Слабилен Таблетки, 20 шт, 5 мг

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Это приводит к стимуляции акта дефекации, уменьшению\nвремени эвакуации и размягчению стула. Действие наступает через            10-12 часов после приема."}},{"type":"paragraph","data":{"text":"Натрия пикосульфат, являясь\nслабительным средством, действующим на уровне толстой кишки, стимулирует\nестественный процесс эвакуации содержимого из нижних отделов\nжелудочно-кишечного тракта. Поэтому натрия пикосульфат не оказывает влияния на\nпереваривание или всасывание калорийной пищи или незаменимых питательных\nвеществ в тонком кишечнике. "}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Абсорбция незначительная, препарат\nпрактически полностью метаболизируется в стенке кишечника и печени до\nнеактивного глюкуронида. "}},{"type":"paragraph","data":{"text":"После перорального приема натрия\nпикосульфат проходит в неизменённом виде через желудок и тонкий кишечник,\nпоступая в толстый кишечник. Абсорбция препарата незначительна, что исключает\nего энтерогепатическую циркуляцию. В дистальном отделе толстого кишечника\nпроисходит расщепление натрия пикосульфата с образованием активного метаболита,\nбис-(п-гидроксифенил)-пиридил-2-метана. "}},{"type":"paragraph","data":{"text":"Взаимосвязь между слабительным\nэффектом активного метаболита и его концентрацией в сыворотке крови\nотсутствует."}},{"type":"paragraph","data":{"text":"После приема 10 мг препарата внутрь\nоколо 10,4 % от величины общей дозы выводится почками в виде глюкуронида через\n48 часов. При применении более высоких доз препарата выведение его почками, в\nцелом, уменьшается."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В качестве слабительного средства в\nследующих случаях:"}},{"type":"paragraph","data":{"text":"-      запор, обусловленный атонией и\nгипотонией толстой кишки (в том числе в пожилом возрасте, у лежачих больных,\nпосле операций, после родов, в период грудного вскармливания);"}},{"type":"paragraph","data":{"text":"-      запор, вызванный приемом\nлекарственных средств;"}},{"type":"paragraph","data":{"text":"-      для регулирования стула при геморрое,\nпроктите, анальных трещинах (для размягчения консистенции кала);"}},{"type":"paragraph","data":{"text":"-      заболевания желчного пузыря, синдром\nраздраженного кишечника с преобладанием запоров;"}},{"type":"paragraph","data":{"text":"-      запор, обусловленный дисбактериозом\nкишечника, нарушением диеты."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"-      Кишечная непроходимость или обструктивные\nзаболевания кишечника"}},{"type":"paragraph","data":{"text":"-      Острые заболевания органов брюшной\nполости или сильная боль в животе, которые могут сопровождаться тошнотой,\nрвотой, повышением температуры тела, включая аппендицит"}},{"type":"paragraph","data":{"text":"-      Острые воспалительные заболевания\nкишечника"}},{"type":"paragraph","data":{"text":"-      Повышенная чувствительность к натрия\nпикосульфату или другим компонентам препарата"}},{"type":"paragraph","data":{"text":"-      Тяжелая дегидратация"}},{"type":"paragraph","data":{"text":"-      Дефицит лактазы, непереносимость\nлактозы, глюкозо-галактозная мальабсорбция;"}},{"type":"paragraph","data":{"text":"-      Детский возраст до 10 лет (для данной\nлекарственной формы, детям младше 10 лет рекомендуется прием препарата Слабилен\u003csup\u003e®\n\u003c/sup\u003eв другой лекарственной форме – капли для приема внутрь)"}},{"type":"paragraph","data":{"text":"-      Беременность (I триместр)"}}]},{"id":13,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"-      II\nи III\nтриместры беременности"}},{"type":"paragraph","data":{"text":"-      Период лактации"}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eПрименение при беременности\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В течение длительного опыта\nприменения препарата нежелательных явлений во время беременности выявлено не\nбыло. Однако, в виду отсутствия достоверных и хорошо контролируемых\nисследований, применение пикосульфата натрия во время беременности\nрекомендовано только в случаях, если потенциальная польза для матери превышает\nвозможный риск для плода.  В период\nбеременности препарат может быть применен только после консультации со\nспециалистом. Применение препарата в I триместре беременности противопоказано."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрименение в период грудного вскармливания\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Активный метаболит и его глюкурониды\nне выделяются с грудным молоком. Таким образом, препарат может быть использован\nв период грудного вскармливания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФертильность\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Исследования о влиянии препарата на\nфертильность не проводились. В ходе доклинических исследований тератогенных\nэффектов на репродуктивность выявлено не было."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь,\nцеликом, не разламывая, запивая небольшим количеством воды, перед сном. Для\nвзрослых и детей старше 10 лет начальная доза – 5 мг (1 таблетка по 5 мг) 1 раз\nв сутки, при стойких запорах – до 10 мг (2 таблетки по 5 мг) 1 раз в сутки. В\nзависимости от полученного эффекта дозу при последующих приемах увеличивают или\nуменьшают. Максимальная суточная доза – 15 мг (3 таблетки по 5 мг или 2\nтаблетки по 7,5 мг или        1 таблетка по 15 мг)."}},{"type":"paragraph","data":{"text":"Рекомендуется начинать с наименьшей\nдозы. Для того, чтобы достичь регулярного стула, доза может повышаться до\nмаксимальной рекомендуемой. Не следует превышать максимальную рекомендуемую\nсуточную дозу. "}},{"type":"paragraph","data":{"text":"Для получения слабительного эффекта в\nутренние часы следует принимать препарат накануне на ночь."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны желудочно-кишечного тракта \u003c/i\u003eвозможны дискомфорт, тошнота, рвота, спазмы и боли в области\nживота, диарея."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы \u003c/i\u003eвозможны головокружение и обморок. Головокружение и обморок,\nвозникающие после приема препарата, по-видимому, связаны с вазовагальным ответом\n(например, напряжением при дефекации, спазмами в области живота). "}},{"type":"paragraph","data":{"text":"Возможны реакции повышенной\nчувствительности со стороны иммунной системы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны кожи и подкожных тканей\u003c/i\u003e возможны кожные реакции, например, ангионевротический отек,\nлекарственная сыпь, кожная сыпь, кожный зуд. \n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: при\nприеме высоких доз возможны:\u003ci\u003e \u003c/i\u003eдиарея, обезвоживание, снижение артериального давления,\nнарушения водно-электролитного баланса, гипокалиемия, судороги. Кроме того,\nимеются сообщения о случаях ишемии мускулатуры толстого кишечника, связанных с\nприемом доз натрия пикосульфата, значительно превышающих рекомендованные для\nобычного лечения запора. "}},{"type":"paragraph","data":{"text":"Препарат Слабилен\u003csup\u003e®\u003c/sup\u003e, как и\nдругие слабительные, при хронической передозировке может привести к хронической\nдиарее, болях в области живота, гипокалиемии, вторичному гиперальдостеронизму,\nмочекаменной болезни. В связи с хроническим злоупотреблением слабительными\nможет развиться повреждение почечных канальцев, метаболический алкалоз и\nмышечная слабость, связанная с гипокалиемией. \n"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение: \u003c/i\u003eдля уменьшения абсорбции препарата\nпосле приема внутрь можно вызвать рвоту или провести промывание желудка. Может\nпотребоваться восполнение жидкости и коррекция баланса электролитов, а также\nназначение спазмолитических средств. \u003ci\u003e\u003c/i\u003e"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Диуретики или глюкокортикостероиды увеличивают риск\nнарушения электролитного баланса (гипокалиемии) при приеме высоких доз препарата. Нарушение электролитного баланса\nможет повышать чувствительность к сердечным гликозидам. "}},{"type":"paragraph","data":{"text":"Совместное\nприменение препарата и антибиотиков может снижать послабляющий эффект препарата."}}]},{"id":8,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат Слабилен\u003csup\u003e®\u003c/sup\u003e\nне следует применять ежедневно без консультации врача более       10 дней. Длительный прием высоких доз\nпрепарата может приводить к потере жидкости, нарушению баланса электролитов,\nгипокалиемии."}},{"type":"paragraph","data":{"text":"Головокружение\nи обмороки наблюдались у пациентов, принимавших пикосульфат натрия. Анализ\nпоказал, что эти случаи связаны с обмороком при дефекации (или обмороком,\nвызванным напряжением при дефекации), или с вазовагальным ответом на боль в\nживоте, которая может быть обусловлена запором, и не обязательно связана с\nприемом препарата."}},{"type":"paragraph","data":{"text":"Препарат\nсодержит лактозы моногидрат."}},{"type":"paragraph","data":{"text":"У детей следует применять только по\nназначению врача."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Специальных\nклинических исследований влияния препарата на способность управлять транспортными\nсредствами, механизмами не проводилось. Несмотря на это пациентам следует\nсообщать, что у них вследствие вазовагальной реакции (т.е. во время спазма\nкишечника) могут возникать головокружение и/или обморок. Если у пациентов\nвозникает спазм кишечника, они должны избегать потенциально опасных видов\nдеятельности, в том числе вождения автотранспорта или управления механизмами."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При\nтемпературе не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей\nместе. "}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока\nгодности, указанного на упаковке.\u003cb\u003e\u003c/b\u003e"}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО «ВЕРОФАРМ»"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЮридический адрес:\u003c/i\u003e Россия, 107023, г. Москва, Барабанный пер., д. 3. \n"}},{"type":"paragraph","data":{"text":"\u003ca\u003e\u003ci\u003eАдрес производства и принятия\nпретензий:\u003c/i\u003e\u003c/a\u003e Россия, 308013, г. Белгород,\nул. Рабочая, д.14."}},{"type":"paragraph","data":{"text":"Тел.:\n(4722) 21-32-26; факс: (4722) 21-34-71. "}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаДействующее вещество – натрия пикосульфат представляет собой слабительное триарилметановой группы. Как местное слабительное натрия пикосульфат после бактериального расщепления в толстом кишечнике оказывает стимулирующее действие на слизистую толстого кишечника, увеличивая перистальтику, способствует накоплению воды и электролитов в толстом кишечнике. Это приводит к стимуляции акта дефекации, уменьшению времени эвакуации и размягчению стула. Действие наступает через 10-12 часов после приема. Натрия пикосульфат, являясь слабительным средством, действующим на уровне толстой кишки, стимулирует естественный процесс эвакуации содержимого из нижних отделов желудочно-кишечного тракта. Поэтому натрия пикосульфат не оказывает влияния на переваривание или всасывание калорийной пищи или незаменимых питательных веществ в тонком кишечнике.ФармакокинетикаАбсорбция незначительная, препарат практически полностью метаболизируется в стенке кишечника и печени до неактивного глюкуронида. После перорального приема натрия пикосульфат проходит в неизменённом виде через желудок и тонкий кишечник, поступая в толстый кишечник. Абсорбция препарата незначительна, что исключает его энтерогепатическую циркуляцию. В дистальном отделе толстого кишечника происходит расщепление натрия пикосульфата с образованием активного метаболита, бис-(п-гидроксифенил)-пиридил-2-метана. Взаимосвязь между слабительным эффектом активного метаболита и его концентрацией в сыворотке крови отсутствует. После приема 10 мг препарата внутрь около 10,4 % от величины общей дозы выводится почками в виде глюкуронида через 48 часов. При применении более высоких доз препарата выведение его почками, в целом, уменьшается.","substance":[{"id":470,"title":"Натрия пикосульфат","title_latin":"Natrii picosulfas","slug":"natriya_pikosulfat_470"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Слабилен - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/61923/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/61923/share_default/"}},"diseases":[{"id":"880","title":"Запор","slug":"880-zapor"},{"id":"1400","title":"Подготовительные процедуры для последующего лечения или обследования, не классифицированные в других рубриках","slug":"1400-podgotovitelnye_protsedury_dlya_posleduyuschego_lecheniya_ili_obsledovaniya_ne_klassifitsirovannye_v_drugih_rubrikah"}],"other_packages":[{"id":166799,"title":"Слабилен","subtitle":{"full":"Таблетки, коробка, 10 шт, 5 мг, для приема внутрь, покрытые 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