Препарат Аркоксиа применяют для симптоматического лечения таких заболеваний и состояний, как: ревматоидный артрит; острый подагрический артрит; анкилозирующий спондилит; остеоартроз. Препарат также назначают после стоматологических операций для лечения выраженной острой и умеренной боли. Противопоказания Абсолютные: обострения воспалительных заболеваний ...
Полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВП (в т.ч. в анамнезе); - эрозивно-язвенные изменения слизистой оболочки желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение, цереброваскулярное или иное кровотечение; ...
Селективный ингибитор ЦОГ-2, в терапевтических концентрациях блокирует образование простагландинов и оказывает противовоспалительное, анальгезирующее и жаропонижающее действие. Селективное угнетение ЦОГ-2 сопровождается уменьшением выраженности клинических симптомов, связанных с воспалительным процессом, при этом отсутствует влияние на функцию тромбоцитов и слизистую оболочку ЖКТ. Эторикоксиб обладает дозозависимым эффектом ингибирования ЦОГ-2, не оказывая влияние на ЦОГ-1 при применении в суточной дозе до 150 мг. Аркоксиа не оказывает влияния на выработку простагландинов в слизистой оболочке желудка и на время кровотечения. В проведенных исследованиях не наблюдалось снижения уровня арахидоновой кислоты и агрегации тромбоцитов, вызываемой коллагеном
Показания к применению
Препарат Аркоксиа применяют для симптоматического лечения таких заболеваний и состояний, как: ревматоидный артрит; острый подагрический артрит; анкилозирующий спондилит; остеоартроз. Препарат также назначают после стоматологических операций для лечения выраженной острой и умеренной боли. Противопоказания Абсолютные: обострения воспалительных заболеваний кишечника (неспецифический язвенный колит и болезнь Крона); тяжелая недостаточность функции почек (клиренс креатинина менее 30 мл/мин), подтвержденная гиперкалиемия, прогрессирующие почечные заболевания; активное желудочно-кишечное, цереброваскулярное или другое кровотечение; эрозивно-язвенные поражения слизистой оболочки 12-перстной кишки или желудка; тяжелая печеночная недостаточность, заболевания печени в активной фазе; стойко сохраняющееся повышенное артериальное давление при неконтролируемой артериальной гипертензии; нарушения свертываемости крови (в том числе гемофилия); клинически выраженная ишемическая болезнь сердца, цереброваскулярные заболевания и заболевания периферических артерий, период после АКШ (аортокоронарного шунтирования); выраженная сердечная недостаточность; неполное или полное сочетание следующих заболеваний (в том числе в анамнезе): рецидивирующий полипоз носа или околоносовых пазух, бронхиальная астма и непереносимость ацетилсалициловой кислоты и других НПВС; детский и подростковый возраст до 16 лет; период беременности и кормления грудью; гиперчувствительность к любому из компонентов препарата. Относительные (Аркоксиа применяют с осторожностью): тяжелые соматические заболевания; наличие в анамнезе данных о развитии язвенного поражения желудочно-кишечного тракта и инфекции Хеликобактер пилори; артериальная гипертензия; сахарный диабет; отеки и задержка жидкости; дислипидемия/гиперлипидемия; почечная недостаточность (при клиренсе креатинина менее 60 мл/мин); курение; частое употребление алкоголя; пожилой возраст; длительное использование НПВС; сопутствующая терапия антиагрегантами, глюкокортикостероидами, антикоагулянтами и селективными ингибиторами обратного захвата серотонина
Противопоказания
Полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВП (в т.ч. в анамнезе); - эрозивно-язвенные изменения слизистой оболочки желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение, цереброваскулярное или иное кровотечение; - воспалительные заболевания кишечника (болезнь Крона, неспецифический язвенный колит) в фазе обострения; - гемофилия и другие нарушения свертываемости крови; - выраженная сердечная недостаточность (II-IV функциональные классы по классификации NYHA); - выраженная печеночная недостаточность (более 9 баллов по шкале Чайлд-Пью) или активное заболевание печени; - почечная недостаточность тяжелой степени (КК менее 30 мл/мин), прогрессирующие заболевания почек, подтвержденная гиперкалиемия; - период после проведения аортокоронарного шунтирования; заболевания периферических артерий, цереброваскулярные заболевания, клинически выраженная ИБС; - стойко сохраняющиеся значения АД, превышающие 140/90 мм рт. ст. при неконтролируемой артериальной гипертензии; - беременность, - период лактации (грудного вскармливания); - детский возраст до 16 лет; - повышенная чувствительность к какому-либо компоненту препарата. С осторожностью применяют препарат при наличии анамнестических данных о развитии язвенного поражения ЖКТ, инфекции Helicobacter pylori, у лиц пожилого возраста, у пациентов, длительно использовавших НПВС, часто употребляющих алкоголь, при тяжелых соматических заболеваниях, дислипидемии/гиперлипидемии, при сахарном диабете, артериальной гипертензии, отеках и задержке жидкости, курении, у пациентов с КК менее 60 мл/мин, при сопутствующей терапии следующими лекарственными средствами: антикоагулянтами (например, варфарином), антиагрегантами (например, ацетилсалициловой кислотой, клопидогрелом), ГКС (например, преднизолоном), селективными ингибиторами обратного захвата серотонина (например, циталопрамом, флуоксетином, пароксетином, сертралином).
Применение при беременности и в период грудного вскармливания
Препарат противопоказан при беременности и в период лактации. Применение препарата может отрицательно влиять на женскую фертильность и не рекомендуется женщинам, планирующим беременность
Способ применения и дозы
Таблетки Аркоксиа предназначены для перорального применения независимо от приема пищи. Препарат запивают небольшим количеством воды. Рекомендуемые дозы: ревматоидный артрит и анкилозирующий спондилит: по 90 мг один раз в сутки (максимальная суточная доза составляет 90 мг); острый подагрический артрит: по 120 мг один раз в сутки (максимальная суточная доза составляет 120 мг); остеоартроз: по 60 мг один раз в сутки (максимальная суточная доза составляет 60 мг). При болевом синдроме средняя терапевтическая доза составляет 60 мг однократно. При использовании Аркоксиа в дозе 120 мг продолжительность лечения должна составлять не более 8 дней. Рекомендуется применять препарат в минимальной эффективной дозе как можно более коротким курсом. Для устранения острой боли после стоматологических операций назначают по 90 мг эторикоксиба один раз в сутки в течение не более 8 дней (максимальная суточная доза составляет 90 мг)
Побочное действие
Пищеварительная система: часто – тошнота, диспепсия, изжога, боли в эпигастрии, метеоризм, диарея; нечасто – усиление перистальтики, язвы и сухость слизистой оболочки ротовой полости, гастрит, рвота, отрыжка, эзофагит, синдром раздраженного кишечника, вздутие живота, запор, язва слизистой оболочки 12-перстной кишки или желудка; очень редко – гепатит, язвы желудочно-кишечного тракта (иногда с перфорацией или кровотечением); дыхательная система: нечасто – носовое кровотечение, одышка, кашель; очень редко – бронхоспазм; сердечно-сосудистая система: часто – повышение артериального давления, сердцебиение; нечасто – фибрилляция предсердий, неспецифические изменения электрокардиограммы, застойная сердечная недостаточность, инфаркт миокарда, нарушение мозгового кровообращения, приливы; очень редко – гипертонический криз; нервная система и органы чувств: часто – слабость, головная боль и головокружение; нечасто – сонливость, нарушение чувствительности, включая гиперестезии/парестезии, нарушение концентрации, тревога, нарушение вкуса, депрессия, нарушения сна, шум в ушах, нечеткость зрения, вертиго, конъюнктивит; очень редко – спутанность сознания и галлюцинации; костно-мышечная система: нечасто – артралгия, мышечные судороги, миалгия; мочевыделительная система: нечасто – обнаружение белка в моче; очень редко – почечная недостаточность, как правило, обратимая после отмены препарата; обмен веществ: часто – задержка жидкости в организме, отеки; нечасто – увеличение массы тела, изменение аппетита; дерматологические и аллергические реакции: часто – экхимозы; нечасто – кожный зуд, отечность лица, сыпь; очень редко – анафилактоидные или анафилактические реакции, синдром Стивенса – Джонсона, крапивница, синдром Лайелла; лабораторные показатели: часто – повышение активности ферментов печени; нечасто – снижение гемоглобина и гематокрита, повышение активности креатинфосфокиназы, повышение азота в моче и крови, лейкопения, повышение мочевой кислоты, тромбоцитопения, гиперкалиемия, повышение креатинина сыворотки; редко – повышение сывороточной концентрации натрия; инфекционные осложнения: нечасто – инфекции мочевыводящих путей и верхних отделов дыхательных путей, гастроэнтерит; прочие реакции: часто – гриппоподобный синдром; нечасто – боль в грудной клетке
Передозировка
В клинических испытаниях о передозировке Аркоксиа не сообщалось. В клинических испытаниях однократный прием Аркоксиа в разовой дозе до 500 мг или многократный прием до 150 мг/сут в течение 21 дня не вызывал существенных токсических эффектов. Симптомы: при передозировке препарата возможно появление нежелательных эффектов со стороны ЖКТ, сердечно-сосудистой системы и почек. Лечение: проводят симптоматическую терапию. Эторикоксиб не выводится при гемодиализе, выведение препарата при перитонеальном диализе не изучалось
Особые указания
Во время лечения препаратом Аркоксиа требуется регулярный контроль артериального давления, особенно в первые две недели. Систематически также необходимо исследовать показатели функции почек и печени. Если уровень активности печеночных трансаминаз превышает показатели верхней границы нормы в три раза и более, препарат следует отменить. При длительном применении эторикоксиба периодически оценивается необходимость дальнейшего приема препарата, а также возможность уменьшения дозы. Одновременный прием с другими НПВС не рекомендуется. В оболочке таблеток в незначительном количестве содержится лактоза, что необходимо учитывать при назначении препарата Аркоксиа пациентам с лактазной недостаточностью. Во время лечения требуется соблюдать осторожность, управляя автомобилем или другим транспортом и занимаясь другой потенциально опасной деятельностью. Пациенты, у которых развивались такие побочные эффекты, как слабость, сонливость и головокружение, должны отказаться от занятий, связанных с высокой концентрацией внимания
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Противопоказания Абсолютные: обострения воспалительных заболеваний кишечника (неспецифический язвенный колит и болезнь Крона); тяжелая недостаточность функции почек (клиренс креатинина менее 30 мл/мин), подтвержденная гиперкалиемия, прогрессирующие почечные заболевания; активное желудочно-кишечное, цереброваскулярное или другое кровотечение; эрозивно-язвенные поражения слизистой оболочки 12-перстной кишки или желудка; тяжелая печеночная недостаточность, заболевания печени в активной фазе; стойко сохраняющееся повышенное артериальное давление при неконтролируемой артериальной гипертензии; нарушения свертываемости крови (в том числе гемофилия); клинически выраженная ишемическая болезнь сердца, цереброваскулярные заболевания и заболевания периферических артерий, период после АКШ (аортокоронарного шунтирования); выраженная сердечная недостаточность; неполное или полное сочетание следующих заболеваний (в том числе в анамнезе): рецидивирующий полипоз носа или околоносовых пазух, бронхиальная астма и непереносимость ацетилсалициловой кислоты и других НПВС; детский и подростковый возраст до 16 лет; период беременности и кормления грудью; гиперчувствительность к любому из компонентов препарата. Относительные (Аркоксиа применяют с осторожностью): тяжелые соматические заболевания; наличие в анамнезе данных о развитии язвенного поражения желудочно-кишечного тракта и инфекции Хеликобактер пилори; артериальная гипертензия; сахарный диабет; отеки и задержка жидкости; дислипидемия/гиперлипидемия; почечная недостаточность (при клиренсе креатинина менее 60 мл/мин); курение; частое употребление алкоголя; пожилой возраст; длительное использование НПВС; сопутствующая терапия антиагрегантами, глюкокортикостероидами, антикоагулянтами и селективными ингибиторами обратного захвата серотонина"}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВП (в т.ч. в анамнезе); - эрозивно-язвенные изменения слизистой оболочки желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение, цереброваскулярное или иное кровотечение; - воспалительные заболевания кишечника (болезнь Крона, неспецифический язвенный колит) в фазе обострения; - гемофилия и другие нарушения свертываемости крови; - выраженная сердечная недостаточность (II-IV функциональные классы по классификации NYHA); - выраженная печеночная недостаточность (более 9 баллов по шкале Чайлд-Пью) или активное заболевание печени; - почечная недостаточность тяжелой степени (КК менее 30 мл/мин), прогрессирующие заболевания почек, подтвержденная гиперкалиемия; - период после проведения аортокоронарного шунтирования; заболевания периферических артерий, цереброваскулярные заболевания, клинически выраженная ИБС; - стойко сохраняющиеся значения АД, превышающие 140/90 мм рт. ст. при неконтролируемой артериальной гипертензии; - беременность, - период лактации (грудного вскармливания); - детский возраст до 16 лет; - повышенная чувствительность к какому-либо компоненту препарата. С осторожностью применяют препарат при наличии анамнестических данных о развитии язвенного поражения ЖКТ, инфекции Helicobacter pylori, у лиц пожилого возраста, у пациентов, длительно использовавших НПВС, часто употребляющих алкоголь, при тяжелых соматических заболеваниях, дислипидемии/гиперлипидемии, при сахарном диабете, артериальной гипертензии, отеках и задержке жидкости, курении, у пациентов с КК менее 60 мл/мин, при сопутствующей терапии следующими лекарственными средствами: антикоагулянтами (например, варфарином), антиагрегантами (например, ацетилсалициловой кислотой, клопидогрелом), ГКС (например, преднизолоном), селективными ингибиторами обратного захвата серотонина (например, циталопрамом, флуоксетином, пароксетином, сертралином)."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат противопоказан при беременности и в период лактации. Применение препарата может отрицательно влиять на женскую фертильность и не рекомендуется женщинам, планирующим беременность"}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетки Аркоксиа предназначены для перорального применения независимо от приема пищи. Препарат запивают небольшим количеством воды. Рекомендуемые дозы: ревматоидный артрит и анкилозирующий спондилит: по 90 мг один раз в сутки (максимальная суточная доза составляет 90 мг); острый подагрический артрит: по 120 мг один раз в сутки (максимальная суточная доза составляет 120 мг); остеоартроз: по 60 мг один раз в сутки (максимальная суточная доза составляет 60 мг). При болевом синдроме средняя терапевтическая доза составляет 60 мг однократно. При использовании Аркоксиа в дозе 120 мг продолжительность лечения должна составлять не более 8 дней. Рекомендуется применять препарат в минимальной эффективной дозе как можно более коротким курсом. Для устранения острой боли после стоматологических операций назначают по 90 мг эторикоксиба один раз в сутки в течение не более 8 дней (максимальная суточная доза составляет 90 мг)"}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Пищеварительная система: часто – тошнота, диспепсия, изжога, боли в эпигастрии, метеоризм, диарея; нечасто – усиление перистальтики, язвы и сухость слизистой оболочки ротовой полости, гастрит, рвота, отрыжка, эзофагит, синдром раздраженного кишечника, вздутие живота, запор, язва слизистой оболочки 12-перстной кишки или желудка; очень редко – гепатит, язвы желудочно-кишечного тракта (иногда с перфорацией или кровотечением); дыхательная система: нечасто – носовое кровотечение, одышка, кашель; очень редко – бронхоспазм; сердечно-сосудистая система: часто – повышение артериального давления, сердцебиение; нечасто – фибрилляция предсердий, неспецифические изменения электрокардиограммы, застойная сердечная недостаточность, инфаркт миокарда, нарушение мозгового кровообращения, приливы; очень редко – гипертонический криз; нервная система и органы чувств: часто – слабость, головная боль и головокружение; нечасто – сонливость, нарушение чувствительности, включая гиперестезии/парестезии, нарушение концентрации, тревога, нарушение вкуса, депрессия, нарушения сна, шум в ушах, нечеткость зрения, вертиго, конъюнктивит; очень редко – спутанность сознания и галлюцинации; костно-мышечная система: нечасто – артралгия, мышечные судороги, миалгия; мочевыделительная система: нечасто – обнаружение белка в моче; очень редко – почечная недостаточность, как правило, обратимая после отмены препарата; обмен веществ: часто – задержка жидкости в организме, отеки; нечасто – увеличение массы тела, изменение аппетита; дерматологические и аллергические реакции: часто – экхимозы; нечасто – кожный зуд, отечность лица, сыпь; очень редко – анафилактоидные или анафилактические реакции, синдром Стивенса – Джонсона, крапивница, синдром Лайелла; лабораторные показатели: часто – повышение активности ферментов печени; нечасто – снижение гемоглобина и гематокрита, повышение активности креатинфосфокиназы, повышение азота в моче и крови, лейкопения, повышение мочевой кислоты, тромбоцитопения, гиперкалиемия, повышение креатинина сыворотки; редко – повышение сывороточной концентрации натрия; инфекционные осложнения: нечасто – инфекции мочевыводящих путей и верхних отделов дыхательных путей, гастроэнтерит; прочие реакции: часто – гриппоподобный синдром; нечасто – боль в грудной клетке"}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В клинических испытаниях о передозировке Аркоксиа не сообщалось. В клинических испытаниях однократный прием Аркоксиа в разовой дозе до 500 мг или многократный прием до 150 мг/сут в течение 21 дня не вызывал существенных токсических эффектов. Симптомы: при передозировке препарата возможно появление нежелательных эффектов со стороны ЖКТ, сердечно-сосудистой системы и почек. Лечение: проводят симптоматическую терапию. Эторикоксиб не выводится при гемодиализе, выведение препарата при перитонеальном диализе не изучалось"}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Во время лечения препаратом Аркоксиа требуется регулярный контроль артериального давления, особенно в первые две недели. Систематически также необходимо исследовать показатели функции почек и печени. Если уровень активности печеночных трансаминаз превышает показатели верхней границы нормы в три раза и более, препарат следует отменить. При длительном применении эторикоксиба периодически оценивается необходимость дальнейшего приема препарата, а также возможность уменьшения дозы. Одновременный прием с другими НПВС не рекомендуется. В оболочке таблеток в незначительном количестве содержится лактоза, что необходимо учитывать при назначении препарата Аркоксиа пациентам с лактазной недостаточностью. Во время лечения требуется соблюдать осторожность, управляя автомобилем или другим транспортом и занимаясь другой потенциально опасной деятельностью. Пациенты, у которых развивались такие побочные эффекты, как слабость, сонливость и головокружение, должны отказаться от занятий, связанных с высокой концентрацией внимания"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Селективный ингибитор ЦОГ-2, в терапевтических концентрациях блокирует образование простагландинов и оказывает противовоспалительное, анальгезирующее и жаропонижающее действие. Селективное угнетение ЦОГ-2 сопровождается уменьшением выраженности клинических симптомов, связанных с воспалительным процессом, при этом отсутствует влияние на функцию тромбоцитов и слизистую оболочку ЖКТ. Эторикоксиб обладает дозозависимым эффектом ингибирования ЦОГ-2, не оказывая влияние на ЦОГ-1 при применении в суточной дозе до 150 мг. Аркоксиа не оказывает влияния на выработку простагландинов в слизистой оболочке желудка и на время кровотечения. В проведенных исследованиях не наблюдалось снижения уровня арахидоновой кислоты и агрегации тромбоцитов, вызываемой коллагеном","substance":[{"id":688,"title":"Эторикоксиб","title_latin":null,"slug":"etorikoksib_688"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":{"count":100,"url":"/review/20208-arcoxia/"},"image_alt":"Аркоксиа - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/826/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/826/share_default/"}},"diseases":[],"other_packages":[{"id":93792,"title":"Аркоксиа","subtitle":{"full":"Таблетки, 14 шт, 60 мг, в пленочной оболочке","short":"Таблетки, 14 шт, 60 мг","package":"14 шт, 60 мг"},"prescription":true,"catalog_section_id":100267,"manufacturer":{"id":122,"title":"Мсд 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