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Максимальная продолжительность лечения - 3 дня."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМаксимальная доза:\u003c/i\u003e 4 разовые дозы в сутки."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e редко - диспептические явления, при длительном применении в высоких дозах - гепатотоксическое действие."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны системы кроветворения:\u003c/i\u003e редко - тромбоцитопения, лейкопения, панцитопения, нейтропения, агранулоцитоз."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e редко - кожная сыпь, зуд, крапивница."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении с индукторами микросомальных ферментов печени, средствами, обладающими гепатотоксическим действием, возникает риск усиления гепатотоксического действия парацетамола."}},{"type":"paragraph","data":{"text":"При одновременном применении с антикоагулянтами возможно небольшое или умеренно выраженное повышение протромбинового времени."}},{"type":"paragraph","data":{"text":"При одновременном применении с антихолинергическими средствами возможно уменьшение всасывания парацетамола."}},{"type":"paragraph","data":{"text":"При одновременном применении с пероральными контрацептивами ускоряется выведение парацетамола из организма и возможно уменьшение его анальгетического действия."}},{"type":"paragraph","data":{"text":"При одновременном применении с урикозурическими средствами снижается их эффективность."}},{"type":"paragraph","data":{"text":"При одновременном применении активированного угля снижается биодоступность парацетамола."}},{"type":"paragraph","data":{"text":"При одновременном применении с диазепамом возможно уменьшение экскреции диазепама."}},{"type":"paragraph","data":{"text":"Имеются сообщения о возможности усиления миелодепрессивного эффекта зидовудина при одновременном применении с парацетамолом. Описан случай тяжелого токсического поражения печени."}},{"type":"paragraph","data":{"text":"Описаны случаи проявлений токсического действия парацетамола при одновременном применении с изониазидом."}},{"type":"paragraph","data":{"text":"При одновременном применении с карбамазепином, фенитоином, фенобарбиталом, примидоном уменьшается эффективность парацетамола, что обусловлено повышением его метаболизма (процессов глюкуронизации и окисления) и выведения из организма. Описаны случаи гепатотоксичности при одновременном применении парацетамола и фенобарбитала."}},{"type":"paragraph","data":{"text":"При применении колестирамина в течение периода менее 1 ч после приема парацетамола возможно уменьшение абсорбции последнего."}},{"type":"paragraph","data":{"text":"При одновременном применении с ламотриджином умеренно повышается выведение ламотриджина из организма."}},{"type":"paragraph","data":{"text":"При одновременном применении с метоклопрамидом возможно увеличение абсорбции парацетамола и повышение его концентрации в плазме крови."}},{"type":"paragraph","data":{"text":"При одновременном применении с пробенецидом возможно уменьшение клиренса парацетамола; с рифампицином, сульфинпиразоном - возможно повышение клиренса парацетамола вследствие повышения его метаболизма в печени."}},{"type":"paragraph","data":{"text":"При одновременном применении с этинилэстрадиолом повышается всасывание парацетамола из кишечника."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"С осторожностью применяют у пациентов с нарушениями функции печени и почек, с доброкачественной гипербилирубинемией, а также у больных пожилого возраста."}},{"type":"paragraph","data":{"text":"При длительном применении парацетамола необходим контроль картины периферической крови и функционального состояния печени."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nСуппозитории ректальные. 5 суппозиториев в стрипы из поливинилхлорида и полиэтилена."}},{"type":"paragraph","data":{"text":"2 стрипа помещают в картонную пачку с инструкцией по применению.\n\n"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °C."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/firm/4838\"\u003eГлаксоСмитКляйн Хелскер, АО\u003c/a\u003e (Россия)  "}}]}],"source":null},"description_toggle":false,"short_description":"Анальгетик-антипиретик. Обладает анальгезирующим, жаропонижающим и слабым противовоспалительным действием. Механизм действия связан с ингибированием синтеза простагландинов, преимущественным влиянием на центр терморегуляции в гипоталамусе.","substance":[{"id":605,"title":"Парацетамол","title_latin":"Paracetamolum","slug":"paratsetamol_605"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Детский панадол - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/72324/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/72324/share_default/"}},"diseases":[{"id":"554","title":"Мигрень","slug":"554-migren"},{"id":"853","title":"Другие уточненные изменения зубов и их опорного аппарата (в т.ч. зубная боль)","slug":"853-drugie_utochnennye_izmeneniya_zubov_i_ih_opornogo_apparata_v_tch_zubnaya_bol"},{"id":"1020","title":"Боль в 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