Равел СР Таблетки, 20 шт, 1,5 мг, в пленочной оболочке, пролонгированного действия

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Одновременная потеря ионов хлора может приводить к компенсаторному метаболическому алкалозу, однако частота развития метаболического алкалоза и его выраженность незначительна . гиперурикемия и гипергликемия (неуточненной частоты), повышение концентрации азота мочевины крови, гиперкреатининемия."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Классификация частоты развития побочных эффектов (ВОЗ): очень часто (≥ . 10%), часто (≥ . 1% - \u003c 10%), нечасто (≥ . 0.1% - \u003c 1%), редко (≥ . 0.01% - \u003c 0.1%), очень редко (≥ . 0.001% - \u003c 0.01%, включая отдельные сообщения). Со стороны сердечно-сосудистой системы: очень редко - снижение АД, аритмия, ортостатическая гипотензия, сердцебиение, изменения на ЭКГ, характерные для гипокалиемии, геморрагический васкулит. Со стороны органов кроветворения: очень редко - тромбоцитопения, лейкопения, агранулоцитоз, апластическая анемия, гемолитическая анемия, аплазия костного мозга. Со стороны ЦНС и периферической нервной системы: редко - головокружение, головная боль, парестезии, повышенная возбудимость, астения, сонливость, вертиго, бессонница, депрессия, повышенная утомляемость, спазмы мышц конечностей, напряженность, раздражительность, тревожность. Со стороны пищеварительной системы: нечасто - рвота . редко - тошнота, запор, сухость слизистой оболочки полости рта . очень редко - панкреатит, анорексия, боль в животе, диарея. У пациентов с печеночной недостаточностью возможно развитие печеночной энцефалопатии. Со стороны мочеполовой системы: очень редко - почечная недостаточность, никтурия, инфекции, полиурия. Со стороны дыхательной системы: кашель, фарингит, синусит, ринит. Аллергические реакции: часто - макуло-папулезная сыпь . нечасто - пурпура, очень редко - ангионевротический отек и/или крапивница, токсический эпидермальный некролиз, синдром Стивенса-Джонсона, кожный зуд. Прочие: отдельные сообщения - обострение СКВ, реакции фоточувствительности. Лабораторные данные: в клинических исследованиях гипокалиемия (содержание калия в плазме крови менее 3.4 ммоль/л) наблюдалась у 10% пациентов и 3.2 ммоль/л - у 4% пациентов после 4-6 недель лечения. После 12 недель терапии содержание калия в плазме крови снижалось, в среднем на 0.23 ммоль/л. Очень редко - гиперкальциемия, неуточненной частоты: снижение содержания калия и развитие гипокалиемии, особенно значимое для пациентов, относящихся к группе риска . гипонатриемия, сопровождающаяся гиповолемией и ортостатической гипотензией. Одновременная потеря ионов хлора может приводить к компенсаторному метаболическому алкалозу, однако частота развития метаболического алкалоза и его выраженность незначительна . гиперурикемия и гипергликемия (неуточненной частоты), повышение концентрации азота мочевины крови, гиперкреатининемия."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Диуретик. Индапамид относится к производным сульфонамида и по фармакологическим свойствам близок к тиазидным диуретикам. Обладает умеренным салуретическим и диуретическим эффектами, которые обусловлены ингибированием реабсорбции ионов натрия, хлора и, в меньшей степени, ионов калия и магния в проксимальных канальцах почек и в кортикальном сегменте дистального канальца нефрона. Индапамид снижает тонус гладкой мускулатуры артерий и оказывает сосудорасширяющее действие, уменьшает ОПСС. 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