Энерион восстанавливает энергоресурсы организма на клеточном уровне: активное вещество аккумулируется в клетках ретикулярной системы, которая регулирует энергетический потенциал.
Энерион помогает справляться с состоянием переутомления, повышенной утомляемостью, снижением работоспособности и слабостью.
Энерион — оригинальный препарат, все стадии производства которого осуществляет компания «Лаборатории Сервье Индастри», Франция.
Круглые, двояковыпуклые таблетки, покрытые оболочкой, оранжевого цвета. Допускаются незначительная неоднородность поверхности (по степени глянцевости), окрашивания и наличие незначительных вкраплений.
Фармакологические свойства
Фармакодинамика: Сульбутиамин является оригинальным соединением, получаемым из тиамина путем ряда структурных модификаций ядра тиамина: образование дисульфидной связи, введение липофильного эфира и открытие тиазольного кольца.
Благодаря такой модификации, сульбутиамин:
o Хорошо растворим в жирах, что позволяет ему быстро всасываться из желудочно- кишечного тракта и легко проникать через гематоэнцефалический барьер;
o Способен накапливаться в клетках ретикулярной формации, гиппокампе и зубчатой извилине, а также клетках Пуркинье и клубочках зернистого слоя коры мозжечка, что подтверждается гистохимическим анализом.
В плацебо-контролируемых исследованиях у человека, а также в исследованиях с активным контролем были получены доказательства эффективности лекарственного препарата Энерион® при симптоматическом лечении функциональной астении.
Сульбутиамин метаболизируется до тиамина (витамина B1). В комплексе с аденозинтрифосфатом (АТФ) тиамин образует тиамина дифосфат (карбоксилазу или тиамина пирофосфат), который в качестве ко-фермента принимает участие в углеводном обмене.
Фармакокинетика
Сульботиамин быстро всасывается, концентрация сульбутиамина в плазме крови достигает максимума (Сmax) через 1-2 часа после приема. В дальнейшем концентрация сульбутиамина в крови уменьшается экспоненциально. Сульбутиамин быстро распределяется в организме, при этом в значительно мере попадает в головной мозг, что было продемонстрировано в экспериментах на животных.
Период полувыведения (T1/2) – около 5 часов. Сульбутиамин выводится с мочой. Сmax в моче наблюдается спустя 2-3 часа после приема.
Показания к применению
Состояния переутомления у взрослых, сопровождающиеся повышенной утомляемостью, снижением работоспособности, слабостью.
Противопоказания
Лицам до 18 лет противопоказан из-за отсутствия клинических данных.
Повышенная чувствительность к действующему веществу (сульбутиамину) или любому из компонентов препарата.
Лактазная недостаточность, галактоземия, синдром глюкозной/галактозной мальабсорбции, сахарозно-изомальтазная недостаточность, непереносимости фруктозы (см. раздел «Особые указания») в следствии содержания в препарате в составе вспомогательных веществ глюкозы, лактозы и сахарозы.
Беременность и период грудного вскармливания.
Применение при беременности и в период грудного вскармливания
Данные по применению сульбутиамина у женщин во время беременности ограничены. В качестве меры предосторожности, применение в период беременности и грудного вскармливания противопоказано.
Способ применения и дозы
Внутрь. Только для взрослых.
Суточная доза препарата: 2-3 таблетки (400 – 600 мг) в два приема (во время завтрака и обеда):
1 таблетка во время завтрака и 1 таблетка во время обеда,
Или 1 таблетка во время завтрака и 2 таблетки во время обеда, o Или 2 таблетки во время завтрака и 2 таблетки во время обеда.
Таблетки следует проглатывать целиком, запивая водой.
Продолжительность лечения не должна превышать 4 недель.
Не превышайте рекомендуемую дозу и продолжительность применения препарата.
Если Ваше состояние ухудшилось или улучшение не наступило через 4 недели, Вам следует обратиться к врачу.
Побочное действие
Частота побочных действий, которые могут возникать во время терапии, приведена в виде следующей градации: очень часто (≥1/10); часто (≥1/100, <1/10); нечасто (≥1/1000, <1/100); редко (≥1/10000, <1/1000); очень редко (<1/10000); неуточненной частоты (частота не может быть подсчитана по доступным данным).
Описанные отдельные нежелательные реакции
Риск развития аллергических реакций повышается из-за присутствия в составе препарата красителя солнечный закат FCF (E110) (см. раздел «Особые указания»).
Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.
Передозировка
Описанные отдельные нежелательные реакции
Риск развития аллергических реакций повышается из-за присутствия в составе препарата красителя солнечный закат FCF (E110) (см. раздел «Особые указания»).
Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.
Взаимодействие с другими лекарственными средствами
Клинических исследований по изучению взаимодействий сульбутиамина с другими лекарственными средствами не проводилось.
Взаимодействия, которые стоит принять во внимание:
o Средства, блокирующие нейромышечную передачу (миорелаксанты): эффект этих препаратов может возрастать при одновременном приеме с тиамином (метаболитом мульбутиамина);
o Диуретики: увеличивается выведение с мочой тиамина (метаболита сульбутиамина).
Особые указания
В состав вспомогательных веществ препарат входит глюкоза, лактоза и сахароза. Вследствие этого данный препарат противопоказан к применению у лиц с лактазной недостаточностью, галактоземией, синдромом глюкозной/галактозной мальабсорбции, сахарозной-изомальтазной недостаточностью, непереносимостью фруктозы.
В состав лекарственного препарата входит краситель солнечный закат FCF (E110). Он может вызвать развитие аллергических реакций (см. раздел «Побочное действие»).
Искажение результатов лабораторных анализов.
Препарат метаболизируется до тиамина, что может повлиять на результаты анализов:
o Определение мочевой кислоты фосфорно-вольфрамовым методом: препарат может вызвать ложноположительные результаты;
o Анализ мочи на уробилиноген с реактивом Эрлиха: может давать ложноположительные результаты.
o Тиамин в больших дозах может повлиять на спектрофотометрическое определение теофиллина в сыворотке крови по методу Шака и Вакслера.
Условия хранения
При температуре не выше 25 °С. Хранить в недоступных для детей местах.
Срок годности
3 года. Не применять после истечения срока годности, указанной на упаковке.
Условия отпуска
Отпускают без рецепта.
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вещество: Сульбутиамин 200,0 мг"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: крахмал кукурузный 12,0 мг, паста крахмальная высушенная 40,0 мг, глюкоза (декстроза) безводная 20,0 мг, лактозы моногидрат 65,5 мг, магния стеарат 3,50 мг, тальк 9,00 мг; Состав оболочки: натрия гидрокарбонат 0,603 мг, кармеллоза натрия 0,556 мг, воск белый пчелиный 0,201 мг, титана диоксид (E171) 8,430 мг, этилцеллюлоза 0,485 мг, краситель солнечный закат желтый FCF (E110) 3,000 мг, глицерола моноолеат 0,242 мг, полисорбат 80 0,302 мг, повидон К-30 0,692 мг, сахароза 106,956 мг, кремния диоксид коллоидный безводный (Aerosil 130®) 0,404 мг, тальк 28,210 мг."}}]},{"id":2,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Энерион восстанавливает энергоресурсы организма на клеточном уровне: активное вещество аккумулируется в клетках ретикулярной системы, которая регулирует энергетический потенциал."}},{"type":"paragraph","data":{"text":"Энерион помогает справляться с состоянием переутомления, повышенной утомляемостью, снижением работоспособности и слабостью."}},{"type":"paragraph","data":{"text":"Энерион — оригинальный препарат, все стадии производства которого осуществляет компания «Лаборатории Сервье Индастри», Франция."}},{"type":"paragraph","data":{"text":"Круглые, двояковыпуклые таблетки, покрытые оболочкой, оранжевого цвета. Допускаются незначительная неоднородность поверхности (по степени глянцевости), окрашивания и наличие незначительных вкраплений."}}]},{"id":3,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Фармакодинамика: Сульбутиамин является оригинальным соединением, получаемым из тиамина путем ряда структурных модификаций ядра тиамина: образование дисульфидной связи, введение липофильного эфира и открытие тиазольного кольца."}},{"type":"paragraph","data":{"text":"Благодаря такой модификации, сульбутиамин:"}},{"type":"paragraph","data":{"text":"o Хорошо растворим в жирах, что позволяет ему быстро всасываться из желудочно- кишечного тракта и легко проникать через гематоэнцефалический барьер;"}},{"type":"paragraph","data":{"text":"o Способен накапливаться в клетках ретикулярной формации, гиппокампе и зубчатой извилине, а также клетках Пуркинье и клубочках зернистого слоя коры мозжечка, что подтверждается гистохимическим анализом."}},{"type":"paragraph","data":{"text":"В плацебо-контролируемых исследованиях у человека, а также в исследованиях с активным контролем были получены доказательства эффективности лекарственного препарата Энерион® при симптоматическом лечении функциональной астении."}},{"type":"paragraph","data":{"text":"Сульбутиамин метаболизируется до тиамина (витамина B1). В комплексе с аденозинтрифосфатом (АТФ) тиамин образует тиамина дифосфат (карбоксилазу или тиамина пирофосфат), который в качестве ко-фермента принимает участие в углеводном обмене."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"Сульботиамин быстро всасывается, концентрация сульбутиамина в плазме крови достигает максимума (Сmax) через 1-2 часа после приема. В дальнейшем концентрация сульбутиамина в крови уменьшается экспоненциально. Сульбутиамин быстро распределяется в организме, при этом в значительно мере попадает в головной мозг, что было продемонстрировано в экспериментах на животных."}},{"type":"paragraph","data":{"text":"Период полувыведения (T1/2) – около 5 часов. Сульбутиамин выводится с мочой. Сmax в моче наблюдается спустя 2-3 часа после приема."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Состояния переутомления у взрослых, сопровождающиеся повышенной утомляемостью, снижением работоспособности, слабостью."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Лицам до 18 лет противопоказан из-за отсутствия клинических данных."}},{"type":"paragraph","data":{"text":"Повышенная чувствительность к действующему веществу (сульбутиамину) или любому из компонентов препарата."}},{"type":"paragraph","data":{"text":"Лактазная недостаточность, галактоземия, синдром глюкозной/галактозной мальабсорбции, сахарозно-изомальтазная недостаточность, непереносимости фруктозы (см. раздел «Особые указания») в следствии содержания в препарате в составе вспомогательных веществ глюкозы, лактозы и сахарозы."}},{"type":"paragraph","data":{"text":"Беременность и период грудного вскармливания."}}]},{"id":6,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Данные по применению сульбутиамина у женщин во время беременности ограничены. В качестве меры предосторожности, применение в период беременности и грудного вскармливания противопоказано."}}]},{"id":7,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь. Только для взрослых."}},{"type":"paragraph","data":{"text":"Суточная доза препарата: 2-3 таблетки (400 – 600 мг) в два приема (во время завтрака и обеда):"}},{"type":"list","data":{"style":"unordered","items":["1 таблетка во время завтрака и 1 таблетка во время обеда,"]}},{"type":"list","data":{"style":"unordered","items":["Или 1 таблетка во время завтрака и 2 таблетки во время обеда, o Или 2 таблетки во время завтрака и 2 таблетки во время обеда."]}},{"type":"paragraph","data":{"text":"Таблетки следует проглатывать целиком, запивая водой."}},{"type":"paragraph","data":{"text":"Продолжительность лечения не должна превышать 4 недель."}},{"type":"paragraph","data":{"text":"Не превышайте рекомендуемую дозу и продолжительность применения препарата."}},{"type":"paragraph","data":{"text":"Если Ваше состояние ухудшилось или улучшение не наступило через 4 недели, Вам следует обратиться к врачу."}}]},{"id":8,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота побочных действий, которые могут возникать во время терапии, приведена в виде следующей градации: очень часто (≥1/10); часто (≥1/100, \u003c1/10); нечасто (≥1/1000, \u003c1/100); редко (≥1/10000, \u003c1/1000); очень редко (\u003c1/10000); неуточненной частоты (частота не может быть подсчитана по доступным данным)."}},{"type":"paragraph","data":{"text":""}},{"type":"paragraph","data":{"text":"Описанные отдельные нежелательные реакции"}},{"type":"paragraph","data":{"text":"Риск развития аллергических реакций повышается из-за присутствия в составе препарата красителя солнечный закат FCF (E110) (см. раздел «Особые указания»)."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Описанные отдельные нежелательные реакции"}},{"type":"paragraph","data":{"text":"Риск развития аллергических реакций повышается из-за присутствия в составе препарата красителя солнечный закат FCF (E110) (см. раздел «Особые указания»)."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":10,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Клинических исследований по изучению взаимодействий сульбутиамина с другими лекарственными средствами не проводилось."}},{"type":"paragraph","data":{"text":"Взаимодействия, которые стоит принять во внимание:"}},{"type":"paragraph","data":{"text":"o Средства, блокирующие нейромышечную передачу (миорелаксанты): эффект этих препаратов может возрастать при одновременном приеме с тиамином (метаболитом мульбутиамина);"}},{"type":"paragraph","data":{"text":"o Диуретики: увеличивается выведение с мочой тиамина (метаболита сульбутиамина)."}}]},{"id":11,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В состав вспомогательных веществ препарат входит глюкоза, лактоза и сахароза. Вследствие этого данный препарат противопоказан к применению у лиц с лактазной недостаточностью, галактоземией, синдромом глюкозной/галактозной мальабсорбции, сахарозной-изомальтазной недостаточностью, непереносимостью фруктозы."}},{"type":"paragraph","data":{"text":"В состав лекарственного препарата входит краситель солнечный закат FCF (E110). Он может вызвать развитие аллергических реакций (см. раздел «Побочное действие»)."}},{"type":"paragraph","data":{"text":"Искажение результатов лабораторных анализов."}},{"type":"paragraph","data":{"text":"Препарат метаболизируется до тиамина, что может повлиять на результаты анализов:"}},{"type":"paragraph","data":{"text":"o Определение мочевой кислоты фосфорно-вольфрамовым методом: препарат может вызвать ложноположительные результаты;"}},{"type":"paragraph","data":{"text":"o Анализ мочи на уробилиноген с реактивом Эрлиха: может давать ложноположительные результаты."}},{"type":"paragraph","data":{"text":"o Тиамин в больших дозах может повлиять на спектрофотометрическое определение теофиллина в сыворотке крови по методу Шака и Вакслера."}}]},{"id":12,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С. 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