Фармакологическое действие - средство для лечения деменции. Инструкция
Показания к применению
Деменция альцгеймеровского типа, сосудистая деменция, смешанная деменция всех степеней тяжести.
Противопоказания
Индивидуальная повышенная чувствительность к препарату. Беременность. Грудное вскармливание. Тяжелая почечная недостаточность ( клиренс креатинина 5 - 29 мл/мин). Тяжелая печеночная недостаточность . Дети до 18 лет (в связи с недостаточностью данных). С осторожностью следует назначать: Тиреотоксикоз. Эпилепсия . Судороги (в том числе в анамнезе). Одновременное ...
Фармакологическое действие - средство для лечения деменции.
Показания к применению
Деменция альцгеймеровского типа, сосудистая деменция, смешанная деменция всех степеней тяжести.
Противопоказания
Индивидуальная повышенная чувствительность к препарату. Беременность. Грудное вскармливание. Тяжелая почечная недостаточность ( клиренс креатинина 5 - 29 мл/мин). Тяжелая печеночная недостаточность . Дети до 18 лет (в связи с недостаточностью данных). С осторожностью следует назначать: Тиреотоксикоз. Эпилепсия . Судороги (в том числе в анамнезе). Одновременное применение антагонистов NMDA - рецепторов: Амантадин . Кетамин . Декстрометорфан . Факторы, повышающие рН мочи: Резкая смена диеты (переход на вегетарианство). Обильный прием щелочных желудочных буферов. Тяжелые инфекции мочевыводящих путей. Инфаркт миокарда (в анамнезе). Хроническая сердечная недостаточность III - IV функциональный класс (по классификации NYHA). Неконтролируемая артериальная гипертензия . Печеночная недостаточность.
Применение при беременности и в период грудного вскармливания
Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание.
Способ применения и дозы
Внутрь, во время еды. Режим дозирования устанавливается индивидуально. Начинать лечение рекомендуется с назначения минимально эффективных доз. Взрослым при деменции в течение 1-й недели терапии - в дозе 5 мг/сут, 2-й недели - в дозе 10 мг/сут, 3-й недели - в дозе 15–20 мг/сут. При необходимости возможно дальнейшее еженедельное повышение дозы на 10 мг до достижения суточной дозы - 30 мг. Оптимальная доза достигается постепенно, при увеличении дозы каждую неделю.
Побочное действие
Побочное реакции классифицированы по клиническим проявлениям (в соответствии с поражением определенных систем органов) и по частоте встречаемости: очень часто - ≥1/10; часто - ≥1/100–<1/10; нечасто - ≥1/1000–≤1/100); редко - ≥1/10000–<1/1000; очень редко - ≤1/10000; частота не установлена - в настоящее время данные о распространенности побочных реакций отсутствуют. Галлюцинации наблюдались, главным образом, у пациентов с болезнью Альцгеймера на стадии тяжелой деменции. Имеются отдельные сообщения о возникновении этих побочных реакций при применении препарата в клинической практике (данные, полученные после появления препарата в продаже).
У пациентов с болезнью Альцгеймера на стадии умеренной и тяжелой деменции обычно нарушена способность к вождению автотранспорта и управлению сложными механизмами. Кроме того, мемантин может вызывать изменение скорости реакции, поэтому пациентам, получающим лечение в амбулаторных условиях, следует соблюдать особую осторожность при вождении автотранспорта или управлении механизмами.
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