаются после нескольких месяцев лечения. Имеются данные о том, что назначение лечения в начале заболевания предотвращает его прогрессирование и/или потерю слуха на более поздних стадиях."}},{"type":"paragraph","data":{"text":"Пожилой возраст"}},{"type":"paragraph","data":{"text":"Пациенты с почечной/печеночной недостаточностью"}},{"type":"paragraph","data":{"text":"Специальные клинические исследования в этой группе пациентов не проводились, однако пострегистрационный опыт дает основания предполагать, что коррекция дозы у данной группы пациентов не требуется."}}]},{"id":0,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Если Вы заметили какие-либо побочные эффекты, не упомянутые в данной инструкции, или какой-либо побочный эффект принял серьезный характер, уведомите, пожалуйста, Вашего лечащего врача."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта: Часто (от ≥1/100 до <1/10): тошнота и диспепсия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы: Часто (от ≥1/100 до <1/10): головная боль."}},{"type":"paragraph","data":{"text":"Кроме этих эффектов, выявленных при проведении клинических исследований, в процессе пострегистрационного применения и в научной литературе сообщалось о нижеследующих нежелательных эффектах. Имеющихся данных недостаточно, чтобы оценить их частоту."}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной системы: реакция гиперчувствительности, в том числе анафилактическая реакция."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта: умеренные расстройства, такие как рвота, желудочно-кишечные боли, вздутие живота. Эти эффекты обычно исчезают после приема препарата одновременно с пищей или после снижения дозы."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей: реакции гиперчувствительности, в особенности ангионевротический отек, крапивница, зуд и сыпь."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nИзвестно несколько случаев передозировки препарата. У некоторых пациентов наблюдались легкие и умеренные симптомы (тошнота, сонливость, боль в животе) после приема препарата в дозах до 640 мг. Более серьезные осложнения (судороги, сердечно-легочные осложнения) наблюдались при преднамеренном приеме повышенных доз бетагистина, особенно в сочетании с передозировкой других лекарственных средств."}},{"type":"paragraph","data":{"text":"Рекомендуется симптоматическое лечение.\n\n"}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Если в настоящее время или в недавнем прошлом Вы принимали другие лекарственные средства, в том числе без назначения врача, сообщите об этом, пожалуйста, своему лечащему врачу."}},{"type":"paragraph","data":{"text":"Исследования in vivo, направленные на изучение взаимодействия с другими лекарственными препаратами, не проводились. Основываясь на данных in vitro, можно предположить отсутствие ингибирования активности изоферментов цитохрома Р450 in vivo."}},{"type":"paragraph","data":{"text":"Данные in vitro показали ингибирование метаболизма бетагистина под действием препаратов, которые ингибируют моноаминоксидазу (МАО), включая МАО подтипа В (например, селегилин). Следует соблюдать осторожность при одновременном назначении бетагистина и ингибиторов МАО (включая МАО-В)."}},{"type":"paragraph","data":{"text":"Бетагистин является аналогом гистамина, взаимодействие бетагистина с блокаторами H1-гистаминовых рецепторов теоретически может влиять на эффективность одного из этих лекарственных средств."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Риска на таблетке предназначена для разламывания таблетки с целью облегчения ее проглатывания и не предназначена для деления её на две равные дозы."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Бетагистин не влияет или незначительно влияет на способность управлять транспортными средствами и работать с механизмами, в клинических исследованиях нежелательные реакции, которые могли бы повлиять на такую способность, не выявлены."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nТаблетки, 24 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток в ПВХ/ПВДХ/Ал блистер, по 5 блистеров вместе с инструкцией по применению в пачку картонную."}},{"type":"paragraph","data":{"text":"По 15 таблеток в ПВХ/ПВДХ/Ал блистер, по 2 блистера вместе с инструкцией по применению в пачку картонную."}},{"type":"paragraph","data":{"text":"По 20 таблеток в ПВХ/ПВДХ/Ал блистер, по 1, 2, 3 или 5 блистеров вместе с инструкцией по применению в пачку картонную."}},{"type":"paragraph","data":{"text":"По 25 таблеток в ПВХ/ПВДХ/Ал блистер, по 1, 2 или 4 блистера вместе с инструкцией по применению в пачку картонную.\n\n"}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nХранить при температуре не выше 25 °C."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте!\n\n"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nМайлан Лэбораториз САС,"}},{"type":"paragraph","data":{"text":"Рут де Бельвилль, Лье-ди Майар,"}},{"type":"paragraph","data":{"text":"01400, Шатийон-сюр-Шаларон, Франция"}},{"type":"paragraph","data":{"text":"или"}},{"type":"paragraph","data":{"text":"АО \"ВЕРОФАРМ\","}},{"type":"paragraph","data":{"text":"308013, Россия, г. Белгород, ул. Рабочая, д. 14\n\n"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"\n\nООО «Эбботт Лэбораториз»"}},{"type":"paragraph","data":{"text":"125171, г. Москва, Ленинградское шоссе, дом 16А, стр. 1\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика Механизм действия бетагистина известен только частично. Существует несколько возможных гипотез, подтвержденных доклиническими и клиническими данными: - Влияние на гистаминергическую систему Частичный агонист Н1-гистаминовых и антагонист НЗ-гистаминовых рецепторов вестибулярных ядер Ц, обладает незначительной активностью в отношении Н2-рецепторов. Бетагистин увеличивает обмен гистамина и его высвобождение путем блокирования пресинаптических НЗ-рецепторов и снижения количества НЗ-рецепторов. - Усиление кровотока кохлеарной области, а также всего головного мозга Согласно доклиническим исследованиям бетагистин улучшает кровообращение в сосудистой полоске внутреннего уха за счет расслабления прекапиллярных сфинктеров сосудов внутреннего уха. Также показано, что бетагистин усиливает кровоток головного мозга у человека. - Облегчение процесса центральной вестибулярной компенсации Бетагистин ускоряет восстановление вестибулярной функции у животных после односторонней вестибулярной нейрэктомии, ускоряя и облегчая центральную вестибулярную компенсацию за счет антагонизма с НЗ-гистаминовыми рецепторами. Время восстановления после вестибулярной нейрэктомии у человека при лечении бетагистином также уменьшается. - Возбуждение нейронов в вестибулярных ядрах Дозозависимо снижает генерацию потенциалов действия в нейронах латеральных и медиальных вестибулярных ядер. Фармакодинамические свойства, выявленные на животных, обеспечивают положительный терапевтический эффект бетагистина в вестибулярной системе. Эффективность бетагистина была продемонстрирована у пациентов с вестибулярным головокружением и синдромом Меньера, что проявлялось уменьшением выраженности и частоты головокружений. Фармакокинетика Всасывание При пероральном приеме бетагистин быстро и практически полностью всасывается в желудочно-кишечном тракте. После всасывания препарат быстро и почти полностью метаболизируется с образованием метаболита 2-пиридилуксусной кислоты. Концентрация бетагистина в плазме крови очень низкая. Таким образом, фармакокинетические анализы основаны на измерении концентрации метаболита 2-пиридилуксусной кислоты в плазме и моче. При приеме препарата с пищей максимальная концентрация (Стах) препарата в крови ниже, чем при приеме натощак. Однако суммарная абсорбция бетагистина одинакова в обоих случаях, что указывает на то, что прием пищи лишь замедляет всасывание бетагистина. Распределение Связывание бетагистина с белками плазмы крови составляет менее 5 %. Биотрансформация После всасывания бетагистин быстро и почти полностью метаболизируется с образованием метаболита 2-пиридилуксусной кислоты (который не обладает фармакологической активностью). Максимальная концентрация 2-пиридилуксусной кислоты в плазме крови (или моче) достигается через час после приема. Период полувыведения приблизительно 3,5 часа. Выведение 2-пиридилуксусная кислота быстро выводится с мочой. При приеме препарата в дозе 8-48 мг около 85 % начальной дозы обнаруживается в моче. Выведение бетагистина почками или через кишечник незначительно. Линейность Скорость выведения остается постоянной при пероральном приеме 8-48 мг препарата, указывая на линейность фармакокинетики бетагистина, и позволяет предположить, что задействованный метаболический путь остается ненасыщенным.","substance":[{"id":424,"title":"Бетагистин","title_latin":"Betahistinum","slug":"betagistin_424"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Бетасерк - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70084/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70084/share_default/"}},"diseases":[{"id":"702","title":"Болезнь Меньера","slug":"702-bolezn_menera"},{"id":"704","title":"Вестибулярный нейронит","slug":"704-vestibulyarnyy_neyronit"},{"id":"1251","title":"Тошнота и рвота","slug":"1251-toshnota_i_rvota"},{"id":"1273","title":"Головокружение и нарушение 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