Реализация физиологического механизма эрекции связана с высв... Инструкция
Показания к применению
Лечение эректильной дисфункции, характеризующейся неспособностью к достижению или сохранению эрекции полового члена, достаточной для удовлетворительного полового акта. Эффективен только при сексуальной стимуляции.
Противопоказания
Гиперчувствительность к силденафилу или любому другому компоненту препарата. При постоянном или с перерывами применении донаторов оксида азота (такие как амилнитрит), органических нитратов или нитратов в любых лекарственных формах, поскольку силденафил усиливает гипотензивное действие нитратов. Применение у пациентов, для которых сексуальная активность ...
В 1 пленке содержится активное вещество: силденафил 100 мг.
Описание
Диспергирующая пленка Динамико - средство лечения эректильной дисфункции. Применяется для лечения эректильной дисфункции, восстанавливает в условиях сексуальной стимуляции нарушенную эректильную функцию путем увеличения кровотока в половом члене.
Фармакологические свойства
Реализация физиологического механизма эрекции связана с высвобождением оксида азота (N0) в пещеристом теле вследствие полового возбуждения. N0 активирует фермент гуанилатциклазу, что приводит к повышению концентрации циклического гуанозинмонофосфата (цГМФ). В свою очередь, цГМФ вызывает расслабление гладких мышц кровеносных сосудов и, соответственно, приток крови в пещеристое тело полового члена. Силденафил представляет собой селективный ингибитор цГМФ-специфической фосфодиэстеразы 5-го типа (ФДЭ5), которая вызывает распад цГМФ в пещеристом теле полового члена. Он не оказывает прямое расслабляющее действие на гладкие мышцы пещеристого тела, но усиливает расслабляющий эффект N0 на эту ткань и увеличивает кровоток в половом члене. При активации цепи N0 - цГМФ. наблюдающейся при сексуальной стимуляции, угнетение ФДЭ5 приводит к увеличению цГМФ в пещеристом теле. Фармакологический эффект достигается только при наличии сексуальной стимуляции. Активность силденафила в отношении ФДЭ5 превосходит активность в отношении других известных изоферментов фосфодиэстеразы: ФДЭ6 - в 10 раз, ФДЭ1 - более чем в 80 раз, ФДЭ2 - ФДЭ4, ФДЭ7 - ФДЭ11 - более чем в 700 раз. Силденафил в 4000 раз более селективен в отношении ФДЭ5, по сравнению с ФДЭЗ, что имеет большое значение, поскольку ФДЭЗ является одним из ключевых ферментов регуляции сократимости миокарда. Силденафил обладает легким и кратковременным гипотензивным действием, в большинстве случаев не имеющим клинического проявления при приеме в рекомендованных дозах. Гипотензивное действие связано с вазодилатирующим эффектом силденафила из-за повышения концентрации цГМФ в гладкомышечной оболочке сосудов.
Показания к применению
Лечение эректильной дисфункции, характеризующейся неспособностью к достижению или сохранению эрекции полового члена, достаточной для удовлетворительного полового акта. Эффективен только при сексуальной стимуляции.
Противопоказания
Гиперчувствительность к силденафилу или любому другому компоненту препарата. При постоянном или с перерывами применении донаторов оксида азота (такие как амилнитрит), органических нитратов или нитратов в любых лекарственных формах, поскольку силденафил усиливает гипотензивное действие нитратов. Применение у пациентов, для которых сексуальная активность нежелательна (например, с тяжелыми сердечно-сосудистыми заболеваниями, такими как тяжелая сердечная недостаточность, нестабильная стенокардия). Перенесенные в течение последних шести месяцев нарушение мозгового кровообращения или инфаркт миокарда. Одновременный прием ритонавира. Хроническая почечная недостаточность тяжелой степени тяжести. Наследственные дегенеративные заболевания сетчатки, в том числе пигментный ретинит (меньшая часть таких пациентов имеет генетическое нарушение фосфодиэстераз сетчатки), в связи с тем, что безопасность применения не изучена. Артериальная гипотензия (АД менее 90/50 мм рт.ст.) Не рекомендуется применять одновременно с другими средствами для лечения нарушений эрекции (безопасность и эффективность комбинированной терапии не изучена). По зарегистрированному показанию не предназначен для применения у женщин и детей до 18 лет.
Способ применения и дозы
Внутрь, примерно за 1 час до планируемой сексуальной активности. Пленку извлекают из саше (пакета) сухими руками, сразу же помещают на язык и держат до полного растворения, затем проглатывают. При приеме во время еды начало действия препарата ДИНАМИКО ФОРВАРД может задерживаться по сравнению с приемом препарата натощак. Рекомендуемая доза для большинства взрослых пациентов составляет 50 мг. С учетом эффективности и переносимости доза препарата Динамико Форвард может быть увеличена до 100 мг или снижена до 25 мг (в этом случае следует применять другую лекарственную форму в дозе 25 мг). Максимальная рекомендуемая доза составляет 100 мг. Максимальная рекомендуемая частота применения 1 раз в день.
Побочное действие
Наиболее частые нежелательные явления - головная боль и «приливы». Обычно побочные эффекты при применении слабо или умеренно выражены и носят преходящий характер. При применении фиксированной дозы частота некоторых нежелательных явлений повышается с увеличением дозы. Побочные эффекты классифицированы согласно следующей частоте: очень часто - >10%, часто - >1%, но <10%, нечасто - >0,1%, но <1%, редко - >0,01%, но <0,1%, очень редко -<0,01%, частота неизвестна - невозможно определить на основе имеющихся данных. Со стороны иммунной системы: нечасто - реакции повышенной чувствительности (в т.ч. кожная сыпь), аллергические реакции. Со стороны крови и лимфатической системы: нечасто - анемия, лейкопения. Со стороны обмена веществ и питания: нечасто - ощущение жажды, отеки, подагра, некомпенсированный сахарный диабет, гипергликемия, периферические отеки, гиперурикемия, гипогликемия, гипернатриемия. Со стороны нервной системы: очень часто - головная боль, часто - головокружение, нечасто - сонливость, мигрень, атаксия, гипертонус, невралгия, нейропатия, парестезия, тремор, вертиго, симптомы депрессии, бессонница, необычные сновидения, повышение рефлексов, гипестезия, редко - судороги, повторные судороги, обморок.
Особые указания
Для диагностики нарушений эрекции, определения их возможных причин и выбора адекватного лечения необходимо собрать полный медицинский анамнез и провести тщательное физикальное обследование. Средства лечения эректильной дисфункции должны применяться с осторожностью у пациентов с анатомической деформацией полового члена (ангуляция, кавернозный фиброз, болезнь Пейрони), или у пациентов с факторами риска развития приапизма (серповидноклеточная анемия, множественная миелома, лейкемия).
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Он не оказывает прямое расслабляющее действие на гладкие мышцы пещеристого тела, но усиливает расслабляющий эффект N0 на эту ткань и увеличивает кровоток в половом члене. При активации цепи N0 - цГМФ. наблюдающейся при сексуальной стимуляции, угнетение ФДЭ5 приводит к увеличению цГМФ в пещеристом теле. Фармакологический эффект достигается только при наличии сексуальной стимуляции. Активность силденафила в отношении ФДЭ5 превосходит активность в отношении других известных изоферментов фосфодиэстеразы: ФДЭ6 - в 10 раз, ФДЭ1 - более чем в 80 раз, ФДЭ2 - ФДЭ4, ФДЭ7 - ФДЭ11 - более чем в 700 раз. Силденафил в 4000 раз более селективен в отношении ФДЭ5, по сравнению с ФДЭЗ, что имеет большое значение, поскольку ФДЭЗ является одним из ключевых ферментов регуляции сократимости миокарда. Силденафил обладает легким и кратковременным гипотензивным действием, в большинстве случаев не имеющим клинического проявления при приеме в рекомендованных дозах. 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Применение у пациентов, для которых сексуальная активность нежелательна (например, с тяжелыми сердечно-сосудистыми заболеваниями, такими как тяжелая сердечная недостаточность, нестабильная стенокардия). Перенесенные в течение последних шести месяцев нарушение мозгового кровообращения или инфаркт миокарда. Одновременный прием ритонавира. Хроническая почечная недостаточность тяжелой степени тяжести. Наследственные дегенеративные заболевания сетчатки, в том числе пигментный ретинит (меньшая часть таких пациентов имеет генетическое нарушение фосфодиэстераз сетчатки), в связи с тем, что безопасность применения не изучена. Артериальная гипотензия (АД менее 90/50 мм рт.ст.) Не рекомендуется применять одновременно с другими средствами для лечения нарушений эрекции (безопасность и эффективность комбинированной терапии не изучена). По зарегистрированному показанию не предназначен для применения у женщин и детей до 18 лет."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь, примерно за 1 час до планируемой сексуальной активности. Пленку извлекают из саше (пакета) сухими руками, сразу же помещают на язык и держат до полного растворения, затем проглатывают. При приеме во время еды начало действия препарата ДИНАМИКО ФОРВАРД может задерживаться по сравнению с приемом препарата натощак. Рекомендуемая доза для большинства взрослых пациентов составляет 50 мг. С учетом эффективности и переносимости доза препарата Динамико Форвард может быть увеличена до 100 мг или снижена до 25 мг (в этом случае следует применять другую лекарственную форму в дозе 25 мг). Максимальная рекомендуемая доза составляет 100 мг. 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Со стороны обмена веществ и питания: нечасто - ощущение жажды, отеки, подагра, некомпенсированный сахарный диабет, гипергликемия, периферические отеки, гиперурикемия, гипогликемия, гипернатриемия. Со стороны нервной системы: очень часто - головная боль, часто - головокружение, нечасто - сонливость, мигрень, атаксия, гипертонус, невралгия, нейропатия, парестезия, тремор, вертиго, симптомы депрессии, бессонница, необычные сновидения, повышение рефлексов, гипестезия, редко - судороги, повторные судороги, обморок."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Для диагностики нарушений эрекции, определения их возможных причин и выбора адекватного лечения необходимо собрать полный медицинский анамнез и провести тщательное физикальное обследование. 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