Лечение и профилактика анемии, обусловленной дефицитом фолиевой кислоты, в том числе при недостаточном ее поступлении с пищей, мальабсорбции, повышенной потребности (включая беременность, период кормления грудью, гемолитическую анемию, гипертиреоз, эксфолиативный дерматит или хронические инфекции); профилактика дефицита фолиевой кислоты во время беременности ...
Повышенная чувствительность к компонентам препарата. В12-дефицитная анемия; непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция; детский возраст до 3 лет.
Инструкция
Фармакологические свойства
Витамин группы В (витамин Вс, витамин В9), может синтезироваться микрофлорой кишечника. В организме фолиевая кислота восстанавливается до тетрагидрофолиевой кислоты, являющейся коферментом, которая служит акцептором одноуглеродных радикалов. Участвует в синтезе пуриновых и пиримидиновых оснований, метаболизме некоторых аминокислот (например, взаимопревращении серина и глицина), биосинтезе метилового радикала метионина и деградации гистидина, а также в созревании быстро пролиферирующих тканей, особенно крови и желудочно-кишечного тракта. Дефицит фолиевой кислоты ведет к мегалобластной анемии; при недостаточности фолиевой кислоты в I триместре беременности нарушается развитие нервной системы плода.
Показания к применению
Лечение и профилактика анемии, обусловленной дефицитом фолиевой кислоты, в том числе при недостаточном ее поступлении с пищей, мальабсорбции, повышенной потребности (включая беременность, период кормления грудью, гемолитическую анемию, гипертиреоз, эксфолиативный дерматит или хронические инфекции); профилактика дефицита фолиевой кислоты во время беременности и период кормления грудью.
Противопоказания
Повышенная чувствительность к компонентам препарата. В12-дефицитная анемия; непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция; детский возраст до 3 лет.
Применение при беременности и в период грудного вскармливания
Фолиевую кислоту можно применять при беременности и в период лактации в рекомендуемых дозах.
Побочное действие
Аллергические реакции: возможны кожная сыпь, зуд.
Особые указания
При пернициозной анемии фолиевую кислоту следует применять только совместно с цианокобаламином, поскольку фолиевая кислота, стимулируя гемопоэз, не предупреждает развития неврологических осложнений (в т.ч. фуникулярного миелоза). Длительное применение фолиевой кислоты (особенно в высоких дозах) не рекомендуется из-за риска снижения концентрации в крови цианокобаламина.
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