Миотропный спазмолитик, по химической структуре и фармакологическим свойствам близок к папаверину, но обладает более сильным и продолжительным действием. Уменьшает поступление ионов кальция в гладкомышечные клетки. Снижает тонус гладких мышц внутренних органов и перистальтику кишечника, расширяет кровеносные сосуды. Не влияет на вегетативную нервную систему, не проникает в ЦНС. Непосредственное влияние на гладкую мускулатуру позволяет использовать его в качестве спазмолитика, когда противопоказаны лекарственные средства из группы м-холиноблокаторов (закрытоугольная глаукома, гиперплазия предстательной железы).
Показания к применению
При спазмах и болевом синдроме спастического характера, возникающих при следующих состояниях:
Спазм гладких мышц внутренних органов (почечная колика, желчная колика, кишечная колика)
Дискинезия желчевыводящих путей и желчного пузыря по гиперкинетическому типу, холецистит, постхолецистэктомический синдром, пиелит
Пилороспазм, гастродуоденит, язвенная болезнь желудка и двенадцатиперстной кишки (в фазе обострения, в составе комплексной терапии - для снятия болевого синдрома спастического характера)
Эндартериит
Спазм периферических, коронарных артерий, а также спазм церебральных артерий, сопровождающийся головными болями
Альгодисменорея
Для снижения возбудимости матки при беременности (угрожающий выкидыш, угрожающие преждевременные роды), спазм зева матки во время родов, затяжное раскрытие зева, послеродовые схватки. Для профилактики возникновения спазма при проведении некоторых инструментальных исследований, холецистографии
Противопоказания
Выраженная печеночная недостаточность
Выраженная почечная недостаточность
Хроническая сердечная недостаточность
AV-блокада II и III степени
Кардиогенный шок
Артериальная гипотензия
Повышенная чувствительность к компонентам препарата. Таблетки Спазмонет содержат лактозу, поэтому пациентам с врожденной непереносимостью галактозы, лактазной недостаточностью или глюкозо-галактозной мальабсорбцией не следует принимать препарат. С осторожностью следует назначать препарат детям в возрасте до 6 лет, при выраженном атеросклерозе коронарных артерий, закрытоугольной глаукоме, гиперплазии предстательной железы
Применение при беременности и в период грудного вскармливания
Назначение препарата при беременности и в период лактации не противопоказано, однако следует применять с осторожностью, особенно в I триместре беременности.
Способ применения и дозы
Внутрь, запивая небольшим количеством жидкости. Детям в возрасте до 6 лет назначают по 10-20 мг 1-2 раза/сут, максимальная суточная доза - 120 мг; детям в возрасте от 6 до 12 лет - 1/2 таб. 2 раза/сут (20-40 мг), максимальная суточная доза - 200 мг; взрослым и детям старше 12 лет - по 1-2 таб. 3 раза/сут (120-240 мг).
Симптомы: в больших дозах дротаверин нарушает AV-проводимость, снижает возбудимость сердечной мышцы, может вызвать остановку сердца и паралич дыхательного центра.
Особые указания
При лечении язвенной болезни желудка и двенадцатиперстной кишки препарат применяют в сочетании с другими противоязвенными средствами. Влияние на способность к вождению автотранспорта и управлению механизмами В период применения препарата необходимо воздерживаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими концентрации внимания и быстроты психомоторных реакций.
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