Препарат, применяемый при астенических состояниях, позитивно влияющий на показатели физической и умственной работоспособности. Является производным адамантана. В спектре действия препарата сочетаются активирующее, анксиолитическое, иммуностимулирующее действия и элементы актопротекторной активности. У Ладастена отсутствуют гипноседативные и миорелаксирующие свойства, препарат не обладает аддиктивным потенциалом.; При применении Ладастена, в отличие от действия типичных психостимуляторов, практически не развиваются явления гиперстимуляции, а также последействия в виде истощения функциональных возможностей организма.; Терапевтическое действие Ладастена у больных с астеническими и тревожно-астеническими расстройствами проявляется с первых дней его применения в виде отчетливой редукции астенической симптоматики, показателей эмоционального напряжения, соматовегетативных проявлений; препарат способствует восстановлению активности и повышению выносливости.; Механизм действия Ладастена связан с усилением выброса допамина из пресинаптических терминалей, блокадой его обратного захвата и усилением биосинтеза, обусловленного экспрессией гена тирозин-гидроксилазы, а также с его модулирующим влиянием на GABA-бензодиазепиновый-хлорионоформный рецепторный комплекс, устраняющий снижение бензодиазепиновой рецепции, развивающейся при стрессе. Ладастен; усиливает GABA-ергическую медиацию, снижая экспрессию гена, контролирующего синтез GABA-транспортера, осуществляющего обратный захват медиатора.
Показания к применению
Астенические состояния различного генеза, в т.ч. при соматических заболеваниях и после перенесенных инфекционных заболеваний
Неврастения
Противопоказания
Беременность
Период лактации
Детский возраст до 18 лет
Повышенная чувствительность к компонентам препарата
Применение при беременности и в период грудного вскармливания
Противопоказано применение препарата Ладастен; при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Ладастен; принимают внутрь, независимо от приема пищи.; Разовая доза препарата - 50-100 мг; суточная доза составляет 100-200 мг в 2 приема.; Препарат не следует применять после 16 ч. Длительность курсового применения препарата составляет 2-4 недели.
Побочное действие
Со стороны ЦНС: могут отмечаться проявления избыточной активации и расстройства засыпания.; Прочие: аллергические реакции (при повышенной индивидуальной чувствительности к препарату).
Передозировка
При значительной передозировке возможно развитие седативного эффекта.; Лечение: неспецифическая дезинтоксикационная терапия.
Особые указания
При возникновении побочных эффектов со стороны ЦНС обычно не требуется отмены препарата, целесообразно уменьшить его дозу.
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